Published in Genome Biol on August 01, 2005
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A (2006) 21.58
Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science (2008) 11.33
Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci U S A (2006) 10.65
Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol (2010) 7.75
Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells (2005) 6.72
A role for Dicer in immune regulation. J Exp Med (2006) 5.81
miRNA profiling of naïve, effector and memory CD8 T cells. PLoS One (2007) 5.43
Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev (2007) 4.79
Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell (2010) 4.57
MicroRNA fingerprints during human megakaryocytopoiesis. Proc Natl Acad Sci U S A (2006) 3.80
The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ. Nat Immunol (2011) 3.77
Expression of microRNA-146 in rheumatoid arthritis synovial tissue. Arthritis Rheum (2008) 3.35
Regulation of microRNA expression and abundance during lymphopoiesis. Immunity (2010) 3.29
MicroRNAs: regulators of gene expression and cell differentiation. Blood (2006) 3.08
MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics (2010) 2.80
microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia. J Exp Med (2010) 2.68
MicroRNA expression profiles predictive of human renal allograft status. Proc Natl Acad Sci U S A (2009) 2.36
miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2. Blood (2008) 2.21
HIV-1 TAR element is processed by Dicer to yield a viral micro-RNA involved in chromatin remodeling of the viral LTR. BMC Mol Biol (2007) 2.20
MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases. Transl Res (2011) 2.15
MicroRNA-126 regulates HOXA9 by binding to the homeobox. Mol Cell Biol (2008) 1.95
Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis. Arthritis Res Ther (2010) 1.94
A simple array platform for microRNA analysis and its application in mouse tissues. RNA (2007) 1.91
MicroRNA in TLR signaling and endotoxin tolerance. Cell Mol Immunol (2011) 1.86
Expression of MicroRNA-146a in osteoarthritis cartilage. Arthritis Rheum (2009) 1.84
miR-146a controls the resolution of T cell responses in mice. J Exp Med (2012) 1.81
Highly complementary target RNAs promote release of guide RNAs from human Argonaute2. Mol Cell (2013) 1.81
MicroRNA-mediated regulation of T helper cell differentiation and plasticity. Nat Rev Immunol (2013) 1.75
Next-generation sequencing identifies the natural killer cell microRNA transcriptome. Genome Res (2010) 1.75
A novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian microRNAs. Nucleic Acids Res (2007) 1.68
Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells. Eur J Immunol (2010) 1.59
Analysis of microRNA knockouts in mice. Hum Mol Genet (2010) 1.59
Maternally imprinted microRNAs are differentially expressed during mouse and human lung development. Dev Dyn (2007) 1.57
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med (2013) 1.42
MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis. Haematologica (2009) 1.40
Costimulation-dependent expression of microRNA-214 increases the ability of T cells to proliferate by targeting Pten. J Immunol (2010) 1.40
MicroRNAs of the immune system: roles in inflammation and cancer. Ann N Y Acad Sci (2010) 1.37
Modulation of TLR2 protein expression by miR-105 in human oral keratinocytes. J Biol Chem (2009) 1.35
Micromanaging vascular biology: tiny microRNAs play big band. J Vasc Res (2009) 1.31
MicroRNAs in the immune response. Cytokine (2008) 1.31
Expression and function of micro-RNAs in immune cells during normal or disease state. Int J Med Sci (2008) 1.30
MiR-146a in Immunity and Disease. Mol Biol Int (2011) 1.28
MicroRNAs expression signatures are associated with lineage and survival in acute leukemias. Blood Cells Mol Dis (2010) 1.26
Characterisation of microRNA expression in post-natal mouse mammary gland development. BMC Genomics (2009) 1.21
Epigenetic regulation in alcoholic liver disease. World J Gastroenterol (2011) 1.21
MicroRNA regulation of molecular networks mapped by global microRNA, mRNA, and protein expression in activated T lymphocytes. J Immunol (2011) 1.18
MicroRNAs in platelet production and activation. Blood (2011) 1.17
Dynamic BRG1 recruitment during T helper differentiation and activation reveals distal regulatory elements. Mol Cell Biol (2011) 1.17
Turning 21: Induction of miR-21 as a Key Switch in the Inflammatory Response. Front Immunol (2015) 1.16
Temporal differences in microRNA expression patterns in astrocytes and neurons after ischemic injury. PLoS One (2011) 1.14
