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Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. Chem Biol (2004) 5.44

Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota. Nature (2010) 5.08

Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing. Cell (2008) 4.59

Structural basis of activity and allosteric control of diguanylate cyclase. Proc Natl Acad Sci U S A (2004) 4.40

Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol Cell (2005) 4.11

Recent developments in phasing and structure refinement for macromolecular crystallography. Curr Opin Struct Biol (2009) 4.09

The architecture of respiratory complex I. Nature (2010) 3.43

Structural basis of abscisic acid signalling. Nature (2009) 3.29

Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. Cell (2009) 3.24

Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. EMBO J (2006) 3.21

Structural basis of RNA recognition and activation by innate immune receptor RIG-I. Nature (2011) 3.05

A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats. J Biol Chem (2008) 3.00

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature (2012) 2.97

Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol (2009) 2.94

The mechanism of ammonia transport based on the crystal structure of AmtB of Escherichia coli. Proc Natl Acad Sci U S A (2004) 2.91

Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids. Cell (2010) 2.83

Structures from anomalous diffraction of native biological macromolecules. Science (2012) 2.83

Crystal structure of the channelrhodopsin light-gated cation channel. Nature (2012) 2.83

Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein. Nature (2006) 2.77

Structure of the periplasmic component of a bacterial drug efflux pump. Proc Natl Acad Sci U S A (2004) 2.66

Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature (2012) 2.64

The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Proc Natl Acad Sci U S A (2006) 2.63

Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen. Mol Cell (2006) 2.63

The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes. Cell (2008) 2.61

High-resolution structure of the E.coli RecQ helicase catalytic core. EMBO J (2003) 2.61

Structural investigation of the GlmS ribozyme bound to Its catalytic cofactor. Chem Biol (2006) 2.60

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Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer. Immunity (2009) 2.46

Structural biology of human H3K9 methyltransferases. PLoS One (2010) 2.45

Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain. Cell Host Microbe (2010) 2.44

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Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. Nature (2008) 2.36

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Structure of a fucose transporter in an outward-open conformation. Nature (2010) 2.28

Crystal structure of the lysine riboswitch regulatory mRNA element. J Biol Chem (2008) 2.27

p31comet blocks Mad2 activation through structural mimicry. Cell (2007) 2.26

Structural insight into the mechanism of substrate specificity and catalytic activity of an HD-domain phosphohydrolase: the 5'-deoxyribonucleotidase YfbR from Escherichia coli. J Mol Biol (2008) 2.19

Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. Nat Struct Mol Biol (2005) 2.18

Structure of the DNA repair helicase XPD. Cell (2008) 2.16

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP. Nat Struct Mol Biol (2013) 2.14

Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor. Proc Natl Acad Sci U S A (2007) 2.13

Crystal structure of a Baeyer-Villiger monooxygenase. Proc Natl Acad Sci U S A (2004) 2.07

X-ray structure of a calcium-activated TMEM16 lipid scramblase. Nature (2014) 2.04

Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target. Science (2014) 2.01

Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1. Nat Struct Mol Biol (2008) 2.00

The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response. Nature (2012) 1.99

Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily. Nat Chem Biol (2008) 1.96

Crystal structure of inhibitor of κB kinase β. Nature (2011) 1.92

Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus. Nat Immunol (2006) 1.92

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis. EMBO J (2012) 1.91

On the structure of the stator of the mitochondrial ATP synthase. EMBO J (2006) 1.90

Structural basis of ultraviolet-B perception by UVR8. Nature (2012) 1.86

Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13. Structure (2011) 1.86

The structure of a cytolytic alpha-helical toxin pore reveals its assembly mechanism. Nature (2009) 1.84

Robust structural analysis of native biological macromolecules from multi-crystal anomalous diffraction data. Acta Crystallogr D Biol Crystallogr (2013) 1.80

Mechanism of actin filament nucleation by the bacterial effector VopL. Nat Struct Mol Biol (2011) 1.80

Structural basis of Sec-independent membrane protein insertion by YidC. Nature (2014) 1.79

The Corynebacterium diphtheriae shaft pilin SpaA is built of tandem Ig-like modules with stabilizing isopeptide and disulfide bonds. Proc Natl Acad Sci U S A (2009) 1.79

Structure of a presenilin family intramembrane aspartate protease. Nature (2012) 1.76

Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport. Nature (2010) 1.76

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Structural basis for the modular recognition of single-stranded RNA by PPR proteins. Nature (2013) 1.66

The Scottish Structural Proteomics Facility: targets, methods and outputs. J Struct Funct Genomics (2010) 1.66

Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases. Nat Struct Mol Biol (2008) 1.65

Detection and analysis of unusual features in the structural model and structure-factor data of a birch pollen allergen. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 1.64

Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein. Cell Res (2012) 1.64

X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers. J Am Chem Soc (2008) 1.64

Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold. Protein Sci (2007) 1.63

Mechanism of the Class I KDPG aldolase. Bioorg Med Chem (2006) 1.62

Doc of prophage P1 is inhibited by its antitoxin partner Phd through fold complementation. J Biol Chem (2008) 1.62

Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins. Proc Natl Acad Sci U S A (2007) 1.62

