Published in Nat Genet on September 23, 2002
Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Nat Rev Cancer (2010) 3.95
Acromegaly pathogenesis and treatment. J Clin Invest (2009) 2.19
Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest (2003) 2.18
Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays. Neoplasia (2004) 2.08
Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China. J Transl Med (2008) 1.57
Pituitary hypoplasia in Pttg-/- mice is protective for Rb+/- pituitary tumorigenesis. Mol Endocrinol (2005) 1.40
p21(Cip1) restrains pituitary tumor growth. Proc Natl Acad Sci U S A (2008) 1.31
Murine candidate bleomycin induced pulmonary fibrosis susceptibility genes identified by gene expression and sequence analysis of linkage regions. J Med Genet (2005) 1.18
Master regulators of FGFR2 signalling and breast cancer risk. Nat Commun (2013) 1.12
PTTG/securin activates expression of p53 and modulates its function. Mol Cancer (2004) 1.11
Pituitary tumor transforming gene interacts with Sp1 to modulate G1/S cell phase transition. Oncogene (2007) 1.06
Overexpressed hPTTG1 promotes breast cancer cell invasion and metastasis by regulating GEF-H1/RhoA signalling. Oncogene (2011) 1.01
Protein phosphatase 2A stabilizes human securin, whose phosphorylated forms are degraded via the SCF ubiquitin ligase. Mol Cell Biol (2006) 0.99
A small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma. Clin Cancer Res (2012) 0.99
Induction of Dlk1 by PTTG1 inhibits adipocyte differentiation and correlates with malignant transformation. Mol Biol Cell (2009) 0.98
Human full-length Securin is a natively unfolded protein. Protein Sci (2005) 0.96
The PTTG1-targeting miRNAs miR-329, miR-300, miR-381, and miR-655 inhibit pituitary tumor cell tumorigenesis and are involved in a p53/PTTG1 regulation feedback loop. Oncotarget (2015) 0.95
PTTG1 overexpression in adrenocortical cancer is associated with poor survival and represents a potential therapeutic target. Surgery (2013) 0.95
Cdc20 and securin overexpression predict short-term breast cancer survival. Br J Cancer (2014) 0.93
The emerging role of pituitary tumor transforming gene in tumorigenesis. Clin Med Res (2006) 0.92
Overexpression of the pituitary tumor transforming gene induces p53-dependent senescence through activating DNA damage response pathway in normal human fibroblasts. J Biol Chem (2010) 0.91
Viral takeover of the host ubiquitin system. Front Microbiol (2011) 0.90
Securin (hPTTG1) expression is regulated by beta-catenin/TCF in human colorectal carcinoma. Br J Cancer (2006) 0.90
Securin is a target of the UV response pathway in mammalian cells. Mol Cell Biol (2004) 0.89
Loss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistance. PLoS One (2011) 0.89
Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence. Endocrinology (2009) 0.89
PTTG1/securin modulates microtubule nucleation and cell migration. Mol Biol Cell (2011) 0.88
E2F1 induces pituitary tumor transforming gene (PTTG1) expression in human pituitary tumors. Mol Endocrinol (2009) 0.84
Glycogen synthase kinase-3beta (GSK3beta) negatively regulates PTTG1/human securin protein stability, and GSK3beta inactivation correlates with securin accumulation in breast tumors. J Biol Chem (2011) 0.84
Proliferation marker securin identifies favourable outcome in invasive ductal breast cancer. Br J Cancer (2008) 0.84
The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells. Endocrinology (2014) 0.84
Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene. FEBS Lett (2010) 0.83
PTTG1 attenuates drug-induced cellular senescence. PLoS One (2011) 0.82
Securin a new role for itself. Nat Genet (2002) 0.82
The influence of the pituitary tumor transforming gene-1 (PTTG-1) on survival of patients with small cell lung cancer and non-small cell lung cancer. J Carcinog (2006) 0.82
High expression of pituitary tumor-transforming gene-1 predicts poor prognosis in clear cell renal cell carcinoma. Mol Clin Oncol (2014) 0.81
Isolation and characterization of novel pituitary tumor related genes: a cDNA representational difference approach. Mol Cell Endocrinol (2010) 0.81
