Published in J Cell Biol on November 11, 2002
The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. Nat Rev Mol Cell Biol (2011) 4.24
MT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrix. J Cell Biol (2004) 2.45
MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway. EMBO J (2007) 2.16
MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signaling. Dev Cell (2010) 1.87
Mapping proteolytic cancer cell-extracellular matrix interfaces. Clin Exp Metastasis (2008) 1.83
Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion. Cancer Res (2006) 1.49
An MT1-MMP-PDGF receptor-beta axis regulates mural cell investment of the microvasculature. Genes Dev (2005) 1.47
Caveolae are a novel pathway for membrane-type 1 matrix metalloproteinase traffic in human endothelial cells. Mol Biol Cell (2003) 1.39
β1A integrin is a master regulator of invadosome organization and function. Mol Biol Cell (2010) 1.31
β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation. Mol Biol Cell (2013) 1.29
Adhesion rings surround invadopodia and promote maturation. Biol Open (2012) 1.23
Physico-mechanical aspects of extracellular matrix influences on tumorigenic behaviors. Semin Cancer Biol (2010) 1.21
The chemokine receptor CXCR4 and the metalloproteinase MT1-MMP are mutually required during melanoma metastasis to lungs. Am J Pathol (2009) 1.17
Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency. Mol Biol Cell (2008) 1.15
Interstitial collagen catabolism. J Biol Chem (2013) 1.13
Interplay between β1-integrin and Rho signaling regulates differential scattering and motility of pancreatic cancer cells by snail and Slug proteins. J Biol Chem (2012) 1.12
Phosphorylation of membrane type 1-matrix metalloproteinase (MT1-MMP) and its vesicle-associated membrane protein 7 (VAMP7)-dependent trafficking facilitate cell invasion and migration. J Biol Chem (2011) 1.11
Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis. Mol Biol Cell (2009) 1.09
Integrins as "functional hubs" in the regulation of pathological angiogenesis. Semin Cancer Biol (2009) 1.05
MMP9 cleavage of the β4 integrin ectodomain leads to recurrent epithelial erosions in mice. J Cell Sci (2011) 1.03
Localizing matrix metalloproteinase activities in the pericellular environment. FEBS J (2010) 1.03
MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin. J Cell Sci (2011) 1.02
Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis. Am J Physiol Lung Cell Mol Physiol (2013) 1.02
Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180. J Cell Sci (2009) 1.00
Digging a little deeper: the stages of invadopodium formation and maturation. Eur J Cell Biol (2014) 1.00
Stromal cells and integrins: conforming to the needs of the tumor microenvironment. Neoplasia (2009) 0.95
Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface. J Biol Chem (2007) 0.95
FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex. Proc Natl Acad Sci U S A (2010) 0.94
Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton. Mol Biol Cell (2014) 0.91
Functional interplay between endothelial nitric oxide synthase and membrane type 1 matrix metalloproteinase in migrating endothelial cells. Blood (2007) 0.91
Matrix metalloproteinase-2 cleavage of the β1 integrin ectodomain facilitates colon cancer cell motility. J Biol Chem (2012) 0.90
Rho-ROCK-myosin signaling mediates membrane type 1 matrix metalloproteinase-induced cellular aggregation of keratinocytes. J Biol Chem (2010) 0.90
Adipose tissue-derived stem cell in vitro differentiation in a three-dimensional dental bud structure. Am J Pathol (2011) 0.90
The inactive 44-kDa processed form of membrane type 1 matrix metalloproteinase (MT1-MMP) enhances proteolytic activity via regulation of endocytosis of active MT1-MMP. J Biol Chem (2008) 0.90
Macrophage migration and invasion is regulated by MMP10 expression. PLoS One (2013) 0.89
Vascular regression and survival are differentially regulated by MT1-MMP and TIMPs in the aortic ring model of angiogenesis. Am J Physiol Cell Physiol (2009) 0.87
MT-LOOP-dependent localization of membrane type I matrix metalloproteinase (MT1-MMP) to the cell adhesion complexes promotes cancer cell invasion. J Biol Chem (2013) 0.87
Self-assembled HCV core virus-like particles targeted and inhibited tumor cell migration and invasion. Nanoscale Res Lett (2013) 0.80
Angiopoietin-like protein 2 regulates endothelial colony forming cell vasculogenesis. Angiogenesis (2014) 0.80
Coupling between acto-adhesive machinery and ECM degradation in invadosomes. Cell Adh Migr (2014) 0.79
Chlorotoxin-Fc fusion inhibits release of MMP-2 from pancreatic cancer cells. Biomed Res Int (2014) 0.78
