Ecto-5'-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits.

PubWeight™: 1.20‹?› | Rank: Top 10%

🔗 View Article (PMC 2826808)

Published in J Neurosci on February 10, 2010

Authors

Nathaniel A Sowa1, Bonnie Taylor-Blake, Mark J Zylka

Author Affiliations

1: Department of Cell and Molecular Physiology, UNC Neuroscience Center and Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Articles citing this

Cellular function and molecular structure of ecto-nucleotidases. Purinergic Signal (2012) 2.13

Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron (2012) 2.11

Pain-relieving prospects for adenosine receptors and ectonucleotidases. Trends Mol Med (2011) 1.28

Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate. J Neurosci (2010) 1.19

PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine. Mol Pain (2011) 1.18

Adenosine enhances sweet taste through A2B receptors in the taste bud. J Neurosci (2012) 1.10

Recombinant ecto-5'-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A1 receptor activation. Mol Pain (2010) 1.04

Tissue-nonspecific alkaline phosphatase acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord. J Neurosci (2013) 0.94

Inhibition of hippocampal synaptic activity by ATP, hypoxia or oxygen-glucose deprivation does not require CD73. PLoS One (2012) 0.92

PAPupuncture has localized and long-lasting antinociceptive effects in mouse models of acute and chronic pain. Mol Pain (2012) 0.91

Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions. J Neurosci (2013) 0.91

Distribution of ecto-nucleotidases in mouse sensory circuits suggests roles for nucleoside triphosphate diphosphohydrolase-3 in nociception and mechanoreception. Neuroscience (2011) 0.89

Needling adenosine receptors for pain relief. Nat Neurosci (2010) 0.88

Adenosine-A1 receptor agonist induced hyperalgesic priming type II. Pain (2016) 0.80

CD73 is a major regulator of adenosinergic signalling in mouse brain. PLoS One (2013) 0.78

Central or peripheral delivery of an adenosine A1 receptor agonist improves mechanical allodynia in a mouse model of painful diabetic neuropathy. Neuroscience (2014) 0.78

Deletion of ENTPD3 does not impair nucleotide hydrolysis in primary somatosensory neurons or spinal cord. F1000Res (2014) 0.77

Skin matters! The role of keratinocytes in nociception: a rational argument for the development of topical analgesics. J Pain Res (2016) 0.77

Emerging roles for ectonucleotidases in pain-sensing neurons. Neuropsychopharmacology (2011) 0.76

Ecto-5' -Nucleotidase CD73 (NT5E), vitamin D receptor and FGF23 gene polymorphisms may play a role in the development of calcific uremic arteriolopathy in dialysis patients - Data from the German Calciphylaxis Registry. PLoS One (2017) 0.75

Chronic nicotine differentially affects murine transcriptome profiling in isolated cortical interneurons and pyramidal neurons. BMC Genomics (2017) 0.75

Uliginosin B, a Possible New Analgesic Drug, Acts by Modulating the Adenosinergic System. Evid Based Complement Alternat Med (2016) 0.75

Different analgesic effects of adenosine between postoperative and neuropathic pain. J Orthop Sci (2012) 0.75

Deceased expression of prostatic acid phosphatase in primary sensory neurons after peripheral nerve injury. Int J Clin Exp Pathol (2014) 0.75

CD73 Controls Extracellular Adenosine Generation in the Trigeminal Nociceptive Nerves. J Dent Res (2017) 0.75

Articles cited by this

The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature (1997) 30.59

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain (1988) 18.17

Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science (2000) 15.16

Molecular mechanisms of nociception. Nature (2001) 7.75

Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev (2007) 6.05

Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med (2004) 4.16

Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Invest (2002) 4.05

Mechanisms of neuropathic pain. Neuron (2006) 4.03

Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia. Trends Neurosci (2005) 4.01

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc Natl Acad Sci U S A (2009) 3.98

Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science (2005) 3.63

Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron (2005) 3.54

Mechanisms of sensory transduction in the skin. Nature (2007) 3.53

Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci (2002) 3.21

IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron (1997) 3.21

CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness. Nat Med (2002) 3.18

5'-Nucleotidase: molecular structure and functional aspects. Biochem J (1992) 3.08

Physiological roles for ecto-5'-nucleotidase (CD73). Purinergic Signal (2006) 2.98

Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc Natl Acad Sci U S A (2001) 2.73

Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nat Med (2004) 2.71

Spared nerve injury model of neuropathic pain in the mouse: a behavioral and anatomic analysis. J Pain (2003) 2.09

Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine. Neuron (2008) 1.96

The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor. Mol Cell Neurosci (1998) 1.92

Spinal delivery of analgesics in experimental models of pain and analgesia. Adv Drug Deliv Rev (2003) 1.84

Hypoxia enhances Ecto-5'-Nucleotidase activity and cell surface expression in endothelial cells: role of membrane lipids. Circ Res (2003) 1.76

TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch (2009) 1.75

Adenosine as a neuromodulator in neurological diseases. Curr Opin Pharmacol (2007) 1.61

An electronic pressure-meter nociception paw test for mice. Braz J Med Biol Res (2004) 1.56

Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors. J Neurosci (2009) 1.53

Ca2+ waves in keratinocytes are transmitted to sensory neurons: the involvement of extracellular ATP and P2Y2 receptor activation. Biochem J (2004) 1.42

Ectonucleotidases in the nervous system. Novartis Found Symp (2006) 1.40

Fiber-coupled light-emitting diode for localized photostimulation of neurons expressing channelrhodopsin-2. J Neurosci Methods (2007) 1.38

trkA, CGRP and IB4 expression in retrogradely labelled cutaneous and visceral primary sensory neurones in the rat. Neurosci Lett (1996) 1.36

Comprehensive immunofluorescence and lectin binding analysis of vibrissal follicle sinus complex innervation in the mystacial pad of the rat. J Comp Neurol (1997) 1.28

Modulation of mechanical and thermal nociceptive sensitivity in the laboratory mouse by behavioral state. J Pain (2007) 1.21

Human prostatic acid phosphatase: a histidine phosphatase. Ann N Y Acad Sci (1982) 1.20

Nucleotide signaling and cutaneous mechanisms of pain transduction. Brain Res Rev (2008) 1.19

Increased nociceptive response in mice lacking the adenosine A1 receptor. Pain (2005) 1.16

Calcitonin gene-related peptide immunoreactivity and afferent receptive properties of dorsal root ganglion neurones in guinea-pigs. J Physiol (2002) 1.15

Recombinant mouse PAP has pH-dependent ectonucleotidase activity and acts through A(1)-adenosine receptors to mediate antinociception. PLoS One (2009) 1.14

Direct cutaneous hyperalgesia induced by adenosine. Neuroscience (1990) 1.11

Adenosine and ATP receptors. Handb Exp Pharmacol (2007) 1.11

Comparative characterization of hair follicle dermal stem cells and bone marrow mesenchymal stem cells. Stem Cells Dev (2006) 1.09

Adenosine inhibition of synaptic transmission in the substantia gelatinosa. J Neurophysiol (1994) 1.09

Regulation of epidermal homeostasis through P2Y2 receptors. Br J Pharmacol (1999) 1.08

Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal. J Neurosci (1995) 1.04

Therapeutic potential of adenosine kinase inhibitors. Expert Opin Investig Drugs (2000) 1.04

ATP modulation of synaptic transmission in the spinal substantia gelatinosa. J Neurosci (1995) 1.04

Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists. J Pharmacol Exp Ther (1996) 1.02

Enhanced thermal avoidance in mice lacking the ATP receptor P2X3. Pain (2005) 1.02

ATP- and adenosine-mediated signaling in the central nervous system: adenosine receptor activation by ATP through rapid and localized generation of adenosine by ecto-nucleotidases. J Pharmacol Sci (2004) 1.02

Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat. Pain (1998) 1.01

IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier. Eur J Immunol (2008) 1.01

Effects of adenosine 5'-monophosphate and adenosine 5'-triphosphate on functionally identified units in the cat spinal dorsal horn. Evidence for a differential effect of adenosine 5'-triphosphate on nociceptive vs non-nociceptive units. Neuroscience (1985) 1.00

Clinical application of adenosine and ATP for pain control. J Anesth (2005) 0.99

Exogenous and endogenous adenosine enhance the spinal antiallodynic effects of morphine in a rat model of neuropathic pain. Pain (1999) 0.98

Involvement of A1 adenosine receptors and neural pathways in adenosine-induced bronchoconstriction in mice. Am J Physiol Lung Cell Mol Physiol (2007) 0.95

Intrathecal adenosine interacts with a spinal noradrenergic system to produce antinociception in nerve-injured rats. Anesthesiology (1999) 0.92

The safety and efficacy of intrathecal adenosine in patients with chronic neuropathic pain. Anesth Analg (1999) 0.91

Distribution of P2X(3)-immunoreactive fibers in hairy and glabrous skin of the rat. J Comp Neurol (2009) 0.91

Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats. Pharmacol Biochem Behav (2002) 0.90

Characterization of the principal human prostatic acid phosphatase isoenzyme, purified by affinity chromatography and isoelectric focusing. Part II. Clin Chem (1978) 0.90

Adenosine inhibits excitatory transmission to substantia gelatinosa neurons of the adult rat spinal cord through the activation of presynaptic A(1) adenosine receptor. Pain (2001) 0.90

A novel transverse push-pull microprobe: in vitro characterization and in vivo demonstration of the enzymatic production of adenosine in the spinal cord dorsal horn. J Neurochem (2001) 0.89

Adenosine and adenine nucleotides inhibit the autonomous and epidermal growth factor-mediated proliferation of cultured human keratinocytes. J Invest Dermatol (1995) 0.89

5'-Nucleotidase and an acid phosphatase of spinal cord. Comparative histochemistry and specificity of the enzymes in mouse and cat spinal cords. Cytologic localization in mouse substantia gelatinosa. J Histochem Cytochem (1974) 0.88

Preliminary efficacy assessment of intrathecal injection of an American formulation of adenosine in humans. Anesthesiology (2002) 0.87

Antinociceptive effects in mice after intrathecal injection of 5'-N-ethylcarboxamide adenosine. Neurosci Lett (1984) 0.86

Anterograde transport of horseradish-peroxidase conjugated isolectin B4 from Griffonia simplicifolia I in spinal primary sensory neurons of the rat. Brain Res (1998) 0.86

Adenosine exerts multiple effects in dorsal horn neurones of the adult rat spinal cord. Brain Res (2001) 0.84

Spinally-mediated antinociception is induced in mice by an adenosine kinase-, but not by an adenosine deaminase-, inhibitor. Life Sci (1992) 0.84

[Activity fluctuations of acid phosphatase in the spinal cord and spinal ganglia of rats after section of the sciatic nerve]. Arch Psychiatr Nervenkr Z Gesamte Neurol Psychiatr (1959) 0.84

Pharmacological evidence for A1 and A2 adenosine receptors in the skin microcirculation. Circ Res (1989) 0.84

Anatomical and cytochemical relationships of adenosine deaminase-containing primary afferent neurons in the rat. Neuroscience (1985) 0.82

Temperature-sensitive adenosine-mediated vasoconstriction in the skin microcirculation. J Pharmacol Exp Ther (1990) 0.81

Nociceptive responses and spinal plastic changes of afferent C-fibers in three neuropathic pain models induced by sciatic nerve injury in the rat. Exp Neurol (2009) 0.81

Purinergic substances promote murine keratinocyte proliferation and enhance impaired wound healing in mice. Wound Repair Regen (2006) 0.81

Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding. Anesthesiology (2002) 0.80

Studies on 5'-nucleotidase histochemistry. II. Differences in 5'-nucleotidase activity in stratified squamous epithelia and skin appendages of mouse, rat and guinea pig. Histochemistry (1974) 0.76

Articles by these authors

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc Natl Acad Sci U S A (2009) 3.98

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature (2011) 3.19

Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine. Neuron (2008) 1.96

Peptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold. Neuron (2013) 1.95

Topoisomerases facilitate transcription of long genes linked to autism. Nature (2013) 1.93

Optimizing promoters for recombinant adeno-associated virus-mediated gene expression in the peripheral and central nervous system using self-complementary vectors. Hum Gene Ther (2011) 1.90

Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch. Nat Neurosci (2007) 1.78

Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes. Trends Neurosci (2011) 1.72

Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Proc Natl Acad Sci U S A (2002) 1.67

Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors. J Neurosci (2009) 1.53

Fiber-coupled light-emitting diode for localized photostimulation of neurons expressing channelrhodopsin-2. J Neurosci Methods (2007) 1.38

Mrgprd-expressing polymodal nociceptive neurons innervate most known classes of substantia gelatinosa neurons. J Neurosci (2009) 1.38

AMP is an adenosine A1 receptor agonist. J Biol Chem (2012) 1.36

CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch. PLoS One (2012) 1.20

Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate. J Neurosci (2010) 1.19

PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine. Mol Pain (2011) 1.18

Recombinant mouse PAP has pH-dependent ectonucleotidase activity and acts through A(1)-adenosine receptors to mediate antinociception. PLoS One (2009) 1.14

Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors. J Neurosci (2008) 1.14

Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol (2013) 1.09

Recombinant ecto-5'-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A1 receptor activation. Mol Pain (2010) 1.04

The F-BAR domains from srGAP1, srGAP2 and srGAP3 regulate membrane deformation differently. J Cell Sci (2012) 1.00

Tissue-nonspecific alkaline phosphatase acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord. J Neurosci (2013) 0.94

Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. PLoS One (2009) 0.93

Prostatic acid phosphatase is expressed in peptidergic and nonpeptidergic nociceptive neurons of mice and rats. PLoS One (2010) 0.92

PAPupuncture has localized and long-lasting antinociceptive effects in mouse models of acute and chronic pain. Mol Pain (2012) 0.91

A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling. J Am Chem Soc (2005) 0.90

Needling adenosine receptors for pain relief. Nat Neurosci (2010) 0.88

Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice. J Med Chem (2012) 0.84

A high throughput assay to identify small molecule modulators of prostatic acid phosphatase. Curr Chem Genomics (2009) 0.82

On the exoneration of Dr. William H. Stewart: debunking an urban legend. Infect Dis Poverty (2013) 0.81

Secretion and N-linked glycosylation are required for prostatic acid phosphatase catalytic and antinociceptive activity. PLoS One (2012) 0.80

The rat kidney contains high levels of prouroguanylin (the uroguanylin precursor) but does not express GC-C (the enteric uroguanylin receptor). Am J Physiol Renal Physiol (2010) 0.79

Overexpression of diacylglycerol kinase η enhances Gαq-coupled G protein-coupled receptor signaling. Mol Pharmacol (2014) 0.78

Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine. PLoS One (2012) 0.78

Emerging roles for ectonucleotidases in pain-sensing neurons. Neuropsychopharmacology (2011) 0.76

Lipid kinases as therapeutic targets for chronic pain. Pain (2015) 0.76

NT5E mutations and arterial calcifications. N Engl J Med (2011) 0.76

Biological constraints limit the use of rapamycin-inducible FKBP12-Inp54p for depleting PIP2 in dorsal root ganglia neurons. J Negat Results Biomed (2013) 0.76

High-throughput screen identifies cyclic nucleotide analogs that inhibit prostatic acid phosphatase. J Biomol Screen (2012) 0.75