Allosteric modulation of DNA by small molecules. Proc Natl Acad Sci U S A (2009) 1.61

Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex. Nature (2016) 1.60

The crystal structure of iron-free human serum transferrin provides insight into inter-lobe communication and receptor binding. J Biol Chem (2006) 1.60

Structural basis for mammalian vitamin B12 transport by transcobalamin. Proc Natl Acad Sci U S A (2006) 1.59

Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family. Nat Struct Mol Biol (2015) 1.59

Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis. PLoS Pathog (2008) 1.57

The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription. PLoS Pathog (2010) 1.57

The active site of a carbohydrate esterase displays divergent catalytic and noncatalytic binding functions. PLoS Biol (2009) 1.57

Relationship between the structure of SET/TAF-Ibeta/INHAT and its histone chaperone activity. Proc Natl Acad Sci U S A (2007) 1.55

Insights into finding a mismatch through the structure of a mispaired DNA bound by a rhodium intercalator. Proc Natl Acad Sci U S A (2006) 1.55

Molecular mechanism of sequence-directed DNA loading and translocation by FtsK. Mol Cell (2008) 1.54

Structural insights into the Slit-Robo complex. Proc Natl Acad Sci U S A (2007) 1.54

Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. EMBO J (2011) 1.52

Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell (2010) 1.51

Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain. J Biol Chem (2010) 1.51

Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. Mol Cell (2008) 1.51

Structural basis for ligand recognition and activation of RAGE. Structure (2010) 1.50

The FACT Spt16 "peptidase" domain is a histone H3-H4 binding module. Proc Natl Acad Sci U S A (2008) 1.50

Structure of the Staphylococcus aureus AgrA LytTR domain bound to DNA reveals a beta fold with an unusual mode of binding. Structure (2008) 1.50

Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. J Biol Chem (2008) 1.49

A catalytic coiled coil: structural insights into the activation of the Rab GTPase Sec4p by Sec2p. Mol Cell (2007) 1.48

Crystal structure of the membrane fusion protein CusB from Escherichia coli. J Mol Biol (2009) 1.47

Separation of domain contacts is required for heterotetrameric assembly of functional NMDA receptors. J Neurosci (2011) 1.47

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ANODE: anomalous and heavy-atom density calculation. J Appl Crystallogr (2011) 8.79

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A magic triangle for experimental phasing of macromolecules. Acta Crystallogr D Biol Crystallogr (2008) 2.07

Improving radiation-damage substructures for RIP. Acta Crystallogr D Biol Crystallogr (2005) 1.80

Structures of viscotoxins A1 and B2 from European mistletoe solved using native data alone. Acta Crystallogr D Biol Crystallogr (2008) 1.64

Structure determination of the O-methyltransferase NovP using the 'free lunch algorithm' as implemented in SHELXE. Acta Crystallogr D Biol Crystallogr (2007) 1.63

A ligand-induced switch in the periplasmic domain of sensor histidine kinase CitA. J Mol Biol (2008) 1.61

Is the bond-valence method able to identify metal atoms in protein structures? Acta Crystallogr D Biol Crystallogr (2002) 1.50

Crystallographic ab initio protein structure solution below atomic resolution. Nat Methods (2009) 1.38

Crystal structure of the alkylsulfatase AtsK: insights into the catalytic mechanism of the Fe(II) alpha-ketoglutarate-dependent dioxygenase superfamily. Biochemistry (2004) 1.27

The solution and crystal structures of a module pair from the Staphylococcus aureus-binding site of human fibronectin--a tale with a twist. J Mol Biol (2007) 1.24

Structure of viscotoxin A3: disulfide location from weak SAD data. Acta Crystallogr D Biol Crystallogr (2003) 1.19

Automatic solution of heavy-atom substructures. Methods Enzymol (2003) 1.18

Locating the anomalous scatterer substructures in halide and sulfur phasing. Acta Crystallogr D Biol Crystallogr (2002) 1.17

How to get the magic triangle and the MAD triangle into your protein crystal. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 1.16

Structural analysis of the PP2C phosphatase tPphA from Thermosynechococcus elongatus: a flexible flap subdomain controls access to the catalytic site. J Mol Biol (2007) 1.14

The 2A resolution crystal structure of HetL, a pentapeptide repeat protein involved in regulation of heterocyst differentiation in the cyanobacterium Nostoc sp. strain PCC 7120. J Struct Biol (2008) 1.14

5-Amino-2,4,6-tribromoisophthalic acid: the MAD triangle for experimental phasing. Acta Crystallogr C (2009) 1.11

In-house measurement of the sulfur anomalous signal and its use for phasing. Acta Crystallogr D Biol Crystallogr (2003) 1.08

Labyrinthopeptins: a new class of carbacyclic lantibiotics. Angew Chem Int Ed Engl (2010) 1.01

In-house phase determination of the lima bean trypsin inhibitor: a low-resolution sulfur-SAD case. Acta Crystallogr D Biol Crystallogr (2003) 0.99

Atomic resolution structure of squash trypsin inhibitor: unexpected metal coordination. Acta Crystallogr D Biol Crystallogr (2002) 0.98

