Published in J Biol Chem on May 07, 2010
Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways. Sci Rep (2013) 0.99
Lineage-specific restraint of pituitary gonadotroph cell adenoma growth. PLoS One (2011) 0.95
Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells. Breast Cancer Res (2012) 0.82
High expression of pituitary tumor-transforming gene-1 predicts poor prognosis in clear cell renal cell carcinoma. Mol Clin Oncol (2014) 0.81
Radiation induces senescence and a bystander effect through metabolic alterations. Cell Death Dis (2014) 0.80
Development of a Bifunctional Andrographolide-Based Chemical Probe for Pharmacological Study. PLoS One (2016) 0.78
Comparative Meta-Analysis of Transcriptomics Data during Cellular Senescence and In Vivo Tissue Ageing. Oxid Med Cell Longev (2015) 0.78
Alteration of Pituitary Tumor Transforming Gene-1 Regulates Trophoblast Invasion via the Integrin/Rho-Family Signaling Pathway. PLoS One (2016) 0.75
Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence. Biol Res (2016) 0.75
Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer. Oncogene (2017) 0.75
A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13
A molecular signature of metastasis in primary solid tumors. Nat Genet (2002) 21.36
Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science (1998) 17.91
Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol (1999) 16.81
Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol (2007) 16.55
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 11.40
Cellular senescence in cancer and aging. Cell (2007) 9.04
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci U S A (2001) 7.93
Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science (1999) 6.07
An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast. Cell (1998) 5.29
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell (2005) 4.83
Splitting the chromosome: cutting the ties that bind sister chromatids. Science (2000) 4.20
Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol Endocrinol (1997) 2.90
A yeast gene essential for regulation of spindle pole duplication. Mol Cell Biol (1988) 2.38
Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene (1999) 2.34
Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis. Nat Genet (2002) 2.32
Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes. EMBO J (1996) 2.23
Regulation of human separase by securin binding and autocleavage. Curr Biol (2002) 1.86
Pituitary tumor-transforming gene: physiology and implications for tumorigenesis. Endocr Rev (2007) 1.79
Structure, expression, and function of human pituitary tumor-transforming gene (PTTG). Mol Endocrinol (1999) 1.78
Requirement for ESP1 in the nuclear division of Saccharomyces cerevisiae. Mol Biol Cell (1992) 1.74
Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis. Nat Med (1999) 1.72
hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG. Oncogene (1998) 1.57
Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion. Oncogene (2002) 1.32
Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells. Endocrinology (2003) 1.29
Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures. Exp Cell Res (1999) 1.29
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer. Genes Dev (2007) 1.23
Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase. Nucleic Acids Res (2001) 1.19
Human pituitary tumor-transforming gene induces angiogenesis. J Clin Endocrinol Metab (2001) 1.17
Development of a sensitive assay for detection of replication-competent recombinant lentivirus in large-scale HIV-based vector preparations. Mol Ther (2003) 1.03
Proteolytic cleavage of the THR subunit during anaphase limits Drosophila separase function. Genes Dev (2002) 0.82
Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWIST. Blood (2010) 2.22
Community-based multiple screening model: design, implementation, and analysis of 42,387 participants. Cancer (2004) 2.17
Regenerative endodontic treatment for necrotic immature permanent teeth. J Endod (2008) 1.95
