Published in Neurobiol Aging on October 23, 2002
Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol (2009) 4.52
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc Natl Acad Sci U S A (2004) 3.61
Ageing and neuronal vulnerability. Nat Rev Neurosci (2006) 3.36
Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging (2007) 2.09
Selective neuronal vulnerability to oxidative stress in the brain. Front Aging Neurosci (2010) 1.96
Oxidative stress in the progression of Alzheimer disease in the frontal cortex. J Neuropathol Exp Neurol (2010) 1.58
Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Curr Neurovasc Res (2007) 1.48
Recruiting adaptive cellular stress responses for successful brain ageing. Nat Rev Neurosci (2012) 1.42
The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal. Arch Biochem Biophys (2008) 1.36
Pyruvate dehydrogenase complex: metabolic link to ischemic brain injury and target of oxidative stress. J Neurosci Res (2004) 1.32
The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy. Br J Pharmacol (2005) 1.32
Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. Arch Neurol (2012) 1.32
Oxidative stress and anxiety: relationship and cellular pathways. Oxid Med Cell Longev (2010) 1.30
Oxidative stress and transcriptional regulation in Alzheimer disease. Alzheimer Dis Assoc Disord (2007) 1.29
Markers of oxidant stress that are clinically relevant in aging and age-related disease. Mech Ageing Dev (2013) 1.24
Effects of age and caloric intake on glutathione redox state in different brain regions of C57BL/6 and DBA/2 mice. Brain Res (2006) 1.22
Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells. FASEB J (2004) 1.18
Markers of oxidative stress in erythrocytes and plasma during aging in humans. Oxid Med Cell Longev (2010) 1.16
Dynamics of DNA methylation in aging and Alzheimer's disease. DNA Cell Biol (2012) 1.13
Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis. Mol Psychiatry (2014) 1.12
Reactive oxygen-mediated damage to a human DNA replication and repair protein. EMBO Rep (2007) 1.11
Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease. J Neurosci (2011) 1.11
Antiinflammatory activity of melatonin in central nervous system. Curr Neuropharmacol (2010) 1.09
Brain region-specific, age-related, alterations in mitochondrial responses to elevated calcium. J Bioenerg Biomembr (2004) 1.08
Neuroprotective strategies in Alzheimer's disease. NeuroRx (2004) 1.05
Physiology and pathology of calcium signaling in the brain. Front Pharmacol (2012) 1.05
Normal brain ageing: models and mechanisms. Philos Trans R Soc Lond B Biol Sci (2005) 1.04
Accumulation of nuclear DNA damage or neuron loss: molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseases. DNA Repair (Amst) (2008) 1.04
NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat. Rejuvenation Res (2010) 1.02
Redox regulation of the intrinsic pathway in neuronal apoptosis. Antioxid Redox Signal (2011) 1.00
Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death. Antioxid Redox Signal (2009) 0.99
Oxidative stress mediates the pathogenic effect of different Alzheimer's disease risk factors. Front Aging Neurosci (2010) 0.98
Ascorbic acid and rates of cognitive decline in Alzheimer's disease. J Alzheimers Dis (2009) 0.98
α-Lipoic acid antioxidant treatment limits glaucoma-related retinal ganglion cell death and dysfunction. PLoS One (2013) 0.97
The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation. Front Pharmacol (2012) 0.96
The role of DNA repair in brain related disease pathology. DNA Repair (Amst) (2013) 0.96
Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: how important is BDNF? Br J Pharmacol (2014) 0.96
Oxidative damage and cognitive dysfunction: antioxidant treatments to promote healthy brain aging. Neurochem Res (2008) 0.95
Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease. Antioxid Redox Signal (2012) 0.94
Redox control of prion and disease pathogenesis. Antioxid Redox Signal (2010) 0.93
Microglial cell dysregulation in brain aging and neurodegeneration. Front Aging Neurosci (2015) 0.92
Presence of antioxidative agent, Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro- in newly isolated Streptomyces mangrovisoli sp. nov. Front Microbiol (2015) 0.92