Extending molecular-replacement solutions with SHELXE. Acta Crystallogr D Biol Crystallogr (2013) 0.95

Practical structure solution with ARCIMBOLDO. Acta Crystallogr D Biol Crystallogr (2012) 0.95

Mapping of a substrate binding site in the protein disulfide isomerase-related chaperone wind based on protein function and crystal structure. J Biol Chem (2004) 0.93

Structures of complexes between echinomycin and duplex DNA. Acta Crystallogr D Biol Crystallogr (2005) 0.92

Structure of tripeptidyl-peptidase I provides insight into the molecular basis of late infantile neuronal ceroid lipofuscinosis. J Biol Chem (2008) 0.90

Refinement of obverse/reverse twins. Acta Crystallogr B (2002) 0.90

The magic triangle goes MAD: experimental phasing with a bromine derivative. Acta Crystallogr D Biol Crystallogr (2010) 0.90

Structure of Ecballium elaterium trypsin inhibitor II (EETI-II): a rigid molecular scaffold. Acta Crystallogr D Biol Crystallogr (2005) 0.89

Crystal structure of trioxacarcin A covalently bound to DNA. Nucleic Acids Res (2008) 0.88

The antiviral antibiotic feglymycin: first direct-methods solution of a 1000+ equal-atom structure. Angew Chem Int Ed Engl (2005) 0.87

Exploiting tertiary structure through local folds for crystallographic phasing. Nat Methods (2013) 0.86

Structures of glycopeptide antibiotics with peptides that model bacterial cell-wall precursors. J Mol Biol (2002) 0.85

Structure of dimeric cytochrome c3 from Desulfovibrio gigas at 1.2 A resolution. Acta Crystallogr D Biol Crystallogr (2003) 0.84

Crystal structure and functional analysis of Drosophila Wind, a protein-disulfide isomerase-related protein. J Biol Chem (2003) 0.84

Unexpected tautomeric equilibria of the carbanion-enamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of thiamin. Proc Natl Acad Sci U S A (2012) 0.84

Structure of the parallel duplex of poly(A) RNA: evaluation of a 50 year-old prediction. Angew Chem Int Ed Engl (2013) 0.83

Geometric properties of nucleic acids with potential for autobuilding. Acta Crystallogr A (2010) 0.83

Crystal and solution structures of 7-amino-actinomycin D complexes with d(TTAGBrUT), d(TTAGTT) and d(TTTAGTTT). Acta Crystallogr D Biol Crystallogr (2005) 0.83

The C2A-C2B linker defines the high affinity Ca(2+) binding mode of rabphilin-3A. J Biol Chem (2006) 0.82

The crystal structure of non-modified and bipyridine-modified PNA duplexes. Chemistry (2010) 0.81

Structure of the lipopeptide antibiotic tsushimycin. Acta Crystallogr D Biol Crystallogr (2005) 0.81

Structural elucidation of the PDI-related chaperone Wind with the help of mutants. Acta Crystallogr D Biol Crystallogr (2006) 0.81

Solution and structure of an alternating D,L-peptide. Acta Crystallogr D Biol Crystallogr (2004) 0.80

Inclusion complexes of V-amylose with undecanoic acid and dodecanol at atomic resolution: X-ray structures with cycloamylose containing 26 D-glucoses (cyclohexaicosaose) as host. Carbohydr Res (2004) 0.80

Structure and activity of the only human RNase T2. Nucleic Acids Res (2012) 0.80

Serendipitous SAD phasing of an echinomycin-(ACGTACGT)2 bisintercalation complex. Acta Crystallogr D Biol Crystallogr (2006) 0.79

The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop. Acta Crystallogr D Biol Crystallogr (2007) 0.79

The thermodynamic influence of trapped water molecules on a protein-ligand interaction. Angew Chem Int Ed Engl (2009) 0.79

Interaction of an echinomycin-DNA complex with manganese ions. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.79

Structure of the C2A domain of rabphilin-3A. Acta Crystallogr D Biol Crystallogr (2006) 0.79

Structure analysis of endosialidase NF at 0.98 A resolution. Acta Crystallogr D Biol Crystallogr (2010) 0.77

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Structure of a highly NADP+-specific isocitrate dehydrogenase. Acta Crystallogr D Biol Crystallogr (2011) 0.76

Crystal structures of cephaibols. J Pept Sci (2003) 0.76

Oxidative ortho C-C coupling of 4-ethylphenol by dual substrate activation at a bioinspired dicopper complex--trapping of an unusual oligophenolic Cu6 species. Chemistry (2009) 0.75

Continuous β-turn fold of an alternating alanyl/homoalanyl peptide nucleic acid. Acta Crystallogr D Biol Crystallogr (2012) 0.75

Syntheses and crystal structures of the new Ag-S clusters [Ag70S16(SPh)34(PhCO2)4(triphos)4] and [Ag188S94(PR3)30]. Angew Chem Int Ed Engl (2002) 0.75

Experimental charge density studies of disordered N-phenylpyrrole and N-(4-fluorophenyl)pyrrole. J Phys Chem A (2009) 0.75