Published in J Mol Biol on December 13, 2002
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nat Chem Biol (2010) 3.44
What determines whether mammalian ribosomes resume scanning after translation of a short upstream open reading frame? Genes Dev (2003) 2.40
Viral IRES RNA structures and ribosome interactions. Trends Biochem Sci (2008) 2.17
Viral subversion of the host protein synthesis machinery. Nat Rev Microbiol (2011) 2.07
Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Proc Natl Acad Sci U S A (2005) 2.00
The fidelity of translation initiation: reciprocal activities of eIF1, IF3 and YciH. EMBO J (2005) 1.96
RPS25 is essential for translation initiation by the Dicistroviridae and hepatitis C viral IRESs. Genes Dev (2009) 1.87
tRNA-mRNA mimicry drives translation initiation from a viral IRES. Nat Struct Mol Biol (2007) 1.84
Structural basis for ribosome recruitment and manipulation by a viral IRES RNA. Science (2006) 1.83
Toward a structural understanding of IRES RNA function. Curr Opin Struct Biol (2009) 1.83
Divergent tRNA-like element supports initiation, elongation, and termination of protein biosynthesis. Proc Natl Acad Sci U S A (2003) 1.83
Structural elements in the internal ribosome entry site of Plautia stali intestine virus responsible for binding with ribosomes. Nucleic Acids Res (2003) 1.68
An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation. J Biol Chem (2009) 1.65
Direct ribosomal binding by a cellular inhibitor of translation. Nat Struct Mol Biol (2006) 1.64
Initiation of translation by cricket paralysis virus IRES requires its translocation in the ribosome. Cell (2014) 1.62
Bridging IRES elements in mRNAs to the eukaryotic translation apparatus. Biochim Biophys Acta (2009) 1.62
rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells. Mol Cell (2011) 1.61
Position of the CrPV IRES on the 40S subunit and factor dependence of IRES/80S ribosome assembly. EMBO Rep (2004) 1.53
Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. Mol Biol Cell (2006) 1.51
L13a blocks 48S assembly: role of a general initiation factor in mRNA-specific translational control. Mol Cell (2007) 1.47
Initiation factor-independent translation mediated by the hepatitis C virus internal ribosome entry site. RNA (2006) 1.43
A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation. PLoS Pathog (2016) 1.42
A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein. Nat Struct Mol Biol (2009) 1.42
RNA regulons in Hox 5' UTRs confer ribosome specificity to gene regulation. Nature (2014) 1.38
A preformed compact ribosome-binding domain in the cricket paralysis-like virus IRES RNAs. RNA (2005) 1.38
IRES-induced conformational changes in the ribosome and the mechanism of translation initiation by internal ribosomal entry. Biochim Biophys Acta (2009) 1.34
The complete genomes of three viruses assembled from shotgun libraries of marine RNA virus communities. Virol J (2007) 1.34
Eukaryotic ribosomal protein RPS25 interacts with the conserved loop region in a dicistroviral intergenic internal ribosome entry site. Nucleic Acids Res (2007) 1.29
Unanticipated antigens: translation initiation at CUG with leucine. PLoS Biol (2004) 1.29
Viral internal ribosome entry site elements: novel ribosome-RNA complexes and roles in viral pathogenesis. J Virol (2003) 1.29
Structural organization of a viral IRES depends on the integrity of the GNRA motif. RNA (2003) 1.26
Human ribosomal protein L13a is dispensable for canonical ribosome function but indispensable for efficient rRNA methylation. RNA (2007) 1.23
Tinkering with translation: protein synthesis in virus-infected cells. Cold Spring Harb Perspect Biol (2013) 1.21
IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells. Virology (2008) 1.20
Structural variant of the intergenic internal ribosome entry site elements in dicistroviruses and computational search for their counterparts. RNA (2004) 1.19
Factor-independent assembly of elongation-competent ribosomes by an internal ribosome entry site located in an RNA virus that infects penaeid shrimp. J Virol (2005) 1.15
