In vivo models of primary brain tumors: pitfalls and perspectives.

PubWeight™: 1.21‹?› | Rank: Top 10%

🔗 View Article (PMC 3408261)

Published in Neuro Oncol on June 07, 2012

Authors

Peter C Huszthy1, Inderjit Daphu, Simone P Niclou, Daniel Stieber, Janice M Nigro, Per Ø Sakariassen, Hrvoje Miletic, Frits Thorsen, Rolf Bjerkvig

Author Affiliations

1: NorLux, Neuro-Oncology Laboratory, Department of Biomedicine, University of Bergen, Bergen, Norway.

Articles citing this

Engraftment of Human Glioblastoma Cells in Immunocompetent Rats through Acquired Immunosuppression. PLoS One (2015) 1.39

Side population in human glioblastoma is non-tumorigenic and characterizes brain endothelial cells. Brain (2013) 1.12

Pediatric high grade glioma: a review and update on tumor clinical characteristics and biology. Front Oncol (2012) 1.10

Brain tumor stem cell multipotency correlates with nanog expression and extent of passaging in human glioblastoma xenografts. Oncotarget (2013) 0.96

Age-Dependent Association between Protein Expression of the Embryonic Stem Cell Marker Cripto-1 and Survival of Glioblastoma Patients. Transl Oncol (2013) 0.94

Serum-free culture success of glial tumors is related to specific molecular profiles and expression of extracellular matrix-associated gene modules. Neuro Oncol (2013) 0.85

Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia. Leukemia (2014) 0.84

Isolation of cancer stem cells from three human glioblastoma cell lines: characterization of two selected clones. PLoS One (2014) 0.83

Establishment and characterization of primary glioblastoma cell lines from fresh and frozen material: a detailed comparison. PLoS One (2013) 0.83

Contemporary murine models in preclinical astrocytoma drug development. Neuro Oncol (2014) 0.81

Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines. Free Radic Biol Med (2013) 0.81

Magnetic resonance spectroscopy for detection of choline kinase inhibition in the treatment of brain tumors. Mol Cancer Ther (2015) 0.81

Glioma Cells in the Tumor Periphery Have a Stem Cell Phenotype. PLoS One (2016) 0.80

Nitroxoline induces apoptosis and slows glioma growth in vivo. Neuro Oncol (2014) 0.79

EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells. Elife (2016) 0.78

An Emerging Allee Effect Is Critical for Tumor Initiation and Persistence. PLoS Comput Biol (2015) 0.78

Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment. J Neuropathol Exp Neurol (2015) 0.78

Vaccine-based immunotherapeutic approaches to gliomas and beyond. Nat Rev Neurol (2017) 0.77

Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts. PLoS One (2015) 0.77

Metabolic Reprogramming in Glioma. Front Cell Dev Biol (2017) 0.77

In vivo models of brain tumors: roles of genetically engineered mouse models in understanding tumor biology and use in preclinical studies. Cell Mol Life Sci (2014) 0.76

PeptideManager: a peptide selection tool for targeted proteomic studies involving mixed samples from different species. Front Genet (2014) 0.76

A tree shrew glioblastoma model recapitulates features of human glioblastoma. Oncotarget (2017) 0.75

Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer. PLoS One (2017) 0.75

Phenotypic dynamics of microglial and monocyte-derived cells in glioblastoma-bearing mice. Sci Rep (2016) 0.75

Glioma: experimental models and reality. Acta Neuropathol (2017) 0.75

Insights into molecular therapy of glioma: current challenges and next generation blueprint. Acta Pharmacol Sin (2017) 0.75

Preclinical Mouse Models for Analysis of the Therapeutic Potential of Engineered Oncolytic Herpes Viruses. ILAR J (2016) 0.75

Failure of a patient-derived xenograft for brain tumor model prepared by implantation of tissue fragments. Cancer Cell Int (2016) 0.75

Brain cancer mortality in an agricultural and a metropolitan region of Rio de Janeiro, Brazil: a population-based, age-period-cohort study, 1996-2010. BMC Cancer (2014) 0.75

Optimized creation of glioblastoma patient derived xenografts for use in preclinical studies. J Transl Med (2017) 0.75

Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma. Oncotarget (2016) 0.75

Comparison of Allogeneic and Syngeneic Rat Glioma Models by Using MRI and Histopathologic Evaluation. Comp Med (2017) 0.75

