Published in FASEB J on November 15, 2002
Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc Natl Acad Sci U S A (2004) 3.31
The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell (2005) 2.71
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment. Nat Struct Mol Biol (2004) 2.52
Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell Metab (2009) 2.45
Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem (2003) 2.17
Mitochondrial CB₁ receptors regulate neuronal energy metabolism. Nat Neurosci (2012) 2.15
Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling. J Clin Invest (2003) 2.15
Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol (2006) 2.05
PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. J Cell Biol (2006) 1.81
Adenylyl cyclase--A-kinase anchoring protein complexes: the next dimension in cAMP signaling. Mol Pharmacol (2009) 1.76
Mitochondria in heart failure. Cardiovasc Res (2010) 1.75
Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. J Cell Biol (2004) 1.68
Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. J Exp Med (2015) 1.64
Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nat Neurosci (2006) 1.41
cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells. Am J Physiol Renal Physiol (2010) 1.40
Intracellular cAMP signaling by soluble adenylyl cyclase. Kidney Int (2011) 1.40
Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. J Biol Chem (2006) 1.30
Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. J Gen Physiol (2007) 1.29
Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol (2010) 1.20
Physiological carbon dioxide, bicarbonate, and pH sensing. Pflugers Arch (2010) 1.18
Modulation of mitochondrial protein phosphorylation by soluble adenylyl cyclase ameliorates cytochrome oxidase defects. EMBO Mol Med (2009) 1.17
Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice. PLoS One (2008) 1.15
Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J Gen Physiol (2008) 1.13
Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem (2009) 1.12
HCO(3)(-)-dependent soluble adenylyl cyclase activates cystic fibrosis transmembrane conductance regulator in corneal endothelium. Am J Physiol Cell Physiol (2003) 1.09
A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC). Proc Natl Acad Sci U S A (2007) 1.08
PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells. J Biol Chem (2010) 1.07
cAMP and mitochondria. Physiology (Bethesda) (2013) 1.07
Soluble adenylyl cyclase-dependent microtubule disassembly reveals a novel mechanism of endothelial cell retraction. Am J Physiol Lung Cell Mol Physiol (2009) 1.07
Targeting G protein coupled receptor-related pathways as emerging molecular therapies. Saudi Pharm J (2013) 1.06
Sensing, physiological effects and molecular response to elevated CO2 levels in eukaryotes. J Cell Mol Med (2009) 1.06
The inner and outer compartments of mitochondria are sites of distinct cAMP/PKA signaling dynamics. J Cell Biol (2013) 1.03
Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells. J Biol Chem (2009) 1.02
Pharmacological distinction between soluble and transmembrane adenylyl cyclases. J Pharmacol Exp Ther (2013) 1.02
cAMP signaling in subcellular compartments. Pharmacol Ther (2014) 1.02
Decreased soluble adenylyl cyclase activity in cystic fibrosis is related to defective apical bicarbonate exchange and affects ciliary beat frequency regulation. J Biol Chem (2010) 0.98
Conservation of functional domain structure in bicarbonate-regulated "soluble" adenylyl cyclases in bacteria and eukaryotes. Dev Genes Evol (2004) 0.96
Molecular mechanisms of acid-base sensing by the kidney. J Am Soc Nephrol (2012) 0.96
CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor. J Biol Chem (2013) 0.94
Intracellular pH in sperm physiology. Biochem Biophys Res Commun (2014) 0.92
Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases. J Invest Dermatol (2010) 0.92
Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits. Front Cell Neurosci (2014) 0.91
Particulate and soluble adenylyl cyclases participate in the sperm acrosome reaction. Biochem Biophys Res Commun (2007) 0.91
[HCO3-]-regulated expression and activity of soluble adenylyl cyclase in corneal endothelial and Calu-3 cells. BMC Physiol (2004) 0.89
Neuronal expression of soluble adenylyl cyclase in the mammalian brain. Brain Res (2013) 0.89
beta-Adrenergic activation of electrogenic K+ and Cl- secretion in guinea pig distal colonic epithelium proceeds via separate cAMP signaling pathways. Am J Physiol Gastrointest Liver Physiol (2010) 0.88
Inhibition of osteoclast formation and function by bicarbonate: role of soluble adenylyl cyclase. J Cell Physiol (2009) 0.88
Protein kinase A-Iα regulates Na,K-ATPase endocytosis in alveolar epithelial cells exposed to high CO(2) concentrations. Am J Respir Cell Mol Biol (2013) 0.87
Physiological sensing of carbon dioxide/bicarbonate/pH via cyclic nucleotide signaling. Sensors (Basel) (2011) 0.87
A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors. Nat Commun (2016) 0.87
