Published in Proc Natl Acad Sci U S A on August 21, 2002
Tolerance for mutations and chemical modifications in a siRNA. Nucleic Acids Res (2003) 3.85
Allele-specific silencing of dominant disease genes. Proc Natl Acad Sci U S A (2003) 3.00
Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents. J Mol Cell Cardiol (2008) 2.09
MYCN silencing induces differentiation and apoptosis in human neuroblastoma cells. Biochem Biophys Res Commun (2006) 1.42
Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing. Proc Natl Acad Sci U S A (2011) 1.26
Short interfering RNA-mediated interference of gene expression and viral DNA accumulation in cultured plant cells. Proc Natl Acad Sci U S A (2003) 1.20
Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG. J Cell Biol (2004) 1.20
Microtubule-associated protein 2 (MAP2) is a neurosteroid receptor. Proc Natl Acad Sci U S A (2006) 1.13
NMDA-induced neuronal survival is mediated through nuclear factor I-A in mice. J Clin Invest (2010) 1.03
Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2. J Cell Sci (2005) 0.99
Stearylated octaarginine and artificial virus-like particles for transfection of siRNA into primary rat neurons. RNA (2006) 0.96
Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation. Biochem Biophys Res Commun (2008) 0.96
Protective effects of tetramethylpyrazine on rat retinal cell cultures. Neurochem Int (2007) 0.96
Efficient delivery of RNA Interference to peripheral neurons in vivo using herpes simplex virus. Nucleic Acids Res (2008) 0.93
Upregulation of BNIP3 and translocation to mitochondria mediates cyanide-induced apoptosis in cortical cells. Neuroscience (2007) 0.89
Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders. Front Genet (2012) 0.89
Low K+ promotes NF-kappaB/DNA binding in neuronal apoptosis induced by K+ loss. Mol Cell Biol (2006) 0.82
Click-modified cyclodextrins as nonviral vectors for neuronal siRNA delivery. ACS Chem Neurosci (2012) 0.81
The search for endogenous siRNAs in the mammalian brain. Exp Neurol (2011) 0.81
Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery. PLoS One (2013) 0.79
Oxygen-glucose deprivation of neurons transfected with toll-like receptor 3-siRNA: Determination of an optimal transfection sequence. Neural Regen Res (2013) 0.78
Mouse neuronal cells expressing exogenous bovine PRNP and simultaneous downregulation of endogenous mouse PRNP using siRNAs. Prion (2010) 0.78
E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis. Am J Pathol (2004) 0.78
Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain. Mol Ther Nucleic Acids (2016) 0.77
Influence of RNA interference on the mitochondrial subcellular localization of alpha-synuclein and on the formation of Lewy body-like inclusions in the cytoplasm of human embryonic kidney 293 cells induced by the overexpression of alpha-synuclein. Neural Regen Res (2012) 0.75
Use of RNA interference by in utero electroporation to study cortical development: the example of the doublecortin superfamily. Genes (Basel) (2012) 0.75
Inhibition of hepatitis B virus surface antigen expression by small hairpin RNA in vitro. World J Gastroenterol (2005) 0.75
Immunocytochemistry and fluorescence imaging efficiently identify individual neurons with CRISPR/Cas9-mediated gene disruption in primary cortical cultures. BMC Neurosci (2017) 0.75
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (2001) 57.23
Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature (2001) 38.75
Identification of tissue-specific microRNAs from mouse. Curr Biol (2002) 34.55
RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell (2000) 20.32
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J (2001) 12.88
Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene (2001) 11.09
Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nat Biotechnol (2002) 8.31
RNA interference--2001. Genes Dev (2001) 7.68
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc Natl Acad Sci U S A (2001) 7.12
RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc Natl Acad Sci U S A (2002) 6.84
Identification of essential genes in cultured mammalian cells using small interfering RNAs. J Cell Sci (2001) 6.66
U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol (2002) 6.66
Effective expression of small interfering RNA in human cells. Nat Biotechnol (2002) 6.02
Post-transcriptional gene silencing by double-stranded RNA. Nat Rev Genet (2001) 5.84
RNAi: nature abhors a double-strand. Curr Opin Genet Dev (2002) 5.74
Stable suppression of gene expression by RNAi in mammalian cells. Proc Natl Acad Sci U S A (2002) 5.05
Novel genomic cDNA hybrids produce effective RNA interference in adult Drosophila. Neuron (2002) 2.65
A primary culture system for functional analysis of C. elegans neurons and muscle cells. Neuron (2002) 2.12
Molecular characterization of the dendritic growth cone: regulated mRNA transport and local protein synthesis. Neuron (1996) 2.05
Suppression of MAP2 in cultured cerebellar macroneurons inhibits minor neurite formation. Neuron (1992) 1.67
Architecture of apical dendrites in the murine neocortex: dual apical dendritic systems. Neuroscience (1986) 0.91
Participation of structural microtubule-associated proteins (MAPs) in the development of neuronal polarity. J Neurosci Res (2002) 0.90
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res (2005) 18.58
A microRNA array reveals extensive regulation of microRNAs during brain development. RNA (2003) 9.76
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell (2009) 8.14
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A (2003) 7.95
Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells (2005) 6.72
The Amphimedon queenslandica genome and the evolution of animal complexity. Nature (2010) 5.11
MicroRNA profiling of the murine hematopoietic system. Genome Biol (2005) 4.94
MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res (2008) 3.70
Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study. Lancet Neurol (2012) 3.48
Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments. J Alzheimers Dis (2011) 2.78