Organoid and Organ-On-A-Chip Systems: New Paradigms for Modeling Neurological and Gastrointestinal Disease. Curr Stem Cell Rep (2017) 0.75

Preclinical Modeling and Therapeutic Avenues for Cancer Metastasis to the Central Nervous System. Front Oncol (2017) 0.75

Articles cited by this

(truncated to the top 100)

Hallmarks of cancer: the next generation. Cell (2011) 140.01

The hallmarks of cancer. Cell (2000) 113.05

Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature (2008) 75.40

An integrated genomic analysis of human glioblastoma multiforme. Science (2008) 51.36

IDH1 and IDH2 mutations in gliomas. N Engl J Med (2009) 32.41

Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science (1992) 19.30

Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell (2006) 15.16

Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res (2004) 14.73

Effects of an Rb mutation in the mouse. Nature (1992) 11.06

Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A (2003) 10.56

CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell (2009) 8.54

Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell (2011) 7.30

Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell (2009) 6.77

Differentiated rat glial cell strain in tissue culture. Science (1968) 6.49

Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia (2002) 5.81

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat Genet (2000) 5.28

'Nude', a new hairless gene with pleiotropic effects in the mouse. Genet Res (1966) 4.89

Long term culture of normal and neoplastic human glia. Acta Pathol Microbiol Scand (1968) 4.82

A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes. J Neurosci (1992) 4.60

PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev (2001) 4.53

CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res (1996) 4.42

Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme. Neuro Oncol (2005) 4.10

Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma. Nat Rev Cancer (2010) 4.10

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat Genet (2000) 3.98

A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev (1998) 3.68

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proc Natl Acad Sci U S A (2011) 3.48

A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. Cancer Cell (2010) 3.34

Murine models to evaluate novel and conventional therapeutic strategies for cancer. Am J Pathol (2007) 3.03

U87MG decoded: the genomic sequence of a cytogenetically aberrant human cancer cell line. PLoS Genet (2010) 2.99

Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria. Oncogene (2007) 2.82

Mouse models of brain tumors and their applications in preclinical trials. Clin Cancer Res (2006) 2.68

Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: better than commonly perceived-but they can be improved. Cancer Biol Ther (2003) 2.61

An athymic nude mutation in the rat. Nature (1978) 2.54

Rat brain tumor models in experimental neuro-oncology: the C6, 9L, T9, RG2, F98, BT4C, RT-2 and CNS-1 gliomas. J Neurooncol (2009) 2.33

[Transplacental induction of malignant tumors of the nervous system. I. Ethyl-nitroso-urea (ENU) in BD IX rats]. Z Krebsforsch (1968) 2.24

Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts. Neuro Oncol (2009) 2.23

Genomic changes and gene expression profiles reveal that established glioma cell lines are poorly representative of primary human gliomas. Mol Cancer Res (2008) 2.22

Critical appraisal of the side population assay in stem cell and cancer stem cell research. Cell Stem Cell (2011) 2.13

A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors. Proc Natl Acad Sci U S A (1994) 1.99

Angiogenesis-independent tumor growth mediated by stem-like cancer cells. Proc Natl Acad Sci U S A (2006) 1.96

Non-stem cell origin for oligodendroglioma. Cancer Cell (2010) 1.95

Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development. Eur J Cancer (2004) 1.92

bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells. Neuron (1993) 1.92

Modeling Adult Gliomas Using RCAS/t-va Technology. Transl Oncol (2009) 1.89

Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells. Neuro Oncol (2011) 1.80

An in vivo patient-derived model of endogenous IDH1-mutant glioma. Neuro Oncol (2011) 1.70

The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids. Oncogene (2007) 1.69

The brain tumor microenvironment. Glia (2012) 1.66

Chemoprevention by cyclooxygenase-2 inhibition reduces immature myeloid suppressor cell expansion. Int Immunopharmacol (2006) 1.61

Genomic and expression profiling of glioblastoma stem cell-like spheroid cultures identifies novel tumor-relevant genes associated with survival. Clin Cancer Res (2009) 1.61

Studies on the chemotherapy of experimental brain tumors: development of an experimental model. Cancer Res (1970) 1.57

