Published in Science on November 15, 2002
Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis. Microbiol Mol Biol Rev (2003) 2.90
Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer (2010) 2.68
IL-6 as a keystone cytokine in health and disease. Nat Immunol (2015) 2.14
Kaposi's sarcoma-associated herpesvirus immunoevasion and tumorigenesis: two sides of the same coin? Annu Rev Microbiol (2003) 2.07
The epigenetic landscape of latent Kaposi sarcoma-associated herpesvirus genomes. PLoS Pathog (2010) 1.97
Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling. Blood (2006) 1.83
Pivotal advance: Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded microRNA specifically induce IL-6 and IL-10 secretion by macrophages and monocytes. J Leukoc Biol (2010) 1.77
An interleukin-6-related systemic inflammatory syndrome in patients co-infected with Kaposi sarcoma-associated herpesvirus and HIV but without Multicentric Castleman disease. Clin Infect Dis (2010) 1.70
Interleukin-6 and its receptor: from bench to bedside. Med Microbiol Immunol (2006) 1.65
Regulation of CD1d expression and function by a herpesvirus infection. J Clin Invest (2005) 1.64
Molecular biology of KSHV in relation to AIDS-associated oncogenesis. Cancer Treat Res (2007) 1.47
Array-based transcript profiling and limiting-dilution reverse transcription-PCR analysis identify additional latent genes in Kaposi's sarcoma-associated herpesvirus. J Virol (2010) 1.42
Genetic disruption of KSHV major latent nuclear antigen LANA enhances viral lytic transcriptional program. Virology (2008) 1.41
Highly selective escape from KSHV-mediated host mRNA shutoff and its implications for viral pathogenesis. J Exp Med (2004) 1.36
Alpha/beta interferons regulate murine gammaherpesvirus latent gene expression and reactivation from latency. J Virol (2005) 1.35
Kaposi's sarcoma-associated herpesvirus K-bZIP represses gene transcription via SUMO modification. J Virol (2005) 1.26
Clinical Manifestations of Kaposi Sarcoma Herpesvirus Lytic Activation: Multicentric Castleman Disease (KSHV-MCD) and the KSHV Inflammatory Cytokine Syndrome. Front Microbiol (2012) 1.25
Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression. J Virol (2011) 1.25
ORF18 is a transfactor that is essential for late gene transcription of a gammaherpesvirus. J Virol (2006) 1.24
Immune defence, parasite evasion strategies and their relevance for 'macroscopic phenomena' such as virulence. Philos Trans R Soc Lond B Biol Sci (2009) 1.20
Dissection of the Kaposi's sarcoma-associated herpesvirus gene expression program by using the viral DNA replication inhibitor cidofovir. J Virol (2004) 1.19
Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest. J Virol (2003) 1.16
Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor. J Virol (2009) 1.14
K13 blocks KSHV lytic replication and deregulates vIL6 and hIL6 expression: a model of lytic replication induced clonal selection in viral oncogenesis. PLoS One (2007) 1.11
Genetic organization and hypoxic activation of the Kaposi's sarcoma-associated herpesvirus ORF34-37 gene cluster. J Virol (2006) 1.11
Intracellular signaling mechanisms and activities of human herpesvirus 8 interleukin-6. J Virol (2008) 1.10
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis. Adv Virus Res (2010) 1.09
Kaposi's sarcoma-associated herpesviral IL-6 and human IL-6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation. J Pathol (2011) 1.08
Antagonism of host antiviral responses by Kaposi's sarcoma-associated herpesvirus tegument protein ORF45. PLoS One (2010) 1.07
HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3β signaling pathway. PLoS One (2013) 1.05
KSHV Rta Promoter Specification and Viral Reactivation. Front Microbiol (2012) 1.04
Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 replication and transcription activator regulates viral and cellular genes via interferon-stimulated response elements. J Virol (2005) 1.02
Murine gammaherpesvirus 68 has evolved gamma interferon and stat1-repressible promoters for the lytic switch gene 50. J Virol (2010) 1.01
