Published in Science on December 12, 2008
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X-ray structures of LeuT in substrate-free outward-open and apo inward-open states. Nature (2012) 3.24
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X-ray structure of dopamine transporter elucidates antidepressant mechanism. Nature (2013) 3.00
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Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter. J Biol Chem (2009) 1.38
Experimental conditions can obscure the second high-affinity site in LeuT. Nat Struct Mol Biol (2012) 1.37
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Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter. J Biol Chem (2009) 1.33
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Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Proc Natl Acad Sci U S A (2011) 1.29
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Conformational dynamics of ligand-dependent alternating access in LeuT. Nat Struct Mol Biol (2014) 1.19
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The binding sites for benztropines and dopamine in the dopamine transporter overlap. Neuropharmacology (2010) 1.11
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Chloride binding site of neurotransmitter sodium symporters. Proc Natl Acad Sci U S A (2013) 1.09
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The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors. PLoS One (2011) 1.07
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Coupled global and local changes direct substrate translocation by neurotransmitter-sodium symporter ortholog LeuT. Biophys J (2013) 1.07
How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters. J Physiol (2013) 1.06
Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue. EMBO Rep (2012) 1.05
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Structural insights into the activation mechanism of melibiose permease by sodium binding. Proc Natl Acad Sci U S A (2010) 0.99
Topologically conserved residues direct heme transport in HRG-1-related proteins. J Biol Chem (2011) 0.98
Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine. J Biol Chem (2010) 0.97
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Visualizing functional motions of membrane transporters with molecular dynamics simulations. Biochemistry (2013) 0.96
The cost of living in the membrane: a case study of hydrophobic mismatch for the multi-segment protein LeuT. Chem Phys Lipids (2013) 0.96
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Cytoplasmic permeation pathway of neurotransmitter transporters. Biochemistry (2011) 0.92
The mechanism of substrate release by the aspartate transporter GltPh: insights from simulations. Mol Biosyst (2010) 0.92
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Microseconds simulations reveal a new sodium-binding site and the mechanism of sodium-coupled substrate uptake by LeuT. J Biol Chem (2014) 0.88
The two Na+ sites in the human serotonin transporter play distinct roles in the ion coupling and electrogenicity of transport. J Biol Chem (2013) 0.88
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Ligand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulations. PLoS One (2013) 0.87
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Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site. J Biol Chem (2014) 0.87
Insights into the Modulation of Dopamine Transporter Function by Amphetamine, Orphenadrine, and Cocaine Binding. Front Neurol (2015) 0.86
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Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter:Sodium Symporter. J Biol Chem (2015) 0.86
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