Chlorotoxin Fused to IgG-Fc Inhibits Glioblastoma Cell Motility via Receptor-Mediated Endocytosis. J Drug Deliv (2012) 0.78
Differential subcellular and extracellular localisations of proteins required for insulin-like growth factor- and extracellular matrix-induced signalling events in breast cancer progression. BMC Cancer (2014) 0.78
TIMP-2 Interaction with MT1-MMP Activates the AKT Pathway and Protects Tumor Cells from Apoptosis. PLoS One (2015) 0.78
Integrative computational and experimental approaches to establish a post-myocardial infarction knowledge map. PLoS Comput Biol (2014) 0.77
High threshold of β1 integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase (MT1-MMP) activation of matrix metalloproteinase 2 (MMP-2). Cancer Cell Int (2014) 0.77
Combinative in vitro studies and computational model to predict 3D cell migration response to drug insult. Integr Biol (Camb) (2014) 0.76
Raf kinase inhibitor protein (RKIP) inhibits the cell migration and invasion in human glioma cell lines in vitro. Int J Clin Exp Pathol (2015) 0.76
Three-dimensional collagen matrix induces a mechanosensitive invasive epithelial phenotype. Sci Rep (2017) 0.75
β3 integrin expression is required for invadopodia-mediated ECM degradation in lung carcinoma cells. PLoS One (2017) 0.75
VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix. Exp Cell Res (2017) 0.75
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ECM and cell surface proteolysis: regulating cellular ecology. Cell (1997) 6.00
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Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration. J Cell Biol (2001) 3.32
Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5. J Cell Biol (2000) 2.94
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Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. J Cell Biol (1993) 2.38
Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion. Proc Natl Acad Sci U S A (1997) 2.35
Proteolysis and cell migration: creating a path? Curr Opin Cell Biol (1999) 2.19
MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells. Exp Cell Res (2001) 2.12
Regulation of endothelial cell motility by complexes of tetraspan molecules CD81/TAPA-1 and CD151/PETA-3 with alpha3 beta1 integrin localized at endothelial lateral junctions. J Cell Biol (1998) 2.06
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Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosis. Proc Natl Acad Sci U S A (2001) 1.83
Signaling networks linking integrins and rho family GTPases. Trends Biochem Sci (2000) 1.81
Cytoplasmic tail-dependent internalization of membrane-type 1 matrix metalloproteinase is important for its invasion-promoting activity. J Cell Biol (2001) 1.71
Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion. J Biol Chem (2001) 1.69
ECM remodeling regulates angiogenesis: endothelial integrins look for new ligands. Sci STKE (2002) 1.63
Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodeling. J Biol Chem (2001) 1.62
A novel protease-docking function of integrin at invadopodia. J Biol Chem (1999) 1.58
Egr-1 mediates extracellular matrix-driven transcription of membrane type 1 matrix metalloproteinase in endothelium. J Biol Chem (1999) 1.41
Functional interplay between type I collagen and cell surface matrix metalloproteinase activity. J Biol Chem (2001) 1.40
Rac1 mediates type I collagen-dependent MMP-2 activation. role in cell invasion across collagen barrier. J Biol Chem (2001) 1.37
Regulation of membrane-type-1 matrix metalloproteinase activity by its cytoplasmic domain. J Biol Chem (2000) 1.36
Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase. J Biol Chem (2001) 1.35
Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases. J Biol Chem (2001) 1.32
Oligomerization through hemopexin and cytoplasmic domains regulates the activity and turnover of membrane-type 1 matrix metalloproteinase. J Biol Chem (2002) 1.30
Transferrin and transferrin receptor function in brain barrier systems. Cell Mol Neurobiol (2000) 1.29
MMP-2 colocalizes with caveolae on the surface of endothelial cells. Exp Cell Res (2001) 1.28
An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase. J Biol Chem (2001) 1.24
Tetraspanins are localized at motility-related structures and involved in normal human keratinocyte wound healing migration. J Invest Dermatol (2000) 1.19
Endothelial adhesion molecules in the development of the vascular tree: the garden of forking paths. Curr Opin Cell Biol (1999) 1.11
Effects of collagenase-cleavage of type I collagen on alpha2beta1 integrin-mediated cell adhesion. J Cell Sci (1998) 1.08
Expression of integrin alpha(v)beta(3) correlates with activation of membrane-type matrix metalloproteinase-1 (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) in human melanoma cells in vitro and in vivo. Int J Cancer (2000) 1.08