"Soluble" adenylyl cyclase-generated cyclic adenosine monophosphate promotes fast migration in PC12 cells. J Neurosci Res (2008) 0.87
Mitochondrial protein phosphorylation as a regulatory modality: implications for mitochondrial dysfunction in heart failure. Congest Heart Fail (2011) 0.87
Soluble adenylyl cyclase antibody profile as a diagnostic adjunct in the assessment of pigmented lesions. Arch Dermatol (2011) 0.86
pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC). Front Physiol (2013) 0.86
Type 10 soluble adenylyl cyclase is overexpressed in prostate carcinoma and controls proliferation of prostate cancer cells. J Biol Chem (2012) 0.86
Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling. PLoS One (2011) 0.85
Soluble adenylyl cyclase mediates bicarbonate-dependent corneal endothelial cell protection. Am J Physiol Cell Physiol (2010) 0.85
International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases. Pharmacol Rev (2017) 0.83
"cAMP sponge": a buffer for cyclic adenosine 3', 5'-monophosphate. PLoS One (2009) 0.83
Requirement of cAMP signaling for Schwann cell differentiation restricts the onset of myelination. PLoS One (2015) 0.83
Regulation of proximal tubule vacuolar H(+)-ATPase by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol (2014) 0.83
Soluble Adenylyl Cyclase Regulates Bile Salt-Induced Apoptosis in Human Cholangiocytes. Hepatology (2016) 0.83
Role of soluble adenylyl cyclase in the heart. Am J Physiol Heart Circ Physiol (2011) 0.83
Signaling Interactions in the Adrenal Cortex. Front Endocrinol (Lausanne) (2016) 0.83
Genetically-encoded yellow fluorescent cAMP indicator with an expanded dynamic range for dual-color imaging. PLoS One (2014) 0.82
Calpain-Mediated Processing of Adenylate Cyclase Toxin Generates a Cytosolic Soluble Catalytically Active N-Terminal Domain. PLoS One (2013) 0.82
Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation. Invest Ophthalmol Vis Sci (2016) 0.82
A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout mice. Am J Respir Cell Mol Biol (2014) 0.81
Role of soluble adenylyl cyclase in mitochondria. Biochim Biophys Acta (2014) 0.81
Investigation of cAMP microdomains as a path to novel cancer diagnostics. Biochim Biophys Acta (2014) 0.81
Established and potential physiological roles of bicarbonate-sensing soluble adenylyl cyclase (sAC) in aquatic animals. J Exp Biol (2014) 0.80
Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanisms. J Nutr Biochem (2010) 0.80
Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors. J Neurosci (2014) 0.80
Cancer cell growth and survival as a system-level property sustained by enhanced glycolysis and mitochondrial metabolic remodeling. Front Physiol (2012) 0.80
Expression of soluble adenylyl cyclase in lentigo maligna: use of immunohistochemistry with anti-soluble adenylyl cyclase antibody (R21) in diagnosis of lentigo maligna and assessment of margins. Arch Pathol Lab Med (2012) 0.80
A cardiac mitochondrial cAMP signaling pathway regulates calcium accumulation, permeability transition and cell death. Cell Death Dis (2016) 0.79
Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells. PLoS One (2012) 0.78
Soluble adenylyl cyclase in health and disease. Biochim Biophys Acta (2014) 0.78
New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice. Biochim Biophys Acta (2014) 0.78
Bicarbonate disruption of the pulmonary endothelial barrier via activation of endogenous soluble adenylyl cyclase, isoform 10. Am J Physiol Lung Cell Mol Physiol (2013) 0.78
Mitochondrial remodeling: Rearranging, recycling, and reprogramming. Cell Calcium (2016) 0.77
Protein Kinase A Governs Oxidative Phosphorylation Kinetics and Oxidant Emitting Potential at Complex I. Front Physiol (2015) 0.77
Soluble adenylyl cyclase of sea urchin spermatozoa. Biochim Biophys Acta (2014) 0.77
Adenylyl cyclases in the digestive system. Cell Signal (2014) 0.77
Chromodomain helicase binding protein 8 (Chd8) is a novel A-kinase anchoring protein expressed during rat cardiac development. PLoS One (2012) 0.77
The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein. Oncotarget (2016) 0.76
Mitochondrial cAMP signaling. Cell Mol Life Sci (2016) 0.76
Intracellular localization of "soluble" adenylate cyclase in potato plants. Dokl Biol Sci (2008) 0.76
Cannabinoid CB1 Receptors Are Localized in Striated Muscle Mitochondria and Regulate Mitochondrial Respiration. Front Physiol (2016) 0.75
Bicarbonate-sensing soluble adenylyl cyclase is present in the cell cytoplasm and nucleus of multiple shark tissues. Physiol Rep (2017) 0.75
Lipopolysaccharide-induced pulmonary endothelial barrier disruption and lung edema: critical role for bicarbonate stimulation of AC10. Am J Physiol Lung Cell Mol Physiol (2015) 0.75
Stimulation of oxidative phosphorylation by calcium in cardiac mitochondria is not influenced by cAMP and PKA activity. Biochim Biophys Acta (2014) 0.75
Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells. Am J Physiol Renal Physiol (2016) 0.75