MicroRNA-221-222 regulate the cell cycle in mast cells. J Immunol (2009) 1.14
MicroRNA-146 inhibits pro-inflammatory cytokine secretion through IL-1 receptor-associated kinase 1 in human gingival fibroblasts. J Inflamm (Lond) (2013) 1.14
MicroRNA regulation of T-cell differentiation and function. Immunol Rev (2013) 1.13
MicroRNAs: control and loss of control in human physiology and disease. World J Surg (2009) 1.12
Immuno-miRs: critical regulators of T-cell development, function and ageing. Immunology (2015) 1.11
Retinoic acid downregulates microRNAs to induce abnormal development of spinal cord in spina bifida rat model. Childs Nerv Syst (2007) 1.09
Dynamic microRNA gene transcription and processing during T cell development. J Immunol (2012) 1.08
Non-coding RNAs: multi-tasking molecules in the cell. Int J Mol Sci (2013) 1.07
MicroRNA-directed program of cytotoxic CD8+ T-cell differentiation. Proc Natl Acad Sci U S A (2013) 1.04
MiR-146a and NF-κB1 regulate mast cell survival and T lymphocyte differentiation. Mol Cell Biol (2012) 1.03
Role of microRNAs in the immune system, inflammation and cancer. World J Gastroenterol (2013) 1.02
Overexpression of the lung cancer-prognostic miR-146b microRNAs has a minimal and negative effect on the malignant phenotype of A549 lung cancer cells. PLoS One (2011) 1.00
Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation. EMBO J (2015) 1.00
MicroRNAs regulate osteogenesis and chondrogenesis of mouse bone marrow stromal cells. Gene Regul Syst Bio (2008) 0.99
Chromatin structure and gene regulation in T cell development and function. Curr Opin Immunol (2006) 0.99
Target labelling for the detection and profiling of microRNAs expressed in CNS tissue using microarrays. BMC Biotechnol (2006) 0.98
MicroRNAs as regulatory elements in immune system logic. Nat Rev Immunol (2016) 0.97
MicroRNA expression in lymphoid malignancies: new hope for diagnosis and therapy? J Cell Mol Med (2008) 0.97
Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells. PLoS One (2011) 0.95
Regulation of B-cell development and function by microRNAs. Immunol Rev (2013) 0.95
MicroRNAs and Multiple Sclerosis. Autoimmune Dis (2010) 0.94
HOXA9 regulates miR-155 in hematopoietic cells. Nucleic Acids Res (2010) 0.94
Intracellular modulation, extracellular disposal and serum increase of MiR-150 mark lymphocyte activation. PLoS One (2013) 0.94
MicroRNA regulation of natural killer cells. Front Immunol (2013) 0.94
Lack of microRNA miR-150 reduces the capacity of epidermal Langerhans cell cross-presentation. Exp Dermatol (2012) 0.93
The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity. Nat Immunol (2016) 0.93
The role of microRNAs in B-cell development and function. Cell Mol Immunol (2013) 0.92
MicroRNA-mediated restriction of HIV-1 in resting CD4+ T cells and monocytes. Viruses (2012) 0.90
Gene expression trees in lymphoid development. BMC Immunol (2007) 0.90
Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a. Sci Rep (2013) 0.89
Involvement of MicroRNA in T-Cell Differentiation and Malignancy. Int J Hematol Oncol Stem Cell Res (2015) 0.88
MicroRNAs in Breastmilk and the Lactating Breast: Potential Immunoprotectors and Developmental Regulators for the Infant and the Mother. Int J Environ Res Public Health (2015) 0.88
microRNAs regulate cell-to-cell variability of endogenous target gene expression in developing mouse thymocytes. PLoS Genet (2015) 0.88
MicroRNAs as novel regulators of neuroinflammation. Mediators Inflamm (2013) 0.88
Clinical and prognostic significance of miR-155 and miR-146a expression levels in formalin-fixed/paraffin-embedded tissue of patients with diffuse large B-cell lymphoma. Exp Ther Med (2012) 0.88
Natural killer cell regulation by microRNAs in health and disease. J Biomed Biotechnol (2012) 0.87
An integrated nano-scale approach to profile miRNAs in limited clinical samples. Am J Clin Exp Immunol (2012) 0.87
Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity. Proc Natl Acad Sci U S A (2014) 0.87
Association between ankylosing spondylitis and the miR-146a and miR-499 polymorphisms. PLoS One (2015) 0.85
Genomics and the immune system. Immunology (2008) 0.84
MicroRNAs Control Macrophage Formation and Activation: The Inflammatory Link between Obesity and Cardiovascular Diseases. Cells (2014) 0.84
MicroRNAs in myeloproliferative neoplasms. Br J Haematol (2013) 0.83
Endothelial microRNA-150 is an intrinsic suppressor of pathologic ocular neovascularization. Proc Natl Acad Sci U S A (2015) 0.83
MicroRNAs implicated in the immunopathogenesis of lupus nephritis. Clin Dev Immunol (2013) 0.83
