Published in J Mol Neurosci on September 05, 2002
Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data. Psychopharmacology (Berl) (2005) 1.29
Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain. Biochemistry (2009) 1.12
Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters. Nature (2005) 12.56
Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH. Nature (2007) 8.04
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell (2010) 6.94
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature (2009) 6.81
Structure of a glutamate transporter homologue from Pyrococcus horikoshii. Nature (2004) 6.02
Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature (2011) 5.93
Mechanism of glutamate receptor desensitization. Nature (2002) 5.36
Structure and conserved RNA binding of the PAZ domain. Nature (2003) 5.28
Subunit arrangement and function in NMDA receptors. Nature (2005) 5.21
A competitive inhibitor traps LeuT in an open-to-out conformation. Science (2008) 4.86
Structural basis for modulation and agonist specificity of HCN pacemaker channels. Nature (2003) 4.80
Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins. Structure (2006) 4.79
Structural basis for partial agonist action at ionotropic glutamate receptors. Nat Neurosci (2003) 4.55
Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol (2006) 4.55
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature (2007) 4.29
Crystal structure of the ATP-gated P2X(4) ion channel in the closed state. Nature (2009) 4.18
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature (2007) 4.14
Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. Mol Cell Biol (2008) 3.74
Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly. Mol Cell (2007) 3.51
Pore architecture and ion sites in acid-sensing ion channels and P2X receptors. Nature (2009) 3.37
Structure and mechanism of a Na+-independent amino acid transporter. Science (2009) 3.30
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states. Nature (2012) 3.24
Unlocking the molecular secrets of sodium-coupled transporters. Nature (2009) 3.23
Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core. EMBO J (2003) 3.15
X-ray structure of dopamine transporter elucidates antidepressant mechanism. Nature (2013) 3.00
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev (2009) 2.98
PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing. Mol Cell (2007) 2.77
Dynamic superresolution imaging of endogenous proteins on living cells at ultra-high density. Biophys J (2010) 2.65
Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor. Cell (2006) 2.63
The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. Blood (2007) 2.58
Molecular mechanism of ATP binding and ion channel activation in P2X receptors. Nature (2012) 2.53
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. Mol Cell (2004) 2.43
Structure and regulation of MAPK phosphatases. Cell Signal (2004) 2.42
Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell (2002) 2.20
Crystal structure and association behaviour of the GluR2 amino-terminal domain. EMBO J (2009) 2.19
Mechanism of partial agonist action at the NR1 subunit of NMDA receptors. Neuron (2005) 2.07
Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b. Nature (2010) 2.02
The role of human bromodomains in chromatin biology and gene transcription. Curr Opin Drug Discov Devel (2009) 1.99
Mechanism of positive allosteric modulators acting on AMPA receptors. J Neurosci (2005) 1.97
BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle (2012) 1.88
Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure (2008) 1.86
Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site. Nature (2010) 1.85
Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes. Nature (2012) 1.84
The PHD finger: a versatile epigenome reader. Trends Biochem Sci (2011) 1.81
Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes. Proc Natl Acad Sci U S A (2003) 1.81
A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3. Nat Struct Biol (2003) 1.67
Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. J Biol Chem (2012) 1.66
Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature (2013) 1.56
Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP. Structure (2003) 1.54
Trimeric subunit stoichiometry of the glutamate transporters from Bacillus caldotenax and Bacillus stearothermophilus. Biochemistry (2003) 1.50
Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. EMBO J (2002) 1.49
Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate. Biochemistry (2002) 1.45
BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy. Cancer Res (2013) 1.43
Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem (2011) 1.43
