Published in Immunity on August 01, 2003
Accessory molecules for Toll-like receptors and their function. Nat Rev Immunol (2012) 2.00
Toll-like receptors in central nervous system glial inflammation and homeostasis. J Neurosci Res (2006) 1.91
Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia. J Infect Dis (2009) 1.49
Bacterial programmed cell death of cerebral endothelial cells involves dual death pathways. J Clin Invest (2005) 1.32
The pneumococcus: epidemiology, microbiology, and pathogenesis. Cold Spring Harb Perspect Med (2013) 1.21
TRAIL limits excessive host immune responses in bacterial meningitis. J Clin Invest (2007) 1.05
Early life stress inhibits expression of a novel innate immune pathway in the developing hippocampus. Neuropsychopharmacology (2011) 0.99
Recombinant bactericidal/permeability-increasing protein rBPI21 protects against pneumococcal disease. Infect Immun (2006) 0.98
Pathophysiology and treatment of bacterial meningitis. Ther Adv Neurol Disord (2009) 0.98
Human lipopolysaccharide-binding protein (LBP) and CD14 independently deliver triacylated lipoproteins to Toll-like receptor 1 (TLR1) and TLR2 and enhance formation of the ternary signaling complex. J Biol Chem (2013) 0.96
Not "molecular patterns" but molecules. Immunity (2003) 0.95
Recognition of Staphylococcus aureus-derived peptidoglycan (PGN) but not intact bacteria is mediated by CD14 in microglia. J Neuroimmunol (2005) 0.92
Recognition of pathogenic microbes by the Drosophila phagocytic pattern recognition receptor Eater. J Biol Chem (2011) 0.92
Hepatocytes: a key cell type for innate immunity. Cell Mol Immunol (2015) 0.86
Pneumococcal cell wall-induced meningitis impairs adult hippocampal neurogenesis. Infect Immun (2007) 0.83
Overview of toll-like receptors in the CNS. Curr Top Microbiol Immunol (2009) 0.83
Structural and Functional Features of a Developmentally Regulated Lipopolysaccharide-Binding Protein. MBio (2015) 0.78
Tyrosine kinase inhibition reduces inflammation in the acute stage of experimental pneumococcal meningitis. Infect Immun (2004) 0.75
3LPS-binding protein and its interactions with P. gingivalis LPS modulate pro-inflammatory response and Toll-like receptor signaling in human oral keratinocytes. PLoS One (2017) 0.75
Identification of novel biomarker and therapeutic target candidates for acute intracerebral hemorrhage by quantitative plasma proteomics. Clin Proteomics (2017) 0.75
Induction of Central Host Signaling Kinases during Pneumococcal Infection of Human THP-1 Cells. Front Cell Infect Microbiol (2016) 0.75
Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol (2008) 4.31
Tissue-specific contributions of pneumococcal virulence factors to pathogenesis. J Infect Dis (2004) 3.43
Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect Dis (2005) 3.39
Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii. J Immunol (2006) 3.24
Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models. J Clin Invest (2009) 2.51
Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis. J Clin Invest (2002) 2.50
Microarray analysis of pneumococcal gene expression during invasive disease. Infect Immun (2004) 2.38
Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease. Infect Immun (2006) 2.33
TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. Proc Natl Acad Sci U S A (2007) 2.28
TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity. Immunobiology (2008) 2.19
Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. J Biol Chem (2004) 2.18
Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. J Immunol (2007) 2.14
Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS One (2007) 2.05
Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model. J Neurosci (2002) 2.05
Role of the manganese efflux system mntE for signalling and pathogenesis in Streptococcus pneumoniae. Mol Microbiol (2009) 2.03
Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria. Proc Natl Acad Sci U S A (2005) 1.95
Serum immunoglobulin G response to candidate vaccine antigens during experimental human pneumococcal colonization. Infect Immun (2003) 1.83
