Published in Nature on December 03, 1998
A polygenic burden of rare disruptive mutations in schizophrenia. Nature (2014) 5.99
Functional requirement for class I MHC in CNS development and plasticity. Science (2000) 5.57
Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proc Natl Acad Sci U S A (2002) 4.77
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Neuron (2003) 3.62
Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron (2004) 3.21
Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin. Nat Neurosci (2007) 2.90
Synapse-specific regulation of AMPA receptor function by PSD-95. Proc Natl Acad Sci U S A (2006) 2.88
Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter. Proc Natl Acad Sci U S A (2005) 2.83
The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95. Proc Natl Acad Sci U S A (2003) 2.82
PSD-95 is required for activity-driven synapse stabilization. Proc Natl Acad Sci U S A (2007) 2.56
A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability. Nat Neurosci (2007) 2.54
Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1. J Neurosci (2008) 2.27
Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins. Mol Syst Biol (2009) 2.17
Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD. Neuron (2008) 2.15
Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticity. Neuron (2008) 2.15
Effects of environmental enrichment on gene expression in the brain. Proc Natl Acad Sci U S A (2000) 2.13
The molecular and cellular biology of enhanced cognition. Nat Rev Neurosci (2009) 2.12
Mutations in the DLG3 gene cause nonsyndromic X-linked mental retardation. Am J Hum Genet (2004) 2.04
Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering. J Cell Biol (2000) 2.04
Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery. Chem Rev (2013) 2.02
PSD-95 regulates synaptic transmission and plasticity in rat cerebral cortex. J Physiol (2003) 1.99
Molecular organization of the postsynaptic specialization. Proc Natl Acad Sci U S A (2001) 1.92
Evolutionary expansion and anatomical specialization of synapse proteome complexity. Nat Neurosci (2008) 1.91
Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95. J Cell Biol (2009) 1.91
Regulation of DLG localization at synapses by CaMKII-dependent phosphorylation. Cell (1999) 1.81
Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking. J Neurosci (2010) 1.76
The role of neuronal complexes in human X-linked brain diseases. Am J Hum Genet (2007) 1.71
Narrowing the boundaries of the genetic architecture of schizophrenia. Schizophr Bull (2009) 1.71
Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice. EMBO J (2000) 1.70
Delayed stabilization of dendritic spines in fragile X mice. J Neurosci (2010) 1.69
Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development. Proc Natl Acad Sci U S A (2008) 1.68
Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies. J Neurosci (2007) 1.68
Composition of the synaptic PSD-95 complex. Mol Cell Proteomics (2007) 1.68
Synaptic scaffold evolution generated components of vertebrate cognitive complexity. Nat Neurosci (2012) 1.67
The proteomes of neurotransmitter receptor complexes form modular networks with distributed functionality underlying plasticity and behaviour. Mol Syst Biol (2006) 1.66
Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling. Proc Natl Acad Sci U S A (2003) 1.66
Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation. J Neurosci (2010) 1.65
Natural patterns of activity and long-term synaptic plasticity. Curr Opin Neurobiol (2000) 1.58
PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2. Nat Neurosci (2012) 1.58
Kalirin-7 is required for synaptic structure and function. J Neurosci (2008) 1.54
The postsynaptic organization of synapses. Cold Spring Harb Perspect Biol (2011) 1.53
Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity. J Physiol (2008) 1.50
Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice. EMBO J (2007) 1.49
ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. J Neurosci (2010) 1.47
PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. J Neurosci (2009) 1.46
NO as a signalling molecule in the nervous system. Br J Pharmacol (2002) 1.46
PSD-95 promotes synaptogenesis and multiinnervated spine formation through nitric oxide signaling. J Cell Biol (2008) 1.43
CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory. Neuron (2016) 1.38
S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95. Neuron (2011) 1.35
The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. J Exp Med (2004) 1.35
Association of mouse Dlg4 (PSD-95) gene deletion and human DLG4 gene variation with phenotypes relevant to autism spectrum disorders and Williams' syndrome. Am J Psychiatry (2010) 1.34
PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity. Curr Opin Neurobiol (2011) 1.34
CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons. Nat Cell Biol (2012) 1.34
Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in Dlg5-/- mice. Dev Cell (2007) 1.33
PSD-95 is required to sustain the molecular organization of the postsynaptic density. J Neurosci (2011) 1.33
Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice. J Neurosci (2011) 1.32
Complexity of calcium signaling in synaptic spines. Bioessays (2002) 1.32
TARP phosphorylation regulates synaptic AMPA receptors through lipid bilayers. Neuron (2010) 1.30
Targeted disruption of the PDZK1 gene by homologous recombination. Mol Cell Biol (2003) 1.30
Key role of tissue plasminogen activator in neurovascular coupling. Proc Natl Acad Sci U S A (2008) 1.30
The role of SAP97 in synaptic glutamate receptor dynamics. Proc Natl Acad Sci U S A (2010) 1.30
Excitation Control: Balancing PSD-95 Function at the Synapse. Front Mol Neurosci (2008) 1.29
E-I balance and human diseases - from molecules to networking. Front Mol Neurosci (2008) 1.29
Enhanced learning after genetic overexpression of a brain growth protein. Proc Natl Acad Sci U S A (2000) 1.27
Clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder. PLoS One (2011) 1.27
Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons. J Neurosci (2008) 1.26
Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior. Nat Neurosci (2012) 1.25
Molecular mechanisms of psychostimulant-induced structural plasticity. Pharmacopsychiatry (2009) 1.25
Neurotransmitters drive combinatorial multistate postsynaptic density networks. Sci Signal (2009) 1.24
Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities. J Biol Chem (2009) 1.24
Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration. J Physiol (2011) 1.24
Inhibition of the dopamine D1 receptor signaling by PSD-95. J Biol Chem (2007) 1.21
Subunit- and pathway-specific localization of NMDA receptors and scaffolding proteins at ganglion cell synapses in rat retina. J Neurosci (2009) 1.21
Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes. J Cell Biol (2007) 1.19
Regulation of postsynaptic structure and function by an A-kinase anchoring protein-membrane-associated guanylate kinase scaffolding complex. J Neurosci (2009) 1.19
Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis. Neural Dev (2009) 1.18
PDZ protein interactions regulating glutamate receptor function and plasticity. J Cell Biol (2001) 1.18
NCAM promotes assembly and activity-dependent remodeling of the postsynaptic signaling complex. J Cell Biol (2006) 1.18
Distinct perisynaptic and synaptic localization of NMDA and AMPA receptors on ganglion cells in rat retina. J Comp Neurol (2006) 1.18
Nuclear and cytosolic JNK signalling in neurons. Nat Rev Neurosci (2014) 1.17
Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95. Nat Neurosci (2010) 1.16
CREB binding protein is required for both short-term and long-term memory formation. J Neurosci (2010) 1.14
Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes. BMC Neurosci (2008) 1.14
SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis. J Cell Biol (2008) 1.14
Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline. Neurobiol Dis (2011) 1.14
PSD-95 and PSD-93 play critical but distinct roles in synaptic scaling up and down. J Neurosci (2011) 1.13
The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity. J Biol Chem (2009) 1.12
Post-synaptic density perturbs insulin-induced Kv1.3 channel modulation via a clustering mechanism involving the SH3 domain. J Neurochem (2007) 1.12
Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents. Br J Pharmacol (2009) 1.11
Comprehensive behavioral phenotyping of calpastatin-knockout mice. Mol Brain (2008) 1.11
A role for calcium-permeable AMPA receptors in synaptic plasticity and learning. PLoS One (2010) 1.11
Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of Schizophrenia. Neuropsychopharmacology (2009) 1.09
Expression of AMPA receptor subunits at synapses in laminae I-III of the rodent spinal dorsal horn. Mol Pain (2008) 1.09
Organization of kinases, phosphatases, and receptor signaling complexes. J Clin Invest (1999) 1.08
E6AP-dependent degradation of DLG4/PSD95 by high-risk human papillomavirus type 18 E6 protein. J Virol (2006) 1.08
PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex. EMBO J (2006) 1.07
DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory. J Biol Chem (2010) 1.07
Dysregulation of presynaptic calcium and synaptic plasticity in a mouse model of 22q11 deletion syndrome. J Neurosci (2010) 1.06
Place navigation impaired in rats with hippocampal lesions. Nature (1982) 15.79
Glycoprotein staining following electrophoresis on acrylamide gels. Anal Biochem (1969) 12.65
