Published in J Mol Biol on October 18, 2002
Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase. Antimicrob Agents Chemother (2004) 1.27
Molecular mechanisms of tenofovir resistance conferred by human immunodeficiency virus type 1 reverse transcriptase containing a diserine insertion after residue 69 and multiple thymidine analog-associated mutations. Antimicrob Agents Chemother (2004) 1.06
Mechanisms involved in the selection of HIV-1 reverse transcriptase thumb subdomain polymorphisms associated with nucleoside analogue therapy failure. Antimicrob Agents Chemother (2010) 0.94
Site-directed mutagenesis in the fingers subdomain of HIV-1 reverse transcriptase reveals a specific role for the beta3-beta4 hairpin loop in dNTP selection. J Mol Biol (2006) 0.92
Thymidine analogue excision and discrimination modulated by mutational complexes including single amino acid deletions of Asp-67 or Thr-69 in HIV-1 reverse transcriptase. J Biol Chem (2011) 0.87
Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination. J Biol Chem (2009) 0.82
Chain-terminating dinucleoside tetraphosphates are substrates for DNA polymerization by human immunodeficiency virus type 1 reverse transcriptase with increased activity against thymidine analogue-resistant mutants. Antimicrob Agents Chemother (2006) 0.81
Utilization of a deoxynucleoside diphosphate substrate by HIV reverse transcriptase. PLoS One (2008) 0.80
Biological and biomedical implications of the co-evolution of pathogens and their hosts. Nat Genet (2002) 4.42
Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA. J Biol Chem (2004) 2.48
Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV). Virology (2003) 1.76
Suppression of viral infectivity through lethal defection. Proc Natl Acad Sci U S A (2005) 1.62
Evolutionary transition toward defective RNAs that are infectious by complementation. J Virol (2004) 1.61
Mutagenesis versus inhibition in the efficiency of extinction of foot-and-mouth disease virus. J Virol (2003) 1.58
Effect of alternating passage on adaptation of sindbis virus to vertebrate and invertebrate cells. J Virol (2005) 1.57
Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: implications for error catastrophe. J Virol (2006) 1.56
The structure of a protein primer-polymerase complex in the initiation of genome replication. EMBO J (2006) 1.54
Curing of foot-and-mouth disease virus from persistently infected cells by ribavirin involves enhanced mutagenesis. Virology (2003) 1.44
Sequential structures provide insights into the fidelity of RNA replication. Proc Natl Acad Sci U S A (2007) 1.37
High mutation rates, bottlenecks, and robustness of RNA viral quasispecies. Gene (2005) 1.31
HIV protease cleaves poly(A)-binding protein. Biochem J (2006) 1.30
Resistance of virus to extinction on bottleneck passages: study of a decaying and fluctuating pattern of fitness loss. Proc Natl Acad Sci U S A (2003) 1.27
Preextinction viral RNA can interfere with infectivity. J Virol (2004) 1.26
Structural insights into replication initiation and elongation processes by the FMDV RNA-dependent RNA polymerase. Curr Opin Struct Biol (2009) 1.22
Duration and fitness dependence of quasispecies memory. J Mol Biol (2002) 1.18
Insights into RNA virus mutant spectrum and lethal mutagenesis events: replicative interference and complementation by multiple point mutants. J Mol Biol (2007) 1.17
Mutant viral polymerase in the transition of virus to error catastrophe identifies a critical site for RNA binding. J Mol Biol (2005) 1.13
Evidence for quasispecies distributions in the human hepatitis A virus genome. Virology (2003) 1.10
A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape. PLoS Pathog (2010) 1.08
Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino acid changes in the hepatitis B virus genome. PLoS One (2012) 1.06
Hidden virulence determinants in a viral quasispecies in vivo. J Virol (2008) 1.06
The eukaryotic translation initiation factor 4GI is cleaved by different retroviral proteases. J Virol (2003) 1.06
Potential benefits of sequential inhibitor-mutagen treatments of RNA virus infections. PLoS Pathog (2009) 1.05
Molecular basis for a lack of correlation between viral fitness and cell killing capacity. PLoS Pathog (2007) 1.04
