Published in Nucleic Acids Res on January 31, 2010
Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq. Genome Res (2012) 1.13
The sodium iodide symporter (NIS): regulation and approaches to targeting for cancer therapeutics. Pharmacol Ther (2012) 1.12
The sodium iodide symporter (NIS) and potential regulators in normal, benign and malignant human breast tissue. PLoS One (2011) 0.94
The sodium/iodide symporter NIS is a transcriptional target of the p53-family members in liver cancer cells. Cell Death Dis (2013) 0.83
Sodium iodide symporter (NIS) in extrathyroidal malignancies: focus on breast and urological cancer. BMC Cancer (2014) 0.82
The Thyroid Na+/I- Symporter: Molecular Characterization and Genomic Regulation. Mol Imaging Radionucl Ther (2016) 0.75
The human genome browser at UCSC. Genome Res (2002) 168.23
High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
VISTA : visualizing global DNA sequence alignments of arbitrary length. Bioinformatics (2000) 12.50
Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell (2003) 10.42
Phylogenetic shadowing of primate sequences to find functional regions of the human genome. Science (2003) 9.93
Active conservation of noncoding sequences revealed by three-way species comparisons. Genome Res (2000) 6.18
Retracted GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. Nature (2009) 3.10
The mammary gland iodide transporter is expressed during lactation and in breast cancer. Nat Med (2000) 3.01
Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acids from salivary gland, mammary gland, and gastric mucosa. J Clin Endocrinol Metab (1998) 2.27
Retinoic acid receptors and cellular retinoid binding proteins: complex interplay in retinoid signaling. Endocr Rev (1994) 2.27
Combinatorial control of exon recognition. J Biol Chem (2007) 2.24
An intron enhancer recognized by splicing factors activates polyadenylation. Genes Dev (1996) 2.08
Orthology and functional conservation in eukaryotes. Annu Rev Genet (2007) 1.74
Immunohistochemical profile of the sodium/iodide symporter in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sections. J Clin Endocrinol Metab (2003) 1.73
An overview of the management of papillary and follicular thyroid carcinoma. Thyroid (1999) 1.72
Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. Endocr Relat Cancer (2006) 1.66
The paired-domain transcription factor Pax8 binds to the upstream enhancer of the rat sodium/iodide symporter gene and participates in both thyroid-specific and cyclic-AMP-dependent transcription. Mol Cell Biol (1999) 1.53
The Na+/I- symporter mediates iodide uptake in breast cancer metastases and can be selectively down-regulated in the thyroid. Clin Cancer Res (2004) 1.52
A Gata2 intronic enhancer confers its pan-endothelia-specific regulation. Development (2007) 1.50
Intronic enhancers control expression of zebrafish sonic hedgehog in floor plate and notochord. Development (1999) 1.39
Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line. Proc Natl Acad Sci U S A (2000) 1.23
Thyroid transcription factor-1 activates the promoter activity of rat thyroid Na+/I- symporter gene. Mol Endocrinol (1997) 1.22
Comparative genomics: methods and applications. Naturwissenschaften (2004) 1.19
Activation of the PI3 kinase pathway by retinoic acid mediates sodium/iodide symporter induction and iodide transport in MCF-7 breast cancer cells. Cancer Res (2009) 1.04
Differential regulation of sodium/iodide symporter gene expression by nuclear receptor ligands in MCF-7 breast cancer cells. Endocrinology (2005) 1.02
Unliganded estrogen receptor-alpha activates transcription of the mammary gland Na+/I- symporter gene. Biochem Biophys Res Commun (2006) 0.99
Signaling through 3',5'-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/iodide symporter expression in breast cancer. J Clin Endocrinol Metab (2004) 0.99
Cloning of the mouse sodium iodide symporter and its expression in the mammary gland and other tissues. J Endocrinol (2001) 0.98
Conservation of regulatory sequences and gene expression patterns in the disintegrating Drosophila Hox gene complex. Genome Res (2005) 0.98
