Published in Biol Chem on April 01, 2010
Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. J Biol Chem (2003) 2.30
Emerging roles of cysteine cathepsins in disease and their potential as drug targets. Curr Pharm Des (2007) 2.26
Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues. J Biol Chem (2008) 1.85
Lysosomes as "suicide bags" in cell death: myth or reality? J Biol Chem (2009) 1.65
Lysosomes and lysosomal cathepsins in cell death. Biochim Biophys Acta (2011) 1.61
Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. Nat Nanotechnol (2011) 1.41
Apoptotic pathways: involvement of lysosomal proteases. Biol Chem (2002) 1.38
Autophagy is involved in nutritional stress response and differentiation in Trypanosoma cruzi. J Biol Chem (2007) 1.31
Lysosomal cysteine cathepsins: signaling pathways in apoptosis. Biol Chem (2007) 1.29
Protease signalling: the cutting edge. EMBO J (2012) 1.24
Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro. Exp Cell Res (2003) 1.20
Interaction between human cathepsins K, L, and S and elastins: mechanism of elastinolysis and inhibition by macromolecular inhibitors. J Biol Chem (2007) 1.14
Lysosomes in apoptosis. Methods Enzymol (2008) 1.13
Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis. Biol Chem (2010) 1.13
Metacaspases of Trypanosoma cruzi: possible candidates for programmed cell death mediators. Mol Biochem Parasitol (2005) 1.10
Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes. PLoS Pathog (2010) 1.07
Glycosaminoglycans facilitate procathepsin B activation through disruption of propeptide-mature enzyme interactions. J Biol Chem (2007) 1.04
Intracellular proteolytic activity of cathepsin B is associated with capillary-like tube formation by endothelial cells in vitro. J Cell Biochem (2006) 1.04
Autocatalytic processing of procathepsin B is triggered by proenzyme activity. FEBS J (2009) 1.02
Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues. Exp Cell Res (2005) 1.02
Lysosomal cysteine proteases: structural features and their role in apoptosis. IUBMB Life (2005) 1.01
Recombinant human procathepsin S is capable of autocatalytic processing at neutral pH in the presence of glycosaminoglycans. FEBS Lett (2005) 1.00
Diversity and evolution of the thyroglobulin type-1 domain superfamily. Mol Biol Evol (2005) 0.98
The novel bovine serpin endopin 2C demonstrates selective inhibition of the cysteine protease cathepsin L compared to the serine protease elastase, in cross-class inhibition. Biochemistry (2005) 0.98
Selective activity-based probes for cysteine cathepsins. Angew Chem Int Ed Engl (2008) 0.94
Interaction of human stefin B in the prefibrillar oligomeric form with membranes. Correlation with cellular toxicity. FEBS J (2005) 0.93
Phylogenomic analysis of the cystatin superfamily in eukaryotes and prokaryotes. BMC Evol Biol (2009) 0.93
Inhibitory properties of cystatin F and its localization in U937 promonocyte cells. FEBS J (2005) 0.93
In vitro study of stability and amyloid-fibril formation of two mutants of human stefin B (cystatin B) occurring in patients with EPM1. Protein Sci (2005) 0.91
Human stefin B readily forms amyloid fibrils in vitro. Biochim Biophys Acta (2002) 0.91
Recombinant human cathepsin H lacking the mini chain is an endopeptidase. Biochemistry (2003) 0.89
Mechanisms of amyloid fibril formation--focus on domain-swapping. FEBS J (2011) 0.89
The mechanism of amyloid-fibril formation by stefin B: temperature and protein concentration dependence of the rates. Proteins (2009) 0.87
Recombinant human SMOCs produced by in vitro refolding: calcium-binding properties and interactions with serum proteins. Protein Expr Purif (2008) 0.87
Cleavage of MAGI-1, a tight junction PDZ protein, by caspases is an important step for cell-cell detachment in apoptosis. Apoptosis (2007) 0.86
Exclusion of the native alpha-helix from the amyloid fibrils of a mixed alpha/beta protein. J Mol Biol (2007) 0.86
Interaction with model membranes and pore formation by human stefin B: studying the native and prefibrillar states. FEBS J (2008) 0.86
Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. Immunology (2010) 0.85
Interaction between oligomers of stefin B and amyloid-beta in vitro and in cells. J Biol Chem (2009) 0.85
Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis. Biol Chem (2007) 0.85
Size and morphology of toxic oligomers of amyloidogenic proteins: a case study of human stefin B. Amyloid (2008) 0.85
Blocking autophagy to prevent parasite differentiation: a possible new strategy for fighting parasitic infections? Autophagy (2008) 0.85