Preinfection systemic inflammatory markers and risk of hospitalization due to pneumonia. Am J Respir Crit Care Med (2005) 1.69
High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR. J Mol Med (Berl) (2003) 1.66
beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae. Infect Immun (2005) 1.60
Caregivers' inability to identify childhood adiposity: a cross-sectional survey of rural children and their caregivers' attitudes. Aust J Rural Health (2006) 1.58
Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin. Blood (2011) 1.54
Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease. J Immunol (2005) 1.49
MyD88 is pivotal for the early inflammatory response and subsequent bacterial clearance and survival in a mouse model of Chlamydia pneumoniae pneumonia. J Biol Chem (2005) 1.47
Control of virulence by small RNAs in Streptococcus pneumoniae. PLoS Pathog (2012) 1.46
Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease. J Clin Invest (2010) 1.44
Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy. J Infect Dis (2006) 1.43
Roller culture of free-floating retinal slices: a new system of organotypic cultures of adult rat retina. Ophthalmic Res (2006) 1.42
Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology. J Immunol (2006) 1.37
Streptococcal M protein: a multipotent and powerful inducer of inflammation. J Immunol (2006) 1.36
Cytokine induction by purified lipoteichoic acids from various bacterial species--role of LBP, sCD14, CD14 and failure to induce IL-12 and subsequent IFN-gamma release. Eur J Immunol (2002) 1.34
Calcium efflux is essential for bacterial survival in the eukaryotic host. Mol Microbiol (2008) 1.33
The role of lipopolysaccharide-binding protein in modulating the innate immune response. Microbes Infect (2006) 1.32
Bacterial programmed cell death of cerebral endothelial cells involves dual death pathways. J Clin Invest (2005) 1.32
Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses. J Immunol (2004) 1.31
Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide-induced cytokine release in human whole blood. J Infect Dis (2003) 1.28
TLR2 mediates neuroinflammation and neuronal damage. J Immunol (2007) 1.26
Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock. Proc Natl Acad Sci U S A (2009) 1.25
Immune responses induced by spirochetal outer membrane lipoproteins and glycolipids. Immunobiology (2008) 1.23
TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis. J Immunol (2008) 1.22
The pneumococcus: epidemiology, microbiology, and pathogenesis. Cold Spring Harb Perspect Med (2013) 1.21
Triptans reduce the inflammatory response in bacterial meningitis. J Cereb Blood Flow Metab (2002) 1.20
A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression. AIDS (2009) 1.18
Innate sensors for Gram-positive bacteria. Curr Opin Immunol (2003) 1.15
Escherichia coli Nissle 1917 distinctively modulates T-cell cycling and expansion via toll-like receptor 2 signaling. Infect Immun (2005) 1.15
Cell wall-mediated neuronal damage in early sepsis. Infect Immun (2006) 1.14
Early biofilm formation on microtiter plates is not correlated with the invasive disease potential of Streptococcus pneumoniae. Microb Pathog (2010) 1.11
Dual phases of apoptosis in pneumococcal meningitis. J Infect Dis (2004) 1.11
CCR5Delta32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Delta32 homozygous individual. PLoS One (2008) 1.10
Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions. J Infect Dis (2009) 1.10
Acylated cholesteryl galactoside as a novel immunogenic motif in Borrelia burgdorferi sensu stricto. J Biol Chem (2003) 1.10
Cellular damage in bacterial meningitis: an interplay of bacterial and host driven toxicity. J Neuroimmunol (2007) 1.09
Interferon-gamma differentially modulates the release of cytokines and chemokines in lipopolysaccharide- and pneumococcal cell wall-stimulated mouse microglia and macrophages. Eur J Neurosci (2002) 1.09
Impaired adrenal stress response in Toll-like receptor 2-deficient mice. Proc Natl Acad Sci U S A (2004) 1.09
