Published in Philos Trans R Soc Lond B Biol Sci on June 27, 2010
Viral quasispecies evolution. Microbiol Mol Biol Rev (2012) 2.69
New experimental and theoretical approaches towards the understanding of the emergence of viral infections. Introduction. Philos Trans R Soc Lond B Biol Sci (2010) 1.18
Lethal mutagenesis and evolutionary epidemiology. Philos Trans R Soc Lond B Biol Sci (2010) 0.98
Single-Cell Analysis of RNA Virus Infection Identifies Multiple Genetically Diverse Viral Genomes within Single Infectious Units. Cell Host Microbe (2015) 0.95
Back to the future: revisiting HIV-1 lethal mutagenesis. Trends Microbiol (2012) 0.90
Tempo and mode of inhibitor-mutagen antiviral therapies: a multidisciplinary approach. Proc Natl Acad Sci U S A (2011) 0.83
Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine. Proc Natl Acad Sci U S A (2014) 0.81
Mutagenesis-mediated virus extinction: virus-dependent effect of viral load on sensitivity to lethal defection. PLoS One (2012) 0.80
Evolutionary invasion and escape in the presence of deleterious mutations. PLoS One (2013) 0.78
Intergenerational phenotypic mixing in viral evolution. Evolution (2013) 0.78
Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations. Sci Rep (2014) 0.75
Severe hindrance of viral infection propagation in spatially extended hosts. PLoS One (2011) 0.75
Selforganization of matter and the evolution of biological macromolecules. Naturwissenschaften (1971) 13.09
Evolution of high mutation rates in experimental populations of E. coli. Nature (1997) 8.68
Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature (2005) 6.78
Epochal evolution shapes the phylodynamics of interpandemic influenza A (H3N2) in humans. Science (2006) 6.01
Nucleotide sequence heterogeneity of an RNA phage population. Cell (1978) 5.55
The maintenance of the accuracy of protein synthesis and its relevance to ageing. Proc Natl Acad Sci U S A (1963) 5.48
RNA virus error catastrophe: direct molecular test by using ribavirin. Proc Natl Acad Sci U S A (2001) 5.21
Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase. Science (1996) 5.08
A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity. Proc Natl Acad Sci U S A (2003) 3.68
Highly variable mutation rates in commensal and pathogenic Escherichia coli. Science (1997) 3.67
Smoothness within ruggedness: the role of neutrality in adaptation. Proc Natl Acad Sci U S A (1996) 3.67
Virus dynamics and drug therapy. Proc Natl Acad Sci U S A (1997) 3.63
Proliferation of mutators in A cell population. J Bacteriol (1997) 3.55
The evolution of mutation rates: separating causes from consequences. Bioessays (2000) 3.48
Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis. J Virol (1990) 3.11
The rate of adaptation in asexuals. Genetics (2000) 3.02
One sequence, two ribozymes: implications for the emergence of new ribozyme folds. Science (2000) 2.53
Evolution of pig influenza viruses. Virology (1991) 2.40
Role of the host cell in persistent viral infection: coevolution of L cells and reovoirus during persistent infection. Cell (1981) 2.23
Theory of lethal mutagenesis for viruses. J Virol (2007) 2.20
Evolution of mutation rates in bacteria. Mol Microbiol (2006) 2.14
Error catastrophe and antiviral strategy. Proc Natl Acad Sci U S A (2002) 2.10
Quasispecies theory in the context of population genetics. BMC Evol Biol (2005) 2.02
Real ribozymes suggest a relaxed error threshold. Nat Genet (2005) 2.00
Experimental tests for an evolutionary trade-off between growth rate and yield in E. coli. Am Nat (2006) 1.99
Coevolution of cells and viruses in a persistent infection of foot-and-mouth disease virus in cell culture. J Virol (1988) 1.90
Limits to adaptation in asexual populations. J Evol Biol (2005) 1.75
Compensating for our load of mutations: freezing the meltdown of small populations. Evolution (2000) 1.72
Balancing robustness and evolvability. PLoS Biol (2006) 1.64
Suppression of viral infectivity through lethal defection. Proc Natl Acad Sci U S A (2005) 1.62
Heterogeneity of the mutation rates of influenza A viruses: isolation of mutator mutants. J Virol (1992) 1.61
Evolutionary transition toward defective RNAs that are infectious by complementation. J Virol (2004) 1.61
Mutagenesis versus inhibition in the efficiency of extinction of foot-and-mouth disease virus. J Virol (2003) 1.58
The fitness effect of mutations across environments: a survey in light of fitness landscape models. Evolution (2006) 1.58
Selection for robustness in mutagenized RNA viruses. PLoS Genet (2007) 1.58
Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: implications for error catastrophe. J Virol (2006) 1.56