Conservation and diversity among the three-dimensional folds of the Dicistroviridae intergenic region IRESes. J Mol Biol (2007) 1.15
Translation initiation factors are not required for Dicistroviridae IRES function in vivo. RNA (2009) 1.12
The structures of nonprotein-coding RNAs that drive internal ribosome entry site function. Wiley Interdiscip Rev RNA (2012) 1.12
Conditional rather than absolute requirements of the capsid coding sequence for initiation of methionine-independent translation in Plautia stali intestine virus. J Virol (2003) 1.10
Host and viral translational mechanisms during cricket paralysis virus infection. J Virol (2009) 1.09
RNA structure-based ribosome recruitment: lessons from the Dicistroviridae intergenic region IRESes. RNA (2008) 1.07
Strong eukaryotic IRESs have weak secondary structure. PLoS One (2009) 1.06
Crystal structures of complexes containing domains from two viral internal ribosome entry site (IRES) RNAs bound to the 70S ribosome. Proc Natl Acad Sci U S A (2011) 1.06
Alternative reading frame selection mediated by a tRNA-like domain of an internal ribosome entry site. Proc Natl Acad Sci U S A (2012) 1.03
The dicistronic RNA from the mouse LINE-1 retrotransposon contains an internal ribosome entry site upstream of each ORF: implications for retrotransposition. Nucleic Acids Res (2006) 1.03
NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response. Cell Death Differ (2009) 1.01
hnRNPL and nucleolin bind LINE-1 RNA and function as host factors to modulate retrotransposition. Nucleic Acids Res (2012) 1.01
Modular domains of the Dicistroviridae intergenic internal ribosome entry site. RNA (2010) 1.00
Cryo-EM of ribosomal 80S complexes with termination factors reveals the translocated cricket paralysis virus IRES. Mol Cell (2015) 0.99
Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit. Nucleic Acids Res (2011) 0.99
Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA-like structural element in the ribosomal decoding center. Proc Natl Acad Sci U S A (2014) 0.99
Ribosomal protein S25 dependency reveals a common mechanism for diverse internal ribosome entry sites and ribosome shunting. Mol Cell Biol (2012) 0.99
Evidence for translational regulation by the herpes simplex virus virion host shutoff protein. J Virol (2010) 0.97
RACK1 controls IRES-mediated translation of viruses. Cell (2014) 0.95
Initiation factor eIF2-independent mode of c-Src mRNA translation occurs via an internal ribosome entry site. J Biol Chem (2009) 0.95
In vivo functional analysis of the Dicistroviridae intergenic region internal ribosome entry sites. Nucleic Acids Res (2011) 0.93
Initiation of translation in bacteria by a structured eukaryotic IRES RNA. Nature (2015) 0.93
Tricks an IRES uses to enslave ribosomes. Trends Microbiol (2012) 0.92
Mechanism of translation initiation by Dicistroviridae IGR IRESs. Virology (2011) 0.90
Purification, characterization and crystallization of the human 80S ribosome. Nucleic Acids Res (2014) 0.89
Bioinformatic evidence for a stem-loop structure 5'-adjacent to the IGR-IRES and for an overlapping gene in the bee paralysis dicistroviruses. Virol J (2009) 0.89
Translation initiation from the ribosomal A site or the P site, dependent on the conformation of RNA pseudoknot I in dicistrovirus RNAs. Mol Cell (2009) 0.89
The efficiency of selenocysteine incorporation is regulated by translation initiation factors. J Mol Biol (2010) 0.87
Stress granules in the viral replication cycle. Viruses (2011) 0.87
Mechanistic role of structurally dynamic regions in Dicistroviridae IGR IRESs. J Mol Biol (2009) 0.86
Determinants of initiation codon selection during translation in mammalian cells. PLoS One (2010) 0.86
Severe acute respiratory syndrome coronavirus protein nsp1 is a novel eukaryotic translation inhibitor that represses multiple steps of translation initiation. J Virol (2012) 0.86