Proinflammatory cytokines provoke oxidative damage to actin in neuronal cells mediated by Rac1 and NADPH oxidase. Mol Cell Neurosci (2009) 0.92
The endocannabinoid system in normal and pathological brain ageing. Philos Trans R Soc Lond B Biol Sci (2012) 0.90
Formaldehyde at low concentration induces protein tau into globular amyloid-like aggregates in vitro and in vivo. PLoS One (2007) 0.90
Age-related changes in mitochondrial respiration and oxidative damage in the cerebral cortex of the Fischer 344 rat. Mech Ageing Dev (2010) 0.90
Intermittent hypoxia from obstructive sleep apnea may cause neuronal impairment and dysfunction in central nervous system: the potential roles played by microglia. Neuropsychiatr Dis Treat (2013) 0.89
Antioxidant role of oleuropein on midbrain and dopaminergic neurons of substantia nigra in aged rats. Iran Biomed J (2014) 0.89
Obesity increases cerebrocortical reactive oxygen species and impairs brain function. Free Radic Biol Med (2012) 0.89
Molecular pathogenesis of Alzheimer's disease: reductionist versus expansionist approaches. Int J Mol Sci (2009) 0.87
Antioxidant effects of statins in patients with atherosclerotic cerebrovascular disease. J Clin Neurol (2014) 0.87
Concentration dependent effect of calcium on brain mitochondrial bioenergetics and oxidative stress parameters. Front Neuroenergetics (2013) 0.86
Calcium homeostasis in aging neurons. Front Genet (2012) 0.86
N-acetylcysteine reverses existing cognitive impairment and increased oxidative stress in glutamate transporter type 3 deficient mice. Neuroscience (2012) 0.86
Mechanism of genotoxicity induced by targeted cytoplasmic irradiation. Br J Cancer (2010) 0.86
Olive oil and cognition: results from the three-city study. Dement Geriatr Cogn Disord (2009) 0.86
Mitochondrial Dysfunction during Brain Aging: Role of Oxidative Stress and Modulation by Antioxidant Supplementation. Aging Dis (2011) 0.85
Induction of methionine-sulfoxide reductases protects neurons from amyloid β-protein insults in vitro and in vivo. Biochemistry (2011) 0.85
N-PEP-12--a novel peptide compound that protects cortical neurons in culture against different age and disease associated lesions. J Neural Transm (Vienna) (2005) 0.85
Decline in cytochrome c oxidase activity in rat-brain mitochondria with aging. Role of peroxidized cardiolipin and beneficial effect of melatonin. J Bioenerg Biomembr (2013) 0.83
Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. ScientificWorldJournal (2010) 0.83
Anti-amnesic activity of Citrus aurantium flowers extract against scopolamine-induced memory impairments in rats. Neurol Sci (2014) 0.82
Treating vascular risk factors and maintaining vascular health: is this the way towards successful cognitive ageing and preventing cognitive decline? Postgrad Med J (2006) 0.82
Age-associated changes in synaptic lipid raft proteins revealed by two-dimensional fluorescence difference gel electrophoresis. Neurobiol Aging (2008) 0.82
The role of mitochondria in brain aging and the effects of melatonin. Curr Neuropharmacol (2010) 0.81
Combined age- and trauma-related proteomic changes in rat neocortex: a basis for brain vulnerability. Neurobiol Aging (2011) 0.81
Improved mitochondrial function in brain aging and Alzheimer disease - the new mechanism of action of the old metabolic enhancer piracetam. Front Neurosci (2010) 0.81
Lactobacillus plantarum NDC 75017 alleviates the learning and memory ability in aging rats by reducing mitochondrial dysfunction. Exp Ther Med (2014) 0.80
G-quadruplex structures formed by expanded hexanucleotide repeat RNA and DNA from the neurodegenerative disease-linked C9orf72 gene efficiently sequester and activate heme. PLoS One (2014) 0.80
Effects of Resveratrol and trans-3,5,4'-Trimethoxystilbene on Glutamate-Induced Cytotoxicity, Heme Oxygenase-1, and Sirtuin 1 in HT22 Neuronal Cells. Biomol Ther (Seoul) (2012) 0.80
White matter changes with age utilizing quantitative diffusion MRI. Neurology (2014) 0.80
The Molecular and Cellular Effect of Homocysteine Metabolism Imbalance on Human Health. Int J Mol Sci (2016) 0.80
