Published in Genes Dev on September 01, 1999
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Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. J Cell Biol (1999) 3.77
An ECT2-centralspindlin complex regulates the localization and function of RhoA. J Cell Biol (2005) 3.74
CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis. J Cell Biol (2000) 3.55
PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone. J Cell Biol (2002) 3.51
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol (2004) 3.39
A microtubule-dependent zone of active RhoA during cleavage plane specification. J Cell Biol (2005) 3.15
Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cells. Mol Biol Cell (2002) 3.13
Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis. J Cell Biol (2003) 3.12
Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. EMBO J (2004) 2.60
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Dissecting the role of Rho-mediated signaling in contractile ring formation. Mol Biol Cell (2005) 2.33
MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. Proc Natl Acad Sci U S A (2005) 2.00
Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac. J Cell Biol (2004) 1.94
Rho GTPase activity zones and transient contractile arrays. Bioessays (2006) 1.79
Mutations in orbit/mast reveal that the central spindle is comprised of two microtubule populations, those that initiate cleavage and those that propagate furrow ingression. J Cell Biol (2004) 1.78
Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis. Proc Natl Acad Sci U S A (2005) 1.73
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The Drosophila mus101 gene, which links DNA repair, replication and condensation of heterochromatin in mitosis, encodes a protein with seven BRCA1 C-terminus domains. Genetics (2000) 1.58
Polo-like kinase controls vertebrate spindle elongation and cytokinesis. PLoS One (2007) 1.53
Genetic dissection of meiotic cytokinesis in Drosophila males. Mol Biol Cell (2004) 1.49
Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins. Genetics (2000) 1.49
Localization of Pavarotti-KLP in living Drosophila embryos suggests roles in reorganizing the cortical cytoskeleton during the mitotic cycle. Mol Biol Cell (2003) 1.48
RhoGEF and positioning of rappaport-like furrows in the early Drosophila embryo. Curr Biol (2012) 1.44
Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression. Dev Cell (2012) 1.43
Stable and dynamic microtubules coordinately shape the myosin activation zone during cytokinetic furrow formation. J Cell Biol (2008) 1.43
Rho-dependent control of anillin behavior during cytokinesis. J Cell Biol (2008) 1.42
Rho-kinase controls cell shape changes during cytokinesis. Curr Biol (2006) 1.42
Identification of chromosome inheritance modifiers in Drosophila melanogaster. Genetics (2001) 1.38
Nuf, a Rab11 effector, maintains cytokinetic furrow integrity by promoting local actin polymerization. J Cell Biol (2008) 1.37
Untying the Gordian knot of cytokinesis. Role of small G proteins and their regulators. J Cell Biol (2000) 1.36
DRhoGEF2 regulates actin organization and contractility in the Drosophila blastoderm embryo. J Cell Biol (2005) 1.33
Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis. Proc Natl Acad Sci U S A (2005) 1.30
The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer. Adv Enzyme Regul (2009) 1.28
Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP-related proteins. EMBO J (2001) 1.28
Self-maintained escort cells form a germline stem cell differentiation niche. Development (2011) 1.27
The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly. J Cell Biol (2011) 1.26
Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase. Hum Mol Genet (2006) 1.25
Drosophila citron kinase is required for the final steps of cytokinesis. Mol Biol Cell (2004) 1.21
Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis. Nat Chem Biol (2010) 1.19
Vesicles and actin are targeted to the cleavage furrow via furrow microtubules and the central spindle. J Cell Biol (2008) 1.19
Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle. Mol Biol Cell (2006) 1.19
An agent-based model contrasts opposite effects of dynamic and stable microtubules on cleavage furrow positioning. J Cell Biol (2008) 1.18
p190RhoGAP is cell cycle regulated and affects cytokinesis. J Cell Biol (2003) 1.18
The degradation of two mitotic cyclins contributes to the timing of cytokinesis. Curr Biol (2003) 1.15
Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells. PLoS Biol (2003) 1.13
A RHO GTPase-mediated pathway is required during P cell migration in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2001) 1.12
Rho GTPases in animal cell cytokinesis: an occupation by the one percent. Cytoskeleton (Hoboken) (2012) 1.11
Understanding cytokinesis failure. Adv Exp Med Biol (2010) 1.06
Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis. Genetics (2011) 1.06
TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila. J Cell Sci (2009) 1.06
Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis. Mol Cell Biol (2002) 1.05
Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle. Mol Biol Cell (2009) 1.04
A Drosophila model of multiple endocrine neoplasia type 2. Genetics (2005) 1.03
Embryonic morphogenesis in Caenorhabditis elegans integrates the activity of LET-502 Rho-binding kinase, MEL-11 myosin phosphatase, DAF-2 insulin receptor and FEM-2 PP2c phosphatase. Genetics (2000) 1.01