Long and short non-coding RNAs as regulators of hematopoietic differentiation. Int J Mol Sci (2013) 0.83
Modulation of immune function by polyphenols: possible contribution of epigenetic factors. Nutrients (2013) 0.82
Role of microRNA-150 in solid tumors. Oncol Lett (2015) 0.82
MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87
The functions of animal microRNAs. Nature (2004) 64.85
Prediction of mammalian microRNA targets. Cell (2003) 53.70
Combinatorial microRNA target predictions. Nat Genet (2005) 50.48
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature (2005) 48.95
Human MicroRNA targets. PLoS Biol (2004) 34.51
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2002) 32.26
Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature (2005) 31.60
MicroRNAs modulate hematopoietic lineage differentiation. Science (2003) 30.05
The microRNA Registry. Nucleic Acids Res (2004) 29.45
Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics (2002) 20.59
Mechanisms of gene silencing by double-stranded RNA. Nature (2004) 16.82
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature (2000) 16.75
A Bayesian framework for the analysis of microarray expression data: regularized t -test and statistical inferences of gene changes. Bioinformatics (2001) 16.47
Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol (2004) 15.15
MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc Natl Acad Sci U S A (2004) 14.59
Processing of primary microRNAs by the Microprocessor complex. Nature (2004) 14.59
Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA (2005) 14.14
MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell (2003) 14.07
Phylogenetic shadowing and computational identification of human microRNA genes. Cell (2005) 13.24
The lineage decisions of helper T cells. Nat Rev Immunol (2002) 10.61
A microRNA array reveals extensive regulation of microRNAs during brain development. RNA (2003) 9.76
A custom microarray platform for analysis of microRNA gene expression. Nat Methods (2004) 9.44
Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biol (2004) 7.33
Computational identification of microRNA targets. Dev Biol (2004) 6.84
MicroRNA-143 regulates adipocyte differentiation. J Biol Chem (2004) 6.78
Microarray-based, high-throughput gene expression profiling of microRNAs. Nat Methods (2004) 5.45
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity (1998) 5.38
Mast cells as "tunable" effector and immunoregulatory cells: recent advances. Annu Rev Immunol (2005) 5.22
Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science (2000) 4.53
T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol (2002) 4.38
An epigenetic view of helper T cell differentiation. Nat Immunol (2003) 3.87
Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates. Immunity (2002) 2.99
Common logic of transcription factor and microRNA action. Trends Biochem Sci (2004) 2.95
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol (2004) 2.38
PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors. EMBO J (1998) 1.84
A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity (2002) 1.74
Combinatorial microRNA target predictions. Nat Genet (2005) 50.48
Human MicroRNA targets. PLoS Biol (2004) 34.51
A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97
Silencing of microRNAs in vivo with 'antagomirs'. Nature (2005) 32.56
Widespread changes in protein synthesis induced by microRNAs. Nature (2008) 31.44
Integration of biological networks and gene expression data using Cytoscape. Nat Protoc (2007) 27.10
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov (2012) 26.98
Integrative genomic profiling of human prostate cancer. Cancer Cell (2010) 23.61
MicroRNA targets in Drosophila. Genome Biol (2003) 23.59
Global mapping of the yeast genetic interaction network. Science (2004) 21.34
International network of cancer genome projects. Nature (2010) 20.35
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol (2008) 19.86
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal (2013) 19.54
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res (2005) 18.58
The microRNA.org resource: targets and expression. Nucleic Acids Res (2007) 16.26
The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data. Nat Biotechnol (2004) 16.08
A pancreatic islet-specific microRNA regulates insulin secretion. Nature (2004) 15.02
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature (2006) 14.78
Characterizing gene sets with FuncAssociate. Bioinformatics (2003) 14.10
Identification of microRNAs of the herpesvirus family. Nat Methods (2005) 12.98
