Published in PLoS Genet on April 24, 2009
Dynamic interactions between transposable elements and their hosts. Nat Rev Genet (2011) 2.61
Extensive somatic L1 retrotransposition in colorectal tumors. Genome Res (2012) 2.29
All y'all need to know 'bout retroelements in cancer. Semin Cancer Biol (2010) 1.52
Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells. Nature (2010) 1.47
Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells. Proc Natl Acad Sci U S A (2011) 1.45
Pathogenesis of chagas' disease: parasite persistence and autoimmunity. Clin Microbiol Rev (2011) 1.38
Mobile DNA elements in the generation of diversity and complexity in the brain. Nat Rev Neurosci (2014) 1.35
Affinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotransposition. Cell (2013) 1.34
A mobile threat to genome stability: The impact of non-LTR retrotransposons upon the human genome. Semin Cancer Biol (2010) 1.34
LINE dancing in the human genome: transposable elements and disease. Genome Med (2009) 1.33
Mapping the LINE1 ORF1 protein interactome reveals associated inhibitors of human retrotransposition. Nucleic Acids Res (2013) 1.31
Slow DNA loss in the gigantic genomes of salamanders. Genome Biol Evol (2012) 1.05
Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions. Mob DNA (2010) 1.00
Poly(A) binding protein C1 is essential for efficient L1 retrotransposition and affects L1 RNP formation. Mol Cell Biol (2012) 0.99
The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition. PLoS Genet (2015) 0.97
Ancient and recent adaptive evolution of primate non-homologous end joining genes. PLoS Genet (2010) 0.96
LINEs, SINEs and other retroelements: do birds of a feather flock together? Front Biosci (Landmark Ed) (2012) 0.93
The retrohoming of linear group II intron RNAs in Drosophila melanogaster occurs by both DNA ligase 4-dependent and -independent mechanisms. PLoS Genet (2012) 0.89
Rescuing Alu: recovery of new inserts shows LINE-1 preserves Alu activity through A-tail expansion. PLoS Genet (2012) 0.88
Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity. Nucleic Acids Res (2013) 0.87
Mechanism by which a LINE protein recognizes its 3' tail RNA. Nucleic Acids Res (2014) 0.85
Feedback inhibition of L1 and alu retrotransposition through altered double strand break repair kinetics. Mob DNA (2010) 0.84
Restless genomes humans as a model organism for understanding host-retrotransposable element dynamics. Adv Genet (2011) 0.84
Different integration site structures between L1 protein-mediated retrotransposition in cis and retrotransposition in trans. Mob DNA (2010) 0.84
Mu insertions are repaired by the double-strand break repair pathway of Escherichia coli. PLoS Genet (2012) 0.83
Self-interaction, nucleic acid binding, and nucleic acid chaperone activities are unexpectedly retained in the unique ORF1p of zebrafish LINE. Mol Cell Biol (2011) 0.82
SVA retrotransposon insertion-associated deletion represents a novel mutational mechanism underlying large genomic copy number changes with non-recurrent breakpoints. Genome Biol (2014) 0.82
Characterization of L1-Ribonucleoprotein Particles. Methods Mol Biol (2016) 0.81
An epi [c] genetic battle: LINE-1 retrotransposons and intragenomic conflict in humans. Mob Genet Elements (2011) 0.81
In vitro screening for compounds that enhance human L1 mobilization. PLoS One (2013) 0.81
Restricting retrotransposons: a review. Mob DNA (2016) 0.79
Retrohoming of a Mobile Group II Intron in Human Cells Suggests How Eukaryotes Limit Group II Intron Proliferation. PLoS Genet (2015) 0.79
Reviving the dead: history and reactivation of an extinct l1. PLoS Genet (2014) 0.78
Mobile Bacterial Group II Introns at the Crux of Eukaryotic Evolution. Microbiol Spectr (2015) 0.77
Integrated mechanism for the generation of the 5' junctions of LINE inserts. Nucleic Acids Res (2014) 0.77
LINE-1 and Alu retrotransposition exhibit clonal variation. Mob DNA (2013) 0.77
Females and males contribute in opposite ways to the evolution of gene order in Drosophila. PLoS One (2013) 0.76
Evidence for a sexual dimorphism in gene expression noise in metazoan species. PeerJ (2015) 0.76
Heads or tails: L1 insertion-associated 5' homopolymeric sequences. Mob DNA (2010) 0.76
Post-Transcriptional Control of LINE-1 Retrotransposition by Cellular Host Factors in Somatic Cells. Front Cell Dev Biol (2016) 0.76
Guardian of the Human Genome: Host Defense Mechanisms against LINE-1 Retrotransposition. Front Chem (2016) 0.75
LINE retrotransposition and host DNA repair machinery. Mob Genet Elements (2015) 0.75
Mobile elements: drivers of genome evolution. Science (2004) 11.78
Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition. Cell (1993) 8.99
