Published in J Biol Chem on November 18, 2002
Homeodomain revisited: a lesson from disease-causing mutations. Hum Genet (2005) 1.18
Nuclear factor I/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. Mol Cell Biol (2003) 1.16
Large scale gene expression profiles of regenerating inner ear sensory epithelia. PLoS One (2007) 1.08
Polymorphic length of FOXE1 alanine stretch: evidence for genetic susceptibility to thyroid dysgenesis. Hum Genet (2007) 0.98
The microRNA-processing enzyme Dicer is essential for thyroid function. PLoS One (2011) 0.94
Thyroid follicle formation and thyroglobulin expression in multipotent endodermal stem cells. Thyroid (2013) 0.94
Pax8 has a critical role in epithelial cell survival and proliferation. Cell Death Dis (2013) 0.89
Identification of novel Pax8 targets in FRTL-5 thyroid cells by gene silencing and expression microarray analysis. PLoS One (2011) 0.87
Deletion of the RNaseIII enzyme dicer in thyroid follicular cells causes hypothyroidism with signs of neoplastic alterations. PLoS One (2012) 0.85
Pendrin is a novel in vivo downstream target gene of the TTF-1/Nkx-2.1 homeodomain transcription factor in differentiated thyroid cells. Mol Cell Biol (2005) 0.84
A role for PAX8 in the tumorigenic phenotype of ovarian cancer cells. BMC Cancer (2014) 0.84
Expression of thyrotropin receptor, thyroglobulin, sodium-iodide symporter, and thyroperoxidase by fibrocytes depends on AIRE. J Clin Endocrinol Metab (2014) 0.84
TTF-1 response element is critical for temporal and spatial regulation and necessary for hormonal regulation of human surfactant protein-A2 promoter activity. Am J Physiol Lung Cell Mol Physiol (2008) 0.82
Comparative genomics reveals a functional thyroid-specific element in the far upstream region of the PAX8 gene. BMC Genomics (2010) 0.81
A novel FOXE1 mutation (R73S) in Bamforth-Lazarus syndrome causing increased thyroidal gene expression. Thyroid (2014) 0.79
Generation of thyroid follicular cells from pluripotent stem cells: potential for regenerative medicine. Front Endocrinol (Lausanne) (2014) 0.79
Low oxygen tension enhances the generation of lung progenitor cells from mouse embryonic and induced pluripotent stem cells. Physiol Rep (2014) 0.78
WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8. Biochem J (2004) 0.76
Identification of a novel pax8 gene sequence variant in four members of the same family: from congenital hypothyroidism with thyroid hypoplasia to mild subclinical hypothyroidism. BMC Endocr Disord (2014) 0.75
Molecular cloning and functional characterization of two forms of Pax8 in the rainbow trout, Oncorhynchus mykiss. Gen Comp Endocrinol (2013) 0.75
Adipogenic Differentiation of Thyroid Cancer Cells Through the Pax8-PPARγ Fusion Protein Is Regulated by Thyroid Transcription Factor 1 (TTF-1). J Biol Chem (2016) 0.75
Screening of HHEX Mutations in Chinese Children with Thyroid Dysgenesis. J Clin Res Pediatr Endocrinol (2015) 0.75
DuOx2 Promoter Regulation by Hormones, Transcriptional Factors and the Coactivator TAZ. Eur Thyroid J (2015) 0.75
Neuropilin-2 Is a Newly Identified Target of PAX8 in Thyroid Cells. PLoS One (2015) 0.75
A De novo PAX8 mutation in a Chinese child with congenital thyroid dysgenesis. Int J Clin Exp Pathol (2015) 0.75
Hypothyroxinemia induced by mild iodine deficiency deregulats thyroid proteins during gestation and lactation in dams. Int J Environ Res Public Health (2013) 0.75
A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03
Thyroid development and its disorders: genetics and molecular mechanisms. Endocr Rev (2004) 2.62
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer. Nat Genet (2008) 2.05
TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. J Biol Chem (2004) 1.98
A mouse model demonstrates a multigenic origin of congenital hypothyroidism. Endocrinology (2005) 1.89
C-reactive protein induces tissue factor expression and promotes smooth muscle and endothelial cell proliferation. Cardiovasc Res (2005) 1.67
Molecular mechanisms generating and stabilizing terminal 22q13 deletions in 44 subjects with Phelan/McDermid syndrome. PLoS Genet (2011) 1.60
Protein oligomerization modulates raft partitioning and apical sorting of GPI-anchored proteins. J Cell Biol (2004) 1.59
An integrated regulatory network controlling survival and migration in thyroid organogenesis. Dev Biol (2004) 1.55