Viral genome segmentation can result from a trade-off between genetic content and particle stability. PLoS Genet (2011) 1.03
Ribavirin can be mutagenic for arenaviruses. J Virol (2011) 1.03
Arenavirus genetic diversity and its biological implications. Infect Genet Evol (2009) 1.03
Initial fitness recovery of HIV-1 is associated with quasispecies heterogeneity and can occur without modifications in the consensus sequence. PLoS One (2010) 1.02
Competition-colonization dynamics in an RNA virus. Proc Natl Acad Sci U S A (2010) 1.01
No evidence of selection for mutational robustness during lethal mutagenesis of lymphocytic choriomeningitis virus. Virology (2008) 1.01
Mechanistic insights into the role of Val75 of HIV-1 reverse transcriptase in misinsertion and mispair extension fidelity of DNA synthesis. J Mol Biol (2007) 1.01
Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin. J Virol (2010) 1.01
Dynamics of mutation and recombination in a replicating population of complementing, defective viral genomes. J Mol Biol (2006) 1.00
Resistance to extinction of low fitness virus subjected to plaque-to-plaque transfers: diversification by mutation clustering. J Mol Biol (2002) 0.98
Quasispecies as a matter of fact: viruses and beyond. Virus Res (2011) 0.98
Mutagenesis-induced, large fitness variations with an invariant arenavirus consensus genomic nucleotide sequence. J Virol (2005) 0.98
Expansion of host-cell tropism of foot-and-mouth disease virus despite replication in a constant environment. J Gen Virol (2004) 0.97
Pathways to extinction: beyond the error threshold. Philos Trans R Soc Lond B Biol Sci (2010) 0.97
Counteracting quasispecies adaptability: extinction of a ribavirin-resistant virus mutant by an alternative mutagenic treatment. PLoS One (2009) 0.94
Mechanisms involved in the selection of HIV-1 reverse transcriptase thumb subdomain polymorphisms associated with nucleoside analogue therapy failure. Antimicrob Agents Chemother (2010) 0.94
Beneficial effects of population bottlenecks in an RNA virus evolving at increased error rate. J Mol Biol (2008) 0.93
Guinea pig-adapted foot-and-mouth disease virus with altered receptor recognition can productively infect a natural host. J Virol (2007) 0.93
Adaptability costs in immune escape variants of vesicular stomatitis virus. Virus Res (2005) 0.92
Minority report: hidden memory genomes in HIV-1 quasispecies and possible clinical implications. AIDS Rev (2008) 0.92
Evolution of cell recognition by viruses: a source of biological novelty with medical implications. Adv Virus Res (2003) 0.92
Lethal mutagenesis of viruses. Curr Opin Virol (2011) 0.92
Combination of a mutagenic agent with a reverse transcriptase inhibitor results in systematic inhibition of HIV-1 infection. Virology (2005) 0.92
Mutation hot spots in hepatitis B surface antigen in chronic carriers from Khoozestan province, southern of Iran. Iran J Allergy Asthma Immunol (2013) 0.92
The impact of quasispecies dynamics on the use of therapeutics. Trends Microbiol (2012) 0.91
Fitness increase of memory genomes in a viral quasispecies. J Mol Biol (2004) 0.91
Invariant aphthovirus consensus nucleotide sequence in the transition to error catastrophe. Infect Genet Evol (2005) 0.90
Evidence of the coevolution of antigenicity and host cell tropism of foot-and-mouth disease virus in vivo. J Virol (2003) 0.90
Modeling viral genome fitness evolution associated with serial bottleneck events: evidence of stationary states of fitness. J Virol (2002) 0.90
Repeated bottleneck transfers can lead to non-cytocidal forms of a cytopathic virus: implications for viral extinction. J Mol Biol (2007) 0.90
Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments. J Med Virol (2007) 0.89
Increased thermostability and fidelity of DNA synthesis of wild-type and mutant HIV-1 group O reverse transcriptases. J Mol Biol (2009) 0.89
Mutational patterns associated with the 69 insertion complex in multi-drug-resistant HIV-1 reverse transcriptase that confer increased excision activity and high-level resistance to zidovudine. J Mol Biol (2006) 0.89