Impaired CD14-dependent and independent response of polymorphonuclear leukocytes in preterm infants. J Perinat Med (2003) 1.08
Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts. Crit Care (2010) 1.08
Activated myeloid dendritic cells accumulate and co-localize with CD3+ T cells in coronary artery lesions in patients with Kawasaki disease. Exp Mol Pathol (2007) 1.08
Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. Proc Natl Acad Sci U S A (2006) 1.08
Pneumolysin causes neuronal cell death through mitochondrial damage. Infect Immun (2007) 1.07
Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state. Proc Natl Acad Sci U S A (2012) 1.07
Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy. BMC Med Genet (2009) 1.04
Vancomycin stress response in a sensitive and a tolerant strain of Streptococcus pneumoniae. J Bacteriol (2005) 1.04
Blocking TLR2 in vivo protects against accumulation of inflammatory cells and neuronal injury in experimental stroke. J Cereb Blood Flow Metab (2010) 1.03
The toll-like receptor 1 variant S248N influences placental malaria. Infect Genet Evol (2010) 1.02
Toll-like receptor (TLR)-9 promotor polymorphisms and atherosclerosis. Clin Chim Acta (2005) 1.00
Interplay of pneumococcal hydrogen peroxide and host-derived nitric oxide. Infect Immun (2006) 1.00
Impact of actin filament stabilization on adult hippocampal and olfactory bulb neurogenesis. J Neurosci (2010) 0.99
Rapid and inexpensive real-time PCR for genotyping functional polymorphisms within the Toll-like receptor -2, -4, and -9 genes. J Immunol Methods (2004) 0.99
Revising the role of the pneumococcal vex-vncRS locus in vancomycin tolerance. J Bacteriol (2004) 0.99
Toll-like receptor 2 mediates fatal immunopathology in mice during treatment of secondary pneumococcal pneumonia following influenza. J Infect Dis (2011) 0.99
Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses. Infect Immun (2004) 0.97
Acylated cholesteryl galactosides are specific antigens of borrelia causing lyme disease and frequently induce antibodies in late stages of disease. J Biol Chem (2009) 0.97
TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia. J Immunol (2007) 0.97
Acute-phase concentrations of lipopolysaccharide (LPS)-binding protein inhibit innate immune cell activation by different LPS chemotypes via different mechanisms. Infect Immun (2005) 0.95
Broadly protective protein-based pneumococcal vaccine composed of pneumolysin toxoid-CbpA peptide recombinant fusion protein. J Infect Dis (2013) 0.94
A frequent toll-like receptor (TLR)-2 polymorphism is a risk factor for coronary restenosis. J Mol Med (Berl) (2005) 0.93
Bacterial inhibition of phosphatidylcholine synthesis triggers apoptosis in the brain. J Exp Med (2004) 0.92
Improved reperfusion and neuroprotection by creatine in a mouse model of stroke. J Cereb Blood Flow Metab (2006) 0.92
Tolerance to vancomycin in pneumococci: detection with a molecular marker and assessment of clinical impact. J Infect Dis (2004) 0.91
Proteomics out of the archive: Two-dimensional electrophoresis and mass spectrometry using HOPE-fixed, paraffin-embedded tissues. J Histochem Cytochem (2009) 0.91
Genetic variation in innate immunity pathways and their potential contribution to the SIRS/CARS debate: evidence from human studies and animal models. J Innate Immun (2010) 0.90
Bacterial pore-forming cytolysins induce neuronal damage in a rat model of neonatal meningitis. J Infect Dis (2010) 0.89
The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity. Immunity (2013) 0.88
The p53-target gene puma drives neutrophil-mediated protection against lethal bacterial sepsis. PLoS Pathog (2010) 0.87
Inhibition of LPS-induced activation of alveolar macrophages by high concentrations of LPS-binding protein. Biochem Biophys Res Commun (2002) 0.87
Association of a common TLR-6 polymorphism with coronary artery disease - implications for healthy ageing? Immun Ageing (2013) 0.87
Platelet function in acute experimental pancreatitis. J Gastrointest Surg (2007) 0.86