Oct-1 induces pituitary tumor transforming gene expression in endocrine tumors. Endocr Relat Cancer (2008) 0.80
Critical differences between isoforms of securin reveal mechanisms of separase regulation. Mol Cell Biol (2013) 0.80
PTTG1 expression is associated with hyperproliferative disease and poor prognosis in multiple myeloma. J Hematol Oncol (2015) 0.79
Evidence for cooperative transforming activity of the human pituitary tumor transforming gene and human T-cell leukemia virus type 1 Tax. J Virol (2007) 0.78
FoxM1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion. BMC Med Genomics (2015) 0.77
Positive and negative regulation of vertebrate separase by Cdk1-cyclin B1 may explain why securin is dispensable. J Biol Chem (2015) 0.76
PTTG1 regulated by miR-146-3p promotes bladder cancer migration, invasion, metastasis and growth. Oncotarget (2016) 0.75
Combining fisetin and ionizing radiation suppresses the growth of mammalian colorectal cancers in xenograft tumor models. Oncol Lett (2016) 0.75
Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer. Oncogene (2017) 0.75
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation. Apoptosis (2007) 1.73
Indexing and retrieving DICOM data in disperse and unstructured archives. Int J Comput Assist Radiol Surg (2008) 1.69
Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism. J Biol Chem (2003) 1.60
Mechanisms establishing TLR4-responsive activation states of inflammatory response genes. PLoS Genet (2011) 1.58
The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability. Mol Biol Cell (2008) 1.51
Genome instability and transcription elongation impairment in human cells depleted of THO/TREX. PLoS Genet (2011) 1.41
p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene. EMBO Rep (2006) 1.34
Defining the CT angiography 'spot sign' in primary intracerebral hemorrhage. Can J Neurol Sci (2009) 1.28
Repair of DNA damage induced by bile salts in Salmonella enterica. Genetics (2006) 1.27
Bile-induced DNA damage in Salmonella enterica. Genetics (2004) 1.22
Transgenic tobacco plants overexpressing chitinases of fungal origin show enhanced resistance to biotic and abiotic stress agents. Plant Physiol (2006) 1.18
The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis. J Biol Chem (2008) 1.18
Temporal profile of recanalization after intravenous tissue plasminogen activator: selecting patients for rescue reperfusion techniques. Stroke (2006) 1.17
Salmonella type III secretion effector SlrP is an E3 ubiquitin ligase for mammalian thioredoxin. J Biol Chem (2009) 1.16
An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination. Mol Cell Biol (2006) 1.14
Engagement of alpha4beta1 integrin by fibronectin induces in vitro resistance of B chronic lymphocytic leukemia cells to fludarabine. J Leukoc Biol (2002) 1.14
Methods of detection of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and Tannerella forsythensis in periodontal microbiology, with special emphasis on advanced molecular techniques: a review. J Clin Periodontol (2004) 1.13
Repression of the RcsC-YojN-RcsB phosphorelay by the IgaA protein is a requisite for Salmonella virulence. Mol Microbiol (2004) 1.10
p53 regulates the proliferation, differentiation and spontaneous transformation of mesenchymal stem cells. Exp Cell Res (2009) 1.09
Different physiological relevance of yeast THO/TREX subunits in gene expression and genome integrity. Mol Genet Genomics (2007) 1.08
Rcs and PhoPQ regulatory overlap in the control of Salmonella enterica virulence. J Bacteriol (2007) 1.07
Expression of proinflammatory cytokines in osteoarthritis of the temporomandibular joint. Arch Oral Biol (2008) 1.07
Quantitative real-time polymerase chain reaction versus culture: a comparison between two methods for the detection and quantification of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and Tannerella forsythensis in subgingival plaque samples. J Clin Periodontol (2004) 1.05
Use of mixed infections to study cell invasion and intracellular proliferation of Salmonella enterica in eukaryotic cell cultures. J Microbiol Methods (2004) 1.05
