Published in Crit Care Clin on April 01, 2005
Intestinal crosstalk: a new paradigm for understanding the gut as the "motor" of critical illness. Shock (2007) 2.37
Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition. Proc Natl Acad Sci U S A (2008) 1.97
Cytoskeletal regulation of epithelial barrier function during inflammation. Am J Pathol (2010) 1.73
Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila. Proc Natl Acad Sci U S A (2012) 1.73
HB-EGF protects the lungs after intestinal ischemia/reperfusion injury. J Surg Res (2010) 1.51
HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol (2010) 1.44
Role of TNF-alpha in lung tight junction alteration in mouse model of acute lung inflammation. Respir Res (2007) 1.29
Introduction of an agent-based multi-scale modular architecture for dynamic knowledge representation of acute inflammation. Theor Biol Med Model (2008) 1.29
Sepsis: Something old, something new, and a systems view. J Crit Care (2011) 1.29
Macrophage stimulating protein may promote tubular regeneration after acute injury. J Am Soc Nephrol (2008) 1.19
Translational systems approaches to the biology of inflammation and healing. Immunopharmacol Immunotoxicol (2010) 1.18
Human intestinal ischemia-reperfusion-induced inflammation characterized: experiences from a new translational model. Am J Pathol (2010) 1.16
Non-invasive assessment of barrier integrity and function of the human gut. World J Gastrointest Surg (2010) 1.16
Redefining the gut as the motor of critical illness. Trends Mol Med (2013) 1.15
Corticotropin releasing factor signaling in colon and ileum: regulation by stress and pathophysiological implications. J Physiol Pharmacol (2009) 1.13
Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury. Am J Physiol Gastrointest Liver Physiol (2010) 1.11
Modulation of acetylation: creating a pro-survival and anti-inflammatory phenotype in lethal hemorrhagic and septic shock. J Biomed Biotechnol (2011) 1.09
High serum nitric oxide levels in patients with severe leptospirosis. Acta Trop (2007) 1.06
Gut barrier dysfunction in the Apc(Min/+) mouse model of colon cancer cachexia. Biochim Biophys Acta (2011) 1.05
Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis. J Immunol (2011) 1.03
Inflammatory Mechanisms of Organ Crosstalk during Ischemic Acute Kidney Injury. Int J Nephrol (2011) 1.01
New Insight in Loss of Gut Barrier during Major Non-Abdominal Surgery. PLoS One (2008) 1.00
Surgical sepsis and organ crosstalk: the role of the kidney. J Surg Res (2010) 1.00
Rapid development of intestinal cell damage following severe trauma: a prospective observational cohort study. Crit Care (2009) 0.96
Chronic alcohol ingestion increases mortality and organ injury in a murine model of septic peritonitis. PLoS One (2013) 0.96
Prognostic impact of fecal pH in critically ill patients. Crit Care (2012) 0.96
Active Negative Pressure Peritoneal Therapy After Abbreviated Laparotomy: The Intraperitoneal Vacuum Randomized Controlled Trial. Ann Surg (2015) 0.93
Creating a pro-survival and anti-inflammatory phenotype by modulation of acetylation in models of hemorrhagic and septic shock. Adv Exp Med Biol (2012) 0.92
Remodeling of the tight junction during recovery from exposure to hydrogen peroxide in kidney epithelial cells. Free Radic Biol Med (2009) 0.91
Non-invasive markers of gut wall integrity in health and disease. World J Gastroenterol (2010) 0.90
Human leukocyte antigen class II transgenic mouse model unmasks the significant extrahepatic pathology in toxic shock syndrome. Am J Pathol (2011) 0.89
Exogenous cytochrome C restores myocardial cytochrome oxidase activity into the late phase of sepsis. Shock (2008) 0.87
Can we protect the gut in critical illness? The role of growth factors and other novel approaches. Crit Care Clin (2010) 0.87
Sepsis: from pattern to mechanism and back. Crit Rev Biomed Eng (2012) 0.87
Protective effect of resin adsorption on septic plasma-induced tubular injury. Crit Care (2010) 0.87
Polyethylene glycol versus dual sugar assay for gastrointestinal permeability analysis: is it time to choose? Clin Exp Gastroenterol (2012) 0.86
Electroacupuncture improves gut barrier dysfunction in prolonged hemorrhagic shock rats through vagus anti-inflammatory mechanism. World J Gastroenterol (2013) 0.86
Intestinal epithelium is more susceptible to cytopathic injury and altered permeability than the lung epithelium in the context of acute sepsis. Int J Exp Pathol (2011) 0.85
Epidermal wound healing in severe sepsis and septic shock in humans. Crit Care (2009) 0.85
