Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis.

PubWeight™: 1.12‹?› | Rank: Top 10%

🔗 View Article (PMC 4211971)

Published in Mol Psychiatry on September 23, 2014

Authors

M W Miller1, N Sadeh1

Author Affiliations

1: Department of Psychiatry, National Center for PTSD, VA Boston Healthcare System and Boston University School of Medicine, Boston, MA, USA.

Articles citing this

Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging. Neurosci Biobehav Rev (2015) 1.05

Accelerated DNA methylation age: Associations with PTSD and neural integrity. Psychoneuroendocrinology (2015) 0.97

Is Post-Traumatic Stress Disorder Associated with Premature Senescence? A Review of the Literature. Am J Geriatr Psychiatry (2015) 0.90

Longitudinal associations between post-traumatic stress disorder and metabolic syndrome severity. Psychol Med (2016) 0.87

SKA2 methylation is associated with decreased prefrontal cortical thickness and greater PTSD severity among trauma-exposed veterans. Mol Psychiatry (2015) 0.87

Prospective Longitudinal Evaluation of the Effect of Deployment-Acquired Traumatic Brain Injury on Posttraumatic Stress and Related Disorders: Results From the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). Am J Psychiatry (2015) 0.85

Posttraumatic Stress Disorder as a Catalyst for the Association Between Metabolic Syndrome and Reduced Cortical Thickness. Biol Psychiatry (2015) 0.84

ROS and intracellular ion channels. Cell Calcium (2016) 0.83

Reactive oxygen species mediate visceral pain-related amygdala plasticity and behaviors. Pain (2015) 0.82

Dark microglia: A new phenotype predominantly associated with pathological states. Glia (2016) 0.82

A novel locus in the oxidative stress-related gene ALOX12 moderates the association between PTSD and thickness of the prefrontal cortex. Psychoneuroendocrinology (2015) 0.81

Neurobiological indicators of disinhibition in posttraumatic stress disorder. Hum Brain Mapp (2015) 0.79

Possible Benefit of Dietary Carnosine towards Depressive Disorders. Aging Dis (2015) 0.79

PTSD-Related Cardiovascular Disease and Accelerated Cellular Aging. Psychiatr Ann (2016) 0.76

Epigenetic Biomarkers of Preterm Birth and Its Risk Factors. Genes (Basel) (2016) 0.76

Attachment, Neurobiology, and Mentalizing along the Psychosis Continuum. Front Hum Neurosci (2016) 0.75

Enantiomeric Lignans and Neolignans from Phyllanthus glaucus: Enantioseparation and Their Absolute Configurations. Sci Rep (2016) 0.75

Developing Comprehensive Models of the Effects of Stress and Trauma on Biology, Brain, Behavior, and Body. Biol Psychiatry (2016) 0.75

Posttraumatic stress disorder symptoms and cognitive function in a large cohort of middle-aged women. Depress Anxiety (2017) 0.75

Peripheral Biomarker Candidates of Posttraumatic Stress Disorder. Exp Neurobiol (2015) 0.75

CHRONICITY OF DEPRESSION AND MOLECULAR MARKERS IN A LARGE SAMPLE OF HAN CHINESE WOMEN. Depress Anxiety (2016) 0.75

Neuropsin Inactivation Has Protective Effects against Depressive-Like Behaviours and Memory Impairment Induced by Chronic Stress. PLoS Genet (2016) 0.75

The Genetics and Epigenetics of PTSD: Overview, Recent Advances, and Future Directions. Curr Opin Psychol (2017) 0.75

Executive Dysfunctions: The Role in Attention Deficit Hyperactivity and Post-traumatic Stress Neuropsychiatric Disorders. Front Psychol (2016) 0.75

Evidence for the Cost of Reproduction in Humans: High Lifetime Reproductive Effort Is Associated with Greater Oxidative Stress in Post-Menopausal Women. PLoS One (2016) 0.75

Short overview on metabolomic approach and redox changes in psychiatric disorders. Redox Biol (2017) 0.75

Contributions of Polygenic Risk for Obesity to PTSD-Related Metabolic Syndrome and Cortical Thickness. Brain Behav Immun (2017) 0.75

Predicting disease onset in clinically healthy people. Interdiscip Toxicol (2017) 0.75

Articles cited by this

(truncated to the top 100)

Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry (1995) 30.84

Oxidants, oxidative stress and the biology of ageing. Nature (2000) 23.21

Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Annu Rev Plant Biol (2004) 18.76

Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A (2004) 12.89

Sleep drives metabolite clearance from the adult brain. Science (2013) 9.65

Oxidative stress shortens telomeres. Trends Biochem Sci (2002) 9.48

DNA methylation age of human tissues and cell types. Genome Biol (2013) 7.48

Neurodegenerative diseases and oxidative stress. Nat Rev Drug Discov (2004) 5.82

Posttraumatic stress disorder: the burden to the individual and to society. J Clin Psychiatry (2000) 5.18

Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry (2000) 4.99

The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology (2010) 4.82

Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol (2009) 4.52

Current and lifetime comorbidity of the DSM-IV anxiety and mood disorders in a large clinical sample. J Abnorm Psychol (2001) 4.30

Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms. Psychol Bull (2011) 4.27

Posttraumatic stress disorder and risk of dementia among US veterans. Arch Gen Psychiatry (2010) 4.27

Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol (2004) 4.10

Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol (1994) 4.04

Dietary intake of antioxidants and risk of Alzheimer disease. JAMA (2002) 4.01

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc Natl Acad Sci U S A (1991) 3.85

Oxidative stress as a mediator of life history trade-offs: mechanisms, measurements and interpretation. Ecol Lett (2008) 3.71

A second look at comorbidity in victims of trauma: the posttraumatic stress disorder-major depression connection. Biol Psychiatry (2000) 3.26

Posttraumatic stress disorder and depression following trauma: understanding comorbidity. Am J Psychiatry (2004) 2.90

Isoprostanes: markers and mediators of oxidative stress. FASEB J (2004) 2.83

Biological studies of post-traumatic stress disorder. Nat Rev Neurosci (2012) 2.78

A genomewide association study of citalopram response in major depressive disorder. Biol Psychiatry (2010) 2.77

Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial. JAMA (2014) 2.75

Psychological and metabolic stress: a recipe for accelerated cellular aging? Hormones (Athens) (2009) 2.61

Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease. Arch Neurol (2002) 2.58

Sleep deprivation as a neurobiologic and physiologic stressor: Allostasis and allostatic load. Metabolism (2006) 2.48

Neurodegenerative diseases and oxidative stress. Biomed Pharmacother (2004) 2.44

Genome-wide association scan of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet (2008) 2.40

Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study. Mol Psychiatry (2012) 2.37

Evidence of increased oxidative damage in subjects with mild cognitive impairment. Neurology (2005) 2.33

Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature (2005) 2.29

A prospective study of PTSD and early-age heart disease mortality among Vietnam veterans: implications for surveillance and prevention. Psychosom Med (2008) 2.28

Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain. FASEB J (2010) 2.23

The psychophysiology of posttraumatic stress disorder: a meta-analysis. Psychol Bull (2007) 2.19

Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol Aging (2002) 2.06

Polysomnographically measured sleep abnormalities in PTSD: a meta-analytic review. Psychophysiology (2007) 1.98

Oxidative stress and genetics in the pathogenesis of Parkinson's disease. Neurobiol Dis (2000) 1.97

Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms. Am J Med Genet B Neuropsychiatr Genet (2009) 1.92

Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study. PLoS One (2011) 1.78

Assessment of lifestyle effects on the overall antioxidant capacity of healthy subjects. Environ Health Perspect (2002) 1.62

Depressive state relates to female oxidative DNA damage via neutrophil activation. Biochem Biophys Res Commun (2003) 1.56

A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus. Mol Psychiatry (2012) 1.55

Increased serum levels of 8-hydroxy-2'-deoxyguanosine in clinical depression. Psychosom Med (2006) 1.46

Utility of psychophysiological measurement in the diagnosis of posttraumatic stress disorder: results from a Department of Veterans Affairs Cooperative Study. J Consult Clin Psychol (1998) 1.44

Cortisol response to a cognitive stress challenge in posttraumatic stress disorder (PTSD) related to childhood abuse. Psychoneuroendocrinology (2003) 1.41

Sex hormones in autism: androgens and estrogens differentially and reciprocally regulate RORA, a novel candidate gene for autism. PLoS One (2011) 1.40

Exercise prevents sleep deprivation-associated anxiety-like behavior in rats: potential role of oxidative stress mechanisms. Behav Brain Res (2011) 1.39

Characteristics and content of intrusive memories in PTSD and their changes with treatment. J Trauma Stress (2004) 1.38

Glucocorticoids may enhance oxygen radical-mediated neurotoxicity. Neurotoxicology (1997) 1.36

Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy. Neurobiol Dis (2002) 1.34

The role of oxidative stress in HIV disease. Free Radic Biol Med (1995) 1.34

Higher cortisol levels following exposure to traumatic reminders in abuse-related PTSD. Neuropsychopharmacology (2003) 1.28

A meta-analysis of glucocorticoids as modulators of oxidative stress in vertebrates. J Comp Physiol B (2011) 1.27

Trauma: prevalence, impairment, service use, and cost. J Clin Psychiatry (1997) 1.27

