Cutting edge: localization of the host recognition functions of complement factor H at the carboxyl-terminal: implications for hemolytic uremic syndrome.

Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome. Blood (2006) 4.51

Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome. J Clin Invest (2003) 2.96

Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. PLoS Genet (2007) 2.79

Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome. Proc Natl Acad Sci U S A (2003) 2.79

Structural basis for engagement by complement factor H of C3b on a self surface. Nat Struct Mol Biol (2011) 2.32

Haemolytic uraemic syndrome and mutations of the factor H gene: a registry-based study of German speaking countries. J Med Genet (2003) 1.92

The development of atypical hemolytic uremic syndrome depends on complement C5. J Am Soc Nephrol (2010) 1.88

Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome. EMBO J (2006) 1.72

The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome. J Immunol (2009) 1.70

Complement control protein factor H: the good, the bad, and the inadequate. Mol Immunol (2010) 1.68

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement. Proc Natl Acad Sci U S A (2011) 1.58

Translational mini-review series on complement factor H: structural and functional correlations for factor H. Clin Exp Immunol (2008) 1.52

The C-terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein. Clin Exp Immunol (2006) 1.50

Factor H mediated cell surface protection from complement is critical for the survival of PNH erythrocytes. Blood (2007) 1.16

The C-terminus of complement factor H is essential for host cell protection. Mol Immunol (2007) 1.14

Eculizumab prevents intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria and unmasks low-level extravascular hemolysis occurring through C3 opsonization. Haematologica (2010) 1.13

Microbes bind complement inhibitor factor H via a common site. PLoS Pathog (2013) 1.06

Atypical haemolytic uraemic syndrome and mutations in complement regulator genes. Springer Semin Immunopathol (2005) 1.05

The relative roles of factor H binding protein, neisserial surface protein A, and lipooligosaccharide sialylation in regulation of the alternative pathway of complement on meningococci. J Immunol (2012) 1.04

Polyanion-induced self-association of complement factor H. J Immunol (2009) 1.01

Factor h: a complement regulator in health and disease, and a mediator of cellular interactions. Biomolecules (2012) 0.99

The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module. J Mol Biol (2009) 0.96

Challenges in the management of infantile factor H associated hemolytic uremic syndrome. Pediatr Nephrol (2004) 0.88

Fusion protein comprising factor H domains 6 and 7 and human IgG1 Fc as an antibacterial immunotherapeutic. Clin Vaccine Immunol (2014) 0.87

Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis. J Immunol (2013) 0.87

Properdin: a tightly regulated critical inflammatory modulator. Immunol Rev (2016) 0.85

Pathogenesis and prognosis of thrombotic microangiopathy. Clin Exp Nephrol (2007) 0.84

Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH). PLoS One (2012) 0.83

The major autoantibody epitope on factor H in atypical hemolytic uremic syndrome is structurally different from its homologous site in factor H-related protein 1, supporting a novel model for induction of autoimmunity in this disease. J Biol Chem (2015) 0.82

Complement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from Complement. J Immunol (2015) 0.80

New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases. Mol Immunol (2014) 0.77

Complementopathies. Blood Rev (2017) 0.76

Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles. J Biol Chem (2015) 0.75

Complete factor I deficiency due to dysfunctional factor I with recurrent aseptic meningo-encephalitis. J Clin Immunol (2013) 0.75

Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self surface-selective regulation of complement activation. J Biol Chem (2017) 0.75