The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation. Nucleic Acids Res (2006) 1.71
Successful treatment of advanced bisphosphonate-related osteonecrosis of the mandible with adjunctive teriparatide therapy. Head Neck (2010) 1.68
Effective indicators for diagnosis of oral cancer using optical coherence tomography. Opt Express (2008) 1.45
Genetic analysis in Leber's hereditary optic neuropathy using the comparative genomic hybridization technique. Clin Experiment Ophthalmol (2003) 1.45
Identification of CD133-positive radioresistant cells in atypical teratoid/rhabdoid tumor. PLoS One (2008) 1.37
Central ossifying fibroma: a clinicopathologic study of 28 cases. J Formos Med Assoc (2008) 1.36
Markedly increased Oct4 and Nanog expression correlates with cisplatin resistance in oral squamous cell carcinoma. J Oral Pathol Med (2011) 1.34
miR145 targets the SOX9/ADAM17 axis to inhibit tumor-initiating cells and IL-6-mediated paracrine effects in head and neck cancer. Cancer Res (2013) 1.31
Detection of quadruplex DNA structures in human telomeres by a fluorescent carbazole derivative. Anal Chem (2004) 1.28
Successful treatment of oral verrucous hyperplasia and oral leukoplakia with topical 5-aminolevulinic acid-mediated photodynamic therapy. Lasers Surg Med (2005) 1.27
Topical photodynamic therapy is very effective for oral verrucous hyperplasia and oral erythroleukoplakia. J Oral Pathol Med (2010) 1.27
Crystal structure of yeast cytosine deaminase. Insights into enzyme mechanism and evolution. J Biol Chem (2003) 1.26
Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis. Cancer Epidemiol Biomarkers Prev (2002) 1.24
Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver. Hepatology (2007) 1.23
Carcinoma and dysplasia in oral leukoplakias in Taiwan: prevalence and risk factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2006) 1.23
Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase α. Cell Res (2010) 1.23
Comparative genomic hybridization study of perivascular epithelioid cell tumor: molecular genetic evidence of perivascular epithelioid cell tumor as a distinctive neoplasm. Hum Pathol (2006) 1.20
Oral verrucous hyperplasia: histologic classification, prognosis, and clinical implications. J Oral Pathol Med (2009) 1.18
Knockdown of p21(Cip1/Waf1) enhances proliferation, the expression of stemness markers, and osteogenic potential in human mesenchymal stem cells. Aging Cell (2011) 1.17
Modulation of alternative pre-mRNA splicing in vivo by pinin. Biochem Biophys Res Commun (2002) 1.17
Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography. J Biomed Opt (2009) 1.17
Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio. Cancer Lett (2005) 1.14
Prognostic utility of anti-EBV antibody testing for defining NPC risk among individuals from high-risk NPC families. Clin Cancer Res (2011) 1.12
Doxorubicin delivery by polyamidoamine dendrimer conjugation and photochemical internalization for cancer therapy. J Control Release (2007) 1.12
Oral verruciform xanthoma: a clinicopathologic study of 15 cases. J Formos Med Assoc (2007) 1.11
Expression of hypoxia-inducible factor-1 alpha is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan. J Oral Pathol Med (2008) 1.10
Odontoma: a clinicopathologic study of 81 cases. J Formos Med Assoc (2003) 1.10
Time-resolved autofluorescence spectroscopy for classifying normal and premalignant oral tissues. Lasers Surg Med (2005) 1.08
Transnasal endoscopy with narrow-band imaging and Lugol staining to screen patients with head and neck cancer whose condition limits oral intubation with standard endoscope (with video). Gastrointest Endosc (2008) 1.07
Interaction of Saccharomyces Cdc13p with Pol1p, Imp4p, Sir4p and Zds2p is involved in telomere replication, telomere maintenance and cell growth control. Nucleic Acids Res (2004) 1.06
Inhibition of metastasis, angiogenesis, and tumor growth by Chinese herbal cocktail Tien-Hsien Liquid. BMC Cancer (2010) 1.05
Impairment of tumor-initiating stem-like property and reversal of epithelial-mesenchymal transdifferentiation in head and neck cancer by resveratrol treatment. Mol Nutr Food Res (2012) 1.05