Dexmedetomidine improves gastrointestinal motility after laparoscopic resection of colorectal cancer: A randomized clinical trial. Medicine (Baltimore) (2016) 0.84
Electroacupuncture at Zusanli Prevents Severe Scalds-Induced Gut Ischemia and Paralysis by Activating the Cholinergic Pathway. Evid Based Complement Alternat Med (2015) 0.84
Anticoagulants influence the in vitro activity and composition of shock lymph but not its in vivo activity. Shock (2011) 0.83
Cardiorenal syndromes and sepsis. Int J Nephrol (2011) 0.82
Periodic Exposure of Keratinocytes to Cold Physical Plasma: An In Vitro Model for Redox-Related Diseases of the Skin. Oxid Med Cell Longev (2016) 0.82
The study of n-3PUFAs protecting the intestinal barrier in rat HS/R model. Lipids Health Dis (2014) 0.81
Heparin-binding EGF-like growth factor (HB-EGF) therapy for intestinal injury: Application and future prospects. Pathophysiology (2013) 0.81
Extracellular activation of arginase-1 decreases enterocyte inducible nitric oxide synthase activity during systemic inflammation. Am J Physiol Gastrointest Liver Physiol (2009) 0.80
Heparin-binding epidermal growth factor-like growth factor improves intestinal barrier function and reduces mortality in a murine model of peritonitis. Surgery (2012) 0.80
Detection of MAPK signal transduction proteins in an ischemia/reperfusion model of mouse intestine using in vivo cryotechnique. Histochem Cell Biol (2013) 0.79
Increased circulatory asymmetric dimethylarginine and multiple organ failure: bile duct ligation in rat as a model. Int J Mol Sci (2014) 0.79
Remediation of hemorrhagic shock-induced intestinal barrier dysfunction by treatment with diphenyldihaloketones EF24 and CLEFMA. J Pharmacol Exp Ther (2014) 0.79
A targeted extracorporeal therapy for endotoxemia: the time has come. Crit Care (2007) 0.79
Gut barrier dysfunction and microbial translocation in cancer cachexia: a new therapeutic target. Curr Opin Support Palliat Care (2013) 0.78
Tight junction physiology of pleural mesothelium. Front Physiol (2014) 0.78
Inhibition of histone deacetylase 6 restores intestinal tight junction in hemorrhagic shock. J Trauma Acute Care Surg (2016) 0.77
Effect of Negative Pressure Therapy on the Inflammatory Response of the Intestinal Microenvironment in a Porcine Septic Model. Mediators Inflamm (2015) 0.77
Real-time in vivo imaging of early mucosal changes during ischemia-reperfusion in human jejunum. PLoS One (2012) 0.77
Protective effect of the traditional Chinese medicine xuesaitong on intestinal ischemia-reperfusion injury in rats. Int J Clin Exp Med (2015) 0.77
Electroacupuncture activates enteric glial cells and protects the gut barrier in hemorrhaged rats. World J Gastroenterol (2015) 0.76
Exploring the physiology and pathology of aging in the intestine of Drosophila melanogaster. Invertebr Reprod Dev (2014) 0.76
Dimethyl sulfoxide inhibits zymosan-induced intestinal inflammation and barrier dysfunction. World J Gastroenterol (2015) 0.75
The intestinal microbiome and surgical disease. Curr Probl Surg (2016) 0.75
Trefoil factor 3 as a marker of intestinal cell damage during sepsis. Open Med (Wars) (2015) 0.75
Effects of glutamine on markers of intestinal inflammatory response and mucosal permeability in abdominal surgery patients: A meta-analysis. Exp Ther Med (2016) 0.75
Prediction of Gut Wall Integrity Loss in Viral Gastroenteritis by Non-Invasive Marker. Open Access Maced J Med Sci (2015) 0.75
Intestinal fatty acid binding protein as a marker for intra-abdominal pressure-related complications in patients admitted to the intensive care unit; study protocol for a prospective cohort study (I-Fabulous study). Scand J Trauma Resusc Emerg Med (2015) 0.75
Inhibitory effects of serum from sepsis patients on epithelial cell migration in vitro: a case control study. J Transl Med (2017) 0.75
Low doses of celecoxib attenuate gut barrier failure during experimental peritonitis. Lab Invest (2013) 0.75
Nutritional stimulation of the autonomic nervous system. World J Gastroenterol (2011) 0.75
Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med (2007) 5.65
Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis. Crit Care Med (2007) 3.27
HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice. Gastroenterology (2002) 2.95
Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis. Crit Care Med (2004) 1.88
Understanding the potential role of statins in pneumonia and sepsis. Crit Care Med (2011) 1.77
Ethyl pyruvate ameliorates acute alcohol-induced liver injury and inflammation in mice. J Lab Clin Med (2003) 1.71
Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol (2002) 1.70
IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice. Am J Physiol Gastrointest Liver Physiol (2003) 1.70
HMGB1 is secreted by immunostimulated enterocytes and contributes to cytomix-induced hyperpermeability of Caco-2 monolayers. Am J Physiol Cell Physiol (2005) 1.51
Ethyl pyruvate inhibits nuclear factor-kappaB-dependent signaling by directly targeting p65. J Pharmacol Exp Ther (2004) 1.51
Increased iNOS activity is essential for intestinal epithelial tight junction dysfunction in endotoxemic mice. Shock (2004) 1.46
Resuscitation from hemorrhagic shock with Ringer's ethyl pyruvate solution improves survival and ameliorates intestinal mucosal hyperpermeability in rats. Shock (2002) 1.35
Proinflammatory cytokines cause NO*-dependent and -independent changes in expression and localization of tight junction proteins in intestinal epithelial cells. Shock (2003) 1.28
Midregional proadrenomedullin as a prognostic tool in community-acquired pneumonia. Chest (2009) 1.17
Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted anti-oxidants. Biochem Pharmacol (2007) 1.13
Increased iNOS activity is essential for pulmonary epithelial tight junction dysfunction in endotoxemic mice. Am J Physiol Lung Cell Mol Physiol (2003) 1.10
Treatment with a novel hemigramicidin-TEMPO conjugate prolongs survival in a rat model of lethal hemorrhagic shock. Ann Surg (2007) 1.06
Cytokines induce HIF-1 DNA binding and the expression of HIF-1-dependent genes in cultured rat enterocytes. Am J Physiol Gastrointest Liver Physiol (2002) 1.03
Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion. Intensive Care Med (2003) 1.02
Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated caco-2 enterocytic monolayers. J Pharmacol Exp Ther (2003) 1.00
Increased iNOS activity is essential for hepatic epithelial tight junction dysfunction in endotoxemic mice. Am J Physiol Gastrointest Liver Physiol (2003) 0.99
The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro. Biochem Pharmacol (2005) 0.97
Ethyl pyruvate provides durable protection against inflammation-induced intestinal epithelial barrier dysfunction. Shock (2003) 0.95
Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted antioxidants. Crit Care Med (2007) 0.95
Preconditioning with high mobility group box 1 (HMGB1) induces lipopolysaccharide (LPS) tolerance. J Leukoc Biol (2008) 0.92
NAD+ ameliorates inflammation-induced epithelial barrier dysfunction in cultured enterocytes and mouse ileal mucosa. J Pharmacol Exp Ther (2003) 0.91
Effect of hemorrhagic shock on gut barrier function and expression of stress-related genes in normal and gnotobiotic mice. Am J Physiol Regul Integr Comp Physiol (2002) 0.91
Comparison of distinct protein isoforms of the receptor for advanced glycation end-products expressed in murine tissues and cell lines. Cell Tissue Res (2009) 0.91
Drag-reducing hyaluronic acid increases survival in profoundly hemorrhaged rats. Shock (2009) 0.88
The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells. J Pharmacol Exp Ther (2005) 0.88
Ethyl pyruvate ameliorates ileus induced by bowel manipulation in mice. Surgery (2005) 0.85
Proinflammatory cytokines increase the rate of glycolysis and adenosine-5'-triphosphate turnover in cultured rat enterocytes. Crit Care Med (2003) 0.85
Liposomal NAD(+) prevents diminished O(2) consumption by immunostimulated Caco-2 cells. Am J Physiol Lung Cell Mol Physiol (2002) 0.82
Duration and magnitude of hypotension and monocyte deactivation in patients with community-acquired pneumonia. Shock (2011) 0.81
Extracellular activation of arginase-1 decreases enterocyte inducible nitric oxide synthase activity during systemic inflammation. Am J Physiol Gastrointest Liver Physiol (2009) 0.80
Ethacrynic acid inhibits multiple steps in the NF-kappaB signaling pathway. Shock (2005) 0.80
LPS increases hepatic HIF-1alpha protein and expression of the HIF-1-dependent gene aldolase A in rats. J Surg Res (2006) 0.80
Would you like your colloid straight or with a twist of an anti-inflammatory antioxidant? Crit Care Med (2009) 0.78
Regulation of hypoxia-inducible factor 1 in enterocytic cells. J Surg Res (2002) 0.78
Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line. J Inflamm (Lond) (2011) 0.75
Breathing normobaric oxygen protects against splanchnic ischemic injury: how does it work? Crit Care Med (2009) 0.75
Characterizing accelerated capture of deoligomerized TNF within hemoadsorption beads used to treat sepsis. J Biomed Mater Res B Appl Biomater (2011) 0.75