Published in Biol Chem on November 19, 2002
Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev (2006) 2.74
Hepatocyte death: a clear and present danger. Physiol Rev (2010) 2.18
Lysosomes as "suicide bags" in cell death: myth or reality? J Biol Chem (2009) 1.65
Lysosomes in iron metabolism, ageing and apoptosis. Histochem Cell Biol (2008) 1.60
S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3. Cell Res (2009) 1.42
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A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases. Cell Death Dis (2010) 1.23
Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis. Front Biosci (2008) 1.20
Increased activity and altered subcellular distribution of lysosomal enzymes determine neuronal vulnerability in Niemann-Pick type C1-deficient mice. Am J Pathol (2009) 1.12
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Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors. J Clin Invest (2012) 1.04
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Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release. Cell Death Dis (2013) 0.92
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Evaluation of an orthogonal pooling strategy for rapid high-throughput screening of proteases. Assay Drug Dev Technol (2008) 0.88
Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells. J Lipid Res (2012) 0.87
Proteomic analysis of enriched lysosomes at early phase of camptothecin-induced apoptosis in human U-937 cells. J Proteomics (2009) 0.86
Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe. Chem Biol (2009) 0.86
The endolysosomal system in cell death and survival. Cold Spring Harb Perspect Biol (2013) 0.85
Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose. PLoS One (2015) 0.83
Monitoring caspase activity in living cells using fluorescent proteins and flow cytometry. Am J Pathol (2004) 0.82
Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft. Biochem J (2004) 0.81
Expression of Cystatin SN significantly correlates with recurrence, metastasis, and survival duration in surgically resected non-small cell lung cancer patients. Sci Rep (2015) 0.80
Low-density lipoprotein receptor-related protein 1 mediates α1-antitrypsin internalization in CD4+ T lymphocytes. J Leukoc Biol (2015) 0.79
Lysosomal-mitochondrial axis in zoledronic acid-induced apoptosis in human follicular lymphoma cells. J Biol Chem (2009) 0.79
The feasibility of enzyme targeted activation for amino acid/dipeptide monoester prodrugs of floxuridine; cathepsin D as a potential targeted enzyme. Molecules (2012) 0.78
Up-regulation of cation-independent mannose 6-phosphate receptor and endosomal-lysosomal markers in surviving neurons after 192-IgG-saporin administrations into the adult rat brain. Am J Pathol (2006) 0.78
Differential sialotranscriptomes of unfed and fed Rhipicephalus haemaphysaloides, with particular regard to differentially expressed genes of cysteine proteases. Parasit Vectors (2015) 0.78
Cathepsin-B and cathepsin-L expression levels do not correlate with sensitivity of tumour cells to TNF-alpha-mediated apoptosis. Br J Cancer (2003) 0.78
Sorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt/PTEN pathway. The Akt inhibitor, perifosine, enhances the sorafenib-induced cytotoxicity against bladder cancer cells. Oncoscience (2015) 0.77
Dependence of cathepsin L-induced coronary endothelial dysfunction upon activation of NAD(P)H oxidase. Microvasc Res (2009) 0.77
Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents. Cell Cycle (2015) 0.77
Crystallization and preliminary crystallographic studies of a cysteine protease inhibitor from the human nematode parasite Ascaris lumbricoides. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.77
Gallic acid as a selective anticancer agent that induces apoptosis in SMMC-7721 human hepatocellular carcinoma cells. Oncol Lett (2015) 0.77
Niemann-Pick type C2 deficiency impairs autophagy-lysosomal activity, mitochondrial function, and TLR signaling in adipocytes. J Lipid Res (2016) 0.76
Neuronal synaptobrevin promotes longevity in Drosophila photoreceptors. Commun Integr Biol (2012) 0.75
Protein kinase C-δ isoform mediates lysosome labilization in DNA damage-induced apoptosis. Int J Oncol (2010) 0.75
Investigation into the distinct subcellular effects of docosahexaenoic acid loaded low-density lipoprotein nanoparticles in normal and malignant murine liver cells. Biochim Biophys Acta (2016) 0.75
Cathepsin B as a potential cystatin M/E target in the mouse hair follicle. FASEB J (2017) 0.75
Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway. J Biol Chem (2002) 2.37
Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. J Biol Chem (2003) 2.30
Emerging roles of cysteine cathepsins in disease and their potential as drug targets. Curr Pharm Des (2007) 2.26
Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues. J Biol Chem (2008) 1.85
Lysosomes as "suicide bags" in cell death: myth or reality? J Biol Chem (2009) 1.65
Lysosomes and lysosomal cathepsins in cell death. Biochim Biophys Acta (2011) 1.61
Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. Nat Nanotechnol (2011) 1.41
Autophagy is involved in nutritional stress response and differentiation in Trypanosoma cruzi. J Biol Chem (2007) 1.31
Lysosomal cysteine cathepsins: signaling pathways in apoptosis. Biol Chem (2007) 1.29
Protease signalling: the cutting edge. EMBO J (2012) 1.24
Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro. Exp Cell Res (2003) 1.20
Interaction between human cathepsins K, L, and S and elastins: mechanism of elastinolysis and inhibition by macromolecular inhibitors. J Biol Chem (2007) 1.14
Lysosomes in apoptosis. Methods Enzymol (2008) 1.13
Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis. Biol Chem (2010) 1.13
Metacaspases of Trypanosoma cruzi: possible candidates for programmed cell death mediators. Mol Biochem Parasitol (2005) 1.10
Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes. PLoS Pathog (2010) 1.07
Glycosaminoglycans facilitate procathepsin B activation through disruption of propeptide-mature enzyme interactions. J Biol Chem (2007) 1.04
Intracellular proteolytic activity of cathepsin B is associated with capillary-like tube formation by endothelial cells in vitro. J Cell Biochem (2006) 1.04
Autocatalytic processing of procathepsin B is triggered by proenzyme activity. FEBS J (2009) 1.02
Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues. Exp Cell Res (2005) 1.02
Lysosomal cysteine proteases: structural features and their role in apoptosis. IUBMB Life (2005) 1.01
Recombinant human procathepsin S is capable of autocatalytic processing at neutral pH in the presence of glycosaminoglycans. FEBS Lett (2005) 1.00
Diversity and evolution of the thyroglobulin type-1 domain superfamily. Mol Biol Evol (2005) 0.98
The novel bovine serpin endopin 2C demonstrates selective inhibition of the cysteine protease cathepsin L compared to the serine protease elastase, in cross-class inhibition. Biochemistry (2005) 0.98
Selective activity-based probes for cysteine cathepsins. Angew Chem Int Ed Engl (2008) 0.94
Inhibitory properties of cystatin F and its localization in U937 promonocyte cells. FEBS J (2005) 0.93
Interaction of human stefin B in the prefibrillar oligomeric form with membranes. Correlation with cellular toxicity. FEBS J (2005) 0.93
Phylogenomic analysis of the cystatin superfamily in eukaryotes and prokaryotes. BMC Evol Biol (2009) 0.93
In vitro study of stability and amyloid-fibril formation of two mutants of human stefin B (cystatin B) occurring in patients with EPM1. Protein Sci (2005) 0.91
Human stefin B readily forms amyloid fibrils in vitro. Biochim Biophys Acta (2002) 0.91
Recombinant human cathepsin H lacking the mini chain is an endopeptidase. Biochemistry (2003) 0.89
Mechanisms of amyloid fibril formation--focus on domain-swapping. FEBS J (2011) 0.89
The mechanism of amyloid-fibril formation by stefin B: temperature and protein concentration dependence of the rates. Proteins (2009) 0.87
Recombinant human SMOCs produced by in vitro refolding: calcium-binding properties and interactions with serum proteins. Protein Expr Purif (2008) 0.87
Cleavage of MAGI-1, a tight junction PDZ protein, by caspases is an important step for cell-cell detachment in apoptosis. Apoptosis (2007) 0.86
Exclusion of the native alpha-helix from the amyloid fibrils of a mixed alpha/beta protein. J Mol Biol (2007) 0.86
Interaction with model membranes and pore formation by human stefin B: studying the native and prefibrillar states. FEBS J (2008) 0.86
Interaction between oligomers of stefin B and amyloid-beta in vitro and in cells. J Biol Chem (2009) 0.85
Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology (2010) 0.85
Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis. Biol Chem (2007) 0.85
Size and morphology of toxic oligomers of amyloidogenic proteins: a case study of human stefin B. Amyloid (2008) 0.85
Blocking autophagy to prevent parasite differentiation: a possible new strategy for fighting parasitic infections? Autophagy (2008) 0.85
Structural characterization of thyroglobulin type-1 domains of equistatin. FEBS Lett (2003) 0.84