High frequency retrotransposition in cultured mammalian cells. Cell (1996) 8.60
Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition. Cell (1996) 8.21
DNA topoisomerase poisons as antitumor drugs. Annu Rev Biochem (1989) 6.58
Biology of mammalian L1 retrotransposons. Annu Rev Genet (2001) 6.52
IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05
Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature (1997) 5.08
Genomic deletions created upon LINE-1 retrotransposition. Cell (2002) 4.92
DNA repair mediated by endonuclease-independent LINE-1 retrotransposition. Nat Genet (2002) 4.58
Human L1 element target-primed reverse transcription in vitro. EMBO J (2002) 3.54
Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells. Mol Cell (2004) 3.32
Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids. Nucleic Acids Res (1998) 3.11
Nucleic acid chaperone activity of the ORF1 protein from the mouse LINE-1 retrotransposon. Mol Cell Biol (2001) 2.98
DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol Cell (1998) 2.97
The human LINE-1 retrotransposon creates DNA double-strand breaks. J Mol Biol (2006) 2.77
Multiple fates of L1 retrotransposition intermediates in cultured human cells. Mol Cell Biol (2005) 2.77
Role of non-homologous end joining (NHEJ) in maintaining genomic integrity. DNA Repair (Amst) (2006) 2.67
Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Res (2003) 2.49
Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair. Mol Cell (2006) 2.43
Cis-preferential LINE-1 reverse transcriptase activity in ribonucleoprotein particles. Nat Struct Mol Biol (2006) 2.23
Transposable elements in sexual and ancient asexual taxa. Proc Natl Acad Sci U S A (2000) 2.18
LINEs mobilize SINEs in the eel through a shared 3' sequence. Cell (2002) 2.15
RAD18 and RAD54 cooperatively contribute to maintenance of genomic stability in vertebrate cells. EMBO J (2002) 2.06
The take and give between retrotransposable elements and their hosts. Annu Rev Genet (2008) 1.86
Endonuclease-independent LINE-1 retrotransposition at mammalian telomeres. Nature (2007) 1.84
SINEs and LINEs: symbionts of eukaryotic genomes with a common tail. Cytogenet Genome Res (2005) 1.66
The domain structure and retrotransposition mechanism of R2 elements are conserved throughout arthropods. Mol Biol Evol (1999) 1.58
DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70: Implications for DNA double-strand break repair. Proc Natl Acad Sci U S A (2001) 1.58
Restraining the V(D)J recombinase. Nat Rev Immunol (2003) 1.56
Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40. DNA Repair (Amst) (2004) 1.51
Analysis of 5' junctions of human LINE-1 and Alu retrotransposons suggests an alternative model for 5'-end attachment requiring microhomology-mediated end-joining. Genome Res (2005) 1.50
L1 integration in a transgenic mouse model. Genome Res (2005) 1.50
The reverse transcriptase of the R2 non-LTR retrotransposon: continuous synthesis of cDNA on non-continuous RNA templates. J Mol Biol (2002) 1.45
End-to-end template jumping by the reverse transcriptase encoded by the R2 retrotransposon. J Biol Chem (2004) 1.38
Analysis of the 5' junctions of R2 insertions with the 28S gene: implications for non-LTR retrotransposition. Genetics (1996) 1.33
DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation. Mol Cell Biol (2004) 1.31
Positive selection of yeast nonhomologous end-joining genes and a retrotransposon conflict hypothesis. Proc Natl Acad Sci U S A (2006) 1.26
DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining. DNA Repair (Amst) (2005) 1.24
ERCC1/XPF limits L1 retrotransposition. DNA Repair (Amst) (2008) 1.23
High processivity of the reverse transcriptase from a non-long terminal repeat retrotransposon. J Biol Chem (2002) 1.13
Isolation and characterization of retrotransposition-competent LINEs from zebrafish. Gene (2005) 1.04
More active human L1 retrotransposons produce longer insertions. Nucleic Acids Res (2004) 0.99
Essential domains for ribonucleoprotein complex formation required for retrotransposition of telomere-specific non-long terminal repeat retrotransposon SART1. Mol Cell Biol (2006) 0.94
Novel retrotransposon analysis reveals multiple mobility pathways dictated by hosts. Genome Res (2006) 0.94
Role of p53 mutations, protein function and DNA damage for the radiosensitivity of human tumour cells. Int J Radiat Biol (2004) 0.93
A new system for analyzing LINE retrotransposition in the chicken DT40 cell line widely used for reverse genetics. Gene (2007) 0.80
Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol (2004) 7.17
Speciation through sensory drive in cichlid fish. Nature (2008) 5.52