Control of outflow resistance by soluble adenylyl cyclase. J Ocul Pharmacol Ther (2013) 0.75
The V-ATPase is expressed in the choroid plexus and mediates cAMP-induced intracellular pH alterations. Physiol Rep (2017) 0.75
The Emerging Role of Soluble Adenylyl Cyclase in Primary Biliary Cholangitis. Dig Dis (2017) 0.75
The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell (2005) 2.71
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment. Nat Struct Mol Biol (2004) 2.52
Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell Metab (2009) 2.45
Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence. Curr Biol (2005) 2.42
Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate. J Biol Chem (2003) 2.41
Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem (2003) 2.17
Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol (2006) 2.05
Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice. J Neurosci (2005) 1.79
Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. J Cell Biol (2004) 1.68
A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily. Pharmacogenetics (2004) 1.65
Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nat Neurosci (2006) 1.41
Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1. Eukaryot Cell (2006) 1.41
Intracellular cAMP signaling by soluble adenylyl cyclase. Kidney Int (2011) 1.40
Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase. Neuron (2012) 1.36
Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. J Biol Chem (2006) 1.30
Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. J Gen Physiol (2007) 1.29
A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen. J Biol Chem (2005) 1.28
Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils. J Exp Med (2005) 1.25
Physiological carbon dioxide, bicarbonate, and pH sensing. Pflugers Arch (2010) 1.18
The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans. Eukaryot Cell (2011) 1.18
DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures. RNA (2010) 1.15
Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice. PLoS One (2008) 1.15
CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans. PLoS Pathog (2010) 1.15
Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J Gen Physiol (2008) 1.13
The C-terminal IgI domains of myosin-binding proteins C and H (MyBP-C and MyBP-H) are both necessary and sufficient for the intracellular crosslinking of sarcomeric myosin in transfected non-muscle cells. J Cell Sci (2002) 1.13
Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem (2009) 1.12
HCO(3)(-)-dependent soluble adenylyl cyclase activates cystic fibrosis transmembrane conductance regulator in corneal endothelium. Am J Physiol Cell Physiol (2003) 1.09
Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis. Proc Natl Acad Sci U S A (2009) 1.08
A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. J Biol Chem (2011) 1.07
Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients. Br J Nutr (2009) 1.07
cAMP and mitochondria. Physiology (Bethesda) (2013) 1.07
DiGeorge critical region 8 (DGCR8) is a double-cysteine-ligated heme protein. J Biol Chem (2011) 1.06
Evidence for an extracellular matrix bridge guiding proepicardial cell migration to the myocardium of chick embryos. Dev Dyn (2003) 1.05
Autoinhibitory regulation of soluble adenylyl cyclase. Mol Reprod Dev (2006) 1.04
Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing. Proc Natl Acad Sci U S A (2012) 1.02
Pharmacological distinction between soluble and transmembrane adenylyl cyclases. J Pharmacol Exp Ther (2013) 1.02
An integrated intervention program to control diabetes in overweight Chinese women and men with type 2 diabetes. Asia Pac J Clin Nutr (2008) 0.99
Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body. J Biol Chem (2011) 0.98
Effects of a flaxseed-derived lignan supplement in type 2 diabetic patients: a randomized, double-blind, cross-over trial. PLoS One (2007) 0.98
Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem (2008) 0.97
Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis. FASEB J (2009) 0.97
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate. Proc Natl Acad Sci U S A (2014) 0.96
Conservation of functional domain structure in bicarbonate-regulated "soluble" adenylyl cyclases in bacteria and eukaryotes. Dev Genes Evol (2004) 0.96
CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor. J Biol Chem (2013) 0.94
Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases. J Invest Dermatol (2010) 0.92
Regulation of intermediary metabolism by the PKCdelta signalosome in mitochondria. FASEB J (2010) 0.91
Purification of soluble adenylyl cyclase. Methods Enzymol (2002) 0.91
Particulate and soluble adenylyl cyclases participate in the sperm acrosome reaction. Biochem Biophys Res Commun (2007) 0.91
Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP-1-dependent energy deprivation. FASEB J (2008) 0.90
Platelet-derived growth factor-AB promotes the generation of adult bone marrow-derived cardiac myocytes. Circ Res (2004) 0.90