Published in J Cell Biol on February 09, 2004
Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc Natl Acad Sci U S A (2004) 3.31
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment. Nat Struct Mol Biol (2004) 2.52
Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol (2006) 2.05
Intracellular cAMP signaling by soluble adenylyl cyclase. Kidney Int (2011) 1.40
Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. J Biol Chem (2006) 1.30
Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. J Gen Physiol (2007) 1.29
Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP. Nat Chem Biol (2012) 1.20
Physiological carbon dioxide, bicarbonate, and pH sensing. Pflugers Arch (2010) 1.18
Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice. PLoS One (2008) 1.15
Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J Gen Physiol (2008) 1.13
Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem (2009) 1.12
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A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. J Biol Chem (2011) 1.07
Soluble adenylyl cyclase activity is necessary for retinal ganglion cell survival and axon growth. J Neurosci (2012) 1.07
Targeting G protein coupled receptor-related pathways as emerging molecular therapies. Saudi Pharm J (2013) 1.06
Sensing, physiological effects and molecular response to elevated CO2 levels in eukaryotes. J Cell Mol Med (2009) 1.06
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Conservation of functional domain structure in bicarbonate-regulated "soluble" adenylyl cyclases in bacteria and eukaryotes. Dev Genes Evol (2004) 0.96
CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor. J Biol Chem (2013) 0.94
Intracellular monovalent ions as second messengers. J Membr Biol (2006) 0.94
Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases. J Invest Dermatol (2010) 0.92
Neuronal expression of soluble adenylyl cyclase in the mammalian brain. Brain Res (2013) 0.89
Lipoic acid attenuates inflammation via cAMP and protein kinase A signaling. PLoS One (2010) 0.88
Physiological sensing of carbon dioxide/bicarbonate/pH via cyclic nucleotide signaling. Sensors (Basel) (2011) 0.87
Modulation of NaCl absorption by [HCO(3)(-)] in the marine teleost intestine is mediated by soluble adenylyl cyclase. Am J Physiol Regul Integr Comp Physiol (2010) 0.87
"Soluble" adenylyl cyclase-generated cyclic adenosine monophosphate promotes fast migration in PC12 cells. J Neurosci Res (2008) 0.87
Soluble adenylyl cyclase antibody profile as a diagnostic adjunct in the assessment of pigmented lesions. Arch Dermatol (2011) 0.86
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Requirement of cAMP signaling for Schwann cell differentiation restricts the onset of myelination. PLoS One (2015) 0.83
Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling. J Cell Biol (2016) 0.83
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Investigation of cAMP microdomains as a path to novel cancer diagnostics. Biochim Biophys Acta (2014) 0.81
The role of soluble adenylyl cyclase in neurite outgrowth. Biochim Biophys Acta (2014) 0.81
Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanisms. J Nutr Biochem (2010) 0.80
Established and potential physiological roles of bicarbonate-sensing soluble adenylyl cyclase (sAC) in aquatic animals. J Exp Biol (2014) 0.80
Expression of soluble adenylyl cyclase in lentigo maligna: use of immunohistochemistry with anti-soluble adenylyl cyclase antibody (R21) in diagnosis of lentigo maligna and assessment of margins. Arch Pathol Lab Med (2012) 0.80
Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors. J Neurosci (2014) 0.80
Expression, purification, crystallization and preliminary X-ray diffraction analysis of a mammalian type 10 adenylyl cyclase. Acta Crystallogr F Struct Biol Commun (2014) 0.79
New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice. Biochim Biophys Acta (2014) 0.78
Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells. PLoS One (2012) 0.78
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Chromodomain helicase binding protein 8 (Chd8) is a novel A-kinase anchoring protein expressed during rat cardiac development. PLoS One (2012) 0.77
Soluble adenylyl cyclase of sea urchin spermatozoa. Biochim Biophys Acta (2014) 0.77
The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein. Oncotarget (2016) 0.76
Lipopolysaccharide-induced pulmonary endothelial barrier disruption and lung edema: critical role for bicarbonate stimulation of AC10. Am J Physiol Lung Cell Mol Physiol (2015) 0.75
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Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment. Nat Struct Mol Biol (2004) 2.52
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Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence. Curr Biol (2005) 2.42
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Intracellular cAMP signaling by soluble adenylyl cyclase. Kidney Int (2011) 1.40
Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase. Neuron (2012) 1.36
Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. J Biol Chem (2006) 1.30
Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. J Gen Physiol (2007) 1.29
A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen. J Biol Chem (2005) 1.28
Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils. J Exp Med (2005) 1.25
Physiological carbon dioxide, bicarbonate, and pH sensing. Pflugers Arch (2010) 1.18
The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans. Eukaryot Cell (2011) 1.18
Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice. PLoS One (2008) 1.15
CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans. PLoS Pathog (2010) 1.15
Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J Gen Physiol (2008) 1.13
The C-terminal IgI domains of myosin-binding proteins C and H (MyBP-C and MyBP-H) are both necessary and sufficient for the intracellular crosslinking of sarcomeric myosin in transfected non-muscle cells. J Cell Sci (2002) 1.13
Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem (2009) 1.12
The psychological functions of music listening. Front Psychol (2013) 1.11
HCO(3)(-)-dependent soluble adenylyl cyclase activates cystic fibrosis transmembrane conductance regulator in corneal endothelium. Am J Physiol Cell Physiol (2003) 1.09
Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis. Proc Natl Acad Sci U S A (2009) 1.08
A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. J Biol Chem (2011) 1.07
cAMP and mitochondria. Physiology (Bethesda) (2013) 1.07
Evidence for an extracellular matrix bridge guiding proepicardial cell migration to the myocardium of chick embryos. Dev Dyn (2003) 1.05
Autoinhibitory regulation of soluble adenylyl cyclase. Mol Reprod Dev (2006) 1.04
Pharmacological distinction between soluble and transmembrane adenylyl cyclases. J Pharmacol Exp Ther (2013) 1.02
Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body. J Biol Chem (2011) 0.98
Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis. FASEB J (2009) 0.97
Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem (2008) 0.97
Conservation of functional domain structure in bicarbonate-regulated "soluble" adenylyl cyclases in bacteria and eukaryotes. Dev Genes Evol (2004) 0.96
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate. Proc Natl Acad Sci U S A (2014) 0.96
CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor. J Biol Chem (2013) 0.94
Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases. J Invest Dermatol (2010) 0.92
Regulation of intermediary metabolism by the PKCdelta signalosome in mitochondria. FASEB J (2010) 0.91
Purification of soluble adenylyl cyclase. Methods Enzymol (2002) 0.91
Particulate and soluble adenylyl cyclases participate in the sperm acrosome reaction. Biochem Biophys Res Commun (2007) 0.91
Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP-1-dependent energy deprivation. FASEB J (2008) 0.90
Neuronal expression of soluble adenylyl cyclase in the mammalian brain. Brain Res (2013) 0.89
Stimulation of mammalian G-protein-responsive adenylyl cyclases by carbon dioxide. J Biol Chem (2008) 0.88
Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa. J Mol Biol (2011) 0.88
Physiological roles of acid-base sensors. Annu Rev Physiol (2014) 0.88
Physiological sensing of carbon dioxide/bicarbonate/pH via cyclic nucleotide signaling. Sensors (Basel) (2011) 0.87
Compartmentalization of distinct cAMP signaling pathways in mammalian sperm. J Biol Chem (2013) 0.87