Published in Chin J Popul Sci on January 01, 1998
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature (2000) 47.15
Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest (2001) 23.21
SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J Struct Biol (1996) 22.89
A protein interaction map of Drosophila melanogaster. Science (2003) 20.06
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science (1997) 16.09
Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association. Nat Genet (2001) 13.05
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell (1997) 12.83
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell (2000) 11.90
A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet (1997) 10.93
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell (1992) 9.19
A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell (1994) 8.44
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature (2001) 7.44
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science (1997) 7.31
Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med (1999) 7.07
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem (1999) 6.88
Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science (2001) 6.84
Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke (2001) 6.61
Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein. Nature (1998) 6.29
RSC, an essential, abundant chromatin-remodeling complex. Cell (1996) 6.17
An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science (2001) 6.07
Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science (1997) 6.00
BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science (1999) 5.99
Steered molecular dynamics and mechanical functions of proteins. Curr Opin Struct Biol (2001) 5.97
The evolution of H5N1 influenza viruses in ducks in southern China. Proc Natl Acad Sci U S A (2004) 5.87
IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages. J Immunol (1998) 5.79
A simple method for clinical assay of superoxide dismutase. Clin Chem (1988) 5.66
Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs. Mol Cell (1998) 5.60
Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus. Arthritis Rheum (2001) 5.36
BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity (2000) 5.36
Genetic diversity and disease control in rice. Nature (2000) 5.34
Structure of the bacteriophage phi29 DNA packaging motor. Nature (2000) 5.25
Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo. J Virol (1992) 5.19
Spin-torque switching with the giant spin Hall effect of tantalum. Science (2012) 5.18
Extensive variation of human immunodeficiency virus type-1 in vivo. Nature (1988) 5.02
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A (1999) 4.90
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell (1995) 4.73
Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet (1998) 4.67
Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor. Cell (1991) 4.66
Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke (2001) 4.64
Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci U S A (1995) 4.54
Genetic evidence for selective transport of opsin and arrestin by kinesin-II in mammalian photoreceptors. Cell (2000) 4.51
Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol Cell (1999) 4.49
Femtosecond electronic response of atoms to ultra-intense X-rays. Nature (2010) 4.46
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene (2008) 4.43
Activation of memory circuits during cue-elicited cocaine craving. Proc Natl Acad Sci U S A (1996) 4.31
SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol (2000) 4.30
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev (1994) 4.30
The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F. J Virol (1998) 4.26
Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res (1999) 4.20
Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Curr Biol (2001) 4.16
A viral phospholipase A2 is required for parvovirus infectivity. Dev Cell (2001) 3.97
Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease. Neurology (2007) 3.97
Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev Biol (2001) 3.82
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol (2007) 3.81
A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme. Mol Cell (1999) 3.80
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest (2001) 3.79
Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nat Genet (2000) 3.72
The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study. Leukemia (2008) 3.69
Auxin-induced expression of the soybean GH3 promoter in transgenic tobacco plants. Plant Mol Biol (1991) 3.67
A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet (2000) 3.63
Green fluorescent protein as a noninvasive intracellular pH indicator. Biophys J (1998) 3.61
Significance of premature stop codons in env of simian immunodeficiency virus. J Virol (1989) 3.60
Statistical power and optimal design for multisite randomized trials. Psychol Methods (2000) 3.58
Tumor necrosis factor-alpha synergizes with IFN-gamma in mediating killing of Leishmania major through the induction of nitric oxide. J Immunol (1990) 3.56
A model of protein synthesis based on cryo-electron microscopy of the E. coli ribosome. Nature (1995) 3.56
The significance of skeletal-related events for the health-related quality of life of patients with metastatic prostate cancer. Ann Oncol (2005) 3.56
Is routine indwelling catheterisation of the bladder for caesarean section necessary? A systematic review. BJOG (2010) 3.54
Olfactory deficits in patients with mild cognitive impairment predict Alzheimer's disease at follow-up. Am J Psychiatry (2000) 3.54
A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nat Genet (2001) 3.52
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci U S A (2000) 3.44
Laboratory tests as predictors of disease exacerbations in systemic lupus erythematosus. Why some tests fail. Arthritis Rheum (1996) 3.40
Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. Cell (2000) 3.39
A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol Cell Biol (1993) 3.38
Disrupted circadian rhythms in VIP- and PHI-deficient mice. Am J Physiol Regul Integr Comp Physiol (2003) 3.37
Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery. EMBO J (1999) 3.35
Changes to AIDS dementia complex in the era of highly active antiretroviral therapy. AIDS (1999) 3.28
A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes Dev (1999) 3.25
Generating yeast transcriptional activators containing no yeast protein sequences. Nature (1991) 3.21
A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity. Pharm Res (1999) 3.19
Size and shape effects in the biodistribution of intravascularly injected particles. J Control Release (2009) 3.08
CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling. Oncogene (2011) 3.08
Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation. J Immunol (2000) 3.07
Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma. J Exp Med (1997) 3.07
Three human transforming genes are related to the viral ras oncogenes. Proc Natl Acad Sci U S A (1983) 3.06
Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiol Aging (2005) 3.00
Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science (2001) 2.97
Clinical and molecular cytogenetic characterisation of a newly recognised microdeletion syndrome involving 2p15-16.1. J Med Genet (2006) 2.97
The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with distinct maternal and paternal roles in the embryo. Cell (2001) 2.92
Antiviral RNA interference in mammalian cells. Science (2013) 2.89
Lead exposure and intelligence in 7-year-old children: the Yugoslavia Prospective Study. Environ Health Perspect (1997) 2.88
Schistosomiasis in the People's Republic of China: prospects and challenges for the 21st century. Clin Microbiol Rev (2001) 2.85
Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats. J Neurol Sci (2001) 2.84
CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell (1992) 2.83
Functional deficits in patients with mild cognitive impairment: prediction of AD. Neurology (2002) 2.79
Genetic properties of chromosomally integrated 2 mu plasmid DNA in yeast. Cell (1982) 2.78
The biological lifetime of nitric oxide: implications for the perivascular dynamics of NO and O2. Proc Natl Acad Sci U S A (2001) 2.75