Comparing the three-dimensional structures of Dicistroviridae IGR IRES RNAs with other viral RNA structures. Virus Res (2008) 0.85
Remodelling of a polypyrimidine tract-binding protein complex during apoptosis activates cellular IRESs. Cell Death Differ (2013) 0.85
Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B. RNA (2011) 0.85
Cell type specificity and structural determinants of IRES activity from the 5' leaders of different HIV-1 transcripts. Nucleic Acids Res (2013) 0.84
Magnesium-dependent folding of a picornavirus IRES element modulates RNA conformation and eIF4G interaction. FEBS J (2014) 0.84
Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome. Elife (2016) 0.84
Structural characterization of ribosome recruitment and translocation by type IV IRES. Elife (2016) 0.84
A dynamic RNA loop in an IRES affects multiple steps of elongation factor-mediated translation initiation. Elife (2015) 0.83
Structural determinants of an internal ribosome entry site that direct translational reading frame selection. Nucleic Acids Res (2014) 0.82
Global shape mimicry of tRNA within a viral internal ribosome entry site mediates translational reading frame selection. Proc Natl Acad Sci U S A (2015) 0.82
Therapeutic potential of targeting IRES-dependent c-myc translation in multiple myeloma cells during ER stress. Oncogene (2015) 0.82
Temporal Regulation of Distinct Internal Ribosome Entry Sites of the Dicistroviridae Cricket Paralysis Virus. Viruses (2016) 0.82
Temperature protects insect cells from infection by cricket paralysis virus. J Virol (2009) 0.81
The 5' leader of the mRNA encoding the mouse neurotrophin receptor TrkB contains two internal ribosomal entry sites that are differentially regulated. PLoS One (2007) 0.81
Dysregulating IRES-dependent translation contributes to overexpression of oncogenic Aurora A Kinase. Mol Cancer Res (2013) 0.81
Switch from cap- to factorless IRES-dependent 0 and +1 frame translation during cellular stress and dicistrovirus infection. PLoS One (2014) 0.80
Multiple Parallel Pathways of Translation Initiation on the CrPV IRES. Mol Cell (2016) 0.79
Insights into factorless translational initiation by the tRNA-like pseudoknot domain of a viral IRES. PLoS One (2012) 0.79
Dynamics of IRES-mediated translation. Philos Trans R Soc Lond B Biol Sci (2017) 0.78
Pantropic retroviruses as a transduction tool for sea urchin embryos. Proc Natl Acad Sci U S A (2012) 0.78
eIF4E as a control target for viruses. Viruses (2015) 0.78
Alternate rRNA secondary structures as regulators of translation. Nat Struct Mol Biol (2011) 0.77
Secondary RNA structure and nucleotide specificity contribute to internal initiation mediated by the human tau 5' leader. RNA Biol (2012) 0.77
Giardiavirus internal ribosome entry site has an apparently unique mechanism of initiating translation. PLoS One (2009) 0.76
Lentiviral vectors can be used for full-length dystrophin gene therapy. Sci Rep (2017) 0.75
Lentiviral vectors can be used for full-length dystrophin gene therapy. Sci Rep (2017) 0.75
tRNA-mimicry in IRES-mediated translation and recoding. RNA Biol (2016) 0.75
Molecular analysis of the factorless internal ribosome entry site in Cricket Paralysis virus infection. Sci Rep (2016) 0.75
Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science (2005) 16.84
LNA-mediated microRNA silencing in non-human primates. Nature (2008) 11.45
Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome. Cell Host Microbe (2008) 3.73
Biological basis for restriction of microRNA targets to the 3' untranslated region in mammalian mRNAs. Nat Struct Mol Biol (2009) 3.70
Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes: the IRES functions as an RNA-based translation factor. Cell (2004) 2.84
Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev (2005) 2.83
Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog (2010) 2.62
Regulation of internal ribosomal entry site-mediated translation by phosphorylation of the translation initiation factor eIF2alpha. J Biol Chem (2002) 2.06
Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex. Proc Natl Acad Sci U S A (2011) 2.06
Hijacking the translation apparatus by RNA viruses. J Cell Biol (2002) 2.04
Inhibition of nuclear import and alteration of nuclear pore complex composition by rhinovirus. J Virol (2002) 1.92
Modulation of hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms. J Virol (2010) 1.88
Divergent tRNA-like element supports initiation, elongation, and termination of protein biosynthesis. Proc Natl Acad Sci U S A (2003) 1.83
Preferential translation of internal ribosome entry site-containing mRNAs during the mitotic cycle in mammalian cells. J Biol Chem (2004) 1.82
Polypyrimidine tract binding protein regulates IRES-mediated gene expression during apoptosis. Mol Cell (2006) 1.71
Determinants of hepatitis C translational initiation in vitro, in cultured cells and mice. Mol Ther (2002) 1.51
Ribosomal proteins mediate the hepatitis C virus IRES-HeLa 40S interaction. RNA (2002) 1.48
The Imd pathway is involved in antiviral immune responses in Drosophila. PLoS One (2009) 1.44
Initiation factor-independent translation mediated by the hepatitis C virus internal ribosome entry site. RNA (2006) 1.43
Stable formation of compositionally unique stress granules in virus-infected cells. J Virol (2010) 1.34
Enterovirus 71 contains a type I IRES element that functions when eukaryotic initiation factor eIF4G is cleaved. Virology (2003) 1.34
OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress. Mol Cell Biol (2010) 1.28
Factor-independent assembly of elongation-competent ribosomes by an internal ribosome entry site located in an RNA virus that infects penaeid shrimp. J Virol (2005) 1.15
Modulation of hepatitis C virus RNA abundance and virus release by dispersion of processing bodies and enrichment of stress granules. Virology (2012) 1.10
Inhibition of U snRNP assembly by a virus-encoded proteinase. Genes Dev (2007) 1.09
Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension. J Exp Med (2014) 1.01
Interaction of viruses with the mammalian RNA interference pathway. Virology (2006) 0.99
How viruses avoid stress. Cell Host Microbe (2007) 0.97
Proteomic analysis of ribosomes: translational control of mRNA populations by glycogen synthase GYS1. J Mol Biol (2011) 0.92
Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens. Nature (2016) 0.92
MicroRNA silencing and the development of novel therapies for liver disease. J Hepatol (2012) 0.91
Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during poliovirus infection. J Virol (2004) 0.90
Reduced DEAF1 function during type 1 diabetes inhibits translation in lymph node stromal cells by suppressing Eif4g3. J Mol Cell Biol (2012) 0.89
LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor. J Cell Sci (2009) 0.85
MicroRNA-mediated gene silencing. Prog Mol Biol Transl Sci (2009) 0.84
Enhancement of hepatitis C viral RNA abundance by precursor miR-122 molecules. RNA (2013) 0.83
Combating hepatitis C virus by targeting microRNA-122 using locked nucleic acids. Curr Gene Ther (2012) 0.82
Escape from transcriptional shutoff during poliovirus infection: NF-κB-responsive genes IκBa and A20. J Virol (2011) 0.82
Micromanaging hepatitis C virus. N Engl J Med (2013) 0.82
Hepatitis C virus core-derived peptides inhibit genotype 1b viral genome replication via interaction with DDX3X. PLoS One (2010) 0.82
Temperature protects insect cells from infection by cricket paralysis virus. J Virol (2009) 0.81
Herpes Simplex Virus is Akt-ing in translational control. Genes Dev (2010) 0.80
Molecular biology. RNAi, Antiviral after all. Science (2013) 0.78
Plasmacytoid dendritic cells as guardians in hepatitis C virus-infected liver. Proc Natl Acad Sci U S A (2010) 0.78
RNA virus harnesses microRNAs to seize host translation control. Cell Host Microbe (2011) 0.78
Modulation of GB virus B RNA abundance by microRNA-122: dependence on and escape from microRNA-122 restriction. J Virol (2013) 0.77
Hepatitis C virus' Achilles' heel--dependence on liver-specific microRNA miR-122. Cell Res (2010) 0.75