Quasispecies made simple. PLoS Comput Biol (2005) 1.56
Evolution of mutational robustness in an RNA virus. PLoS Biol (2005) 1.54
Theories of adaptation: what they do and don't say. Genetica (2005) 1.47
Negative effects of chemical mutagenesis on the adaptive behavior of vesicular stomatitis virus. J Virol (1997) 1.45
Density-dependent selection in vesicular stomatitis virus. J Virol (2004) 1.37
Co-infection weakens selection against epistatic mutations in RNA viruses. Genetics (2004) 1.31
3'-Azido-3'-deoxythymidine (AZT) and AZT-resistant reverse transcriptase can increase the in vivo mutation rate of human immunodeficiency virus type 1. J Virol (2000) 1.26
The ascent of the abundant: how mutational networks constrain evolution. PLoS Comput Biol (2008) 1.20
Population bottlenecks in quasispecies dynamics. Curr Top Microbiol Immunol (2006) 1.17
Phenotypic error threshold; additivity and epistasis in RNA evolution. BMC Evol Biol (2005) 1.17
In silico predicted robustness of viroids RNA secondary structures. I. The effect of single mutations. Mol Biol Evol (2006) 1.12
Evolution at a high imposed mutation rate: adaptation obscures the load in phage T7. Genetics (2009) 1.11
Error threshold for spatially resolved evolution in the quasispecies model. Phys Rev Lett (2001) 1.08
Error-threshold exists in fitness landscapes with lethal mutants. BMC Evol Biol (2007) 1.07
Potential benefits of sequential inhibitor-mutagen treatments of RNA virus infections. PLoS Pathog (2009) 1.05
Molecular basis for a lack of correlation between viral fitness and cell killing capacity. PLoS Pathog (2007) 1.04
No evidence of selection for mutational robustness during lethal mutagenesis of lymphocytic choriomeningitis virus. Virology (2008) 1.01
Quasispecies and the development of new antiviral strategies. Prog Drug Res (2003) 0.98
Collective properties of evolving molecular quasispecies. BMC Evol Biol (2007) 0.95
Counteracting quasispecies adaptability: extinction of a ribavirin-resistant virus mutant by an alternative mutagenic treatment. PLoS One (2009) 0.94
Exact solution of the Eigen model with general fitness functions and degradation rates. Proc Natl Acad Sci U S A (2006) 0.94
Beneficial effects of population bottlenecks in an RNA virus evolving at increased error rate. J Mol Biol (2008) 0.93
Phenotypic effect of mutations in evolving populations of RNA molecules. BMC Evol Biol (2010) 0.92
Modeling viral genome fitness evolution associated with serial bottleneck events: evidence of stationary states of fitness. J Virol (2002) 0.90
A trade-off between neutrality and adaptability limits the optimization of viral quasispecies. J Theor Biol (2009) 0.89
Variable mutation rates as an adaptive strategy in replicator populations. PLoS One (2010) 0.80
Effects of spatial competition on the diversity of a quasispecies. Phys Rev Lett (2008) 0.79
Biological and biomedical implications of the co-evolution of pathogens and their hosts. Nat Genet (2002) 4.42
Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA. J Biol Chem (2004) 2.48
Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV). Virology (2003) 1.76
Suppression of viral infectivity through lethal defection. Proc Natl Acad Sci U S A (2005) 1.62
Evolutionary transition toward defective RNAs that are infectious by complementation. J Virol (2004) 1.61
Mutagenesis versus inhibition in the efficiency of extinction of foot-and-mouth disease virus. J Virol (2003) 1.58
Effect of alternating passage on adaptation of sindbis virus to vertebrate and invertebrate cells. J Virol (2005) 1.57
Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: implications for error catastrophe. J Virol (2006) 1.56
The structure of a protein primer-polymerase complex in the initiation of genome replication. EMBO J (2006) 1.54
Curing of foot-and-mouth disease virus from persistently infected cells by ribavirin involves enhanced mutagenesis. Virology (2003) 1.44
Sequential structures provide insights into the fidelity of RNA replication. Proc Natl Acad Sci U S A (2007) 1.37
Quasispecies dynamics and RNA virus extinction. Virus Res (2005) 1.35
High mutation rates, bottlenecks, and robustness of RNA viral quasispecies. Gene (2005) 1.31
Resistance of virus to extinction on bottleneck passages: study of a decaying and fluctuating pattern of fitness loss. Proc Natl Acad Sci U S A (2003) 1.27
Preextinction viral RNA can interfere with infectivity. J Virol (2004) 1.26
Structural insights into replication initiation and elongation processes by the FMDV RNA-dependent RNA polymerase. Curr Opin Struct Biol (2009) 1.22
