Published in Proc Natl Acad Sci U S A on February 24, 2014
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Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling. J Cell Biol (2016) 0.83
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Ae4 (Slc4a9) Anion Exchanger Drives Cl- Uptake-dependent Fluid Secretion by Mouse Submandibular Gland Acinar Cells. J Biol Chem (2015) 0.81
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New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice. Biochim Biophys Acta (2014) 0.78
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Distinct roles of soluble and transmembrane adenylyl cyclases in the regulation of flagellar motility in Ciona sperm. Int J Mol Sci (2014) 0.77
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Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site. J Biol Chem (2016) 0.76
Soluble adenylyl cyclase is essential for proper lysosomal acidification. J Gen Physiol (2016) 0.75
New structural forms of a mycobacterial adenylyl cyclase Rv1625c. IUCrJ (2014) 0.75
The YHS-Domain of an Adenylyl Cyclase from Mycobacterium phlei Is a Probable Copper-Sensor Module. PLoS One (2015) 0.75
Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat Chem Biol (2016) 0.75
Regulation by the quorum sensor from Vibrio indicates a receptor function for the membrane anchors of adenylate cyclases. Elife (2016) 0.75
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Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Proc Natl Acad Sci U S A (2004) 2.62
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Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell Metab (2009) 2.45
Facilities for macromolecular crystallography at the Helmholtz-Zentrum Berlin. J Synchrotron Radiat (2012) 2.43
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Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa. Proc Natl Acad Sci U S A (2003) 1.99
Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase. J Biol Chem (2001) 1.73
Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. J Cell Biol (2004) 1.68
Capturing adenylyl cyclases as potential drug targets. Nat Rev Drug Discov (2009) 1.66
Crystal structure of the guanylyl cyclase Cya2. Proc Natl Acad Sci U S A (2008) 1.44
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Intracellular cAMP signaling by soluble adenylyl cyclase. Kidney Int (2011) 1.40
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Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c. EMBO J (2005) 1.23
Physiological carbon dioxide, bicarbonate, and pH sensing. Pflugers Arch (2010) 1.18
SH3 domain ligand binding: What's the consensus and where's the specificity? FEBS Lett (2012) 1.18
CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans. PLoS Pathog (2010) 1.15
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Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J Gen Physiol (2008) 1.13
Metal and metal-ATP interactions with brain and cardiac adenylate cyclases. J Biol Chem (1975) 1.08
Structural basis for inhibition of mammalian adenylyl cyclase by calcium. Biochemistry (2009) 1.06
Autoinhibitory regulation of soluble adenylyl cyclase. Mol Reprod Dev (2006) 1.04
Mitochondrial Ca²⁺ uptake induces cyclic AMP generation in the matrix and modulates organelle ATP levels. Cell Metab (2013) 1.04
Pharmacological distinction between soluble and transmembrane adenylyl cyclases. J Pharmacol Exp Ther (2013) 1.02
Spatial control of cAMP signalling in health and disease. Curr Opin Pharmacol (2011) 0.98
Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem (2008) 0.97
Conservation of functional domain structure in bicarbonate-regulated "soluble" adenylyl cyclases in bacteria and eukaryotes. Dev Genes Evol (2004) 0.96
CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor. J Biol Chem (2013) 0.94
Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases. J Invest Dermatol (2010) 0.92
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Type 10 soluble adenylyl cyclase is overexpressed in prostate carcinoma and controls proliferation of prostate cancer cells. J Biol Chem (2012) 0.86
Computational and structural characterisation of protein associations. Adv Exp Med Biol (2012) 0.83
Identification of a haem domain in human soluble adenylate cyclase. Biosci Rep (2012) 0.83
Expression, purification, crystallization and preliminary X-ray diffraction analysis of a mammalian type 10 adenylyl cyclase. Acta Crystallogr F Struct Biol Commun (2014) 0.79
X-ray phase imaging with a grating interferometer. Opt Express (2005) 5.70
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. J Mol Biol (2008) 3.27
Structural insight into filament formation by mammalian septins. Nature (2007) 2.90
The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell (2005) 2.71
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment. Nat Struct Mol Biol (2004) 2.52
Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell Metab (2009) 2.45
Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence. Curr Biol (2005) 2.42
Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate. J Biol Chem (2003) 2.41
Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. FASEB J (2002) 2.40
Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem (2003) 2.17
The GTPase-activating protein Rap1GAP uses a catalytic asparagine. Nature (2004) 2.06
Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol (2006) 2.05
Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons? Hum Mol Genet (2002) 2.05
Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB. Cell (2007) 2.02
First successful implantation of a biodegradable metal stent into the left pulmonary artery of a preterm baby. Catheter Cardiovasc Interv (2005) 1.89
VEGFR-1-selective VEGF homologue PlGF is arteriogenic: evidence for a monocyte-mediated mechanism. Circ Res (2003) 1.82
Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice. J Neurosci (2005) 1.79
Extending the host range of Listeria monocytogenes by rational protein design. Cell (2007) 1.76
Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans. EMBO J (2005) 1.74
Human homozygous R403W mutant cardiac myosin presents disproportionate enhancement of mechanical and enzymatic properties. J Mol Cell Cardiol (2004) 1.72
Metabolomic profile of human myocardial ischemia by nuclear magnetic resonance spectroscopy of peripheral blood serum: a translational study based on transient coronary occlusion models. J Am Coll Cardiol (2012) 1.70
Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. J Cell Biol (2004) 1.68
Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy. Mol Cell (2007) 1.67
A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily. Pharmacogenetics (2004) 1.65
Augmented expression of cardiotrophin-1 in failing human hearts is accompanied by diminished glycoprotein 130 receptor protein abundance. Circulation (2002) 1.65
Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase. EMBO J (2008) 1.62
Right ventricular involvement in anterior myocardial infarction: a translational approach. Cardiovasc Res (2010) 1.54
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol Cell (2013) 1.52
Crystal structure of the guanylyl cyclase Cya2. Proc Natl Acad Sci U S A (2008) 1.44
Cardiac grafting of engineered heart tissue in syngenic rats. Circulation (2002) 1.43
Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nat Neurosci (2006) 1.41
Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1. Eukaryot Cell (2006) 1.41
Intracellular cAMP signaling by soluble adenylyl cyclase. Kidney Int (2011) 1.40
Recommendations for improving the quality of the interdisciplinary medical care of grown-ups with congenital heart disease (GUCH). Int J Cardiol (2010) 1.39
Phase tomography from x-ray coherent diffractive imaging projections. Opt Express (2011) 1.38
Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis. EMBO J (2007) 1.38
Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase. Neuron (2012) 1.36
A common toxin fold mediates microbial attack and plant defense. Proc Natl Acad Sci U S A (2009) 1.35
Characterization of high-resolution diffractive X-ray optics by ptychographic coherent diffractive imaging. Opt Express (2011) 1.31
Primary and metastatic cardiac tumors: imaging characteristics, surgical treatment, and histopathological spectrum: a 10-year-experience at a German heart center. Cardiovasc Pathol (2012) 1.31
Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. J Biol Chem (2006) 1.30
Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. J Gen Physiol (2007) 1.29
A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen. J Biol Chem (2005) 1.28
A molecular mechanism for direct sirtuin activation by resveratrol. PLoS One (2012) 1.26
Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils. J Exp Med (2005) 1.25
Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization. J Mol Biol (2003) 1.19
Structure-based development of novel sirtuin inhibitors. Aging (Albany NY) (2011) 1.19
The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans. Eukaryot Cell (2011) 1.18
Physiological carbon dioxide, bicarbonate, and pH sensing. Pflugers Arch (2010) 1.18
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Proc Natl Acad Sci U S A (2013) 1.18
Dietary restriction: standing up for sirtuins. Science (2010) 1.17
Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice. PLoS One (2008) 1.15
CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans. PLoS Pathog (2010) 1.15
Primary and metastatic cardiac sarcomas: a 12-year experience at a German heart center. Int J Clin Exp Pathol (2012) 1.13
Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J Gen Physiol (2008) 1.13
Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem (2009) 1.12
Translation position determination in ptychographic coherent diffraction imaging. Opt Express (2013) 1.10
Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison. Biol Chem (2003) 1.10
Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer. FEBS Lett (2010) 1.10
HCO(3)(-)-dependent soluble adenylyl cyclase activates cystic fibrosis transmembrane conductance regulator in corneal endothelium. Am J Physiol Cell Physiol (2003) 1.09
High-throughput ptychography using Eiger: scanning X-ray nano-imaging of extended regions. Opt Express (2014) 1.08
Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis. Proc Natl Acad Sci U S A (2009) 1.08
Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency. Metabolism (2002) 1.08
Human metastasis regulator protein H-prune is a short-chain exopolyphosphatase. Biochemistry (2008) 1.08
A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. J Biol Chem (2011) 1.07
cAMP and mitochondria. Physiology (Bethesda) (2013) 1.07
The Lifespan-regulator p66Shc in mitochondria: redox enzyme or redox sensor? Antioxid Redox Signal (2010) 1.06
Influence of inflow cannula length in axial-flow pumps on neurologic adverse event rate: results from a multi-center analysis. J Heart Lung Transplant (2008) 1.06