Oxidative stress and epigenetic regulation in ageing and age-related diseases. Int J Mol Sci (2013) 1.25

Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. Mol Psychiatry (2010) 1.24

Oxidative stress in anxiety and comorbid disorders. Neurosci Res (2010) 1.24

Role of hippocampal oxidative stress in memory deficits induced by sleep deprivation in mice. Neuropharmacology (2004) 1.24

Antioxidant therapy: current status and future prospects. Curr Med Chem (2011) 1.23

Towards a "free radical theory of graying": melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage. FASEB J (2006) 1.21

Internalizing disorders and leukocyte telomere erosion: a prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder. Mol Psychiatry (2014) 1.21

Urinary biomarkers of oxidative status. Clin Chim Acta (2012) 1.20

Quantification of oxidized RNAs in Alzheimer's disease. Neurobiol Aging (2005) 1.17

Objective evidence of sleep disturbance in women with posttraumatic stress disorder. J Trauma Stress (2007) 1.17

The relation between psychological factors and DNA-damage: a critical review. Biol Psychol (2006) 1.17

The role of DNA methylation in aging, rejuvenation, and age-related disease. Rejuvenation Res (2012) 1.16

Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis. Psychosom Med (2013) 1.16

Human retinoic acid receptor-related orphan receptor alpha1 overexpression protects neurones against oxidative stress-induced apoptosis. J Neurochem (2006) 1.15

Modulation of in vivo oxidative status by exogenous corticosterone and restraint stress in rats. Stress (2009) 1.15

Sudden whitening of the hair. Bull N Y Acad Med (1972) 1.15

RORA, a large common fragile site gene, is involved in cellular stress response. Oncogene (2006) 1.14

Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster. PLoS One (2012) 1.14

Immunohistochemical characterization of the orphan nuclear receptor ROR alpha in the mouse nervous system. J Histochem Cytochem (2004) 1.14

Gray matter correlates of posttraumatic stress disorder: a quantitative meta-analysis. Biol Psychiatry (2012) 1.14

Antioxidant measurements. Physiol Meas (2007) 1.14

Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Mol Psychiatry (2000) 1.13

Neuroendocrine and psychophysiologic responses in PTSD: a symptom provocation study. Neuropsychopharmacology (1999) 1.13

Good stress, bad stress and oxidative stress: insights from anticipatory cortisol reactivity. Psychoneuroendocrinology (2013) 1.12

Dysregulated mitochondrial genes and networks with drug targets in postmortem brain of patients with posttraumatic stress disorder (PTSD) revealed by human mitochondria-focused cDNA microarrays. Int J Biol Sci (2008) 1.11

Oxidative stress: a potential recipe for anxiety, hypertension and insulin resistance. Brain Res (2010) 1.11

Gray matter density in limbic and paralimbic cortices is associated with trauma load and EMDR outcome in PTSD patients. J Psychiatr Res (2009) 1.09

Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain. Front Neurosci (2011) 1.09

Depression and possible cancer risk due to oxidative DNA damage. J Psychiatr Res (2005) 1.06

Glucocorticoid Generates ROS to Induce Oxidative Injury in the Hippocampus, Leading to Impairment of Cognitive Function of Rats. J Clin Biochem Nutr (2010) 1.06

Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal. J Clin Invest (2012) 1.06

Global DNA methylation in old subjects is correlated with frailty. Age (Dordr) (2011) 1.05

Inflammation and oxidative stress are elevated in the brain, blood, and adrenal glands during the progression of post-traumatic stress disorder in a predator exposure animal model. PLoS One (2013) 1.05

Oxidative stress and neurodegenerative disorders. Int J Mol Sci (2013) 1.04

Level of an advanced glycated end product is genetically determined: a study of normal twins. Diabetes (2003) 1.02

Comparison of immediate-onset and delayed-onset posttraumatic stress disorder in military veterans. J Abnorm Psychol (2009) 1.02

Protein carbonylation as a major hallmark of oxidative damage: update of analytical strategies. Mass Spectrom Rev (2013) 1.01

Depression and oxidative stress: results from a meta-analysis of observational studies. Psychosom Med (2013) 1.01

The relevance of oxidative stress status in first episode and recurrent depression. J Affect Disord (2012) 1.00

The neuroendocrinology of posttraumatic stress disorder: new directions. CNS Spectr (2003) 0.99

Post-traumatic stress symptoms correlate with smaller subgenual cingulate, caudate, and insula volumes in unmedicated combat veterans. Psychiatry Res (2012) 0.98

Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study. PLoS One (2013) 0.98

Effects of trauma-related audiovisual stimulation on cerebrospinal fluid norepinephrine and corticotropin-releasing hormone concentrations in post-traumatic stress disorder. Psychoneuroendocrinology (2008) 0.98