Identification of virus-encoded microRNAs. Science (2004) 12.56
Regulation of the germinal center response by microRNA-155. Science (2007) 12.25
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15
The somatic genomic landscape of glioblastoma. Cell (2013) 11.73
The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet (2013) 11.29
Predicting the functional impact of protein mutations: application to cancer genomics. Nucleic Acids Res (2011) 10.99
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol (2008) 10.42
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med (2012) 10.20
Discovering microRNAs from deep sequencing data using miRDeep. Nat Biotechnol (2008) 10.17
A genome-wide map of conserved microRNA targets in C. elegans. Curr Biol (2006) 10.14
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science (2010) 9.78
A microRNA array reveals extensive regulation of microRNAs during brain development. RNA (2003) 9.76
Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev (2003) 9.39
MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell (2007) 9.33
FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 9.24
The BioPAX community standard for pathway data sharing. Nat Biotechnol (2010) 9.19
Pathway Commons, a web resource for biological pathway data. Nucleic Acids Res (2010) 9.18
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature (2010) 8.87
A novel class of small RNAs bind to MILI protein in mouse testes. Nature (2006) 8.80
Orai1 is an essential pore subunit of the CRAC channel. Nature (2006) 8.60
Circular RNAs are a large class of animal RNAs with regulatory potency. Nature (2013) 8.54
The Systems Biology Graphical Notation. Nat Biotechnol (2009) 8.53
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell (2009) 8.14
The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS One (2010) 8.10
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A (2003) 7.95
The evolution of gene regulation by transcription factors and microRNAs. Nat Rev Genet (2007) 7.92
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature (2011) 7.43
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell (2011) 7.41
Mutual exclusivity analysis identifies oncogenic network modules. Genome Res (2011) 7.22
MicroRNA control in the immune system: basic principles. Cell (2009) 7.16
Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol (2010) 7.15
Cell-type-specific signatures of microRNAs on target mRNA expression. Proc Natl Acad Sci U S A (2006) 7.11
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol (2003) 7.06
Computational identification of microRNA targets. Dev Biol (2004) 6.84
Cellular cofactors affecting hepatitis C virus infection and replication. Proc Natl Acad Sci U S A (2007) 6.79
(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway. Proc Natl Acad Sci U S A (2009) 6.78
microRNA target predictions across seven Drosophila species and comparison to mammalian targets. PLoS Comput Biol (2005) 6.77
Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells (2005) 6.72
Genome sequencing identifies a basis for everolimus sensitivity. Science (2012) 6.71
Aberrant T cell differentiation in the absence of Dicer. J Exp Med (2005) 6.58
Emerging landscape of oncogenic signatures across human cancers. Nat Genet (2013) 6.48
miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1. RNA Biol (2004) 6.44
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet (2010) 6.10
Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol (2006) 6.10
Pathguide: a pathway resource list. Nucleic Acids Res (2006) 6.05
IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05
Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science (2002) 5.89
A human snoRNA with microRNA-like functions. Mol Cell (2008) 5.84
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res (2011) 5.83
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat Immunol (2006) 5.70
Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor. Proc Natl Acad Sci U S A (2010) 5.59
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev (2005) 5.56
Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell (2008) 5.53
Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev (2008) 5.34
Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet (2009) 5.31
Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science (2006) 5.31
MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol (2008) 5.21
Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol (2007) 5.14
Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu Rev Immunol (2010) 5.11