Crystal structure of the Vibrio cholerae cytolysin (VCC) pro-toxin and its assembly into a heptameric transmembrane pore. J Mol Biol (2005) 1.42
Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores. Proc Natl Acad Sci U S A (2010) 1.41
A fluorescence-detection size-exclusion chromatography-based thermostability assay for membrane protein precrystallization screening. Structure (2012) 1.38
Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat Struct Mol Biol (2012) 1.37
A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem Biol (2011) 1.35
Structure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulator. Structure (2009) 1.35
Epigenetic transcriptional repression of cellular genes by a viral SET protein. Nat Cell Biol (2008) 1.34
Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing. Nat Struct Mol Biol (2008) 1.32
Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression. Cancer Res (2011) 1.31
Structural insights of the specificity and catalysis of a viral histone H3 lysine 27 methyltransferase. J Mol Biol (2006) 1.30
Keeping it in the family: diverse histone recognition by conserved structural folds. Crit Rev Biochem Mol Biol (2010) 1.29
Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal. Biochemistry (2003) 1.27
Structure and hemimethylated CpG binding of the SRA domain from human UHRF1. J Biol Chem (2008) 1.26
Target structure-based discovery of small molecules that block human p53 and CREB binding protein association. Chem Biol (2006) 1.25
Beta-barrel membrane protein folding and structure viewed through the lens of alpha-hemolysin. Biochim Biophys Acta (2003) 1.20
Amino terminal domains of the NMDA receptor are organized as local heterodimers. PLoS One (2011) 1.18
Arresting and releasing Staphylococcal alpha-hemolysin at intermediate stages of pore formation by engineered disulfide bonds. Protein Sci (2003) 1.18
Selective small molecules blocking HIV-1 Tat and coactivator PCAF association. J Am Chem Soc (2005) 1.18
p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase. PLoS One (2010) 1.18
High resolution crystallographic studies of alpha-hemolysin-phospholipid complexes define heptamer-lipid head group interactions: implication for understanding protein-lipid interactions. Protein Sci (2004) 1.15
Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX. J Med Chem (2003) 1.10
Structure and mechanisms of lysine methylation recognition by the chromodomain in gene transcription. Biochemistry (2011) 1.10
The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins. J Struct Funct Genomics (2010) 1.07
How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters. J Physiol (2013) 1.06
Structure and chromosomal DNA binding of the SWIRM domain. Nat Struct Mol Biol (2005) 1.06
Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue. EMBO Rep (2012) 1.05
T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation. J Exp Med (2013) 1.03
Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2. Cell Res (2010) 1.02
Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation. Novartis Found Symp (2004) 1.01
A 14-amino acid sequence with a beta-turn structure is required for apical membrane sorting of the rat ileal bile acid transporter. J Biol Chem (2002) 1.01
A vibrational spectroscopic investigation of interactions of agonists with GluR0, a prokaryotic glutamate receptor. Biochemistry (2002) 1.01
Structure of the neural (N-) cadherin prodomain reveals a cadherin extracellular domain-like fold without adhesive characteristics. Structure (2004) 1.01
Insights into transport mechanism from LeuT engineered to transport tryptophan. EMBO J (2011) 1.00
The SUVR4 histone lysine methyltransferase binds ubiquitin and converts H3K9me1 to H3K9me3 on transposon chromatin in Arabidopsis. PLoS Genet (2011) 0.95
Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity. J Med Chem (2003) 0.95
Viral-encoded enzymes that target host chromatin functions. Biochim Biophys Acta (2009) 0.93
Computer aided identification of small molecules disrupting uPAR/alpha5beta1--integrin interaction: a new paradigm for metastasis prevention. PLoS One (2009) 0.93
Biochemical profiling of histone binding selectivity of the yeast bromodomain family. PLoS One (2010) 0.93
Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J Med Chem (2013) 0.93
Structure-guided optimization of small molecules inhibiting human immunodeficiency virus 1 Tat association with the human coactivator p300/CREB binding protein-associated factor. J Med Chem (2007) 0.92
Molecular basis of distinct interactions between Dok1 PTB domain and tyrosine-phosphorylated EGF receptor. J Mol Biol (2004) 0.91
Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2. J Med Chem (2008) 0.90
Vibrio cholerae cytolysin is composed of an alpha-hemolysin-like core. Protein Sci (2003) 0.90