Published in J Biol Chem on October 07, 2013
cAMP signaling in subcellular compartments. Pharmacol Ther (2014) 1.02
Pharmacological distinction between soluble and transmembrane adenylyl cyclases. J Pharmacol Exp Ther (2013) 1.02
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate. Proc Natl Acad Sci U S A (2014) 0.96
Central role of soluble adenylyl cyclase and cAMP in sperm physiology. Biochim Biophys Acta (2014) 0.94
pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC). Front Physiol (2013) 0.86
Proton Fall or Bicarbonate Rise: GLYCOLYTIC RATE IN MOUSE ASTROCYTES IS PAVED BY INTRACELLULAR ALKALINIZATION. J Biol Chem (2016) 0.83
Role of soluble adenylyl cyclase in mitochondria. Biochim Biophys Acta (2014) 0.81
Investigation of cAMP microdomains as a path to novel cancer diagnostics. Biochim Biophys Acta (2014) 0.81
The role of soluble adenylyl cyclase in neurite outgrowth. Biochim Biophys Acta (2014) 0.81
Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors. J Neurosci (2014) 0.80
Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion. Mol Endocrinol (2015) 0.80
Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase A. Mol Metab (2015) 0.80
New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice. Biochim Biophys Acta (2014) 0.78
Soluble adenylyl cyclase in health and disease. Biochim Biophys Acta (2014) 0.78
Adenylyl cyclases in the digestive system. Cell Signal (2014) 0.77
Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site. J Biol Chem (2016) 0.76
The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein. Oncotarget (2016) 0.76
Mitochondrial cAMP signaling. Cell Mol Life Sci (2016) 0.76
Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat Chem Biol (2016) 0.75
The Catsper channel and its roles in male fertility: a systematic review. Reprod Biol Endocrinol (2017) 0.75
Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab (1965) 14.95
Physiological concentrations of purines and pyrimidines. Mol Cell Biochem (1994) 6.95
Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science (2000) 5.36
Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology (2003) 5.09
Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. Proc Natl Acad Sci U S A (1999) 3.26
Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis. Obes Res (2004) 3.05
Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. Endocrinology (2003) 2.86
cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol (2000) 2.83
The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell (2005) 2.71
Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Proc Natl Acad Sci U S A (2004) 2.62
Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell Metab (2009) 2.45
Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate. J Biol Chem (2003) 2.41
Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. FASEB J (2002) 2.40
Calcium-independent potentiation of insulin release by cyclic AMP in single beta-cells. Nature (1993) 2.40
Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell. Diabetes (2004) 2.17
Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem (2003) 2.17
Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells. J Biol Chem (2002) 2.12
Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells. J Physiol (1997) 2.06
Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol (2006) 2.05
Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa. Proc Natl Acad Sci U S A (2003) 1.99
Metabolic cycling in control of glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab (2008) 1.99
Oscillations of cyclic AMP in hormone-stimulated insulin-secreting beta-cells. Nature (2006) 1.98
Glucose-stimulated signaling pathways in biphasic insulin secretion. Diabetes Metab Res Rev (2002) 1.96
Dynamics of insulin secretion and the clinical implications for obesity and diabetes. J Clin Invest (2011) 1.90
Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis. J Biol Chem (2002) 1.85
Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line. J Biol Chem (2005) 1.80
Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase. J Biol Chem (2001) 1.73
Nutrient-secretion coupling in the pancreatic islet beta-cell: recent advances. Mol Aspects Med (2001) 1.70
Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. J Cell Biol (2004) 1.68
Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis. J Biol Chem (2003) 1.66
CO(2)/HCO(3)(-)-responsive soluble adenylyl cyclase as a putative metabolic sensor. Trends Endocrinol Metab (2001) 1.52
Insulin secretion. Interrelationships of glucose, cyclic adenosine 3:5-monophosphate, and calcium. J Biol Chem (1975) 1.50
Adenosine 3',5'-monophosphate in pancreatic islets: glucose-induced insulin release. Science (1973) 1.43
Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nat Neurosci (2006) 1.41
cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells. Am J Physiol Renal Physiol (2010) 1.40
Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase. Neuron (2012) 1.36
Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion. Cell Metab (2008) 1.33
Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation. Cell Metab (2011) 1.29
A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen. J Biol Chem (2005) 1.28
Glucose- and hormone-induced cAMP oscillations in α- and β-cells within intact pancreatic islets. Diabetes (2011) 1.25
Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells. Am J Physiol Renal Physiol (2007) 1.21
Physiological carbon dioxide, bicarbonate, and pH sensing. Pflugers Arch (2010) 1.18
Multiple forms of adenylate cyclase. Adv Cyclic Nucleotide Res (1978) 1.16
Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J Gen Physiol (2008) 1.13
Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues. J Biol Chem (2002) 1.12
Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism. Proc Natl Acad Sci U S A (2003) 1.11
Mitochondrial Ca²⁺ uptake induces cyclic AMP generation in the matrix and modulates organelle ATP levels. Cell Metab (2013) 1.04
The inner and outer compartments of mitochondria are sites of distinct cAMP/PKA signaling dynamics. J Cell Biol (2013) 1.03
Purification of soluble form of adenylyl cyclase from testes. Methods Enzymol (1991) 1.02
Pharmacological distinction between soluble and transmembrane adenylyl cyclases. J Pharmacol Exp Ther (2013) 1.02
Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body. J Biol Chem (2011) 0.98
Expression of carbonic anhydrase V in pancreatic beta cells suggests role for mitochondrial carbonic anhydrase in insulin secretion. J Biol Chem (1998) 0.91
Neuronal expression of soluble adenylyl cyclase in the mammalian brain. Brain Res (2013) 0.89
Cyclic AMP dynamics in the pancreatic β-cell. Ups J Med Sci (2012) 0.84