Array-comparative genomic hybridization to detect genomewide changes in microdissected primary and metastatic oral squamous cell carcinomas. Mol Carcinog (2006) 1.05
Histone deacetylase 2 expression predicts poorer prognosis in oral cancer patients. Oral Oncol (2008) 1.05
Chromosome instability modulated by BMI1-AURKA signaling drives progression in head and neck cancer. Cancer Res (2012) 1.04
Genetic changes and clonality relationship between primary colorectal cancers and their pulmonary metastases--an analysis by comparative genomic hybridization. Genes Chromosomes Cancer (2005) 1.04
Lymphoepithelial carcinoma versus large cell undifferentiated carcinoma of the major salivary glands. Cancer (2004) 1.03
Increased prevalence of interleukin-17-producing CD4(+) tumor infiltrating lymphocytes in human oral squamous cell carcinoma. Head Neck (2010) 1.02
Desmoid tumor of the head and neck. Head Neck (2006) 1.01
Factors associated with underdiagnosis from incisional biopsy of oral leukoplakic lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2007) 1.00
An epidemiologic study of tooth retention after nonsurgical endodontic treatment in a large population in Taiwan. J Endod (2007) 0.99
Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase. Proc Natl Acad Sci U S A (2014) 0.98
Image-guided intensity modulated radiotherapy with helical tomotherapy for postoperative treatment of high-risk oral cavity cancer. BMC Cancer (2011) 0.98
Unsedated transnasal esophagogastroduodenoscopy for the evaluation of dysphagia following treatment for previous primary head neck cancer. Oral Oncol (2008) 0.97
Diagnosis of oral precancer with optical coherence tomography. Biomed Opt Express (2012) 0.97
Metabolic reprogramming orchestrates cancer stem cell properties in nasopharyngeal carcinoma. Cell Cycle (2015) 0.97
Transcutaneous ultrasound for evaluation of vocal fold movement in patients with thyroid disease. Eur J Radiol (2011) 0.96
PLS-ANN based classification model for oral submucous fibrosis and oral carcinogenesis. Lasers Surg Med (2003) 0.96
Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation. Evid Based Complement Alternat Med (2013) 0.95
Higher expressions of p53 and proliferating cell nuclear antigen (PCNA) in atrophic oral lichen planus and patients with areca quid chewing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2005) 0.95
Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma. Int J Oncol (2009) 0.95
The chinese herbal medicine Tien-Hsien liquid inhibits cell growth and induces apoptosis in a wide variety of human cancer cells. J Altern Complement Med (2005) 0.95
Overlapping high-resolution copy number alterations in cancer genomes identified putative cancer genes in hepatocellular carcinoma. Hepatology (2010) 0.95
Photodynamic Therapy of oral dysplasia with topical 5-aminolevulinic acid and light-emitting diode array. Lasers Surg Med (2004) 0.94
Resveratrol-induced apoptosis and increased radiosensitivity in CD133-positive cells derived from atypical teratoid/rhabdoid tumor. Int J Radiat Oncol Biol Phys (2009) 0.94
Copy number changes of target genes in chromosome 3q25.3-qter of esophageal squamous cell carcinoma: TP63 is amplified in early carcinogenesis but down-regulated as disease progressed. World J Gastroenterol (2005) 0.94
c-Jun N-terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP2 via phosphorylation of Runx2 at Ser104. J Bone Miner Res (2012) 0.94
In vivo optical virtual biopsy of human oral mucosa with harmonic generation microscopy. Biomed Opt Express (2011) 0.94
Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma. Radiat Oncol (2011) 0.94
High mitochondrial DNA copy number and bioenergetic function are associated with tumor invasion of esophageal squamous cell carcinoma cell lines. Int J Mol Sci (2012) 0.94
Design and synthesis of class-selective activity probes for protein tyrosine phosphatases. J Proteome Res (2003) 0.94