Genetic determinants of malignancy in a mouse model for oligodendroglioma. Cancer Res (2003) 1.46

Multicellular tumor spheroids from human gliomas maintained in organ culture. J Neurosurg (1990) 1.45

Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors. Cancer Res (1994) 1.43

The retinoblastoma gene is involved in malignant progression of astrocytomas. Ann Neurol (1994) 1.37

Expression of extracellular matrix components in a highly infiltrative in vivo glioma model. Acta Neuropathol (2002) 1.35

A reproducible brain tumour model established from human glioblastoma biopsies. BMC Cancer (2009) 1.35

Insights into cancer from transgenic mouse models. J Pathol (1999) 1.31

The perivascular niche microenvironment in brain tumor progression. Cell Cycle (2010) 1.30

Helper-independent retrovirus vectors with Rous-associated virus type O long terminal repeats. J Virol (1988) 1.29

A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. FASEB J (2008) 1.29

Genetic modeling of gliomas in mice: new tools to tackle old problems. Glia (2011) 1.28

Oligodendroglioma cell lines containing t(1;19)(q10;p10). Neuro Oncol (2010) 1.27

Neoplastic transformation of fetal rat brain cells in culture after exposure to ethylnitrosourea in vivo. J Natl Cancer Inst (1975) 1.26

Morphological studies of rat brain tumors induced by N-nitrosomethylurea. J Neurosurg (1971) 1.20

Antiphosphatidylserine antibody combined with irradiation damages tumor blood vessels and induces tumor immunity in a rat model of glioblastoma. Clin Cancer Res (2009) 1.17

Growth of precultured human glioma specimens in nude rat brain. J Neurosurg (1999) 1.15

[SELECTIVE INDUCTION OF MALIGNANT TUMORS IN THE BRAIN AND SPINAL CORD OF RATS BY N-METHYL-N-NITROSOUREA]. Z Krebsforsch (1965) 1.15

Growth and chemotherapeutic response in athymic mice of tumors arising from human glioma-derived cell lines. J Neuropathol Exp Neurol (1981) 1.15

Heterologous transplantation of human neural tumors. Cancer (1953) 1.13

A distinct subset of glioma cell lines with stem cell-like properties reflects the transcriptional phenotype of glioblastomas and overexpresses CXCR4 as therapeutic target. Glia (2011) 1.13

Growth and migration markers of rat C6 glioma cells identified by serial analysis of gene expression. Glia (2000) 1.10

The utility and limitations of neurosphere assay, CD133 immunophenotyping and side population assay in glioma stem cell research. Brain Pathol (2010) 1.08

Limitations of the C6/Wistar rat intracerebral glioma model: implications for evaluating immunotherapy. Neurosurgery (2000) 1.07

Genetic alterations and in vivo tumorigenicity of neurospheres derived from an adult glioblastoma. Mol Cancer (2004) 1.06

Models for neuro-oncological preclinical studies: solid orthotopic and heterotopic grafts of human gliomas into nude mice. J Neurosci Methods (2003) 1.06

What is the optimal rodent model for anti-tumor drug testing? Cancer Metastasis Rev (1999) 1.04

Phenotypic and genotypic characterization of orthotopic human glioma models and its relevance for the study of anti-glioma therapy. Brain Pathol (2008) 1.04

The athymic nude rat: an animal experimental model to reveal novel aspects of innate immune responses? Immunol Rev (2001) 1.01

Genetic characterization of commonly used glioma cell lines in the rat animal model system. Neurosurg Focus (2005) 1.01

Cancer stem cells and angiogenesis. Semin Cancer Biol (2009) 0.99

Using mice to decipher the molecular genetics of brain tumors. Neurosurgery (2003) 0.99

Occupational exposure to pesticides and risk of adult brain tumors. Am J Epidemiol (2008) 0.99

Animal models for brain tumors: historical perspectives and future directions. J Neurosurg (1994) 0.96

Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy. PLoS One (2009) 0.96

Phase III comparative evaluation of PCNU and carmustine combined with radiation therapy for high-grade glioma. J Clin Oncol (1993) 0.96

Changes in the immunologic phenotype of human malignant glioma cells after passaging in vitro. Clin Immunol (2002) 0.95

Collagens, integrins and the mesenchymal drift in glioblastomas: a comparison of biopsy specimens, spheroid and early monolayer cultures. Int J Cancer (1994) 0.92

