Published in Cell on August 09, 2002
The impact of retrotransposons on human genome evolution. Nat Rev Genet (2009) 8.08
Mobile elements create structural variation: analysis of a complete human genome. Genome Res (2009) 7.06
Hot L1s account for the bulk of retrotransposition in the human population. Proc Natl Acad Sci U S A (2003) 6.16
LINE-1 retrotransposition activity in human genomes. Cell (2010) 4.60
Retroviral DNA integration: viral and cellular determinants of target-site selection. PLoS Pathog (2006) 3.67
Mosaic copy number variation in human neurons. Science (2013) 3.57
Human L1 element target-primed reverse transcription in vitro. EMBO J (2002) 3.54
A human genome structural variation sequencing resource reveals insights into mutational mechanisms. Cell (2010) 3.22
Selection of target sites for mobile DNA integration in the human genome. PLoS Comput Biol (2006) 3.21
Human genomic deletions mediated by recombination between Alu elements. Am J Hum Genet (2006) 3.15
The human LINE-1 retrotransposon creates DNA double-strand breaks. J Mol Biol (2006) 2.77
Multiple fates of L1 retrotransposition intermediates in cultured human cells. Mol Cell Biol (2005) 2.77
Dynamic interactions between transposable elements and their hosts. Nat Rev Genet (2011) 2.61
LINE-1 elements in structural variation and disease. Annu Rev Genomics Hum Genet (2011) 2.42
Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma. Cell (2013) 2.28
LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes? Trends Neurosci (2010) 2.12
A systematic analysis of LINE-1 endonuclease-dependent retrotranspositional events causing human genetic disease. Hum Genet (2005) 2.10
Analysis of primate genomic variation reveals a repeat-driven expansion of the human genome. Genome Res (2003) 2.07
Inviting instability: Transposable elements, double-strand breaks, and the maintenance of genome integrity. Mutat Res (2006) 2.00
Environmental epigenetics. Heredity (Edinb) (2010) 1.99
LINE drive. retrotransposition and genome instability. Cell (2002) 1.92
All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition. Nucleic Acids Res (2007) 1.79
Selective inhibition of Alu retrotransposition by APOBEC3G. Gene (2006) 1.75
Genomic rearrangements by LINE-1 insertion-mediated deletion in the human and chimpanzee lineages. Nucleic Acids Res (2005) 1.73
L1 retrotransposition in nondividing and primary human somatic cells. Proc Natl Acad Sci U S A (2006) 1.73
Genes and transposons are differentially methylated in plants, but not in mammals. Genome Res (2003) 1.66
L1 mobile element expression causes multiple types of toxicity. Gene (2008) 1.60
Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells. Cancer Cell Int (2006) 1.59
A YY1-binding site is required for accurate human LINE-1 transcription initiation. Nucleic Acids Res (2004) 1.59
Gene-breaking: a new paradigm for human retrotransposon-mediated gene evolution. Genome Res (2005) 1.58
All y'all need to know 'bout retroelements in cancer. Semin Cancer Biol (2010) 1.52
L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci (2016) 1.51
Analysis of 5' junctions of human LINE-1 and Alu retrotransposons suggests an alternative model for 5'-end attachment requiring microhomology-mediated end-joining. Genome Res (2005) 1.50
L1 integration in a transgenic mouse model. Genome Res (2005) 1.50
LINE-1 expression and retrotransposition in Barrett's esophagus and esophageal carcinoma. Proc Natl Acad Sci U S A (2015) 1.49
The rice nuclear genome continuously integrates, shuffles, and eliminates the chloroplast genome to cause chloroplast-nuclear DNA flux. Plant Cell (2005) 1.49
Active retrotransposition by a synthetic L1 element in mice. Proc Natl Acad Sci U S A (2006) 1.48