Transcriptional analysis of latent and inducible Kaposi's sarcoma-associated herpesvirus transcripts in the K4 to K7 region. J Virol (2005) 1.00
KSHV: pathways to tumorigenesis and persistent infection. Adv Virus Res (2014) 0.99
Chemotherapeutic resistance: surviving stressful situations. Cancer Res (2011) 0.99
Subversion of cytokine networks by virally encoded decoy receptors. Immunol Rev (2012) 0.98
Intracellular Kaposi's sarcoma-associated herpesvirus load determines early loss of immune synapse components. J Virol (2007) 0.97
Treatment of Kaposi sarcoma-associated herpesvirus-associated cancers. Front Microbiol (2012) 0.97
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies. Front Microbiol (2012) 0.97
Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus. J Virol (2004) 0.96
Immune evasion by Kaposi's sarcoma-associated herpesvirus. Future Microbiol (2010) 0.96
Structural requirements for gp80 independence of human herpesvirus 8 interleukin-6 (vIL-6) and evidence for gp80 stabilization of gp130 signaling complexes induced by vIL-6. J Virol (2006) 0.95
A gammaherpesvirus cooperates with interferon-alpha/beta-induced IRF2 to halt viral replication, control reactivation, and minimize host lethality. PLoS Pathog (2011) 0.93
The KSHV viral interleukin-6 is not essential for latency or lytic replication in BJAB cells. Virology (2006) 0.92
An alternative Kaposi's sarcoma-associated herpesvirus replication program triggered by host cell apoptosis. J Virol (2012) 0.92
An important role for mitochondrial antiviral signaling protein in the Kaposi's sarcoma-associated herpesvirus life cycle. J Virol (2014) 0.90
Restricted Kaposi's sarcoma (KS) herpesvirus transcription in KS lesions from patients on successful antiretroviral therapy. MBio (2011) 0.89
The open chromatin landscape of Kaposi's sarcoma-associated herpesvirus. J Virol (2013) 0.87
The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation. Virology (2012) 0.86
Plasmablastic lymphoma in the ano-rectal junction presenting in an immunocompetent man: a case report. J Med Case Rep (2011) 0.86
N-linked glycosylation is required for optimal function of Kaposi's sarcoma herpesvirus-encoded, but not cellular, interleukin 6. J Exp Med (2004) 0.86
Blockade of viral interleukin-6 expression of Kaposi's sarcoma-associated herpesvirus. Mol Cancer Ther (2008) 0.85
A purine scaffold HSP90 inhibitor BIIB021 has selective activity against KSHV-associated primary effusion lymphoma and blocks vFLIP K13-induced NF-κB. Clin Cancer Res (2013) 0.85
Kaposi's sarcoma-associated herpesvirus and innate immunity. Future Virol (2010) 0.85
The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells. PLoS Pathog (2013) 0.84
Comparative pathobiology of Kaposi sarcoma-associated herpesvirus and related primate rhadinoviruses. Comp Med (2008) 0.84
KSHV Induction of Angiogenic and Lymphangiogenic Phenotypes. Front Microbiol (2012) 0.83
Cytokine homologs of human gammaherpesviruses. J Interferon Cytokine Res (2011) 0.83
Kaposi sarcoma-associated herpesvirus: immunobiology, oncogenesis, and therapy. J Clin Invest (2016) 0.82
KSHV ORF57, a protein of many faces. Viruses (2015) 0.82
A candidate gene approach for virally induced cancer with application to HIV-related Kaposi's sarcoma. Int J Cancer (2013) 0.81
Interplay between Kaposi's sarcoma-associated herpesvirus and the innate immune system. Cytokine Growth Factor Rev (2014) 0.80
Pathology of Kaposi's Sarcoma-Associated Herpesvirus Infection. Front Microbiol (2011) 0.79
Kaposi Sarcoma Pathogenesis: A Triad of Viral Infection, Oncogenesis and Chronic Inflammation. Transl Biomed (2010) 0.79
Prevalence of human herpesvirus 8 infection in systemic lupus erythematosus. Virol J (2011) 0.79
Regulation of growth signalling and cell cycle by Kaposi's sarcoma-associated herpesvirus genes. Int J Exp Pathol (2004) 0.79
Complex N-linked glycans on Asn-89 of Kaposi sarcoma herpes virus-encoded interleukin-6 mediate optimal function by affecting cytokine protein conformation. J Biol Chem (2009) 0.79
What lies within: coinfections and immunity. Cell Host Microbe (2014) 0.78