Dose-dependent inhibition of thyroid differentiation by RAS oncogenes. Mol Endocrinol (2004) 1.51
Distribution of the titf2/foxe1 gene product is consistent with an important role in the development of foregut endoderm, palate, and hair. Dev Dyn (2002) 1.44
Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice. EMBO Rep (2005) 1.43
The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neurons. Mol Cell Neurosci (2007) 1.33
The transcription factor encyclopedia. Genome Biol (2012) 1.28
A dynamic podosome-like structure of epithelial cells. Exp Cell Res (2004) 1.25
Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy. BMC Genomics (2007) 1.24
Missense mutation in the transcription factor NKX2-5: a novel molecular event in the pathogenesis of thyroid dysgenesis. J Clin Endocrinol Metab (2006) 1.21
Rhes is involved in striatal function. Mol Cell Biol (2004) 1.17
Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage. J Biol Chem (2006) 1.16
An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionarily conserved enhancer. Mol Cell Biol (2006) 1.13
TAZ/WWTR1 is overexpressed in papillary thyroid carcinoma. Eur J Cancer (2010) 1.12
Minireview: Intrinsic and extrinsic factors in thyroid gland development: an update. Endocrinology (2011) 1.10
In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1. BMC Dev Biol (2011) 1.10
TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. Exp Cell Res (2008) 1.08
PrP(C) association with lipid rafts in the early secretory pathway stabilizes its cellular conformation. Mol Biol Cell (2004) 1.07
Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult. J Endocrinol (2007) 1.04
Familial PAX8 small deletion (c.989_992delACCC) associated with extreme phenotype variability. J Clin Endocrinol Metab (2004) 1.03
PrPC is sorted to the basolateral membrane of epithelial cells independently of its association with rafts. Traffic (2002) 0.98
Physiology, pathology and relatedness of human tissues from gene expression meta-analysis. PLoS One (2008) 0.97
Unusual number and genomic organization of Hox genes in the tunicate Ciona intestinalis. Gene (2003) 0.96
Characterization of a novel loss-of-function mutation of PAX8 associated with congenital hypothyroidism. Clin Endocrinol (Oxf) (2010) 0.96
Increased levels of d-aspartate in the hippocampus enhance LTP but do not facilitate cognitive flexibility. Mol Cell Neurosci (2007) 0.95
Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes. Nat Commun (2013) 0.95
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response. Proc Natl Acad Sci U S A (2014) 0.94
The microRNA-processing enzyme Dicer is essential for thyroid function. PLoS One (2011) 0.94
Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning. Dev Biol (2011) 0.91
Clinical description of a patient carrying the smallest reported deletion involving 10p14 region. Am J Med Genet A (2012) 0.90
Complex chromosomal rearrangements causing Langer-Giedion syndrome atypical phenotype: genotype-phenotype correlation and literature review. Am J Med Genet A (2013) 0.89
The transcriptional repressor DREAM is involved in thyroid gene expression. Exp Cell Res (2005) 0.89
The DREAM protein is associated with thyroid enlargement and nodular development. Mol Endocrinol (2009) 0.89
Wide gene expression profiling of ischemia-reperfusion injury in human liver transplantation. Liver Transpl (2007) 0.89
Intracellular route and mechanism of action of ERB-hRNase, a human anti-ErbB2 anticancer immunoagent. FEBS Lett (2007) 0.89
Tissue factor binding of activated factor VII triggers smooth muscle cell proliferation via extracellular signal-regulated kinase activation. Circulation (2004) 0.88
A preservation method that allows recovery of intact RNA from tissues dissected by laser capture microdissection. Anal Biochem (2002) 0.87
Identification of novel Pax8 targets in FRTL-5 thyroid cells by gene silencing and expression microarray analysis. PLoS One (2011) 0.87
Conditional inactivation of the E-cadherin gene in thyroid follicular cells affects gland development but does not impair junction formation. Endocrinology (2007) 0.87
Intracranial gene delivery of LV-NAGLU vector corrects neuropathology in murine MPS IIIB. Am J Med Genet A (2009) 0.85
CDH16/Ksp-cadherin is expressed in the developing thyroid gland and is strongly down-regulated in thyroid carcinomas. Endocrinology (2011) 0.85