Sensitization of stefin B-deficient thymocytes towards staurosporin-induced apoptosis is independent of cysteine cathepsins. FEBS Lett (2005) 0.84
Differential regulation of the intrinsic pathway of apoptosis in brain and liver during ageing. FEBS Lett (2006) 0.84
Increased expression of stefin B in the nucleus of T98G astrocytoma cells delays caspase activation. Front Mol Neurosci (2012) 0.84
Structural characterization of thyroglobulin type-1 domains of equistatin. FEBS Lett (2003) 0.84
Differentiation- and maturation-dependent content, localization, and secretion of cystatin C in human dendritic cells. J Leukoc Biol (2005) 0.84
Intracellular aggregation of human stefin B: confocal and electron microscopy study. Biol Cell (2010) 0.83
Novel aspartyl proteinase associated to fat body histolysis during Ceratitis capitata early metamorphosis. Arch Insect Biochem Physiol (2004) 0.82
Papain-like lysosomal cysteine proteases and their inhibitors: drug discovery targets? Biochem Soc Symp (2003) 0.81
hDLG/SAP97, a member of the MAGUK protein family, is a novel caspase target during cell-cell detachment in apoptosis. Biol Chem (2005) 0.81
Amyloid fibril formation by human stefin B in vitro: immunogold labelling and comparison to stefin A. Biol Chem (2002) 0.80
Inhibitory p41 isoform of invariant chain and its potential target enzymes cathepsins L and H in distinct populations of macrophages in human lymph nodes. Immunology (2004) 0.80
Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery. Biol Chem (2009) 0.80
Protein aggregation as a possible cause for pathology in a subset of familial Unverricht-Lundborg disease. Med Hypotheses (2005) 0.80
The proinflammatory cytokines interleukin-1α and tumor necrosis factor α promote the expression and secretion of proteolytically active cathepsin S from human chondrocytes. Biol Chem (2013) 0.79
Developmental shift in the apostat: comparison of neurones and astrocytes. FEBS Lett (2005) 0.79
Dual concentration-dependent activity of thyroglobulin type-1 domain of testican: specific inhibitor and substrate of cathepsin L. Biol Chem (2005) 0.79
Human brain cathepsin H as a neuropeptide and bradykinin metabolizing enzyme. Peptides (2003) 0.79
Cysteine cathepsins are not involved in Fas/CD95 signalling in primary skin fibroblasts. FEBS Lett (2007) 0.79
Mouse stefins A1 and A2 (Stfa1 and Stfa2) differentiate between papain-like endo- and exopeptidases. FEBS Lett (2006) 0.79
Cysteine cathepsins are not critical for TRAIL- and CD95-induced apoptosis in several human cancer cell lines. Biol Chem (2012) 0.78
The Expression of Lysosomal Proteinases and Their Inhibitors in Breast Cancer: Possible Relationship to Prognosis of the Disease. Pathol Oncol Res (1997) 0.77
Cathepsin C and plasma glutamate carboxypeptidase secreted from Fischer rat thyroid cells liberate thyroxin from the N-terminus of thyroglobulin. Biochimie (2011) 0.77
Modulation of contact order effects in the two-state folding of stefins A and B. Biophys J (2011) 0.77
Resistance of cathepsin L compared to elastase to proteolysis when complexed with the serpin endopin 2C, and recovery of cathepsin L activity. Biochem Biophys Res Commun (2006) 0.77
N-terminally truncated forms of human cathepsin F accumulate in aggresome-like inclusions. Biochim Biophys Acta (2013) 0.77
A novel caspase-7 specific monoclonal antibody. Immunol Lett (2005) 0.77
Individual recombinant thyroglobulin type-1 domains are substrates for lysosomal cysteine proteinases. Biol Chem (2002) 0.77
Conformational changes preceding amyloid-fibril formation of amyloid-beta and stefin B; parallels in pH dependence. Curr Med Chem (2002) 0.76
Do lysosomes induce cell death? IUBMB Life (2006) 0.76
Human cathepsin F: expression in baculovirus system, characterization and inhibition by protein inhibitors. Biol Chem (2004) 0.76
Special issue: Proteolysis 50 years after the discovery of lysosome in honor of Christian de Duve. Biochim Biophys Acta (2012) 0.75
Biochemical characterization and structural modeling of human cathepsin E variant 2 in comparison to the wild-type protein. Biol Chem (2012) 0.75
Differential regulation of Smac/DIABLO and Hsp-70 during brain maturation. Neuromolecular Med (2007) 0.75
Cysteine cathepsins are not critical for TNF-alpha-induced cell death in T98G and U937 cells. Biochim Biophys Acta (2009) 0.75
Presence of the propeptide on recombinant lysosomal dipeptidase controls both activation and dimerization. Biol Chem (2007) 0.75
Purification and characterization of two cysteine peptidases of the Mediterranean fruit fly Ceratitis capitata during metamorphosis. Arch Insect Biochem Physiol (2008) 0.75