Differential regulation of the intrinsic pathway of apoptosis in brain and liver during ageing. FEBS Lett (2006) 0.84
Sensitization of stefin B-deficient thymocytes towards staurosporin-induced apoptosis is independent of cysteine cathepsins. FEBS Lett (2005) 0.84
Increased expression of stefin B in the nucleus of T98G astrocytoma cells delays caspase activation. Front Mol Neurosci (2012) 0.84
Differentiation- and maturation-dependent content, localization, and secretion of cystatin C in human dendritic cells. J Leukoc Biol (2005) 0.84
Intracellular aggregation of human stefin B: confocal and electron microscopy study. Biol Cell (2010) 0.83
Novel aspartyl proteinase associated to fat body histolysis during Ceratitis capitata early metamorphosis. Arch Insect Biochem Physiol (2004) 0.82
Papain-like lysosomal cysteine proteases and their inhibitors: drug discovery targets? Biochem Soc Symp (2003) 0.81
hDLG/SAP97, a member of the MAGUK protein family, is a novel caspase target during cell-cell detachment in apoptosis. Biol Chem (2005) 0.81
Amyloid fibril formation by human stefin B in vitro: immunogold labelling and comparison to stefin A. Biol Chem (2002) 0.80
Protein aggregation as a possible cause for pathology in a subset of familial Unverricht-Lundborg disease. Med Hypotheses (2005) 0.80
Inhibitory p41 isoform of invariant chain and its potential target enzymes cathepsins L and H in distinct populations of macrophages in human lymph nodes. Immunology (2004) 0.80
Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery. Biol Chem (2009) 0.80
Human brain cathepsin H as a neuropeptide and bradykinin metabolizing enzyme. Peptides (2003) 0.79
Cysteine cathepsins are not involved in Fas/CD95 signalling in primary skin fibroblasts. FEBS Lett (2007) 0.79
Developmental shift in the apostat: comparison of neurones and astrocytes. FEBS Lett (2005) 0.79
Mouse stefins A1 and A2 (Stfa1 and Stfa2) differentiate between papain-like endo- and exopeptidases. FEBS Lett (2006) 0.79
Dual concentration-dependent activity of thyroglobulin type-1 domain of testican: specific inhibitor and substrate of cathepsin L. Biol Chem (2005) 0.79
The proinflammatory cytokines interleukin-1α and tumor necrosis factor α promote the expression and secretion of proteolytically active cathepsin S from human chondrocytes. Biol Chem (2013) 0.79
Cysteine cathepsins are not critical for TRAIL- and CD95-induced apoptosis in several human cancer cell lines. Biol Chem (2012) 0.78
N-terminally truncated forms of human cathepsin F accumulate in aggresome-like inclusions. Biochim Biophys Acta (2013) 0.77
Individual recombinant thyroglobulin type-1 domains are substrates for lysosomal cysteine proteinases. Biol Chem (2002) 0.77
Cathepsin C and plasma glutamate carboxypeptidase secreted from Fischer rat thyroid cells liberate thyroxin from the N-terminus of thyroglobulin. Biochimie (2011) 0.77
The Expression of Lysosomal Proteinases and Their Inhibitors in Breast Cancer: Possible Relationship to Prognosis of the Disease. Pathol Oncol Res (1997) 0.77
Modulation of contact order effects in the two-state folding of stefins A and B. Biophys J (2011) 0.77
A novel caspase-7 specific monoclonal antibody. Immunol Lett (2005) 0.77
Resistance of cathepsin L compared to elastase to proteolysis when complexed with the serpin endopin 2C, and recovery of cathepsin L activity. Biochem Biophys Res Commun (2006) 0.77
Human cathepsin F: expression in baculovirus system, characterization and inhibition by protein inhibitors. Biol Chem (2004) 0.76
Do lysosomes induce cell death? IUBMB Life (2006) 0.76
Conformational changes preceding amyloid-fibril formation of amyloid-beta and stefin B; parallels in pH dependence. Curr Med Chem (2002) 0.76
Special issue: Proteolysis 50 years after the discovery of lysosome in honor of Christian de Duve. Biochim Biophys Acta (2012) 0.75
Cysteine cathepsins are not critical for TNF-alpha-induced cell death in T98G and U937 cells. Biochim Biophys Acta (2009) 0.75
Differential regulation of Smac/DIABLO and Hsp-70 during brain maturation. Neuromolecular Med (2007) 0.75
Biochemical characterization and structural modeling of human cathepsin E variant 2 in comparison to the wild-type protein. Biol Chem (2012) 0.75
A structural network associated with the kallikrein-kinin and renin-angiotensin systems. Biol Chem (2010) 0.75
Presence of the propeptide on recombinant lysosomal dipeptidase controls both activation and dimerization. Biol Chem (2007) 0.75
Purification and characterization of two cysteine peptidases of the Mediterranean fruit fly Ceratitis capitata during metamorphosis. Arch Insect Biochem Physiol (2008) 0.75