Duration and fitness dependence of quasispecies memory. J Mol Biol (2002) 1.18
Insights into RNA virus mutant spectrum and lethal mutagenesis events: replicative interference and complementation by multiple point mutants. J Mol Biol (2007) 1.17
Mutant viral polymerase in the transition of virus to error catastrophe identifies a critical site for RNA binding. J Mol Biol (2005) 1.13
Analysis of ribavirin mutagenicity in human hepatitis C virus infection. J Virol (2007) 1.10
Evidence for quasispecies distributions in the human hepatitis A virus genome. Virology (2003) 1.10
A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape. PLoS Pathog (2010) 1.08
Hidden virulence determinants in a viral quasispecies in vivo. J Virol (2008) 1.06
Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino acid changes in the hepatitis B virus genome. PLoS One (2012) 1.06
Potential benefits of sequential inhibitor-mutagen treatments of RNA virus infections. PLoS Pathog (2009) 1.05
Molecular basis for a lack of correlation between viral fitness and cell killing capacity. PLoS Pathog (2007) 1.04
Ribavirin can be mutagenic for arenaviruses. J Virol (2011) 1.03
Viral genome segmentation can result from a trade-off between genetic content and particle stability. PLoS Genet (2011) 1.03
Arenavirus genetic diversity and its biological implications. Infect Genet Evol (2009) 1.03
Initial fitness recovery of HIV-1 is associated with quasispecies heterogeneity and can occur without modifications in the consensus sequence. PLoS One (2010) 1.02
No evidence of selection for mutational robustness during lethal mutagenesis of lymphocytic choriomeningitis virus. Virology (2008) 1.01
Competition-colonization dynamics in an RNA virus. Proc Natl Acad Sci U S A (2010) 1.01
Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin. J Virol (2010) 1.01
Dynamics of mutation and recombination in a replicating population of complementing, defective viral genomes. J Mol Biol (2006) 1.00
Quasispecies as a matter of fact: viruses and beyond. Virus Res (2011) 0.98
Resistance to extinction of low fitness virus subjected to plaque-to-plaque transfers: diversification by mutation clustering. J Mol Biol (2002) 0.98
Mutagenesis-induced, large fitness variations with an invariant arenavirus consensus genomic nucleotide sequence. J Virol (2005) 0.98
Expansion of host-cell tropism of foot-and-mouth disease virus despite replication in a constant environment. J Gen Virol (2004) 0.97
Multidrug-resistant HIV-1 reverse transcriptase: involvement of ribonucleotide-dependent phosphorolysis in cross-resistance to nucleoside analogue inhibitors. J Mol Biol (2002) 0.96
Counteracting quasispecies adaptability: extinction of a ribavirin-resistant virus mutant by an alternative mutagenic treatment. PLoS One (2009) 0.94
Guinea pig-adapted foot-and-mouth disease virus with altered receptor recognition can productively infect a natural host. J Virol (2007) 0.93
Beneficial effects of population bottlenecks in an RNA virus evolving at increased error rate. J Mol Biol (2008) 0.93
Evolution of cell recognition by viruses: a source of biological novelty with medical implications. Adv Virus Res (2003) 0.92
Adaptability costs in immune escape variants of vesicular stomatitis virus. Virus Res (2005) 0.92
Phenotypic effect of mutations in evolving populations of RNA molecules. BMC Evol Biol (2010) 0.92
Lethal mutagenesis of viruses. Curr Opin Virol (2011) 0.92
Combination of a mutagenic agent with a reverse transcriptase inhibitor results in systematic inhibition of HIV-1 infection. Virology (2005) 0.92
Minority report: hidden memory genomes in HIV-1 quasispecies and possible clinical implications. AIDS Rev (2008) 0.92
Mutation hot spots in hepatitis B surface antigen in chronic carriers from Khoozestan province, southern of Iran. Iran J Allergy Asthma Immunol (2013) 0.92
The impact of quasispecies dynamics on the use of therapeutics. Trends Microbiol (2012) 0.91
Fitness increase of memory genomes in a viral quasispecies. J Mol Biol (2004) 0.91
Repeated bottleneck transfers can lead to non-cytocidal forms of a cytopathic virus: implications for viral extinction. J Mol Biol (2007) 0.90
Evidence of the coevolution of antigenicity and host cell tropism of foot-and-mouth disease virus in vivo. J Virol (2003) 0.90
Invariant aphthovirus consensus nucleotide sequence in the transition to error catastrophe. Infect Genet Evol (2005) 0.90
Modeling viral genome fitness evolution associated with serial bottleneck events: evidence of stationary states of fitness. J Virol (2002) 0.90