Recurrent duplication-driven transposition of DNA during hominoid evolution. Proc Natl Acad Sci U S A (2006) 1.47
Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells. Nature (2010) 1.47
Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells. Proc Natl Acad Sci U S A (2011) 1.45
Retrotransposition of marked SVA elements by human L1s in cultured cells. Hum Mol Genet (2011) 1.45
R2 target-primed reverse transcription: ordered cleavage and polymerization steps by protein subunits asymmetrically bound to the target DNA. Mol Cell Biol (2005) 1.39
The non-autonomous retrotransposon SVA is trans-mobilized by the human LINE-1 protein machinery. Nucleic Acids Res (2011) 1.35
Mobile DNA elements in the generation of diversity and complexity in the brain. Nat Rev Neurosci (2014) 1.35
A potential role for RNA interference in controlling the activity of the human LINE-1 retrotransposon. Nucleic Acids Res (2005) 1.34
A mobile threat to genome stability: The impact of non-LTR retrotransposons upon the human genome. Semin Cancer Biol (2010) 1.34
Genome-wide analysis of the human Alu Yb-lineage. Hum Genomics (2004) 1.33
Extensive individual variation in L1 retrotransposition capability contributes to human genetic diversity. Proc Natl Acad Sci U S A (2006) 1.32
Reprogramming somatic cells into iPS cells activates LINE-1 retroelement mobility. Hum Mol Genet (2011) 1.31
Gamma radiation increases endonuclease-dependent L1 retrotransposition in a cultured cell assay. Nucleic Acids Res (2006) 1.30
Endonuclease-independent insertion provides an alternative pathway for L1 retrotransposition in the human genome. Nucleic Acids Res (2007) 1.29
Genetic evidence that the non-homologous end-joining repair pathway is involved in LINE retrotransposition. PLoS Genet (2009) 1.28
Epigenetic control of mammalian LINE-1 retrotransposon by retinoblastoma proteins. Mutat Res (2009) 1.27
Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications. Clin Epigenetics (2011) 1.26
Different evolutionary fates of recently integrated human and chimpanzee LINE-1 retrotransposons. Gene (2006) 1.26
DNA transposons: nature and applications in genomics. Curr Genomics (2010) 1.25
ERCC1/XPF limits L1 retrotransposition. DNA Repair (Amst) (2008) 1.23
The NF1 gene contains hotspots for L1 endonuclease-dependent de novo insertion. PLoS Genet (2011) 1.23
Molecular evolution of piRNA and transposon control pathways in Drosophila. Cold Spring Harb Symp Quant Biol (2010) 1.21
Loss of LINE-1 activity in the megabats. Genetics (2008) 1.21
SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age. Nat Commun (2014) 1.19
Allelic heterogeneity in LINE-1 retrotransposition activity. Am J Hum Genet (2003) 1.13
Cell divisions are required for L1 retrotransposition. Mol Cell Biol (2006) 1.13
Association of nuclear localization of a long interspersed nuclear element-1 protein in breast tumors with poor prognostic outcomes. Genes Cancer (2010) 1.12
Repetitive sequence environment distinguishes housekeeping genes. Gene (2006) 1.12
Computational identification of 69 retroposons in Arabidopsis. Plant Physiol (2005) 1.12
Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic. Proc Natl Acad Sci U S A (2003) 1.09
Blood leukocyte Alu and LINE-1 methylation and gastric cancer risk in the Shanghai Women's Health Study. Br J Cancer (2011) 1.08
Retrotransposition-Competent Human LINE-1 Induces Apoptosis in Cancer Cells With Intact p53. J Biomed Biotechnol (2004) 1.08
The genomic distribution of L1 elements: the role of insertion bias and natural selection. J Biomed Biotechnol (2006) 1.08
Species specificity in rodent pheromone receptor repertoires. Genome Res (2004) 1.05
Nickel stimulates L1 retrotransposition by a post-transcriptional mechanism. J Mol Biol (2005) 1.05