The Salmonella type III secretion effector, salmonella leucine-rich repeat protein (SlrP), targets the human chaperone ERdj3. J Biol Chem (2010) 1.04
A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J (2011) 1.04
Over-expression of forkhead box P3 and its association with receptor activator of nuclear factor-kappa B ligand, interleukin (IL) -17, IL-10 and transforming growth factor-beta during the progression of chronic periodontitis. J Clin Periodontol (2009) 1.04
Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants. Mol Cell Biol (2006) 1.04
Dicoogle - an open source peer-to-peer PACS. J Digit Imaging (2011) 1.03
Quantitative real-time polymerase chain reaction based on single copy gene sequence for detection of periodontal pathogens. J Clin Periodontol (2004) 1.01
Protein phosphatase 2A stabilizes human securin, whose phosphorylated forms are degraded via the SCF ubiquitin ligase. Mol Cell Biol (2006) 0.99
Induction of Dlk1 by PTTG1 inhibits adipocyte differentiation and correlates with malignant transformation. Mol Biol Cell (2009) 0.98
Characterization of two highly similar Rad51 homologs of Physcomitrella patens. J Mol Biol (2002) 0.98
Virulence attenuation in Salmonella enterica rcsC mutants with constitutive activation of the Rcs system. Microbiology (2005) 0.97
Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers. BMC Cancer (2011) 0.96
Involvement of p53 in alpha4beta1 integrin-mediated resistance of B-CLL cells to fludarabine. Biochem Biophys Res Commun (2003) 0.95
IB-00208, a new cytotoxic polycyclic xanthone produced by a marine-derived Actinomadura. I. Isolation of the strain, taxonomy and biological activites. J Antibiot (Tokyo) (2003) 0.94
Differential cytokine expression by human dendritic cells in response to different Porphyromonas gingivalis capsular serotypes. J Clin Periodontol (2009) 0.93
The GATC-binding protein SeqA is required for bile resistance and virulence in Salmonella enterica serovar typhimurium. J Bacteriol (2007) 0.93
R-loop mediated transcription-associated recombination in trf4Δ mutants reveals new links between RNA surveillance and genome integrity. PLoS One (2013) 0.92
New knowledge of the pathogenesis of periodontal disease. Quintessence Int (2004) 0.92
Nab2 functions in the metabolism of RNA driven by polymerases II and III. Mol Biol Cell (2011) 0.92
Quantitative real-time PCR based on single copy gene sequence for detection of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. J Periodontal Res (2003) 0.91
Serum low-density lipoprotein cholesterol level predicts hematoma growth and clinical outcome after acute intracerebral hemorrhage. Stroke (2011) 0.90
Expression of hpttg proto-oncogene in lymphoid neoplasias. Oncogene (2002) 0.90
Roles of the outer membrane protein AsmA of Salmonella enterica in the control of marRAB expression and invasion of epithelial cells. J Bacteriol (2009) 0.90
Detoxifying antitumoral drugs via nanoconjugation: the case of gold nanoparticles and cisplatin. PLoS One (2012) 0.90
Double bolt regulation of Rad51 by p53: a role for transcriptional repression. Cell Cycle (2006) 0.89
Securin is a target of the UV response pathway in mammalian cells. Mol Cell Biol (2004) 0.89
A reduction in RNA polymerase II initiation rate suppresses hyper-recombination and transcription-elongation impairment of THO mutants. Mol Genet Genomics (2008) 0.89
Prognostic significance of human pituitary tumor-transforming gene immunohistochemical expression in differentiated thyroid cancer. J Clin Endocrinol Metab (2006) 0.89
PTTG1/securin modulates microtubule nucleation and cell migration. Mol Biol Cell (2011) 0.88
UV-induced degradation of securin is mediated by SKP1-CUL1-beta TrCP E3 ubiquitin ligase. J Cell Sci (2008) 0.88
Live imaging of mouse endogenous neural progenitors migrating in response to an induced tumor. PLoS One (2012) 0.88
High expression levels of receptor activator of nuclear factor-kappa B ligand associated with human chronic periodontitis are mainly secreted by CD4+ T lymphocytes. J Periodontol (2006) 0.88