Systemic retinoic acid treatment induces sodium/iodide symporter expression and radioiodide uptake in mouse breast cancer models. Cancer Res (2004) 0.96
Retinoic acid stimulation of the sodium/iodide symporter in MCF-7 breast cancer cells is mediated by the insulin growth factor-I/phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase signaling pathways. J Clin Endocrinol Metab (2008) 0.93
Identification and analysis of a conserved Tcfap2a intronic enhancer element required for expression in facial and limb bud mesenchyme. Mol Cell Biol (2007) 0.92
Cloning of a functional promoter of the human sodium/iodide-symporter gene. Biochem J (1998) 0.92
Hormonal regulation of radioiodide uptake activity and Na+/I- symporter expression in mammary glands. J Clin Endocrinol Metab (2000) 0.92
Transcription factor Nkx-2.5 induces sodium/iodide symporter gene expression and participates in retinoic acid- and lactation-induced transcription in mammary cells. Mol Cell Biol (2004) 0.90
Immunoanalysis indicates that the sodium iodide symporter is not overexpressed in intracellular compartments in thyroid and breast cancers. Eur J Endocrinol (2008) 0.89
Induction of follicle formation in long-term cultured normal human thyroid cells treated with thyrotropin stimulates iodide uptake but not sodium/iodide symporter messenger RNA and protein expression. J Endocrinol (2000) 0.86
An intron is required for dihydrofolate reductase protein stability. J Biol Chem (2003) 0.86
Gene regulation through chromatin remodelling by members of the nuclear receptor superfamily. Biochem Soc Trans (2000) 0.84
Iodine deficiency and brain development. Bibl Nutr Dieta (1986) 0.84
The promoter of the human sodium/iodide-symporter gene responds to retinoic acid. Mol Cell Endocrinol (2002) 0.84
Effect of ligands of nuclear hormone receptors on sodium/iodide symporter expression and activity in breast cancer cells. Breast Cancer Res Treat (2003) 0.83
Will radioiodine be useful in treatment of breast cancer? Nat Med (2000) 0.82
Taking up iodide in breast tissue. Nature (2000) 0.80
A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03
Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev (2002) 5.15
Thyroid development and its disorders: genetics and molecular mechanisms. Endocr Rev (2004) 2.62
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer. Nat Genet (2008) 2.05
A mouse model demonstrates a multigenic origin of congenital hypothyroidism. Endocrinology (2005) 1.89
Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium. J Clin Endocrinol Metab (2003) 1.58
An integrated regulatory network controlling survival and migration in thyroid organogenesis. Dev Biol (2004) 1.55
Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes. Proc Natl Acad Sci U S A (2007) 1.54
Dose-dependent inhibition of thyroid differentiation by RAS oncogenes. Mol Endocrinol (2004) 1.51
The impact of management on medical professionalism: a review. Sociol Health Illn (2011) 1.47
Distribution of the titf2/foxe1 gene product is consistent with an important role in the development of foregut endoderm, palate, and hair. Dev Dyn (2002) 1.44
Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice. EMBO Rep (2005) 1.43
Social network analysis in primary care: the impact of interactions on prescribing behaviour. Health Policy (2009) 1.37
The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration. J Clin Invest (2010) 1.35
The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neurons. Mol Cell Neurosci (2007) 1.33
Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes. J Biol Chem (2002) 1.26
The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription. J Biol Chem (2002) 1.22
Missense mutation in the transcription factor NKX2-5: a novel molecular event in the pathogenesis of thyroid dysgenesis. J Clin Endocrinol Metab (2006) 1.21
Deiodinases: the balance of thyroid hormone: local impact of thyroid hormone inactivation. J Endocrinol (2011) 1.20
Rhes is involved in striatal function. Mol Cell Biol (2004) 1.17
Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage. J Biol Chem (2006) 1.16
Minireview: Intrinsic and extrinsic factors in thyroid gland development: an update. Endocrinology (2011) 1.10
In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1. BMC Dev Biol (2011) 1.10
A 21-year-old woman with consumptive hypothyroidism due to a vascular tumor expressing type 3 iodothyronine deiodinase. J Clin Endocrinol Metab (2002) 1.10
Type 2 iodothyronine deiodinase levels are higher in slow-twitch than fast-twitch mouse skeletal muscle and are increased in hypothyroidism. Endocrinology (2010) 1.06
p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome. Hum Mol Genet (2012) 1.04
Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult. J Endocrinol (2007) 1.04
β-Catenin regulates deiodinase levels and thyroid hormone signaling in colon cancer cells. Gastroenterology (2012) 1.04
The different cardiac expression of the type 2 iodothyronine deiodinase gene between human and rat is related to the differential response of the Dio2 genes to Nkx-2.5 and GATA-4 transcription factors. Mol Endocrinol (2003) 1.02
Unliganded estrogen receptor-alpha activates transcription of the mammary gland Na+/I- symporter gene. Biochem Biophys Res Commun (2006) 0.99
Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models. Clin Exp Metastasis (2012) 0.97
Unusual number and genomic organization of Hox genes in the tunicate Ciona intestinalis. Gene (2003) 0.96
Consumptive hypothyroidism resulting from hepatic vascular tumors in an athyreotic adult. J Clin Endocrinol Metab (2011) 0.95
Dopamine D2 receptor dysfunction is rescued by adenosine A2A receptor antagonism in a model of DYT1 dystonia. Neurobiol Dis (2010) 0.95
Increased levels of d-aspartate in the hippocampus enhance LTP but do not facilitate cognitive flexibility. Mol Cell Neurosci (2007) 0.95
The microRNA-processing enzyme Dicer is essential for thyroid function. PLoS One (2011) 0.94
Fine needle cytology and flow cytometry of ectopic cervical thymoma: a case report. Acta Cytol (2010) 0.93
Pretranslational regulation of type 2 deiodinase. Thyroid (2005) 0.93
Type II iodothyronine deiodinase provides intracellular 3,5,3'-triiodothyronine to normal and regenerating mouse skeletal muscle. Am J Physiol Endocrinol Metab (2011) 0.93
Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning. Dev Biol (2011) 0.91
Transcription factor Nkx-2.5 induces sodium/iodide symporter gene expression and participates in retinoic acid- and lactation-induced transcription in mammary cells. Mol Cell Biol (2004) 0.90
The ability to generate senescent progeny as a mechanism underlying breast cancer cell heterogeneity. PLoS One (2010) 0.90
Tprg, a gene predominantly expressed in skin, is a direct target of the transcription factor p63. J Invest Dermatol (2008) 0.89
The deiodinases and the control of intracellular thyroid hormone signaling during cellular differentiation. Biochim Biophys Acta (2012) 0.89
Conditional inactivation of the E-cadherin gene in thyroid follicular cells affects gland development but does not impair junction formation. Endocrinology (2007) 0.87
A preservation method that allows recovery of intact RNA from tissues dissected by laser capture microdissection. Anal Biochem (2002) 0.87
Dipyridamole prevents triple-negative breast-cancer progression. Clin Exp Metastasis (2012) 0.87
Role of type 3 deiodinase in cancer. Expert Opin Ther Targets (2009) 0.87
Type 3 deiodinase and solid tumors: an intriguing pair. Expert Opin Ther Targets (2013) 0.85
Zebrafish bcl2l is a survival factor in thyroid development. Dev Biol (2012) 0.85
Functional inactivation of the transcription factor Pax8 through oligomerization chain reaction. Mol Endocrinol (2006) 0.84
Identification and functional characterization of a novel mutation in the NKX2-1 gene: comparison with the data in the literature. Thyroid (2013) 0.84
Minireview: thyrotropin receptor signaling in development and differentiation of the thyroid gland: insights from mouse models and human diseases. Endocrinology (2004) 0.84