Diverse mechanisms evolved by DNA viruses to inhibit early host defenses. Crit Rev Biochem Mol Biol (2016) 0.78
Human herpesvirus 8-encoded cytokines. Future Virol (2010) 0.77
Expression level of IL-6 secreted by bone marrow stromal cells in mice with aplastic anemia. ISRN Hematol (2013) 0.77
Induction of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interleukin-6 by X-Box Binding Protein 1. J Virol (2015) 0.76
Kaposi sarcoma herpesvirus pathogenesis. Philos Trans R Soc Lond B Biol Sci (2017) 0.76
Selection on Network Dynamics Drives Differential Rates of Protein Domain Evolution. PLoS Genet (2016) 0.75
Angiogenesis, Kaposi's Sarcoma and Kaposi's Sarcoma-Associated Herpesvirus. Virol Sin (2008) 0.75
Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science (2008) 16.60
T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci U S A (2008) 4.74
Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium. Lancet Oncol (2006) 4.13
Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens. J Virol (2010) 2.88
Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int J Cancer (2009) 2.78
Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. Int J Cancer (2009) 2.77
Human transcriptome subtraction by using short sequence tags to search for tumor viruses in conjunctival carcinoma. J Virol (2007) 2.68
Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer (2010) 2.68
Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator. J Clin Invest (2011) 2.37
Quantitation of human seroresponsiveness to Merkel cell polyomavirus. PLoS Pathog (2009) 2.08
Kaposi's sarcoma-associated herpesvirus immunoevasion and tumorigenesis: two sides of the same coin? Annu Rev Microbiol (2003) 2.07
Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis. J Rheumatol (2007) 1.87
A sensitive non-radioactive northern blot method to detect small RNAs. Nucleic Acids Res (2010) 1.81
Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas. Am J Surg Pathol (2009) 1.79
A third genotype of the human parvovirus PARV4 in sub-Saharan Africa. J Gen Virol (2008) 1.74
Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs. Nucleic Acids Res (2012) 1.66
Survivin is a therapeutic target in Merkel cell carcinoma. Sci Transl Med (2012) 1.61
The minimum replication origin of merkel cell polyomavirus has a unique large T-antigen loading architecture and requires small T-antigen expression for optimal replication. J Virol (2009) 1.52
Human parvovirus 4 in the bone marrow of Italian patients with AIDS. AIDS (2007) 1.48
Merkel cell carcinoma: a virus-induced human cancer. Annu Rev Pathol (2011) 1.46
Merkel cell carcinoma: incidence, mortality, and risk of other cancers. J Natl Cancer Inst (2010) 1.43
Update on human polyomaviruses and cancer. Adv Cancer Res (2010) 1.40
Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7. Cell Host Microbe (2013) 1.27
Microsatellite instability in gastric cancer is associated with better prognosis in only stage II cancers. Surgery (2006) 1.25
Characterization of viral and human RNAs smaller than canonical MicroRNAs. J Virol (2009) 1.23
Cellular and viral factors regulating Merkel cell polyomavirus replication. PLoS One (2011) 1.21
Use of a multiantigen detection algorithm for diagnosis of Kaposi's sarcoma-associated herpesvirus infection. J Clin Microbiol (2006) 1.21
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts preferentially with the terminal repeats of the genome in vivo and this complex is sufficient for episomal DNA replication. J Gen Virol (2003) 1.17
Multicolor microRNA FISH effectively differentiates tumor types. J Clin Invest (2013) 1.16
MCV and Merkel cell carcinoma: a molecular success story. Curr Opin Virol (2012) 1.14
Chromosomal alterations detected by comparative genomic hybridization in nonfunctioning endocrine pancreatic tumors. Cancer Genet Cytogenet (2005) 1.14
Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation. Virchows Arch (2006) 1.09
Coupled transcriptome and proteome analysis of human lymphotropic tumor viruses: insights on the detection and discovery of viral genes. BMC Genomics (2011) 1.09