A trade-off between neutrality and adaptability limits the optimization of viral quasispecies. J Theor Biol (2009) 0.89
Molecular characterization of a dual inhibitory and mutagenic activity of 5-fluorouridine triphosphate on viral RNA synthesis. Implications for lethal mutagenesis. J Mol Biol (2008) 0.89
A segmented form of foot-and-mouth disease virus interferes with standard virus: a link between interference and competitive fitness. Virology (2005) 0.88
Response of hepatitis C virus to long-term passage in the presence of alpha interferon: multiple mutations and a common phenotype. J Virol (2013) 0.88
Topology of evolving, mutagenized viral populations: quasispecies expansion, compression, and operation of negative selection. BMC Evol Biol (2008) 0.88
Synchronous loss of quasispecies memory in parallel viral lineages: a deterministic feature of viral quasispecies. J Mol Biol (2003) 0.88
Deletion mutants of VPg reveal new cytopathology determinants in a picornavirus. PLoS One (2010) 0.87
Fitness distributions in exponentially growing asexual populations. Phys Rev Lett (2003) 0.87
An interfering activity against lymphocytic choriomeningitis virus replication associated with enhanced mutagenesis. J Gen Virol (2009) 0.86
Minority memory genomes can influence the evolution of HIV-1 quasispecies in vivo. Gene (2006) 0.86
Few mutations in the 5' leader region mediate fitness recovery of debilitated human immunodeficiency type 1 viruses. J Virol (2005) 0.86
Biological effect of Muller's Ratchet: distant capsid site can affect picornavirus protein processing. J Virol (2009) 0.85
Influence of mutagenesis and viral load on the sustained low-level replication of an RNA virus. J Mol Biol (2011) 0.85
Monitoring sequence space as a test for the target of selection in viruses. J Mol Biol (2005) 0.84
Memory in retroviral quasispecies: experimental evidence and theoretical model for human immunodeficiency virus. J Mol Biol (2003) 0.84
Identification of mutations conferring 5-azacytidine resistance in bacteriophage Qβ. Virology (2011) 0.84
5-fluorouracil in lethal mutagenesis of foot-and-mouth disease virus. Future Med Chem (2009) 0.84
Tempo and mode of inhibitor-mutagen antiviral therapies: a multidisciplinary approach. Proc Natl Acad Sci U S A (2011) 0.83
Transdisciplinary EU science institute needs funds urgently. Nature (2010) 0.83
Analysis of sequential hepatitis A virus strains reveals coexistence of distinct viral subpopulations. J Gen Virol (2006) 0.82
Persistence of foot-and-mouth disease virus in cell culture revisited: implications for contingency in evolution. J Gen Virol (2008) 0.82
Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis. PLoS One (2013) 0.81
Reconstructing evolutionary relationships from functional data: a consistent classification of organisms based on translation inhibition response. Mol Phylogenet Evol (2004) 0.81
Microarray-based identification of antigenic variants of foot-and-mouth disease virus: a bioinformatics quality assessment. BMC Genomics (2006) 0.81
Viral fitness can influence the repertoire of virus variants selected by antibodies. J Mol Biol (2006) 0.81
Identification of host and viral factors involved in a dissimilar resolution of a hepatitis C virus infection. Liver Int (2013) 0.80
Competition-colonization dynamics: An ecology approach to quasispecies dynamics and virulence evolution in RNA viruses. Commun Integr Biol (2010) 0.80
Mutagenesis-mediated virus extinction: virus-dependent effect of viral load on sensitivity to lethal defection. PLoS One (2012) 0.80
Variable mutation rates as an adaptive strategy in replicator populations. PLoS One (2010) 0.80
Influence of the mutant spectrum in viral evolution: focused selection of antigenic variants in a reconstructed viral quasispecies. Mol Biol Evol (2008) 0.79
New vaccine design based on defective genomes that combines features of attenuated and inactivated vaccines. PLoS One (2010) 0.79
Arenaviruses and lethal mutagenesis. Prospects for new ribavirin-based interventions. Viruses (2012) 0.79
Evolution at increased error rate leads to the coexistence of multiple adaptive pathways in an RNA virus. BMC Evol Biol (2013) 0.79
Characterization of minority subpopulations in the mutant spectrum of HIV-1 quasispecies by successive specific amplifications. Virus Res (2007) 0.79
Exploration of sequence space as the basis of viral RNA genome segmentation. Proc Natl Acad Sci U S A (2014) 0.78
Evidence of Muller's ratchet in herpes simplex virus type 1. J Gen Virol (2012) 0.78
Quasispecies dynamics in hepatitis C liver transplant recipients receiving grafts from hepatitis C virus infected donors. J Gen Virol (2015) 0.78