Brain aging phenomena in migrating sockeye salmon Oncorhynchus nerka nerka. J Neural Transm (Vienna) (2005) 0.79
Antioxidants in the canine model of human aging. Biochim Biophys Acta (2011) 0.79
Mechanisms of action of brain insulin against neurodegenerative diseases. J Neural Transm (Vienna) (2014) 0.79
Malondialdehyde suppresses cerebral function by breaking homeostasis between excitation and inhibition in turtle Trachemys scripta. PLoS One (2010) 0.79
Electrophysiological and behavioral changes by phosphodiesterase 4 inhibitor in a rat model of alcoholic neuropathy. J Korean Neurosurg Soc (2012) 0.78
4-Hydroxynonenal activates Src through a non-canonical pathway that involves EGFR/PTP1B. Free Radic Biol Med (2015) 0.78
Protective effects of YC-1 against glutamate induced PC12 cell apoptosis. Cell Mol Neurobiol (2010) 0.78
Sulforaphane induces Nrf2 target genes and attenuates inflammatory gene expression in microglia from brain of young adult and aged mice. Exp Gerontol (2015) 0.78
The influence of oxidative stress on symptom occurrence, severity, and distress during childhood leukemia treatment. Oncol Nurs Forum (2014) 0.78
The effect of phosphodiesterase-4-specific inhibitor in the rat model of spinal nerve ligation. J Korean Neurosurg Soc (2011) 0.77
Neuroprotective effects of Withania coagulans root extract on CA1 hippocampus following cerebral ischemia in rats. Avicenna J Phytomed (2016) 0.77
Critical evaluation of ayurvedic plants for stimulating intrinsic antioxidant response. Front Neurosci (2012) 0.77
Do we age because we have mitochondria? Protoplasma (2013) 0.77
Age-related alterations in the expression of genes and synaptic plasticity associated with nitric oxide signaling in the mouse dorsal striatum. Neural Plast (2015) 0.77
Selected biomarkers as predictive tools in testing efficacy of melatonin and coenzyme Q on propionic acid - induced neurotoxicity in rodent model of autism. BMC Neurosci (2014) 0.76
FLZ, synthetic squamosamide cyclic derivative, attenuates memory deficit and pathological changes in mice with experimentally induced aging. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.76
Antioxidant and Antiacetylcholinesterase Activity of Teucrium hyrcanicum. Pharmacognosy Res (2015) 0.75
Age-Related Decrease in Heat Shock 70-kDa Protein 8 in Cerebrospinal Fluid Is Associated with Increased Oxidative Stress. Front Aging Neurosci (2016) 0.75
Tempol Ameliorates and Prevents Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain. Front Pharmacol (2017) 0.75
Insulin resistance in Alzheimer's disease. Transl Res (2016) 0.75
Aged neuronal nitric oxide knockout mice show preserved olfactory learning in both social recognition and odor-conditioning tasks. Front Cell Neurosci (2015) 0.75
The Anti-Inflammatory Activity of Eucommia ulmoides Oliv. Bark. Involves NF-κB Suppression and Nrf2-Dependent HO-1 Induction in BV-2 Microglial Cells. Biomol Ther (Seoul) (2016) 0.75
Genome instability in Alzheimer disease. Mech Ageing Dev (2016) 0.75
In vivo and In vitro Anti-Inflammatory Activity of Indazole and Its Derivatives. J Clin Diagn Res (2016) 0.75
Methionine sulfoxide reductase A affects β-amyloid solubility and mitochondrial function in a mouse model of Alzheimer's disease. Am J Physiol Endocrinol Metab (2016) 0.75
Increased Consumption of Fruit and Vegetables Is Related to a Reduced Risk of Cognitive Impairment and Dementia: Meta-Analysis. Front Aging Neurosci (2017) 0.75
Proteomic approaches to quantify cysteine reversible modifications in aging and neurodegenerative diseases. Proteomics Clin Appl (2016) 0.75
Tempol protects sleep-deprivation induced behavioral deficits in aggressive male Long-Evans rats. Neurosci Lett (2015) 0.75
Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis. Free Radic Biol Med (2005) 2.51
Antioxidants in central nervous system diseases: preclinical promise and translational challenges. J Alzheimers Dis (2008) 1.88
Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci (2006) 1.34
A comparative review of cell culture systems for the study of microglial biology in Alzheimer's disease. J Neuroinflammation (2012) 1.21
Oxidatively modified autoantigens in autoimmune diseases. Free Radic Biol Med (2006) 1.20