Patterns of antigenic expression of human glioma cells. Crit Rev Neurobiol (1991) 0.89

Brain cancer stem cells: Think twice before going flat. Cell Stem Cell (2009) 0.89

Brain tumor chemotherapy: an evaluation of agents in current use for phase II and III trials. Cancer Treat Rep (1980) 0.89

The significance of the heterologous transplantability of human cancer. Cancer (1952) 0.89

Regression of C6 rat brain tumors by cells expressing an antisense insulin-like growth factor I receptor RNA. J Exp Ther Oncol (1996) 0.87

Tumor gene therapy made easy: allogeneic major histocompatibility complex in the C6 rat glioma model. Hum Gene Ther (1999) 0.87

Anaplastic human gliomas grown in athymic mice. Morphology and glial fibrillary acidic protein expression. Am J Pathol (1981) 0.86

Morphology of spontaneous brain tumors in the rat. Vet Pathol (1979) 0.86

The p16/Cdkn2a/Ink4a gene is frequently deleted in nitrosourea-induced rat glial tumors. Pathobiology (2000) 0.85

Ras activation in astrocytomas and neurofibromas. Can J Neurol Sci (1998) 0.85

Receptor expression, cytogenetic, and molecular analysis of six continuous human glioma cell lines. In Vitro Cell Dev Biol Anim (1998) 0.84

Radiobiology of radiosurgery: Part II. The rat C6 glioma model. Neurosurgery (1992) 0.84

Articles by these authors

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell (2006) 21.66

Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. Cancer Res (2009) 4.58

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proc Natl Acad Sci U S A (2011) 3.48

CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. Int J Cancer (2008) 3.46

Contribution of Notch signaling activation to human glioblastoma multiforme. J Neurosurg (2007) 2.43

γ knife surgery versus reoperation for recurrent glioblastoma multiforme. World Neurosurg (2012) 2.28

Critical appraisal of the side population assay in stem cell and cancer stem cell research. Cell Stem Cell (2011) 2.13

Spontaneous malignant transformation of human mesenchymal stem cells reflects cross-contamination: putting the research field on track - letter. Cancer Res (2010) 2.09

Gene expression profiling-based identification of molecular subtypes in stage IV melanomas with different clinical outcome. Clin Cancer Res (2010) 2.01

Angiogenesis-independent tumor growth mediated by stem-like cancer cells. Proc Natl Acad Sci U S A (2006) 1.96

Protein disulfide isomerase expression is related to the invasive properties of malignant glioma. Cancer Res (2006) 1.75

Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma. Proc Natl Acad Sci U S A (2007) 1.54

In vivo animal models for studying brain metastasis: value and limitations. Clin Exp Metastasis (2013) 1.52

Delineation of brain tumor extent with [11C]L-methionine positron emission tomography: local comparison with stereotactic histopathology. Clin Cancer Res (2004) 1.48

Glioma proliferation as assessed by 3'-fluoro-3'-deoxy-L-thymidine positron emission tomography in patients with newly diagnosed high-grade glioma. Clin Cancer Res (2008) 1.36

Expression of extracellular matrix components in a highly infiltrative in vivo glioma model. Acta Neuropathol (2002) 1.35

A reproducible brain tumour model established from human glioblastoma biopsies. BMC Cancer (2009) 1.35

Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous system. BMC Neurosci (2010) 1.33

DNA repair and cancer stem-like cells--potential partners in glioma drug resistance? Cancer Treat Rev (2008) 1.30

A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. FASEB J (2008) 1.29

Formation of composite endothelial cell-mesenchymal stem cell islets: a novel approach to promote islet revascularization. Diabetes (2008) 1.26

Glioma cell populations grouped by different cell type markers drive brain tumor growth. Cancer Res (2010) 1.24

NG2 proteoglycan promotes angiogenesis-dependent tumor growth in CNS by sequestering angiostatin. FASEB J (2002) 1.18

Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors. BMC Neurosci (2004) 1.18

Both TLR2 and TLR4 are required for the effective immune response in Staphylococcus aureus-induced experimental murine brain abscess. Am J Pathol (2007) 1.16

Cancer initiation and progression: involvement of stem cells and the microenvironment. Biochim Biophys Acta (2007) 1.16

