Published in J Biol Chem on December 12, 2002
Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. J Neurosci (2010) 1.58
Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain. Sci Rep (2012) 1.54
Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members. Biochem J (2006) 1.13
Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates. Mol Neurodegener (2006) 1.05
Identification of novel genes and pathways regulating SREBP transcriptional activity. PLoS One (2009) 0.97
SORCS1 contributes to the development of renal disease in rats and humans. Physiol Genomics (2013) 0.83
SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells. J Clin Invest (2014) 0.82
Do GGA adaptors bind internal DXXLL motifs? Traffic (2012) 0.80
Sortilin is essential for proNGF-induced neuronal cell death. Nature (2004) 5.62
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat Neurosci (2007) 2.10
VPS10P-domain receptors - regulators of neuronal viability and function. Nat Rev Neurosci (2008) 1.98
Identification of the receptor scavenging hemopexin-heme complexes. Blood (2005) 1.97
The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett (2005) 1.96
Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. Cell Metab (2010) 1.94
Extracellular superoxide dismutase (EC-SOD) binds to type i collagen and protects against oxidative fragmentation. J Biol Chem (2004) 1.86
Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. Mol Cell Biol (2007) 1.70
SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors. Traffic (2007) 1.66
Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing. J Neurosci (2012) 1.52
Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain. Nat Struct Mol Biol (2009) 1.50
The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding. FEBS Lett (2002) 1.48
The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors. J Biol Chem (2006) 1.36
Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein. Blood (2006) 1.31
MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation. J Immunol (2009) 1.26
Megalin deficiency offers protection from renal aminoglycoside accumulation. J Biol Chem (2001) 1.23
Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cells. Proc Natl Acad Sci U S A (2007) 1.21
Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin. J Am Soc Nephrol (2002) 1.21
Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region. J Biol Chem (2004) 1.20
Receptor-mediated endocytosis of α-galactosidase A in human podocytes in Fabry disease. PLoS One (2011) 1.15
LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein. J Cell Sci (2008) 1.15
Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development. FEBS Lett (2004) 1.13
Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system. J Comp Neurol (2003) 1.10
Functional organization of the sortilin Vps10p domain. J Biol Chem (2004) 1.05
p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. J Biol Chem (2004) 1.02
The yeast Vps10p cytoplasmic tail mediates lysosomal sorting in mammalian cells and interacts with human GGAs. J Biol Chem (2002) 1.01
Different motifs regulate trafficking of SorCS1 isoforms. Traffic (2008) 0.98
Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons. Eur J Neurosci (2011) 0.97
Metallothionein and a peptide modeled after metallothionein, EmtinB, induce neuronal differentiation and survival through binding to receptors of the low-density lipoprotein receptor family. J Neurochem (2007) 0.95
A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex. J Biol Chem (2006) 0.95
Distribution of alpha-galactosidase A in normal human kidney and renal accumulation and distribution of recombinant alpha-galactosidase A in Fabry mice. J Am Soc Nephrol (2007) 0.93
Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein. J Neurosci (2013) 0.92
Cubilin and megalin co-localize in the neonatal inner ear. Audiol Neurootol (2009) 0.90
Effects of glycosylation on the structure and function of the extracellular chaperone clusterin. Biochemistry (2007) 0.89
Structural insight into the function of myelin basic protein as a ligand for integrin alpha M beta 2. J Immunol (2008) 0.89
GGA autoinhibition revisited. Traffic (2009) 0.89
Sortilin is a putative postendocytic receptor of thyroglobulin. Endocrinology (2008) 0.88
Evidence for a two-step mechanism involved in the formation of covalent HC x TSG-6 complexes. Biochemistry (2006) 0.88
Mapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosis. J Biol Chem (2012) 0.88
Megalin binds and mediates cellular internalization of folate binding protein. FEBS J (2005) 0.87
Calumenin but not reticulocalbin forms a Ca2+-dependent complex with thrombospondin-1. A potential role in haemostasis and thrombosis. Mol Cell Biochem (2008) 0.86
Expression of single-chain variable fragments fused with the Fc-region of rabbit IgG in Leishmania tarentolae. Microb Cell Fact (2014) 0.85
Revisiting the structure of the Vps10 domain of human sortilin and its interaction with neurotensin. Protein Sci (2014) 0.85
Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer. Mol Cell Biol (2010) 0.84
The concentration of extracellular superoxide dismutase in plasma is maintained by LRP-mediated endocytosis. Free Radic Biol Med (2010) 0.83
The prodomain of a secreted hydrophobic mini-protein facilitates its export from the endoplasmic reticulum by hitchhiking on sorting receptors. J Biol Chem (2003) 0.83
Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin. Am J Physiol Renal Physiol (2003) 0.83
Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. J Cell Sci (2003) 0.82
Identification and characterization of novel ERC-55 interacting proteins: evidence for the existence of several ERC-55 splicing variants; including the cytosolic ERC-55-C. Proteomics (2009) 0.81
SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET. Cell Rep (2013) 0.81
Specificity determinants in the interaction of apolipoprotein(a) kringles with tetranectin and LDL. Biol Chem (2002) 0.81
Oxidative folding of nerve growth factor can be mediated by the pro-peptide of neurotrophin-3. FEBS Lett (2007) 0.81
ABSENCE OF A THYROID PHENOTYPE IN SORTILIN-DEFICIENT MICE. Endocr Pract (2015) 0.79
The C-terminal proteolytic processing of extracellular superoxide dismutase is redox regulated. Free Radic Biol Med (2011) 0.78
Identification and characterization of endonuclein binding proteins: evidence of modulatory effects on signal transduction and chaperone activity. BMC Biochem (2009) 0.77
Correction: Fibulin-1C, C1 Esterase Inhibitor and Glucose Regulated Protein 75 Interact with the CREC Proteins, Calumenin and Reticulocalbin. PLoS One (2015) 0.75
Generation of a haptoglobin-hemoglobin complex-specific Fab antibody blocking the binding of the complex to CD163. Eur J Haematol (2003) 0.75
Recombinant activated factor VII is reabsorbed in renal proximal tubules and is a ligand to megalin and cubilin. Nephron Exp Nephrol (2010) 0.75
Highly polarized photonic crystal fiber laser. Opt Express (2004) 0.75