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors. Cancer Res (2012) 3.74
Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair (Amst) (2006) 3.61
Bidirectional gene organization: a common architectural feature of the human genome. Cell (2002) 3.47
A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Mol Cell (2007) 3.23
DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. Mol Cell Biol (2007) 3.03
Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis. Mol Cell (2005) 2.88
Inhibition of homologous recombination by the PCNA-interacting protein PARI. Mol Cell (2011) 2.61
Functional noncoding sequences derived from SINEs in the mammalian genome. Genome Res (2006) 2.50
Cyclin-dependent kinases and cell-cycle transitions: does one fit all? Nat Rev Mol Cell Biol (2008) 2.48
Alternative tertiary structure of tRNA for recognition by a posttranscriptional modification enzyme. Cell (2003) 2.29
Whole-genome screening indicates a possible burst of formation of processed pseudogenes and Alu repeats by particular L1 subfamilies in ancestral primates. Genome Biol (2003) 2.19
Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science (2011) 2.17
LINEs mobilize SINEs in the eel through a shared 3' sequence. Cell (2002) 2.15
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature (2008) 2.12
Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates. EMBO J (2003) 2.12
Divergent selection on opsins drives incipient speciation in Lake Victoria cichlids. PLoS Biol (2006) 2.08
RAD18 and RAD54 cooperatively contribute to maintenance of genomic stability in vertebrate cells. EMBO J (2002) 2.06
Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells. Cancer Res (2005) 2.05
Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage. Mol Cell Biol (2006) 2.02
Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells. EMBO J (2006) 1.97
Pegasoferae, an unexpected mammalian clade revealed by tracking ancient retroposon insertions. Proc Natl Acad Sci U S A (2006) 1.95
XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Mol Cell (2003) 1.94
Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde. Cancer Res (2007) 1.92
Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature (2002) 1.89
Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM. EMBO J (2004) 1.89
Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines. Nat Biotechnol (2002) 1.87
Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway. Proc Natl Acad Sci U S A (2011) 1.86
REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo. Mol Cell (2006) 1.85
Spot pattern of leopard Danio is caused by mutation in the zebrafish connexin41.8 gene. EMBO Rep (2006) 1.83
Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis. EMBO J (2002) 1.82
Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage. Mol Cell (2006) 1.79
A mutated EGFR is sufficient to induce malignant melanoma with genetic background-dependent histopathologies. J Invest Dermatol (2010) 1.78
Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase. Mol Cell Biol (2007) 1.75
RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors. Cancer Res (2007) 1.68
Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair. PLoS Genet (2010) 1.66
An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells. J Cell Biol (2007) 1.65
SINEs of speciation: tracking lineages with retroposons. Trends Ecol Evol (2004) 1.64
Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM. EMBO J (2004) 1.56
Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib. Mol Cancer Ther (2013) 1.55
Possible involvement of SINEs in mammalian-specific brain formation. Proc Natl Acad Sci U S A (2008) 1.54
Pigment pattern in jaguar/obelix zebrafish is caused by a Kir7.1 mutation: implications for the regulation of melanosome movement. PLoS Genet (2006) 1.53
PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA. J Cell Biol (2008) 1.53
Retroposon analysis and recent geological data suggest near-simultaneous divergence of the three superorders of mammals. Proc Natl Acad Sci U S A (2009) 1.52
Multiple roles of vertebrate REV genes in DNA repair and recombination. Mol Cell Biol (2005) 1.52
Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40. DNA Repair (Amst) (2004) 1.51
Involvement of vertebrate polkappa in Rad18-independent postreplication repair of UV damage. J Biol Chem (2002) 1.48
Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells. Cancer Res (2007) 1.48
Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193: implications for the repair of topoisomerase II-mediated DNA damage. J Biol Chem (2003) 1.47
Gender difference in baroreflex sensitivity to predict cardiac and cerebrovascular events in type 2 diabetic patients. Circ J (2011) 1.47
Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks. DNA Repair (Amst) (2006) 1.46
Mitochondrial phylogenetics and evolution of mysticete whales. Syst Biol (2005) 1.44
Poxviruses as possible vectors for horizontal transfer of retroposons from reptiles to mammals. Proc Natl Acad Sci U S A (2007) 1.44
The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants. DNA Repair (Amst) (2002) 1.41
RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair. Mol Cell Biol (2007) 1.41
Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1. J Biol Chem (2010) 1.40
Cooperative roles of vertebrate Fbh1 and Blm DNA helicases in avoidance of crossovers during recombination initiated by replication fork collapse. Mol Cell Biol (2007) 1.36
Simple one-week method to construct gene-targeting vectors: application to production of human knockout cell lines. Biotechniques (2006) 1.36
A retroposon analysis of Afrotherian phylogeny. Mol Biol Evol (2005) 1.34
Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2. Mol Cell (2003) 1.33
Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination. Mol Cell Biol (2005) 1.33
The evolution of the pro-domain of bone morphogenetic protein 4 (Bmp4) in an explosively speciated lineage of East African cichlid fishes. Mol Biol Evol (2002) 1.32
Loss of nonhomologous end joining confers camptothecin resistance in DT40 cells. Implications for the repair of topoisomerase I-mediated DNA damage. J Biol Chem (2004) 1.31
DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation. Mol Cell Biol (2004) 1.31
Rooting the eutherian tree: the power and pitfalls of phylogenomics. Genome Biol (2007) 1.31
The USP1/UAF1 complex promotes double-strand break repair through homologous recombination. Mol Cell Biol (2011) 1.31
Generation of medaka gene knockout models by target-selected mutagenesis. Genome Biol (2006) 1.30
Differential and collaborative actions of Rad51 paralog proteins in cellular response to DNA damage. Nucleic Acids Res (2005) 1.30
Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity. Proc Natl Acad Sci U S A (2012) 1.29
Regulation of the Fanconi anemia pathway by a SUMO-like delivery network. Genes Dev (2011) 1.28
Parallelism of amino acid changes at the RH1 affecting spectral sensitivity among deep-water cichlids from Lakes Tanganyika and Malawi. Proc Natl Acad Sci U S A (2005) 1.27
Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells. J Biol Chem (2012) 1.26
Novel sex pheromone desaturases in the genomes of corn borers generated through gene duplication and retroposon fusion. Proc Natl Acad Sci U S A (2007) 1.26
KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents. Proc Natl Acad Sci U S A (2010) 1.25
LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs. PLoS Pathog (2012) 1.25
Generation and characterization of endonuclease G null mice. Mol Cell Biol (2005) 1.25
Genetic interactions between BLM and DNA ligase IV in human cells. J Biol Chem (2004) 1.25
Rapid generation of specific antibodies by enhanced homologous recombination. Nat Biotechnol (2005) 1.24
V-SINEs: a new superfamily of vertebrate SINEs that are widespread in vertebrate genomes and retain a strongly conserved segment within each repetitive unit. Genome Res (2002) 1.22
Werner and Bloom helicases are involved in DNA repair in a complementary fashion. Oncogene (2002) 1.22
The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination. PLoS Genet (2011) 1.21
Using SINEs to probe ancient explosive speciation: "hidden" radiation of African cichlids? Mol Biol Evol (2003) 1.21
The effect of selection on a long wavelength-sensitive (LWS) opsin gene of Lake Victoria cichlid fishes. Proc Natl Acad Sci U S A (2002) 1.20
Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition. J Pharmacol Exp Ther (2014) 1.19
Implications of popliteal lymph node detected by sentinel lymph node biopsy. Dermatol Surg (2005) 1.19
TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1. Nucleic Acids Res (2012) 1.18
The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells. Cancer Res (2009) 1.17
CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1. Nucleic Acids Res (2010) 1.16
Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans. J Infect Dis (2002) 1.16
Afrotherian phylogeny as inferred from complete mitochondrial genomes. Mol Phylogenet Evol (2003) 1.16
Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation. Nucleic Acids Res (2010) 1.15
Development of the embryo, larva and early juvenile of Nile tilapia Oreochromis niloticus (Pisces: Cichlidae). Developmental staging system. Dev Growth Differ (2007) 1.15
Enforced cytokinesis without complete nuclear division in embryonic cells depleting the activity of DNA topoisomerase IIalpha. Genes Cells (2003) 1.14