The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt. FEBS J (2010) 0.87
Conjugal transfer of the Salmonella enterica virulence plasmid in the mouse intestine. J Bacteriol (2008) 0.87
Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS. Cell Cycle (2007) 0.87
Dicoogle, a PACS featuring profiled content based image retrieval. PLoS One (2013) 0.86
SrfJ, a Salmonella type III secretion system effector regulated by PhoP, RcsB, and IolR. J Bacteriol (2012) 0.85
Haematopoietic progenitor cells from adult bone marrow differentiate into cells that express oligodendroglial antigens in the neonatal mouse brain. Eur J Neurosci (2002) 0.85
Isolation of a heat-resistant allergen from the fish parasite Anisakis simplex. Parasitol Res (2005) 0.85
Analysis of the expression, secretion and translocation of the Salmonella enterica type III secretion system effector SteA. PLoS One (2011) 0.84
Glycogen synthase kinase-3beta (GSK3beta) negatively regulates PTTG1/human securin protein stability, and GSK3beta inactivation correlates with securin accumulation in breast tumors. J Biol Chem (2011) 0.84
Regulation of igaA and the Rcs system by the MviA response regulator in Salmonella enterica. J Bacteriol (2009) 0.84
CCL2 inhibits the apoptosis program induced by growth factor deprivation, rescuing functional T cells. J Immunol (2007) 0.84
The effect of FITA mutations on the symbiotic properties of Sinorhizobium fredii varies in a chromosomal-background-dependent manner. Arch Microbiol (2003) 0.83
Bile-induced curing of the virulence plasmid in Salmonella enterica serovar Typhimurium. J Bacteriol (2006) 0.83
A single mutation in Securin induces chromosomal instability and enhances cell invasion. Eur J Cancer (2012) 0.83
Differentiating ischemic from hemorrhagic stroke using plasma biomarkers: the S100B/RAGE pathway. J Proteomics (2012) 0.82
Web-based adaptive training simulator system for cardiac life support. Artif Intell Med (2006) 0.82
Dicoumarol down-regulates human PTTG1/Securin mRNA expression through inhibition of Hsp90. Mol Cancer Ther (2008) 0.82
Quantitative evaluation of a pulmonary contour segmentation algorithm in X-ray computed tomography images. Acad Radiol (2004) 0.82
HDAC and Hsp90 inhibitors down-regulate PTTG1/securin but do not induce aneuploidy. Genes Chromosomes Cancer (2009) 0.81
Taxonomy and chemically semi-defined media for the analysis of the tacrolimus producer 'Streptomyces tsukubaensis'. Appl Microbiol Biotechnol (2012) 0.80
PipB2 is a substrate of the Salmonella pathogenicity island 1-encoded type III secretion system. Biochem Biophys Res Commun (2012) 0.80
The effect of omalizumab on small airway inflammation as measured by exhaled nitric oxide in moderate-to-severe asthmatic patients. Allergy Asthma Proc (2014) 0.80
Bcl-2 family gene modulation during spontaneous apoptosis of B-chronic lymphocytic leukemia cells. Biochem Biophys Res Commun (2004) 0.80
Distinct human T-lymphocyte responses triggered by Porphyromonas gingivalis capsular serotypes. J Clin Periodontol (2013) 0.80
Novel small RNA expression libraries uncover hsa-miR-30b and hsa-miR-30c as important factors in anoikis resistance. RNA (2013) 0.79
DsbA and MgrB regulate steA expression through the two-component system PhoQ/PhoP in Salmonella enterica. J Bacteriol (2013) 0.79
Targeting neural stem cells with titanium dioxide nanoparticles coupled to specific monoclonal antibodies. J Biomater Appl (2011) 0.78
Activation of RANKL-induced osteoclasts and memory T lymphocytes by Porphyromonas gingivalis is serotype dependant. J Clin Periodontol (2014) 0.77
Dyspnea and obesity in African American women. Ann Allergy Asthma Immunol (2008) 0.77
Usefulness of liposomes loaded with cytostatic bile acid derivatives to circumvent chemotherapy resistance of enterohepatic tumors. Mol Pharmacol (2003) 0.76
Immunomodulation by Yersinia enterocolitica: comparison of live and heat-killed bacteria. FEMS Immunol Med Microbiol (2003) 0.76
Expression pattern of Anosmin-1 during pre- and postnatal rat brain development. Dev Dyn (2008) 0.76