Genotypic analysis of esophageal squamous cell carcinoma by molecular cytogenetics and real-time quantitative polymerase chain reaction. Int J Oncol (2003) 0.94
Nuclear localization of annexin A1 is a prognostic factor in oral squamous cell carcinoma. J Surg Oncol (2008) 0.94
Expression of hepatocyte growth factor and c-met protein is significantly associated with the progression of oral squamous cell carcinoma in Taiwan. J Oral Pathol Med (2004) 0.94
Photodynamic therapy with topical 5-aminolevulinic acid as a post-operative adjuvant therapy for an incompletely resected primary nasopharyngeal papillary adenocarcinoma: a case report. Lasers Surg Med (2006) 0.93
Epithelial-mesenchymal transition transcription factor ZEB1/ZEB2 co-expression predicts poor prognosis and maintains tumor-initiating properties in head and neck cancer. Oral Oncol (2012) 0.92
Establishment of OC3 oral carcinoma cell line and identification of NF-kappa B activation responses to areca nut extract. J Oral Pathol Med (2004) 0.92
Plasma globotriaosylsphingosine (lysoGb3) could be a biomarker for Fabry disease with a Chinese hotspot late-onset mutation (IVS4+919G>A). Clin Chim Acta (2013) 0.92
Malignant fibrous histiocytoma of the sinonasal tract. Head Neck (2009) 0.92
Expression of p53, MDM2, p21, heat shock protein 70, and HPV 16/18 E6 proteins in oral verrucous carcinoma and oral verrucous hyperplasia. Head Neck (2011) 0.92
HMB-45 may be a more sensitive maker than S-100 or Melan-A for immunohistochemical diagnosis of primary oral and nasal mucosal melanomas. J Oral Pathol Med (2005) 0.92
Diagnosis of oral submucous fibrosis with optical coherence tomography. J Biomed Opt (2009) 0.91
Induction of global stress response in Saccharomyces cerevisiae cells lacking telomerase. Biochem Biophys Res Commun (2002) 0.91
Intercellular calcium waves mediate preferential cell growth toward the wound edge in polarized hepatic cells. Exp Cell Res (2003) 0.91
Levamisole can modulate the serum tumor necrosis factor-alpha level in patients with recurrent aphthous ulcerations. J Oral Pathol Med (2006) 0.91
Facial Candida albicans cellulitis occurring in a patient with oral submucous fibrosis and unknown diabetes mellitus after local corticosteroid injection treatment. J Oral Pathol Med (2004) 0.91
Successful treatment of oral verrucous hyperplasia with topical 5-aminolevulinic acid-mediated photodynamic therapy. Oral Oncol (2004) 0.91
Perineural invasion and expression of nerve growth factor can predict the progression and prognosis of oral tongue squamous cell carcinoma. J Oral Pathol Med (2014) 0.90
Immunomodulating effects of "tien-hsien liquid" on peripheral blood mononuclear cells and T-lymphocytes from patients with recurrent aphthous ulcerations. Am J Chin Med (2004) 0.90
Serum interleukin-6 level is a useful marker in evaluating therapeutic effects of levamisole and Chinese medicinal herbs on patients with oral lichen planus. J Oral Pathol Med (2002) 0.90
Application of unsedated transnasal esophagogastroduodenoscopy in the diagnosis of hypopharyngeal cancer. Head Neck (2009) 0.90
Chromosomal aberrations of malignant pleural effusions of lung adenocarcinoma: different cytogenetic changes are correlated with genders and smoking habits. Lung Cancer (2007) 0.90
Infiltrating macrophage count: a significant predictor for the progression and prognosis of oral squamous cell carcinomas in Taiwan. Head Neck (2010) 0.90
Rare involvement of submandibular gland by oral squamous cell carcinoma. Head Neck (2009) 0.90
Deep neck infection as the main initial presentation of primary head and neck cancer. J Laryngol Otol (2006) 0.89
Over-expression of c-kit in a primary leiomyosarcoma of the thyroid gland. Eur Arch Otorhinolaryngol (2007) 0.89
Elevation of plasma and cerebrospinal fluid osteopontin levels in patients with atypical teratoid/rhabdoid tumor. Am J Clin Pathol (2005) 0.89
Increased serum placenta growth factor level is significantly associated with progression, recurrence and poor prognosis of oral squamous cell carcinoma. Oral Oncol (2012) 0.88