The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice. J Neurochem (2004) 1.15
Translational research involving oxidative stress and diseases of aging. Free Radic Biol Med (2011) 1.10
Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading. Free Radic Biol Med (2005) 1.09
Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis. Free Radic Biol Med (2005) 1.03
Identification of lanthionine synthase C-like protein-1 as a prominent glutathione binding protein expressed in the mammalian central nervous system. Biochemistry (2007) 1.03
Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis: common links and potential therapeutic targets. J Alzheimers Dis (2004) 1.03
Nitrones as neuroprotectants and antiaging drugs. Ann N Y Acad Sci (2002) 1.03
Immuno-spin trapping of protein and DNA radicals: "tagging" free radicals to locate and understand the redox process. Free Radic Biol Med (2009) 1.01
Lenalidomide (Revlimid) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis. Exp Neurol (2009) 0.99
A survey of sesamin and composition of tocopherol variability from seeds of eleven diverse sesame (Sesamum indicum L.) genotypes using HPLC-PAD-ECD. Phytochem Anal (2008) 0.99
Opening Pandora's jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders. Future Neurol (2012) 0.95
Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione. Genes Dev (2009) 0.94
Anti-inflammatory effects of tocopherol metabolites. Biochem Biophys Res Commun (2004) 0.94
The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain. Nitric Oxide (2002) 0.91
Reactive oxygen species in choline deficiency induced carcinogenesis and nitrone inhibition. Mol Cell Biochem (2002) 0.90
Inhalation of environmental stressors & chronic inflammation: autoimmunity and neurodegeneration. Mutat Res (2008) 0.89
A derivative of the CRMP2 binding compound lanthionine ketimine provides neuroprotection in a mouse model of cerebral ischemia. Neurochem Int (2012) 0.89
Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE. BMC Med Genet (2008) 0.88
Biomarkers of Oxidative Stress Study IV: ozone exposure of rats and its effect on antioxidants in plasma and bronchoalveolar lavage fluid. Free Radic Biol Med (2011) 0.84
Immuno-spin trapping from biochemistry to medicine: advances, challenges, and pitfalls. Focus on protein-centered radicals. Biochim Biophys Acta (2013) 0.83
Sensitivity of protein tyrosine phosphatase activity to the redox environment, cytochrome C, and microperoxidase. Antioxid Redox Signal (2005) 0.81
In vivo detection of free radicals using molecular MRI and immuno-spin trapping in a mouse model for amyotrophic lateral sclerosis. Free Radic Biol Med (2013) 0.81
Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines. Free Radic Biol Med (2013) 0.81
Oxidized LDLs affect nitric oxide and radical generation in brain endothelial cells. Biochem Biophys Res Commun (2003) 0.80
Nitrones, their value as therapeutics and probes to understand aging. Mech Ageing Dev (2002) 0.80
5-HT3 antagonist ICS 205-930 enhances naltrexone's effects on ethanol intake. Eur J Pharmacol (2004) 0.79
Semaphorin 3A signaling through neuropilin-1 is an early trigger for distal axonopathy in the SOD1G93A mouse model of amyotrophic lateral sclerosis. J Neuropathol Exp Neurol (2014) 0.79
Degree of modification of Ro60 by the lipid peroxidation by-product 4-hydroxy-2-nonenal may differentially induce Sjögren syndrome or systemic lupus erythematosus in BALB/c mice. Free Radic Biol Med (2010) 0.79
Lanthionine ketimine ethyl ester partially rescues neurodevelopmental defects in unc-33 (DPYSL2/CRMP2) mutants. J Neurosci Res (2013) 0.79
Progress in therapy development for amyotrophic lateral sclerosis. Neurol Res Int (2012) 0.79
Oxidative modification of proteins in cell signaling. Antioxid Redox Signal (2005) 0.79
Chronic thrombin exposure results in an increase in apolipoprotein-E levels. J Neurosci Res (2006) 0.78
Tianeptine interferes with microtubule organization and hormone secretion of pheochromocytoma cells. Mol Cell Endocrinol (2013) 0.75
Amyotrophic lateral sclerosis and novel therapeutic strategies. Neurol Res Int (2012) 0.75
SOD1 interacts directly with hemoglobin in vitro. Thromb Haemost (2004) 0.75