Regulation of the Rac GTPase pathway by the multifunctional Rho GEF Pebble is essential for mesoderm migration in the Drosophila gastrula. Development (2009) 1.00
Coordination of Rho family GTPase activities to orchestrate cytoskeleton responses during cell wound repair. Curr Biol (2014) 1.00
Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells. Small GTPases (2014) 1.00
Rho1 has multiple functions in Drosophila wing planar polarity. Dev Biol (2009) 0.99
Anillin: a pivotal organizer of the cytokinetic machinery. Biochem Soc Trans (2008) 0.99
The Caenorhabditis elegans ect-2 RhoGEF gene regulates cytokinesis and migration of epidermal P cells. EMBO Rep (2005) 0.97
p190RhoGAP negatively regulates Rho activity at the cleavage furrow of mitotic cells. Exp Cell Res (2009) 0.95
Novel functions of Ect2 in polar lamellipodia formation and polarity maintenance during "contractile ring-independent" cytokinesis in adherent cells. Mol Biol Cell (2007) 0.95
A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain. Biochem J (2002) 0.94
Cell elongation is an adaptive response for clearing long chromatid arms from the cleavage plane. J Cell Biol (2012) 0.94
The Control of semaphorin-1a-mediated reverse signaling by opposing pebble and RhoGAPp190 functions in drosophila. Neuron (2012) 0.93
Citron kinase controls a molecular network required for midbody formation in cytokinesis. Proc Natl Acad Sci U S A (2013) 0.93
Mitotic down-regulation of p190RhoGAP is required for the successful completion of cytokinesis. J Biol Chem (2010) 0.91
Cooperation between the septins and the actomyosin ring and role of a cell-integrity pathway during cell division in fission yeast. Genetics (2010) 0.91
Formins in development: orchestrating body plan origami. Biochim Biophys Acta (2008) 0.91
RNA interference screen to identify genes required for Drosophila embryonic nervous system development. Proc Natl Acad Sci U S A (2007) 0.91
The protein tyrosine phosphatase PTP-BL associates with the midbody and is involved in the regulation of cytokinesis. Mol Biol Cell (2003) 0.90
A genome-wide screen identifies genes that affect somatic homolog pairing in Drosophila. G3 (Bethesda) (2012) 0.89
The Caenorhabditis elegans homologue of the proto-oncogene ect-2 positively regulates RAS signalling during vulval development. EMBO Rep (2005) 0.88
Polo kinase interacts with RacGAP50C and is required to localize the cytokinesis initiation complex. J Biol Chem (2010) 0.86
A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response. Immunogenetics (2011) 0.86
The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration. Genes Cancer (2011) 0.85
Rho-guanine nucleotide exchange factors during development: Force is nothing without control. Small GTPases (2010) 0.85
A second-site noncomplementation screen for modifiers of Rho1 signaling during imaginal disc morphogenesis in Drosophila. PLoS One (2009) 0.84
Ect2/Pbl acts via Rho and polarity proteins to direct the assembly of an isotropic actomyosin cortex upon mitotic entry. Dev Cell (2015) 0.83
Genetic evidence for antagonism between Pak protein kinase and Rho1 small GTPase signaling in regulation of the actin cytoskeleton during Drosophila oogenesis. Genetics (2010) 0.83
Kinesins to the core: The role of microtubule-based motor proteins in building the mitotic spindle midzone. Semin Cell Dev Biol (2010) 0.83
Ect2, an ortholog of Drosophila's pebble, negatively regulates neurite outgrowth in neuroblastoma × glioma hybrid NG108-15 cells. Cell Mol Neurobiol (2011) 0.81
Ect2, an ortholog of Drosophila Pebble, regulates formation of growth cones in primary cortical neurons. Neurochem Int (2012) 0.79
The molecular biology of the olive fly comes of age. BMC Genet (2014) 0.79
Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster. Int J Mol Sci (2013) 0.78
Orbit/CLASP is required for myosin accumulation at the cleavage furrow in Drosophila male meiosis. PLoS One (2014) 0.78
A functional genomic screen combined with time-lapse microscopy uncovers a novel set of genes involved in dorsal closure of Drosophila embryos. PLoS One (2011) 0.78
An astral simulacrum of the central spindle accounts for normal, spindle-less, and anucleate cytokinesis in echinoderm embryos. Mol Biol Cell (2014) 0.77
The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis. Elife (2016) 0.77
Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway. Development (2013) 0.76
Isoform-specific functions of Mud/NuMA mediate binucleation of Drosophila male accessory gland cells. BMC Dev Biol (2014) 0.76
Identification and comparative analysis of novel alternatively spliced transcripts of RhoGEF domain encoding gene in C. elegans and C. briggsae. Bioinformation (2007) 0.75
Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis. Cell Rep (2016) 0.75
Sema-1a Reverse Signaling Promotes Midline Crossing in Response to Secreted Semaphorins. Cell Rep (2017) 0.75
Snail-dependent repression of the RhoGEF pebble is required for gastrulation consistency in Drosophila melanogaster. Dev Genes Evol (2012) 0.75
RhoA phosphorylation mediated by Rho/RhoA-associated kinase pathway improves the anti-freezing potentiality of murine hatched and diapaused blastocysts. Sci Rep (2017) 0.75
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