Apolipoprotein Eepsilon4 modifies Alzheimer's disease onset in an E280A PS1 kindred. Ann Neurol (2003) 2.72
Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study. Lancet Neurol (2012) 2.65
Heterogeneous dysregulation of microRNAs across the autism spectrum. Neurogenetics (2008) 2.50
CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. J Biol Chem (2003) 2.27
MicroRNAs potentiate neural development. Neuron (2009) 2.25
Somatodendritic microRNAs identified by laser capture and multiplex RT-PCR. RNA (2007) 2.01
A post-synaptic scaffold at the origin of the animal kingdom. PLoS One (2007) 1.96
A coordinated local translational control point at the synapse involving relief from silencing and MOV10 degradation. Neuron (2009) 1.96
Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction. Curr Biol (2004) 1.80
Synaptic tagging -- who's it? Nat Rev Neurosci (2002) 1.75
MicroRNA regulation of neural stem cells and neurogenesis. J Neurosci (2010) 1.64
The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. J Biol Chem (2002) 1.59
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol (2002) 1.54
Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease. Neurobiol Aging (2013) 1.53
MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states. Cell Stem Cell (2010) 1.49
Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival. J Biol Chem (2004) 1.42
Detection of a microRNA signal in an in vivo expression set of mRNAs. PLoS One (2007) 1.40
Identification of piRNAs in the central nervous system. RNA (2011) 1.39
The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule. J Neurosci (2009) 1.38
Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho. J Cell Biol (2003) 1.35
Highly conserved O-fucose sites have distinct effects on Notch1 function. J Biol Chem (2005) 1.35
MicroRNAs: regulators of oncogenesis and stemness. BMC Med (2008) 1.29
Deep annotation of mouse iso-miR and iso-moR variation. Nucleic Acids Res (2012) 1.27
Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice. J Neurosci (2010) 1.23
Stabilization of the tau exon 10 stem loop alters pre-mRNA splicing. J Biol Chem (2006) 1.22
Noncoding RNAs in Long-Term Memory Formation. Neuroscientist (2008) 1.22
Activation of the neuronal c-Abl tyrosine kinase by amyloid-beta-peptide and reactive oxygen species. Neurobiol Dis (2004) 1.20
Transcriptional profiling reveals regulated genes in the hippocampus during memory formation. Hippocampus (2002) 1.19
BACE1 suppression by RNA interference in primary cortical neurons. J Biol Chem (2003) 1.19
A delta-catenin signaling pathway leading to dendritic protrusions. J Biol Chem (2008) 1.17
Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells. Stem Cell Reports (2013) 1.16
MUC1* mediates the growth of human pluripotent stem cells. PLoS One (2008) 1.10
Growth hormone is produced within the hippocampus where it responds to age, sex, and stress. Proc Natl Acad Sci U S A (2006) 1.06
Reconstructing ancestral genome content based on symmetrical best alignments and Dollo parsimony. Bioinformatics (2008) 1.00
Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau. J Biol Chem (2004) 0.99
Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation. Chem Biol (2005) 0.98
Functionalization of a protosynaptic gene expression network. Proc Natl Acad Sci U S A (2012) 0.98
Transcriptome profiling of the demosponge Amphimedon queenslandica reveals genome-wide events that accompany major life cycle transitions. BMC Genomics (2012) 0.96
Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells. Stem Cells (2014) 0.96
NMDA mediated contextual conditioning changes miRNA expression. PLoS One (2011) 0.96
Attenuated hippocampus-dependent learning and memory decline in transgenic TgAPPswe Fischer-344 rats. Mol Med (2004) 0.94
MicroRNA-124: micromanager of neurogenesis. Cell Stem Cell (2009) 0.92
Statistical analysis of dendritic spine distributions in rat hippocampal cultures. BMC Bioinformatics (2013) 0.91
CADASIL mutations impair Notch3 glycosylation by Fringe. Hum Mol Genet (2005) 0.90
Regulation of AMPA receptor trafficking by delta-catenin. Mol Cell Neurosci (2008) 0.90
The mammalian RNA-binding protein Staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons. Neuromolecular Med (2004) 0.87
Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains. FEBS Lett (2009) 0.85
Distribution pattern of Notch3 mutations suggests a gain-of-function mechanism for CADASIL. Genomics (2004) 0.85
Particle display: a quantitative screening method for generating high-affinity aptamers. Angew Chem Int Ed Engl (2014) 0.84
Exploratory data from complete genomes of familial alzheimer disease age-at-onset outliers. Hum Mutat (2012) 0.84
Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models. J Biol Chem (2013) 0.83
Development of an assay to screen for inhibitors of tau phosphorylation by cdk5. J Biomol Screen (2004) 0.83
New approaches to the discovery of cdk5 inhibitors. Curr Alzheimer Res (2007) 0.83
Molecular biology: Circles reshape the RNA world. Nature (2013) 0.82
Vulnerabilities in the tau network and the role of ultrasensitive points in tau pathophysiology. PLoS Comput Biol (2010) 0.82
Staged miRNA re-regulation patterns during reprogramming. Genome Biol (2013) 0.82
Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors. Bioorg Med Chem Lett (2011) 0.82
Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP. Neurobiol Dis (2004) 0.81
Genetic testing must recognize impact of bad news on recipient. Nature (2008) 0.78
MUC1* ligand, NM23-H1, is a novel growth factor that maintains human stem cells in a more naïve state. PLoS One (2013) 0.78
Spatial learning and memory is preserved in rats after early development in a microgravity environment. Neurobiol Learn Mem (2002) 0.78
Neuroscience gears up for duel on the issue of brain versus deity. Nature (2006) 0.76
Diseases: Study neuron networks to tackle Alzheimer's. Nature (2013) 0.76
Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron (2016) 0.76
Tau-er of Power. Cerebrum (2015) 0.75
PhDs: what's left if science abdicates? Nature (2011) 0.75
Development of a fluorescent high throughput assay for tau aggregation. Assay Drug Dev Technol (2004) 0.75