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1
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Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid.
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Proc Natl Acad Sci U S A
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2002
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2.28
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2
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Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals.
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Am J Clin Nutr
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2005
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2.21
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3
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Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction?
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FASEB J
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2007
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2.17
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4
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Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats.
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FASEB J
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2003
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2.14
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5
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An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function.
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Am J Clin Nutr
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2007
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2.05
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6
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Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging.
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Proc Natl Acad Sci U S A
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2002
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1.93
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7
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Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.
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Aging Cell
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2013
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1.71
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8
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Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line.
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Proc Natl Acad Sci U S A
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2002
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1.54
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9
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gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis.
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Proc Natl Acad Sci U S A
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2004
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1.52
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10
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Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation.
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Free Radic Biol Med
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2002
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1.46
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11
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Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid.
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Proc Natl Acad Sci U S A
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2002
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1.46
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12
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Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways.
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FASEB J
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1.44
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13
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Time to talk SENS: critiquing the immutability of human aging.
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Ann N Y Acad Sci
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2002
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1.42
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14
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Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats.
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Proc Natl Acad Sci U S A
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2002
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1.41
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15
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Unusual clustering of coefficients of variation in published articles from a medical biochemistry department in India.
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FASEB J
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2008
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1.39
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16
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Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites.
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17
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Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.
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Proc Natl Acad Sci U S A
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2002
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1.29
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18
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Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts.
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J Nutr
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2003
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1.25
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19
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Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro.
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J Immunol
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2004
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1.24
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20
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The case for strategic international alliances to harness nutritional genomics for public and personal health.
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Br J Nutr
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2005
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1.24
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21
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Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid.
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Invest Ophthalmol Vis Sci
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2007
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1.24
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22
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Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?
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Am J Clin Nutr
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2009
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1.20
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23
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The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with age.
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Arch Biochem Biophys
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2002
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1.18
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24
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An overview of evidence for a causal relationship between dietary availability of choline during development and cognitive function in offspring.
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Neurosci Biobehav Rev
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2006
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1.12
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25
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Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease.
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Nutr Neurosci
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2005
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1.10
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26
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(R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage.
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Invest Ophthalmol Vis Sci
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2005
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1.06
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27
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The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease.
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J Neurol Sci
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2009
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1.04
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28
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Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherol.
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Free Radic Biol Med
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2007
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1.00
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29
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Analysis of plasma tocopherols alpha, gamma, and 5-nitro-gamma in rats with inflammation by HPLC coulometric detection.
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J Lipid Res
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2002
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0.98
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Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats.
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J Cell Mol Med
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2008
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0.98
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31
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Gamma-tocopherol induces apoptosis in androgen-responsive LNCaP prostate cancer cells via caspase-dependent and independent mechanisms.
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Ann N Y Acad Sci
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2004
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0.96
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32
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Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine.
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Neurochem Res
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2008
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0.96
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33
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Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts.
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Proc Natl Acad Sci U S A
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2008
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0.95
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34
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Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes.
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Anal Biochem
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2004
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0.94
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35
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Enough is enough.
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Gamma-tocopherol attenuates ozone-induced exacerbation of allergic rhinosinusitis in rats.
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Toxicol Pathol
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37
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5-Chlorouracil, a marker of DNA damage from hypochlorous acid during inflammation. A gas chromatography-mass spectrometry assay.
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J Biol Chem
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Adaptive dysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging.
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FASEB J
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39
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Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison.
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Vitamin E forms inhibit IL-13/STAT6-induced eotaxin-3 secretion by up-regulation of PAR4, an endogenous inhibitor of atypical PKC in human lung epithelial cells.
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J Nutr Biochem
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Iron accumulation during cellular senescence in human fibroblasts in vitro.
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A simple assay for frequency of chromosome breaks and loss (micronuclei) by flow cytometry of human reticulocytes.
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Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats.
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Ann N Y Acad Sci
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Biotin deficiency inhibits heme synthesis and impairs mitochondria in human lung fibroblasts.
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45
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Moderate antioxidant supplementation has no effect on biomarkers of oxidant damage in healthy men with low fruit and vegetable intakes.
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A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial.
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An assay for uracil in human DNA at baseline: effect of marginal vitamin B6 deficiency.
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Anal Biochem
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A combination of aspirin and gamma-tocopherol is superior to that of aspirin and alpha-tocopherol in anti-inflammatory action and attenuation of aspirin-induced adverse effects.
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Daily supplementation with iron increases lipid peroxidation in young women with low iron stores.
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Association of chromosome damage detected as micronuclei with hematological diseases and micronutrient status.
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Chronic ethanol perturbs testicular folate metabolism and dietary folate deficiency reduces sex hormone levels in the Yucatan micropig.
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5-Methyltetrahydrofolate inhibits photosensitization reactions and strand breaks in DNA.
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