Pendrin is a novel in vivo downstream target gene of the TTF-1/Nkx-2.1 homeodomain transcription factor in differentiated thyroid cells. Mol Cell Biol (2005) 0.84
Texturing of titanium (Ti6Al4V) medical implant surfaces with MHz-repetition-rate femtosecond and picosecond Yb-doped fiber lasers. Opt Express (2011) 0.84
Murine models for the study of thyroid gland development. Endocr Dev (2007) 0.83
A locus on mouse chromosome 2 is involved in susceptibility to congenital hypothyroidism and contains an essential gene expressed in thyroid. Endocrinology (2010) 0.83
Network organizations of general practitioners: antecedents of formation and consequences of participation. BMC Health Serv Res (2010) 0.83
Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction. Sci Rep (2013) 0.82
RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange. FEBS J (2009) 0.82
Epigenetic control of type 2 and 3 deiodinases in myogenesis: role of Lysine-specific Demethylase enzyme and FoxO3. Nucleic Acids Res (2013) 0.82
A physiological mechanism to regulate D-aspartic acid and NMDA levels in mammals revealed by D-aspartate oxidase deficient mice. Gene (2006) 0.82
Are public health authorities able to "steer" rather than "row"? An empirical analysis in the Italian National Health Service. Int J Health Plann Manage (2011) 0.82
Comparative genomics reveals a functional thyroid-specific element in the far upstream region of the PAX8 gene. BMC Genomics (2010) 0.81
The quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal tumors. Mol Cancer Ther (2010) 0.81
The comparative effects of gene modulators on thyroid-specific genes and radioiodine uptake. Cancer Biother Radiopharm (2007) 0.81
Type 3 deiodinase and consumptive hypothyroidism: a common mechanism for a rare disease. Front Endocrinol (Lausanne) (2013) 0.81
Oncogenic ras blocks the cAMP pathway and dedifferentiates thyroid cells via an impairment of pax8 transcriptional activity. Mol Endocrinol (2009) 0.79
The growth and composition of primary and community-based care services. Metrics and evidence from the Italian National Health Service. BMC Health Serv Res (2012) 0.78
The selective loss of the type 2 iodothyronine deiodinase in mouse thyrotrophs increases basal TSH but blunts the thyrotropin response to hypothyroidism. Endocrinology (2014) 0.78
Interplay of negative and positive signals controls endoderm-specific expression of the ascidian Cititf1 gene promoter. Dev Biol (2003) 0.78
Antiangiogenic response after 70% hepatectomy and its relationship with hepatic regeneration and angiogenesis in rats. Surgery (2009) 0.78
Novel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune in breast cancer. Eur J Med Chem (2012) 0.77
Coiled-coil domain containing protein 124 is a novel centrosome and midbody protein that interacts with the Ras-guanine nucleotide exchange factor 1B and is involved in cytokinesis. PLoS One (2013) 0.77
Deiodinases: keeping the thyroid hormone supply in balance. J Endocrinol (2011) 0.77
Reciprocal interplay between thyroid hormone and microRNA-21 regulates hedgehog pathway-driven skin tumorigenesis. J Clin Invest (2016) 0.77
PAX8 expression in human bladder cancer. Oncol Rep (2006) 0.76
The comparative effects of gene modulators on thyroid-specific genes and radioiodine uptake. Cancer Biother Radiopharm (2007) 0.76
Fiber laser-microscope system for femtosecond photodisruption of biological samples. Biomed Opt Express (2012) 0.75
Mice with hepatocyte-specific deficiency of type 3 deiodinase have intact liver regeneration and accelerated recovery from nonthyroidal illness after toxin-induced hepatonecrosis. Endocrinology (2014) 0.75
Studies of molecular mechanisms associated with increased deiodinase 3 expression in a case of consumptive hypothyroidism. J Clin Endocrinol Metab (2014) 0.75
Functional analysis of the murine Pax8 promoter reveals autoregulation and the presence of a novel thyroid-specific DNA-binding activity. Thyroid (2013) 0.75
Proteins, fatty acids and nutritional value in the muscle of the fish species Mora moro (Risso, 1810). Mol Nutr Food Res (2005) 0.75