Published in J Biol Chem on November 22, 2006
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature (2009) 3.36
Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein. J Neurochem (2007) 1.61
Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions. J Biol Chem (2008) 1.35
Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role. Mol Neurodegener (2008) 1.28
The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease. J Neurosci (2011) 1.26
A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts. Cell Death Differ (2011) 1.19
Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo. PLoS One (2010) 1.11
Oxidative stress mediates the pathogenic effect of different Alzheimer's disease risk factors. Front Aging Neurosci (2010) 0.98
Fe65 is required for Tip60-directed histone H4 acetylation at DNA strand breaks. Proc Natl Acad Sci U S A (2009) 0.88
Brain ischemia activates β- and γ-secretase cleavage of amyloid precursor protein: significance in sporadic Alzheimer's disease. Mol Neurobiol (2012) 0.86
Increased origin activity in transformed versus normal cells: identification of novel protein players involved in DNA replication and cellular transformation. Nucleic Acids Res (2010) 0.85
Immune response profiling identifies autoantibodies specific to Moyamoya patients. Orphanet J Rare Dis (2013) 0.84
Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain. Mol Cell Proteomics (2013) 0.82
Chromatin modifications associated with DNA double-strand breaks repair as potential targets for neurological diseases. Neurotherapeutics (2013) 0.81
The amyloid precursor protein intracellular domain-fe65 multiprotein complexes: a challenge to the amyloid hypothesis for Alzheimer's disease? Int J Alzheimers Dis (2012) 0.81
Ubiquitylation of Fe65 adaptor protein by neuronal precursor cell expressed developmentally down regulated 4-2 (Nedd4-2) via the WW domain interaction with Fe65. Exp Mol Med (2009) 0.81
Connecting chromatin modifying factors to DNA damage response. Int J Mol Sci (2013) 0.79
Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation. Sci Rep (2015) 0.79
A novel function of the Fe65 neuronal adaptor in estrogen receptor action in breast cancer cells. J Biol Chem (2014) 0.78
UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport. J Neurosci (2014) 0.77
An epigenomic role of Fe65 in the cellular response to DNA damage. Mutat Res (2015) 0.75
Fe65 Is Phosphorylated on Ser289 after UV-Induced DNA Damage. PLoS One (2016) 0.75
A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature (2009) 3.36
Thyroid development and its disorders: genetics and molecular mechanisms. Endocr Rev (2004) 2.62
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer. Nat Genet (2008) 2.05
RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells. Cell Rep (2012) 2.03
A mouse model demonstrates a multigenic origin of congenital hypothyroidism. Endocrinology (2005) 1.89
p53 suppresses the Nrf2-dependent transcription of antioxidant response genes. J Biol Chem (2006) 1.84
Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia. Nat Neurosci (2011) 1.74
MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma. PLoS One (2009) 1.73
Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice. Nat Med (2005) 1.64
Correlation between fatigue and brain atrophy and lesion load in multiple sclerosis patients independent of disability. J Neurol Sci (2007) 1.61
Bcl-2 Phosphorylation by p38 MAPK: identification of target sites and biologic consequences. J Biol Chem (2006) 1.60
Integrated software for the analysis of brain PET/SPECT studies with partial-volume-effect correction. J Nucl Med (2004) 1.56
Interleukin-1β causes anxiety by interacting with the endocannabinoid system. J Neurosci (2012) 1.55
An integrated regulatory network controlling survival and migration in thyroid organogenesis. Dev Biol (2004) 1.55
Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans. Leuk Lymphoma (2007) 1.53
Klf5 is involved in self-renewal of mouse embryonic stem cells. J Cell Sci (2008) 1.51
The "eye of the tiger" sign in pure akinesia with gait freezing. Neurol Sci (2011) 1.51
Dose-dependent inhibition of thyroid differentiation by RAS oncogenes. Mol Endocrinol (2004) 1.51
miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J (2010) 1.49
Loss of striatal cannabinoid CB1 receptor function in attention-deficit / hyperactivity disorder mice with point-mutation of the dopamine transporter. Eur J Neurosci (2011) 1.45
Distribution of the titf2/foxe1 gene product is consistent with an important role in the development of foregut endoderm, palate, and hair. Dev Dyn (2002) 1.44
Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice. EMBO Rep (2005) 1.43
Anticoagulant therapy in oncologic patients undergoing venous stenting for superior vena cava syndrome and other interventional procedures. Cardiovasc Intervent Radiol (2014) 1.38
Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth. Proc Natl Acad Sci U S A (2009) 1.36
The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neurons. Mol Cell Neurosci (2007) 1.33
Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling. J Biol Chem (2007) 1.31
Mice anesthesia, analgesia, and care, Part I: anesthetic considerations in preclinical research. ILAR J (2012) 1.28
The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription. J Biol Chem (2002) 1.22
Missense mutation in the transcription factor NKX2-5: a novel molecular event in the pathogenesis of thyroid dysgenesis. J Clin Endocrinol Metab (2006) 1.21
CT appearance of the normal appendix in adults. Eur Radiol (2005) 1.21
Age-Related Reference Intervals of the Main Biochemical and Hematological Parameters in C57BL/6J, 129SV/EV and C3H/HeJ Mouse Strains. PLoS One (2008) 1.19
Identification of a hormone-regulated dynamic nuclear actin network associated with estrogen receptor alpha in human breast cancer cell nuclei. Mol Cell Proteomics (2010) 1.19
Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain. J Biol Chem (2002) 1.18
Rhes is involved in striatal function. Mol Cell Biol (2004) 1.17
Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET. EMBO Rep (2005) 1.17
Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach. Mol Ther (2009) 1.14
Thyroid V30 predicts radiation-induced hypothyroidism in patients treated with sequential chemo-radiotherapy for Hodgkin's lymphoma. Int J Radiat Oncol Biol Phys (2011) 1.12
Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression. J Biol Chem (2002) 1.12
DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophrenia. Proc Natl Acad Sci U S A (2010) 1.11
Minireview: Intrinsic and extrinsic factors in thyroid gland development: an update. Endocrinology (2011) 1.10
In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1. BMC Dev Biol (2011) 1.10
Atorvastatin combined to interferon to verify the efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: a longitudinal controlled trial of combination therapy. Mult Scler (2010) 1.09
Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway. J Biol Chem (2003) 1.08
Protein kinase B activation by reactive oxygen species is independent of tyrosine kinase receptor phosphorylation and requires SRC activity. J Biol Chem (2003) 1.07
Direct targets of Klf5 transcription factor contribute to the maintenance of mouse embryonic stem cell undifferentiated state. BMC Biol (2010) 1.07
Mice anesthesia, analgesia, and care, Part II: anesthetic considerations in preclinical imaging studies. ILAR J (2012) 1.06
Stereotaxy-based regional brain volumetry applied to segmented MRI: validation and results in deficit and nondeficit schizophrenia. Neuroimage (2002) 1.05
Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult. J Endocrinol (2007) 1.04
Evidence for a role of the nerve growth factor receptor TrkA in tyrosine phosphorylation and processing of beta-APP. Biochem Biophys Res Commun (2002) 1.04
miRNA and protein expression profiles of visceral adipose tissue reveal miR-141/YWHAG and miR-520e/RAB11A as two potential miRNA/protein target pairs associated with severe obesity. J Proteome Res (2012) 1.04
Unilateral proptosis in thyroid eye disease with subsequent contralateral involvement: retrospective follow-up study. BMC Ophthalmol (2013) 1.04
feh-1 and apl-1, the Caenorhabditis elegans orthologues of mammalian Fe65 and beta-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumping. J Cell Sci (2002) 1.03
Phosphorylation of a tyrosine in the amyloid-beta protein precursor intracellular domain inhibits Fe65 binding and signaling. J Alzheimers Dis (2009) 1.03
Redox control of signal transduction, gene expression and cellular senescence. Neurochem Res (2004) 1.02
D-aspartate prevents corticostriatal long-term depression and attenuates schizophrenia-like symptoms induced by amphetamine and MK-801. J Neurosci (2008) 0.99
Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth. Nat Commun (2013) 0.99
Patterns of structural MRI abnormalities in deficit and nondeficit schizophrenia. Schizophr Bull (2007) 0.98
Increased D-aspartate brain content rescues hippocampal age-related synaptic plasticity deterioration of mice. Neurobiol Aging (2010) 0.96
Multiple sclerosis: cerebral circulation time. Radiology (2012) 0.96
Unusual number and genomic organization of Hox genes in the tunicate Ciona intestinalis. Gene (2003) 0.96
Increased levels of d-aspartate in the hippocampus enhance LTP but do not facilitate cognitive flexibility. Mol Cell Neurosci (2007) 0.95
Chronic cerebrospinal venous insufficiency in multiple sclerosis: a highly prevalent age-dependent phenomenon. BMC Neurol (2013) 0.94
The microRNA-processing enzyme Dicer is essential for thyroid function. PLoS One (2011) 0.94
Dosimetric predictors of asymptomatic heart valvular dysfunction following mediastinal irradiation for Hodgkin's lymphoma. Radiother Oncol (2011) 0.94
Differentiation of embryonic stem cells 1 (Dies1) is a component of bone morphogenetic protein 4 (BMP4) signaling pathway required for proper differentiation of mouse embryonic stem cells. J Biol Chem (2009) 0.94
Radiation therapy in primary orbital lymphoma: a single institution retrospective analysis. Radiat Oncol (2009) 0.94
Radiotherapy of large target volumes in Hodgkin's lymphoma: normal tissue sparing capability of forward IMRT versus conventional techniques. Radiat Oncol (2010) 0.93
MSX1 and TGF-beta3 are novel target genes functionally regulated by FOXE1. Hum Mol Genet (2010) 0.91
A regulatory loop involving Dies1 and miR-125a controls BMP4 signaling in mouse embryonic stem cells. FASEB J (2012) 0.91
Fe65 is not involved in the platelet-derived growth factor-induced processing of Alzheimer's amyloid precursor protein, which activates its caspase-directed cleavage. J Biol Chem (2004) 0.91
Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning. Dev Biol (2011) 0.91
NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning. Stroke (2011) 0.90
Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications. Head Neck (2015) 0.90
Chemical composition and antimicrobial activity of the essential oils from two species of Thymus growing wild in southern Italy. Molecules (2009) 0.90
Persistent increase of D-aspartate in D-aspartate oxidase mutant mice induces a precocious hippocampal age-dependent synaptic plasticity and spatial memory decay. Neurobiol Aging (2009) 0.89
Bisphenol A interferes with thyroid specific gene expression. Toxicology (2012) 0.89
Non-alcoholic acute Wernicke's encephalopathy: role of MRI in non typical cases. Eur J Radiol (2012) 0.89
New insights on the role of free D-aspartate in the mammalian brain. Amino Acids (2012) 0.89
Signal transduction through tyrosine-phosphorylated carboxy-terminal fragments of APP via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain. Ann N Y Acad Sci (2002) 0.88