Adhesion-dependent control of matrix metalloproteinase-2 activation in human capillary endothelial cells. J Cell Sci (2000) 1.02
Cell surface molecular changes on the activation of human thymocytes. J Immunol (1985) 0.92
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat Commun (2011) 5.95
Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells. N Engl J Med (2003) 5.01
Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biol (2012) 3.18
Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Cell (2002) 2.94
CD69 is an immunoregulatory molecule induced following activation. Trends Immunol (2005) 2.83
Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes. Trends Cell Biol (2009) 2.82
HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions. Trends Cell Biol (2008) 2.71
Intercellular communication: diverse structures for exchange of genetic information. Nat Rev Mol Cell Biol (2012) 2.28
MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway. EMBO J (2007) 2.16
Role of the cytoskeleton during leukocyte responses. Nat Rev Immunol (2004) 2.11
MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signaling. Dev Cell (2010) 1.87
HDAC6 deacetylase activity links the tubulin cytoskeleton with immune synapse organization. Immunity (2004) 1.82
Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms. J Cell Biol (2008) 1.75
MTOC translocation modulates IS formation and controls sustained T cell signaling. J Cell Biol (2008) 1.75
ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. Immunity (2002) 1.73
In vivo modulation of the inflammatory response by nonsteroidal antiinflammatory drug-related compounds that trigger L-selectin shedding. Eur J Immunol (2012) 1.63
Angiogenesis in chronic inflammatory liver disease. Hepatology (2004) 1.57
Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation. Blood (2004) 1.56
The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression. J Clin Invest (2002) 1.55
EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. J Biol Chem (2006) 1.50
Tetraspanins CD9 and CD81 modulate HIV-1-induced membrane fusion. J Immunol (2006) 1.48
Increased circulating pro-inflammatory cytokines and Th17 lymphocytes in Hashimoto's thyroiditis. J Clin Endocrinol Metab (2009) 1.45
The metalloprotease ADAM8 is associated with and regulates the function of the adhesion receptor PSGL-1 through ERM proteins. Eur J Immunol (2011) 1.45
Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation. Dev Biol (2005) 1.42
Specific targeting of human inflamed endothelium and in situ vascular tissue transfection by the use of ultrasound contrast agents. JACC Cardiovasc Imaging (2009) 1.42
CD69 downregulates autoimmune reactivity through active transforming growth factor-beta production in collagen-induced arthritis. J Clin Invest (2003) 1.41
Cutting edge: dynamic redistribution of tetraspanin CD81 at the central zone of the immune synapse in both T lymphocytes and APC. J Immunol (2002) 1.41
Membrane type 1-matrix metalloproteinase is involved in migration of human monocytes and is regulated through their interaction with fibronectin or endothelium. Blood (2005) 1.40
Caveolae are a novel pathway for membrane-type 1 matrix metalloproteinase traffic in human endothelial cells. Mol Biol Cell (2003) 1.39
Stromal cell-derived factor-1alpha promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities. Cancer Res (2004) 1.38
Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection. Mol Biol Cell (2005) 1.37
Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes. J Cell Sci (2008) 1.35
VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses. Proc Natl Acad Sci U S A (2004) 1.31
Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity. Mol Biol Cell (2006) 1.29
Enhanced antitumor immunity in mice deficient in CD69. J Exp Med (2003) 1.29
Role of the von Hippel-Lindau tumor suppressor gene in the formation of beta1-integrin fibrillar adhesions. Cancer Res (2002) 1.27
Relevance of CD6-mediated interactions in T cell activation and proliferation. J Immunol (2004) 1.27
Functional insights on the polarized redistribution of leukocyte integrins and their ligands during leukocyte migration and immune interactions. Immunol Rev (2007) 1.26
CD69: an unexpected regulator of TH17 cell-driven inflammatory responses. Sci Signal (2011) 1.26
Transfer of extracellular vesicles during immune cell-cell interactions. Immunol Rev (2013) 1.25
Regulation of microtubule-organizing center orientation and actomyosin cytoskeleton rearrangement during immune interactions. Immunol Rev (2002) 1.25
Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR. J Immunol (2006) 1.20