Zebrafish bcl2l is a survival factor in thyroid development. Dev Biol (2012) 0.85
Essential stations in the intracellular pathway of cytotoxic bovine seminal ribonuclease. Biochem J (2002) 0.84
Let-7a down-regulation plays a role in thyroid neoplasias of follicular histotype affecting cell adhesion and migration through its ability to target the FXYD5 (Dysadherin) gene. J Clin Endocrinol Metab (2012) 0.84
Prenatal BACs-on-Beads™: the prospective experience of five prenatal diagnosis laboratories. Prenat Diagn (2012) 0.84
Minireview: thyrotropin receptor signaling in development and differentiation of the thyroid gland: insights from mouse models and human diseases. Endocrinology (2004) 0.84
Pendrin is a novel in vivo downstream target gene of the TTF-1/Nkx-2.1 homeodomain transcription factor in differentiated thyroid cells. Mol Cell Biol (2005) 0.84
Functional inactivation of the transcription factor Pax8 through oligomerization chain reaction. Mol Endocrinol (2006) 0.84
Selective cognitive impairment and tall stature due to chromosome 19 supernumerary ring. Clin Dysmorphol (2012) 0.84
Pax8 protein stability is controlled by sumoylation. J Mol Endocrinol (2008) 0.84
Quality assessment in cytogenetic and molecular genetic testing: the experience of the Italian Project on Standardisation and Quality Assurance. Clin Chem Lab Med (2004) 0.83
Murine models for the study of thyroid gland development. Endocr Dev (2007) 0.83
A locus on mouse chromosome 2 is involved in susceptibility to congenital hypothyroidism and contains an essential gene expressed in thyroid. Endocrinology (2010) 0.83
A physiological mechanism to regulate D-aspartic acid and NMDA levels in mammals revealed by D-aspartate oxidase deficient mice. Gene (2006) 0.82
Intronic elements in the Na+/I- symporter gene (NIS) interact with retinoic acid receptors and mediate initiation of transcription. Nucleic Acids Res (2010) 0.82
The ribonuclease/angiogenin inhibitor is also present in mitochondria and nuclei. FEBS Lett (2011) 0.82
Inverted duplication of 15q with terminal deletion in a multiple malformed newborn with intrauterine growth failure and lethal phenotype. Am J Med Genet A (2004) 0.82
Comparative genomics reveals a functional thyroid-specific element in the far upstream region of the PAX8 gene. BMC Genomics (2010) 0.81
Functional interaction between p75NTR and TrkA: the endocytic trafficking of p75NTR is driven by TrkA and regulates TrkA-mediated signalling. Biochem J (2005) 0.81
An emerging phenotype of proximal 11q deletions. Eur J Med Genet (2010) 0.81
Differential recognition of a tyrosine-dependent signal in the basolateral and endocytic pathways of thyroid epithelial cells. Endocrinology (2002) 0.81
The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures. Biol Chem (2002) 0.79
Oncogenic ras blocks the cAMP pathway and dedifferentiates thyroid cells via an impairment of pax8 transcriptional activity. Mol Endocrinol (2009) 0.79
An essential role for Pax8 in the transcriptional regulation of cadherin-16 in thyroid cells. Mol Endocrinol (2011) 0.79
Mental retardation, congenital heart malformation, and myelodysplasia in a patient with a complex chromosomal rearrangement involving the critical region 21q22. Am J Med Genet A (2011) 0.79
AMOTL2 interaction with TAZ causes the inhibition of surfactant proteins expression in lung cells. Gene (2013) 0.78
Interplay of negative and positive signals controls endoderm-specific expression of the ascidian Cititf1 gene promoter. Dev Biol (2003) 0.78
Variegated silencing through epigenetic modifications of a large Xq region in a case of balanced X;2 translocation with Incontinentia Pigmenti-like phenotype. Epigenetics (2011) 0.78
Chronic pro-oxidative state and mitochondrial dysfunctions are more pronounced in fibroblasts from Down syndrome foeti with congenital heart defects. Hum Mol Genet (2012) 0.77
Poly(ADP-ribose) polymerase 1 binds to Pax8 and inhibits its transcriptional activity. J Mol Endocrinol (2008) 0.77
De novo 13q12.3-q14.11 deletion involving BRCA2 gene in a patient with developmental delay, elevated IgM levels, transient ataxia, and cerebellar hypoplasia, mimicking an A-T like phenotype. Am J Med Genet A (2012) 0.76
WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8. Biochem J (2004) 0.76