Telomere reduction in human colorectal carcinoma and with ageing. Nature (1990) 11.24
Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature (1993) 10.72
Synaptic plasticity and memory: an evaluation of the hypothesis. Annu Rev Neurosci (2000) 8.20
Synaptic tagging and long-term potentiation. Nature (1997) 7.65
Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature (1986) 7.10
Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med (1999) 7.07
Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J Pathol (1984) 6.67
Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. Nat Neurosci (2000) 6.10
An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science (2001) 6.07
IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages. J Immunol (1998) 5.79
Apoptosis. The role of the endonuclease. Am J Pathol (1990) 5.43
BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity (2000) 5.36
Structure of the bacteriophage phi29 DNA packaging motor. Nature (2000) 5.25
Human telomeres contain at least three types of G-rich repeat distributed non-randomly. Nucleic Acids Res (1989) 4.72
Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science (1992) 4.58
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol (2007) 3.81
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology (2003) 3.62
Delay-dependent impairment of a matching-to-place task with chronic and intrahippocampal infusion of the NMDA-antagonist D-AP5. Hippocampus (1999) 3.55
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci U S A (2000) 3.44
Spatial learning with a minislab in the dorsal hippocampus. Proc Natl Acad Sci U S A (1995) 3.42
Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices. J Neurosci (1987) 3.39
Evidence for cortical "disconnection" as a mechanism of age-related cognitive decline. Neurology (2001) 3.30
A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease. Nature (2001) 3.28
A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes Dev (1999) 3.25
Reward-related reversal learning after surgical excisions in orbito-frontal or dorsolateral prefrontal cortex in humans. J Cogn Neurosci (2004) 3.10
Localization of amyloid beta protein messenger RNA in brains from patients with Alzheimer's disease. Science (1987) 3.07
Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex. Neuroscience (2004) 3.06
Synaptic tagging: implications for late maintenance of hippocampal long-term potentiation. Trends Neurosci (1998) 3.00
Memory consolidation and NMDA receptors: discrepancy between genetic and pharmacological approaches. Science (2001) 2.97
Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome. Nat Genet (1997) 2.81
Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (1995) 2.79
Macrophage recognition of cells undergoing programmed cell death (apoptosis). Immunology (1985) 2.77
Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease. J Neurosci (1985) 2.72
Mortality attributable to cigarette smoking in China. JAMA (1997) 2.72
Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats. J Neurosci (2000) 2.51
Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A (1997) 2.48
Distinct components of spatial learning revealed by prior training and NMDA receptor blockade. Nature (1995) 2.47
White matter damage on diffusion tensor imaging correlates with age-related cognitive decline. Neurology (2006) 2.42
Synthesis of epothilones A and B in solid and solution phase. Nature (1997) 2.35
Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy. J Exp Med (1999) 2.33
Reversible neural inactivation reveals hippocampal participation in several memory processes. Nat Neurosci (1999) 2.32
Changes in emotion after circumscribed surgical lesions of the orbitofrontal and cingulate cortices. Brain (2003) 2.32
A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease. Brain (1988) 2.32
Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell (1998) 2.21
Impaired spatial learning after saturation of long-term potentiation. Science (1998) 2.17
CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP. Cell (1995) 2.16
A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature (1997) 2.16
Mental-physical co-morbidity and its relationship with disability: results from the World Mental Health Surveys. Psychol Med (2008) 2.15
High interlaboratory reproducibility of matrix-assisted laser desorption ionization-time of flight mass spectrometry-based species identification of nonfermenting bacteria. J Clin Microbiol (2009) 2.13
A vascular endothelial growth factor antagonist is produced by the human placenta and released into the maternal circulation. Biol Reprod (1998) 2.12
Depression-anxiety relationships with chronic physical conditions: results from the World Mental Health Surveys. J Affect Disord (2007) 2.12
Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin. J Biol Chem (1997) 2.06
Functional magnetic resonance imaging of synesthesia: activation of V4/V8 by spoken words. Nat Neurosci (2002) 2.05
Activation of cAMP-responsive genes by stimuli that produce long-term facilitation in Aplysia sensory neurons. Neuron (1993) 2.05
Hippocampal representation in place learning. J Neurosci (1990) 2.05
Hormone-induced cell death. Purification ad properties of thymocytes undergoing apoptosis after glucocorticoid treatment. Am J Pathol (1982) 2.04
NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling. Proc Natl Acad Sci U S A (1999) 2.03
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature (1991) 2.02
The enigma of olfactory learning. Trends Neurosci (1993) 2.02
Methods for diagnosis and treatment of stimulus-correlated motion in generic brain activation studies using fMRI. Hum Brain Mapp (1999) 2.01
Transcriptional repression by the proto-oncogene BCL-6. Oncogene (1996) 1.94
A structural equation modeling investigation of age-related variance in executive function and DTI measured white matter damage. Neurobiol Aging (2007) 1.92
Quantitative specificity of the Mnt repressor. J Mol Biol (1997) 1.91
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence. Science (2013) 1.91
Microsatellite instability and the role of hMSH2 in sporadic colorectalcancer. Oncogene (1996) 1.89
Impaired extra-dimensional shift performance in medicated and unmedicated Parkinson's disease: evidence for a specific attentional dysfunction. Neuropsychologia (1989) 1.87
Occupational exposure to bisphenol-A (BPA) and the risk of self-reported male sexual dysfunction. Hum Reprod (2009) 1.87
Deficiency in fatty acid synthase leads to premature cell death and dramatic alterations in plant morphology. Plant Cell (2000) 1.84
The 289-amino acid E1A protein of adenovirus binds zinc in a region that is important for trans-activation. Proc Natl Acad Sci U S A (1988) 1.84
Hormone-induced cell death. 2. Surface changes in thymocytes undergoing apoptosis. Am J Pathol (1984) 1.83
Development of neuroendocrine tumors in the gastrointestinal tract of transgenic mice. Heterogeneity of hormone expression. Am J Pathol (1990) 1.80
Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene. Proc Natl Acad Sci U S A (1997) 1.75
Structure determination of the head-tail connector of bacteriophage phi29. Acta Crystallogr D Biol Crystallogr (2001) 1.74
The functional neuroanatomy of comprehension and memory: the importance of prior knowledge. Brain (1999) 1.74
Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: a quantitative evaluation of a one-year autopsy population from a geriatric hospital. Cereb Cortex (1994) 1.73
Detection of incidental colorectal tumours with 18F-labelled 2-fluoro-2-deoxyglucose positron emission tomography/computed tomography scans: results of a prospective study. Colorectal Dis (2011) 1.73
Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis. J Neurol Neurosurg Psychiatry (2004) 1.72
Quantum criticality and nodal superconductivity in the FeAs-based superconductor KFe2As2. Phys Rev Lett (2010) 1.68
Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery. Neuroscience (2009) 1.68
Landmark stability is a prerequisite for spatial but not discrimination learning. Nature (1993) 1.66
P-element mutations affecting embryonic peripheral nervous system development in Drosophila melanogaster. Genetics (1995) 1.65
Activity-dependent beta-adrenergic modulation of low frequency stimulation induced LTP in the hippocampal CA1 region. Neuron (1996) 1.65
Different modes of hippocampal plasticity in response to estrogen in young and aged female rats. Proc Natl Acad Sci U S A (2001) 1.64
Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. Neuron (1995) 1.63
Field performance of transgenic elite commercial hybrid rice expressing bacillus thuringiensis delta-endotoxin. Nat Biotechnol (2000) 1.62
Postsynaptic complex spike bursting enables the induction of LTP by theta frequency synaptic stimulation. J Neurosci (1998) 1.62
A multichamber equilibrium dialysis apparatus. Anal Biochem (1972) 1.61
P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: mutations affecting embryonic PNS development. Genetics (1997) 1.60
Atypical form of Alzheimer's disease with prominent posterior cortical atrophy: a review of lesion distribution and circuit disconnection in cortical visual pathways. Vision Res (1997) 1.59
Dissociation between components of spatial memory in rats after recovery from the effects of retrohippocampal lesions. Exp Brain Res (1985) 1.59
atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain. Neuron (2000) 1.58
Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I. Superior frontal and inferior temporal cortex. J Comp Neurol (1990) 1.58