Myosin IIA is involved in the endocytosis of CXCR4 induced by SDF-1alpha. J Cell Sci (2007) 1.20
The mitochondrial fission factor dynamin-related protein 1 modulates T-cell receptor signalling at the immune synapse. EMBO J (2011) 1.19
Molecular cues guiding inflammatory responses. Cardiovasc Res (2010) 1.19
A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting. J Biol Chem (2002) 1.17
The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells. Sci Signal (2012) 1.17
CD69 association with Jak3/Stat5 proteins regulates Th17 cell differentiation. Mol Cell Biol (2010) 1.17
MT1-MMP: universal or particular player in angiogenesis? Cancer Metastasis Rev (2006) 1.15
A juxta-membrane amino acid sequence of P-selectin glycoprotein ligand-1 is involved in moesin binding and ezrin/radixin/moesin-directed targeting at the trailing edge of migrating lymphocytes. Eur J Immunol (2002) 1.14
Regulatory T cells in human autoimmune thyroid disease. J Clin Endocrinol Metab (2006) 1.14
G protein-coupled receptor kinase 2 positively regulates epithelial cell migration. EMBO J (2008) 1.14
Endothelial nitric oxide synthase regulates T cell receptor signaling at the immunological synapse. Immunity (2006) 1.13
Role of ICAM-3 in the initial interaction of T lymphocytes and APCs. Nat Immunol (2002) 1.13
Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression. Proc Natl Acad Sci U S A (2010) 1.13
Recruitment of transferrin receptor to immunological synapse in response to TCR engagement. J Immunol (2004) 1.12
Complex pattern of membrane type 1 matrix metalloproteinase shedding. Regulation by autocatalytic cells surface inactivation of active enzyme. J Biol Chem (2002) 1.12
Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding. J Immunol (2007) 1.11
The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. J Biol Chem (2013) 1.10
Synaptic clusters of MHC class II molecules induced on DCs by adhesion molecule-mediated initial T-cell scanning. Mol Biol Cell (2005) 1.10
CD69 limits the severity of cardiomyopathy after autoimmune myocarditis. Circulation (2010) 1.09
The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells. J Biol Chem (2002) 1.09
Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor. J Immunol (2009) 1.07
Membrane type 1-matrix metalloproteinase is regulated by chemokines monocyte-chemoattractant protein-1/ccl2 and interleukin-8/CXCL8 in endothelial cells during angiogenesis. J Biol Chem (2004) 1.07
Role of tetraspanins CD9 and CD151 in primary melanocyte motility. J Invest Dermatol (2005) 1.07
Is CD69 an effective brake to control inflammatory diseases? Trends Mol Med (2013) 1.06
Selective inactivation of p27(Kip1) in hematopoietic progenitor cells increases neointimal macrophage proliferation and accelerates atherosclerosis. Blood (2003) 1.06
Molecular basis of leukocyte-endothelium interactions during the inflammatory response. Rev Esp Cardiol (2009) 1.05
PGE2 induces angiogenesis via MT1-MMP-mediated activation of the TGFbeta/Alk5 signaling pathway. Blood (2008) 1.05
A role for the Rho-p160 Rho coiled-coil kinase axis in the chemokine stromal cell-derived factor-1alpha-induced lymphocyte actomyosin and microtubular organization and chemotaxis. J Immunol (2002) 1.05
MT1-MMP collagenolytic activity is regulated through association with tetraspanin CD151 in primary endothelial cells. Blood (2008) 1.05
HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5. Mol Cell (2012) 1.05
Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes. J Immunol (2002) 1.05
Rapamycin attenuates atherosclerosis induced by dietary cholesterol in apolipoprotein-deficient mice through a p27 Kip1 -independent pathway. Atherosclerosis (2004) 1.05
Lipopolysaccharide and sphingosine-1-phosphate cooperate to induce inflammatory molecules and leukocyte adhesion in endothelial cells. J Immunol (2012) 1.05
Lipid rafts mediate biosynthetic transport to the T lymphocyte uropod subdomain and are necessary for uropod integrity and function. Blood (2002) 1.05
Functional role of P-selectin glycoprotein ligand 1/P-selectin interaction in the generation of tolerogenic dendritic cells. J Immunol (2007) 1.04
Miro-1 links mitochondria and microtubule Dynein motors to control lymphocyte migration and polarity. Mol Cell Biol (2014) 1.04
Signaling through the leukocyte integrin LFA-1 in T cells induces a transient activation of Rac-1 that is regulated by Vav and PI3K/Akt-1. J Biol Chem (2004) 1.04
Ligand-induced conformational change in the T-cell receptor associated with productive immune synapses. Blood (2005) 1.04
End-binding protein 1 controls signal propagation from the T cell receptor. EMBO J (2012) 1.04