The effect of divalent cations on bovine spermatozoal adenylate cyclase activity. J Cyclic Nucleotide Res (1975) 0.82
X-ray phase imaging with a grating interferometer. Opt Express (2005) 5.70
FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J Biol Chem (2006) 3.35
A controlled high-fat diet induces an obese syndrome in rats. J Nutr (2003) 2.80
The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell (2005) 2.71
In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest (2003) 2.63
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment. Nat Struct Mol Biol (2004) 2.52
Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell Metab (2009) 2.45
Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence. Curr Biol (2005) 2.42
Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate. J Biol Chem (2003) 2.41
Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. FASEB J (2002) 2.40
Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment. Blood (2002) 2.28
Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem (2003) 2.17
Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells. J Biol Chem (2002) 2.12
Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol (2006) 2.05
CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood. J Clin Invest (2005) 2.04
A novel, noninvasive method for the measurement of intestinal fat absorption. Gastroenterology (2004) 2.02
Glucose-stimulated signaling pathways in biphasic insulin secretion. Diabetes Metab Res Rev (2002) 1.96
Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line. J Biol Chem (2005) 1.80
Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice. J Neurosci (2005) 1.79
Metabolomic profile of human myocardial ischemia by nuclear magnetic resonance spectroscopy of peripheral blood serum: a translational study based on transient coronary occlusion models. J Am Coll Cardiol (2012) 1.70
Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. J Cell Biol (2004) 1.68
CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine. Gastroenterology (2006) 1.67
Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. Biol Psychiatry (2006) 1.67
Apolipoprotein A-IV inhibits experimental colitis. J Clin Invest (2004) 1.66
Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study. Am J Clin Nutr (2010) 1.66
A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily. Pharmacogenetics (2004) 1.65
Sleeve gastrectomy in rats improves postprandial lipid clearance by reducing intestinal triglyceride secretion. Gastroenterology (2011) 1.64
Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells. Biochem J (2003) 1.58
Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism. J Gastrointest Surg (2009) 1.54
Right ventricular involvement in anterior myocardial infarction: a translational approach. Cardiovasc Res (2010) 1.54
Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. Am J Physiol Gastrointest Liver Physiol (2010) 1.54
Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins. Nat Med (2007) 1.51
Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion. Diabetes (2002) 1.47
Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. Prostaglandins Leukot Essent Fatty Acids (2011) 1.46
Consumption of a high-fat diet alters the homeostatic regulation of energy balance. Physiol Behav (2004) 1.43
Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nat Neurosci (2006) 1.41
Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1. Eukaryot Cell (2006) 1.41
Intracellular cAMP signaling by soluble adenylyl cyclase. Kidney Int (2011) 1.40
A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells. J Physiol (2005) 1.40
GATA4 is essential for jejunal function in mice. Gastroenterology (2008) 1.39
Phase tomography from x-ray coherent diffractive imaging projections. Opt Express (2011) 1.38
Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase. Neuron (2012) 1.36
cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells. J Physiol (2006) 1.36
Characterization of high-resolution diffractive X-ray optics by ptychographic coherent diffractive imaging. Opt Express (2011) 1.31
Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet. J Biol Chem (2008) 1.31
Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. J Biol Chem (2006) 1.30
Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. J Gen Physiol (2007) 1.29
A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen. J Biol Chem (2005) 1.28
Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc Natl Acad Sci U S A (2012) 1.27
Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system. Am J Physiol Regul Integr Comp Physiol (2007) 1.27
Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice. Am J Physiol Gastrointest Liver Physiol (2008) 1.26
Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils. J Exp Med (2005) 1.25
Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. Am J Physiol Regul Integr Comp Physiol (2005) 1.23
Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder. J Affect Disord (2010) 1.23
Assessment of feeding behavior in laboratory mice. Cell Metab (2010) 1.22
A novel cyclic adenosine monophosphate responsive luciferase reporter incorporating a nonpalindromic cyclic adenosine monophosphate response element provides optimal performance for use in G protein coupled receptor drug discovery efforts. J Biomol Screen (2007) 1.20
Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells. Prog Biophys Mol Biol (2011) 1.20
GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats. Am J Physiol Gastrointest Liver Physiol (2005) 1.18
Why does the gut choose apolipoprotein B48 but not B100 for chylomicron formation? Am J Physiol Gastrointest Liver Physiol (2007) 1.18
Physiological carbon dioxide, bicarbonate, and pH sensing. Pflugers Arch (2010) 1.18
The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans. Eukaryot Cell (2011) 1.18
Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. Psychiatry Res (2008) 1.17
Stimulation of insulin release by glucose is associated with an increase in the number of docked granules in the beta-cells of rat pancreatic islets. Diabetes (2004) 1.16
Amplification of exocytosis by Ca2+-induced Ca2+ release in INS-1 pancreatic beta cells. J Physiol (2003) 1.16
Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats. Diabetes (2010) 1.15
DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures. RNA (2010) 1.15
Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice. PLoS One (2008) 1.15
CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans. PLoS Pathog (2010) 1.15
Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM. J Biol Chem (2009) 1.13
Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J Gen Physiol (2008) 1.13