Characterization of active R2 retrotransposition in the rDNA locus of Drosophila simulans. Genetics (2005) 1.05
Transcriptional regulation of the human LINE-1 retrotransposon L1.2B. Mol Genet Genomics (2003) 1.04
Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons. Nucleic Acids Res (2011) 1.04
Analysis of the human Alu Ye lineage. BMC Evol Biol (2005) 1.03
High-resolution comparative mapping among man, cattle and mouse suggests a role for repeat sequences in mammalian genome evolution. BMC Genomics (2006) 1.03
Characterization of pre-insertion loci of de novo L1 insertions. Gene (2006) 1.01
Transposable element detection from whole genome sequence data. Mob DNA (2015) 0.99
Role of RNA polymerase III transcription factors in the selection of integration sites by the dictyostelium non-long terminal repeat retrotransposon TRE5-A. Mol Cell Biol (2006) 0.99
More active human L1 retrotransposons produce longer insertions. Nucleic Acids Res (2004) 0.99
Comprehensive analysis of endogenous bornavirus-like elements in eukaryote genomes. Philos Trans R Soc Lond B Biol Sci (2013) 0.98
Prognostic value of LINE-1 retrotransposon expression and its subcellular localization in breast cancer. Breast Cancer Res Treat (2012) 0.98
The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes. Microbiol Spectr (2015) 0.96
Functional endogenous LINE-1 retrotransposons are expressed and mobilized in rat chloroleukemia cells. Nucleic Acids Res (2007) 0.95
euL1db: the European database of L1HS retrotransposon insertions in humans. Nucleic Acids Res (2014) 0.95
An active non-LTR retrotransposon with tandem structure in the compact genome of the pufferfish Tetraodon nigroviridis. Genome Res (2003) 0.95
An improved method for genome wide DNA methylation profiling correlated to transcription and genomic instability in two breast cancer cell lines. BMC Genomics (2009) 0.95
Expressing genes do not forget their LINEs: transposable elements and gene expression. Front Biosci (Landmark Ed) (2012) 0.94
LINE-1 endonuclease-dependent retrotranspositional events causing human genetic disease: mutation detection bias and multiple mechanisms of target gene disruption. J Biomed Biotechnol (2006) 0.94
Novel retrotransposon analysis reveals multiple mobility pathways dictated by hosts. Genome Res (2006) 0.94
Essential domains for ribonucleoprotein complex formation required for retrotransposition of telomere-specific non-long terminal repeat retrotransposon SART1. Mol Cell Biol (2006) 0.94
Teaching an old dog new tricks: SINEs of canine genomic diversity. Proc Natl Acad Sci U S A (2006) 0.94
Alu distribution and mutation types of cancer genes. BMC Genomics (2011) 0.93
Targeted nuclear import of open reading frame 1 protein is required for in vivo retrotransposition of a telomere-specific non-long terminal repeat retrotransposon, SART1. Mol Cell Biol (2004) 0.93
Increased expression and copy number amplification of LINE-1 and SINE B1 retrotransposable elements in murine mammary carcinoma progression. Oncotarget (2013) 0.93
Determinants for DNA target structure selectivity of the human LINE-1 retrotransposon endonuclease. Nucleic Acids Res (2007) 0.93
Roles for retrotransposon insertions in human disease. Mob DNA (2016) 0.92
Mutagenesis in rodents using the L1 retrotransposon. Genome Biol (2007) 0.92
Identifying related L1 retrotransposons by analyzing 3' transduced sequences. Genome Biol (2003) 0.92
Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature (2005) 6.95
Hot L1s account for the bulk of retrotransposition in the human population. Proc Natl Acad Sci U S A (2003) 6.16
L1 retrotransposition in human neural progenitor cells. Nature (2009) 4.78
LINE-1 retrotransposition activity in human genomes. Cell (2010) 4.60