Molecular characterization of a dual inhibitory and mutagenic activity of 5-fluorouridine triphosphate on viral RNA synthesis. Implications for lethal mutagenesis. J Mol Biol (2008) 0.89
HIV-1 protease dimer interface mutations that compensate for viral reverse transcriptase instability in infectious virions. J Mol Biol (2007) 0.88
Topology of evolving, mutagenized viral populations: quasispecies expansion, compression, and operation of negative selection. BMC Evol Biol (2008) 0.88
Response of hepatitis C virus to long-term passage in the presence of alpha interferon: multiple mutations and a common phenotype. J Virol (2013) 0.88
A segmented form of foot-and-mouth disease virus interferes with standard virus: a link between interference and competitive fitness. Virology (2005) 0.88
Synchronous loss of quasispecies memory in parallel viral lineages: a deterministic feature of viral quasispecies. J Mol Biol (2003) 0.88
Thymidine analogue excision and discrimination modulated by mutational complexes including single amino acid deletions of Asp-67 or Thr-69 in HIV-1 reverse transcriptase. J Biol Chem (2011) 0.87
HIV-1 reverse transcriptase thumb subdomain polymorphisms associated with virological failure to nucleoside drug combinations. J Antimicrob Chemother (2009) 0.87
Fitness distributions in exponentially growing asexual populations. Phys Rev Lett (2003) 0.87
Increased G-->A transition frequencies displayed by primer grip mutants of human immunodeficiency virus type 1 reverse transcriptase. J Virol (2004) 0.87
Deletion mutants of VPg reveal new cytopathology determinants in a picornavirus. PLoS One (2010) 0.87
Suppression of multidrug-resistant HIV-1 reverse transcriptase primer unblocking activity by alpha-phosphate-modified thymidine analogues. J Mol Biol (2005) 0.86
Few mutations in the 5' leader region mediate fitness recovery of debilitated human immunodeficiency type 1 viruses. J Virol (2005) 0.86
Minority memory genomes can influence the evolution of HIV-1 quasispecies in vivo. Gene (2006) 0.86
An interfering activity against lymphocytic choriomeningitis virus replication associated with enhanced mutagenesis. J Gen Virol (2009) 0.86
Biological effect of Muller's Ratchet: distant capsid site can affect picornavirus protein processing. J Virol (2009) 0.85
Influence of mutagenesis and viral load on the sustained low-level replication of an RNA virus. J Mol Biol (2011) 0.85
Memory in retroviral quasispecies: experimental evidence and theoretical model for human immunodeficiency virus. J Mol Biol (2003) 0.84
5-fluorouracil in lethal mutagenesis of foot-and-mouth disease virus. Future Med Chem (2009) 0.84
Monitoring sequence space as a test for the target of selection in viruses. J Mol Biol (2005) 0.84
Tempo and mode of inhibitor-mutagen antiviral therapies: a multidisciplinary approach. Proc Natl Acad Sci U S A (2011) 0.83
A376S in the connection subdomain of HIV-1 reverse transcriptase confers increased risk of virological failure to nevirapine therapy. J Infect Dis (2011) 0.83
Transdisciplinary EU science institute needs funds urgently. Nature (2010) 0.83
Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination. J Biol Chem (2009) 0.82
Mechanistic basis of zidovudine hypersusceptibility and lamivudine resistance conferred by the deletion of codon 69 in the HIV-1 reverse transcriptase coding region. J Mol Biol (2008) 0.82
Analysis of sequential hepatitis A virus strains reveals coexistence of distinct viral subpopulations. J Gen Virol (2006) 0.82
Persistence of foot-and-mouth disease virus in cell culture revisited: implications for contingency in evolution. J Gen Virol (2008) 0.82
A Mg2+-induced conformational switch rendering a competent DNA polymerase catalytic complex. Proteins (2008) 0.82
DR_SEQAN: a PC/Windows-based software to evaluate drug resistance using human immunodeficiency virus type 1 genotypes. BMC Infect Dis (2006) 0.82
Nucleotide specificity of HIV-1 reverse transcriptases with amino acid substitutions affecting Ala-114. Biochem J (2005) 0.82
Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis. PLoS One (2013) 0.81
Microarray-based identification of antigenic variants of foot-and-mouth disease virus: a bioinformatics quality assessment. BMC Genomics (2006) 0.81