Trichostatin A, an inhibitor of histone deacetylases, strongly suppresses growth of pancreatic adenocarcinoma cells. Mol Carcinog (2003) 1.07
Merkel cell polyomavirus status is not associated with clinical course of Merkel cell carcinoma. J Invest Dermatol (2011) 1.06
Infection with Brugia microfilariae induces apoptosis of CD4(+) T lymphocytes: a mechanism of immune unresponsiveness in filariasis. Eur J Immunol (2002) 1.05
Mutations of NFKBIA, encoding IkappaB alpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases. Int J Cancer (2009) 1.05
Lack of evidence for basal or squamous cell carcinoma infection with Merkel cell polyomavirus in immunocompetent patients with Merkel cell carcinoma. J Am Acad Dermatol (2010) 1.03
SEL1L expression in pancreatic adenocarcinoma parallels SMAD4 expression and delays tumor growth in vitro and in vivo. Oncogene (2003) 1.01
Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus. J Biol Chem (2011) 1.01
Transcriptional analysis of latent and inducible Kaposi's sarcoma-associated herpesvirus transcripts in the K4 to K7 region. J Virol (2005) 1.00
Asymptomatic primary Merkel cell polyomavirus infection among adults. Emerg Infect Dis (2011) 0.99
Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas. Haematologica (2004) 0.99
Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice. J Virol Methods (2012) 0.96
Activation of JNK signaling mediates connective tissue growth factor expression and scar formation in corneal wound healing. PLoS One (2012) 0.94
The T antigen locus of Merkel cell polyomavirus downregulates human Toll-like receptor 9 expression. J Virol (2013) 0.94
Asymmetric assembly of Merkel cell polyomavirus large T-antigen origin binding domains at the viral origin. J Mol Biol (2011) 0.92
The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation. Virology (2011) 0.92
An enduring association? Microfilariae and immunosuppression [correction of immunosupression] in lymphatic filariasis. Trends Parasitol (2003) 0.89
KSHV: forgotten but not gone. Blood (2011) 0.89
Liver-related factors associated with low vitamin D levels in HIV and HIV/HCV coinfected patients and comparison to general population. Curr HIV Res (2011) 0.88
The role of connective tissue growth factor, transforming growth factor beta1 and Smad signaling pathway in cornea wound healing. Chin Med J (Engl) (2006) 0.87
Kaposi sarcoma-associated herpesvirus and primary and secondary pulmonary hypertension. Chest (2005) 0.86
Is real-time polymerase chain reaction (PCR) more useful than a conventional PCR for the clinical management of leishmaniasis? Am J Trop Med Hyg (2009) 0.86
Low Expression of Mucin-4 Predicts Poor Prognosis in Patients With Clear-Cell Renal Cell Carcinoma. Medicine (Baltimore) (2016) 0.85
Role of IRF4 in IFN-stimulated gene induction and maintenance of Kaposi sarcoma-associated herpesvirus latency in primary effusion lymphoma cells. J Immunol (2013) 0.84
Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells. Blood (2005) 0.84
Interleukin-1B (IL1B) and interleukin-6 (IL6) gene polymorphisms are associated with risk of chronic lymphocytic leukaemia. Hematol Oncol (2008) 0.84
Mucinous cystic carcinoma of the pancreas: a unique cell line and xenograft model of a preinvasive lesion. Virchows Arch (2005) 0.84
Induction of CCL20 production by Kaposi sarcoma-associated herpesvirus: role of viral FLICE inhibitory protein K13-induced NF-kappaB activation. Blood (2009) 0.84
Response of Merkel cell polyomavirus-positive merkel cell carcinoma xenografts to a survivin inhibitor. PLoS One (2013) 0.83
A novel cell line and xenograft model of ampulla of Vater adenocarcinoma. Virchows Arch (2003) 0.83
Lack of evidence for direct involvement of Merkel cell polyomavirus (MCV) in chronic lymphocytic leukemia (CLL). Blood (2010) 0.82
Durable remission of HIV-negative, Kaposi's sarcoma herpes virus-associated multicentric Castleman disease in patient with rheumatoid arthritis treated with methotrexate. Clin Rheumatol (2006) 0.81
Dpc4 is expressed in virtually all primary and metastatic pancreatic endocrine carcinomas. Virchows Arch (2002) 0.81