DNA repair mediated by endonuclease-independent LINE-1 retrotransposition. Nat Genet (2002) 4.58
Cellular inhibitors of long interspersed element 1 and Alu retrotransposition. Proc Natl Acad Sci U S A (2006) 3.76
Mobile elements and mammalian genome evolution. Curr Opin Genet Dev (2003) 3.68
Research capacity. Enabling the genomic revolution in Africa. Science (2014) 3.05
Multiple fates of L1 retrotransposition intermediates in cultured human cells. Mol Cell Biol (2005) 2.77
Dynamic interactions between transposable elements and their hosts. Nat Rev Genet (2011) 2.61
A comprehensive analysis of recently integrated human Ta L1 elements. Am J Hum Genet (2002) 2.47
LINE-1 elements in structural variation and disease. Annu Rev Genomics Hum Genet (2011) 2.42
Cis-preferential LINE-1 reverse transcriptase activity in ribonucleoprotein particles. Nat Struct Mol Biol (2006) 2.23
LINE-1 retrotransposition in human embryonic stem cells. Hum Mol Genet (2007) 2.13
Active Alu retrotransposons in the human genome. Genome Res (2008) 2.09
Ribonucleoprotein particle formation is necessary but not sufficient for LINE-1 retrotransposition. Hum Mol Genet (2005) 2.02
ATLAS: a system to selectively identify human-specific L1 insertions. Am J Hum Genet (2003) 2.00
Endonuclease-independent LINE-1 retrotransposition at mammalian telomeres. Nature (2007) 1.84
Selective inhibition of Alu retrotransposition by APOBEC3G. Gene (2006) 1.75
L1 retrotransposition in nondividing and primary human somatic cells. Proc Natl Acad Sci U S A (2006) 1.73
A YY1-binding site is required for accurate human LINE-1 transcription initiation. Nucleic Acids Res (2004) 1.59
Unconventional translation of mammalian LINE-1 retrotransposons. Genes Dev (2006) 1.58
Characterization of LINE-1 ribonucleoprotein particles. PLoS Genet (2010) 1.56
Distinct mechanisms for trans-mediated mobilization of cellular RNAs by the LINE-1 reverse transcriptase. Genome Res (2007) 1.50
Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells. Nature (2010) 1.47
Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells. Proc Natl Acad Sci U S A (2011) 1.45
Reprogramming somatic cells into iPS cells activates LINE-1 retroelement mobility. Hum Mol Genet (2011) 1.31
Endogenous APOBEC3B restricts LINE-1 retrotransposition in transformed cells and human embryonic stem cells. J Biol Chem (2011) 1.18
Allelic heterogeneity in LINE-1 retrotransposition activity. Am J Hum Genet (2003) 1.13
Characterization of pre-insertion loci of de novo L1 insertions. Gene (2006) 1.01
The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes. Microbiol Spectr (2015) 0.96
Similarities between long interspersed element-1 (LINE-1) reverse transcriptase and telomerase. Proc Natl Acad Sci U S A (2011) 0.95
Transduction-specific ATLAS reveals a cohort of highly active L1 retrotransposons in human populations. Hum Mutat (2013) 0.86
Genomic impact of eukaryotic transposable elements. Mob DNA (2012) 0.84
Characterization of a mutagenic B1 retrotransposon insertion in the jittery mouse. Hum Mutat (2004) 0.84
RNase L restricts the mobility of engineered retrotransposons in cultured human cells. Nucleic Acids Res (2013) 0.83
Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3-q27 are associated with development of esophageal adenocarcinoma. Genes Chromosomes Cancer (2006) 0.81
Introduction for the Gene special issue dedicated to the meeting "Genomic impact of eukaryotic transposable elements" at Asilomar. Gene (2006) 0.77
Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science (2017) 0.76
Dealing with dangerous accidents: DNA double-strand breaks take centre stage. Symposium on Genome Instability and DNA Repair. EMBO Rep (2009) 0.75
Of man in mice. Nat Genet (2002) 0.75