The astrocyte/meningeal cell interface is a barrier to neurite outgrowth which can be overcome by manipulation of inhibitory molecules or axonal signalling pathways. Mol Cell Neurosci (2003) 1.16

Molecular mechanisms of temozolomide resistance in glioblastoma multiforme. Expert Rev Anticancer Ther (2012) 1.15

iTRAQ-based proteomics profiling reveals increased metabolic activity and cellular cross-talk in angiogenic compared with invasive glioblastoma phenotype. Mol Cell Proteomics (2009) 1.14

EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Acta Neuropathol (2013) 1.13

Side population in human glioblastoma is non-tumorigenic and characterizes brain endothelial cells. Brain (2013) 1.12

Atrial natriuretic peptide modulation of albumin clearance and contrast agent permeability in mouse skeletal muscle and skin: role in regulation of plasma volume. J Physiol (2009) 1.12

The expression of the chemorepellent Semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display limited anatomical plasticity and enhanced vulnerability in motor neuron disease. Mol Cell Neurosci (2006) 1.11

Mesenchymal stem cell signaling in cancer progression. Cancer Treat Rev (2012) 1.10

Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres. Nucleic Acids Res (2007) 1.10

Anti-VEGF therapies for malignant glioma: treatment effects and escape mechanisms. Expert Opin Ther Targets (2009) 1.09

PML-nuclear bodies accumulate DNA in response to polyomavirus BK and simian virus 40 replication. Exp Cell Res (2004) 1.08

Immunohistochemical expression of stem cell, endothelial cell, and chemosensitivity markers in primary glioma spheroids cultured in serum-containing and serum-free medium. Neurosurgery (2010) 1.06

HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects. Adv Cancer Res (2003) 1.05

Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma. PLoS One (2011) 1.05

Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas. Acta Neuropathol (2014) 1.04

An essential role for tumor necrosis factor in the formation of experimental murine Staphylococcus aureus-induced brain abscess and clearance. J Neuropathol Exp Neurol (2005) 1.04

Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. Acta Neuropathol (2011) 1.03

Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes. Acta Neuropathol (2013) 1.03

Interstitial fluid: the overlooked component of the tumor microenvironment? Fibrogenesis Tissue Repair (2010) 1.02

Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival. Cancer Res (2004) 1.01

Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival. Oncotarget (2013) 0.99

Promyelocytic leukemia nuclear bodies are predetermined processing sites for damaged DNA. J Cell Sci (2006) 0.99

Severe nigrostriatal degeneration without clinical parkinsonism in patients with polymerase gamma mutations. Brain (2013) 0.99

Cancer stem cells and angiogenesis. Semin Cancer Biol (2009) 0.99

Proteomics strategies for target identification and biomarker discovery in cancer. Front Biosci (Landmark Ed) (2009) 0.99

Low expression levels of ATM may substitute for CHEK2 /TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer. Breast Cancer Res (2012) 0.98

The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status. Neuro Oncol (2013) 0.97

Lentiviral-mediated transfer of CNTF to schwann cells within reconstructed peripheral nerve grafts enhances adult retinal ganglion cell survival and axonal regeneration. Mol Ther (2005) 0.97

Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors. BMC Cancer (2007) 0.97

Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia. Proc Natl Acad Sci U S A (2013) 0.96

Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy. PLoS One (2009) 0.96

Multimodal imaging of neural progenitor cell fate in rodents. Mol Imaging (2008) 0.96

A novel role for Sema3A in neuroprotection from injury mediated by activated microglia. J Neurosci (2006) 0.96

Cellular host responses to gliomas. PLoS One (2012) 0.95

Methyl-L-11C-methionine PET as a diagnostic marker for malignant progression in patients with glioma. J Nucl Med (2009) 0.94

[11C]-L-methionine positron emission tomography in the management of children and young adults with brain tumors. J Neurooncol (2009) 0.94

αB-crystallin is elevated in highly infiltrative apoptosis-resistant glioblastoma cells. Am J Pathol (2010) 0.94

Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis. Angiogenesis (2012) 0.94

Endostatin reduces vascularization, blood flow, and growth in a rat gliosarcoma. Neuro Oncol (2002) 0.94

Automated tracking of nanoparticle-labeled melanoma cells improves the predictive power of a brain metastasis model. Cancer Res (2013) 0.94