Published in J Cell Sci on January 15, 2003
Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11. Am J Hum Genet (2009) 2.29
Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells. J Clin Invest (2009) 2.08
Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J Cell Biol (2005) 1.91
Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells. Mol Biol Cell (2004) 1.85
Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cells. J Leukoc Biol (2010) 1.73
New insights on mast cell activation via the high affinity receptor for IgE. Adv Immunol (2008) 1.51
Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms. Proc Natl Acad Sci U S A (2008) 1.48
Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation. Cell (2008) 1.41
Multiple roles for the actin cytoskeleton during regulated exocytosis. Cell Mol Life Sci (2012) 1.35
Munc18b/STXBP2 is required for platelet secretion. Blood (2012) 1.30
An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. J Exp Med (2006) 1.15
Familial haemophagocytic lymphohistiocytosis: advances in the genetic basis, diagnosis and management. Clin Exp Immunol (2011) 1.12
Mast cell mediators: their differential release and the secretory pathways involved. Front Immunol (2014) 1.04
Stem cell factor programs the mast cell activation phenotype. J Immunol (2012) 1.03
A role for Sec1/Munc18 proteins in platelet exocytosis. Biochem J (2003) 1.00
Arginase activity differs with allergen in the effector phase of ovalbumin- versus trimellitic anhydride-induced asthma. Toxicol Sci (2005) 1.00
The SNARE Machinery in Mast Cell Secretion. Front Immunol (2012) 0.98
Vesicular trafficking and signaling for cytokine and chemokine secretion in mast cells. Front Immunol (2014) 0.94
A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini. Mol Biol Cell (2007) 0.93
Cytoskeleton in mast cell signaling. Front Immunol (2012) 0.93
Hemophagocytic lymphohistiocytosis caused by dominant-negative mutations in STXBP2 that inhibit SNARE-mediated membrane fusion. Blood (2015) 0.91
Munc18-1 and Munc18-2 proteins modulate beta-cell Ca2+ sensitivity and kinetics of insulin exocytosis differently. J Biol Chem (2011) 0.88
Munc18-2 and syntaxin 3 control distinct essential steps in mast cell degranulation. J Immunol (2013) 0.87
Late steps in secretory lysosome exocytosis in cytotoxic lymphocytes. Front Immunol (2013) 0.87
Graded defects in cytotoxicity determine severity of hemophagocytic lymphohistiocytosis in humans and mice. Front Immunol (2013) 0.86
SNARE complex-mediated degranulation in mast cells. J Cell Mol Med (2012) 0.85
Pivotal advance: IgE accelerates in vitro development of mast cells and modifies their phenotype. J Leukoc Biol (2008) 0.83
Munc18-1 protein molecules move between membrane molecular depots distinct from vesicle docking sites. J Biol Chem (2012) 0.83
Morphological docking of secretory vesicles. Histochem Cell Biol (2010) 0.83
Cab45b, a Munc18b-interacting partner, regulates exocytosis in pancreatic beta-cells. J Biol Chem (2009) 0.82
DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation. J Exp Med (2014) 0.80
Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells. Biochem J (2012) 0.80
Munc18-1 controls SNARE protein complex assembly during human sperm acrosomal exocytosis. J Biol Chem (2012) 0.78
Munc18-2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T-Lymphocytes. Traffic (2015) 0.78
Differential Effects of Munc18s on Multiple Degranulation-Relevant Trans-SNARE Complexes. PLoS One (2015) 0.77
Syntaxin binding protein 1 is not required for allergic inflammation via IgE-mediated mast cell activation. PLoS One (2013) 0.76
Yessotoxin, a Marine Toxin, Exhibits Anti-Allergic and Anti-Tumoural Activities Inhibiting Melanoma Tumour Growth in a Preclinical Model. PLoS One (2016) 0.76
Maternal and child undernutrition: global and regional exposures and health consequences. Lancet (2008) 26.44
Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses. Blood (2008) 4.10
Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. Am J Clin Nutr (2002) 3.88
Improvement of child survival in Mexico: the diagonal approach. Lancet (2006) 3.87
Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat Immunol (2002) 3.60
Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med (2010) 3.24
The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. Immunity (2007) 2.83
Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. J Exp Med (2004) 2.44
BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis. Nature (2013) 2.36
The tyrosine kinase network regulating mast cell activation. Immunol Rev (2009) 2.29
Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM. Immunity (2005) 2.27
Mouse and human neutrophils induce anaphylaxis. J Clin Invest (2011) 2.21
Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells. J Clin Invest (2009) 2.08
The ins and outs of IgE-dependent mast-cell exocytosis. Trends Immunol (2004) 2.01
CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction. Immunity (2008) 1.95
Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. J Exp Med (2004) 1.91
Human FcγRIIA induces anaphylactic and allergic reactions. Blood (2011) 1.86
Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cells. J Leukoc Biol (2010) 1.73
Neutrophils mediate antibody-induced antitumor effects in mice. Blood (2013) 1.66
Efficacy of rice-based oral rehydration solution containing recombinant human lactoferrin and lysozyme in Peruvian children with acute diarrhea. J Pediatr Gastroenterol Nutr (2007) 1.66
Down-regulation of CXCR4 and CD62L in chronic lymphocytic leukemia cells is triggered by B-cell receptor ligation and associated with progressive disease. Cancer Res (2009) 1.65
Mast cell-mediated remodeling and fibrinolytic activity protect against fatal glomerulonephritis. J Immunol (2006) 1.63
IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses. J Biol Chem (2005) 1.55
Effects of docosahexaenoic acid supplementation during pregnancy on gestational age and size at birth: randomized, double-blind, placebo-controlled trial in Mexico. Food Nutr Bull (2010) 1.55
Molecular editing of cellular responses by the high-affinity receptor for IgE. Science (2014) 1.53
E-prostanoid 2 receptors dampen mast cell degranulation via cAMP/PKA-mediated suppression of IgE-dependent signaling. J Leukoc Biol (2012) 1.47
Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells. J Exp Med (2003) 1.42
Survival response to B-cell receptor ligation is restricted to progressive chronic lymphocytic leukemia cells irrespective of Zap70 expression. Cancer Res (2006) 1.40
Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse. EMBO J (2010) 1.40
FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation. J Clin Invest (2008) 1.35
Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival. J Immunol (2006) 1.35
Multiple micronutrient supplementation during pregnancy does not lead to greater infant birth size than does iron-only supplementation: a randomized controlled trial in a semirural community in Mexico. Am J Clin Nutr (2003) 1.33
Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice. J Clin Invest (2010) 1.31
Peritoneal cell-derived mast cells: an in vitro model of mature serosal-type mouse mast cells. J Immunol (2007) 1.30
Sphingolipids and the balancing of immune cell function: lessons from the mast cell. J Immunol (2005) 1.28
Coronary artery calcium for the prediction of mortality in young adults <45 years old and elderly adults >75 years old. Eur Heart J (2012) 1.27
Cutting edge: genetic variation influences Fc epsilonRI-induced mast cell activation and allergic responses. J Immunol (2007) 1.26
VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways. Blood (2008) 1.26
Impaired FcepsilonRI-dependent gene expression and defective eicosanoid and cytokine production as a consequence of Fyn deficiency in mast cells. J Immunol (2005) 1.24
Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells. Cell Signal (2007) 1.21
The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation. J Exp Med (2003) 1.21
Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls multiple activating responses and prevents renal inflammation. J Immunol (2008) 1.20
Inhibitory ITAM signaling traps activating receptors with the phosphatase SHP-1 to form polarized "inhibisome" clusters. Sci Signal (2011) 1.19
Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation. J Allergy Clin Immunol (2013) 1.19
Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation. Immunity (2009) 1.17
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. Eur J Immunol (2008) 1.15
Mast cell interleukin-2 production contributes to suppression of chronic allergic dermatitis. Immunity (2011) 1.15
The death domain of Rab3 guanine nucleotide exchange protein in GDP/GTP exchange activity in living cells. Biochem J (2002) 1.15
Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria. J Exp Med (2011) 1.13
Iron supplementation improves progressive fatigue resistance during dynamic knee extensor exercise in iron-depleted, nonanemic women. Am J Clin Nutr (2003) 1.10
Anti-beta2-glycoprotein I antibodies in complex with beta2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V. Arthritis Rheum (2006) 1.09
Early activation of sphingosine kinase in mast cells and recruitment to FcepsilonRI are mediated by its interaction with Lyn kinase. Mol Cell Biol (2004) 1.09
The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production. J Biol Chem (2004) 1.08
Constitutive and B-cell receptor-induced activation of STAT3 are important signaling pathways targeted by bortezomib in leukemic mantle cell lymphoma. Haematologica (2010) 1.08
A STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-κB. BMC Cell Biol (2011) 1.07
SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway. Oncogene (2003) 1.06
Cholesterol deficiency in a mouse model of Smith-Lemli-Opitz syndrome reveals increased mast cell responsiveness. J Exp Med (2006) 1.05
Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis. J Immunol (2012) 1.03
Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis. J Immunol (2011) 1.03
The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy. Blood (2013) 1.03
Munc18-2/syntaxin3 complexes are spatially separated from syntaxin3-containing SNARE complexes. FEBS Lett (2003) 1.03
Adapters in the organization of mast cell signaling. Immunol Rev (2009) 1.03
Assays for regulated exocytosis of mast cell granules. Curr Protoc Cell Biol (2006) 1.02
Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity. Proc Natl Acad Sci U S A (2005) 1.01
The engagement of activating FcgammaRs inhibits primate lentivirus replication in human macrophages. J Immunol (2006) 1.00
TGF-beta 1 inhibits mast cell Fc epsilon RI expression. J Immunol (2005) 1.00
An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease. Adv Exp Med Biol (2011) 0.99
Oxidative stress stimulates IL-4 and IL-6 production in mast cells by an APE/Ref-1-dependent pathway. Eur J Immunol (2003) 0.99
Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms. Blood (2010) 0.99
Selective activation of Fyn/PI3K and p38 MAPK regulates IL-4 production in BMMC under nontoxic stress condition. J Immunol (2007) 0.98
The SNARE Machinery in Mast Cell Secretion. Front Immunol (2012) 0.98
Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells. Blood (2008) 0.98
Vav1 is a component of transcriptionally active complexes. J Exp Med (2002) 0.98
Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis. J Immunol (2010) 0.97
[Factors associated with physical activity among Mexican women of childbearing age]. Rev Panam Salud Publica (2003) 0.96
IgE-induced mast cell survival requires the prolonged generation of reactive oxygen species. J Immunol (2008) 0.95
IgG1 and IVIg induce inhibitory ITAM signaling through FcγRIII controlling inflammatory responses. Blood (2012) 0.95
Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice. J Immunol (2009) 0.95
Dietary intakes of polyunsaturated fatty acids among pregnant Mexican women. Matern Child Nutr (2011) 0.95
The Helicobacter pylori VacA cytotoxin activates RBL-2H3 cells by inducing cytosolic calcium oscillations. Cell Microbiol (2005) 0.95
Mast cell and T cell communication; amplification and control of adaptive immunity. Immunol Lett (2009) 0.95
IL-10 inhibits Fc epsilon RI expression in mouse mast cells. J Immunol (2004) 0.94
The Oportunidades program increases the linear growth of children enrolled at young ages in urban Mexico. J Nutr (2008) 0.93
Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils. Biochim Biophys Acta (2008) 0.93
Flow cytometry APC-tandem dyes are degraded through a cell-dependent mechanism. Cytometry A (2009) 0.93
Dimerization of hSiah proteins regulates their stability. Biochem Biophys Res Commun (2006) 0.93
Long-term cabergoline therapy is not associated with valvular heart disease in patients with prolactinomas. Pituitary (2009) 0.92
Fc alpha receptor I activation induces leukocyte recruitment and promotes aggravation of glomerulonephritis through the FcR gamma adaptor. Eur J Immunol (2007) 0.92
The degree of BCR and NFAT activation predicts clinical outcomes in chronic lymphocytic leukemia. Blood (2012) 0.92
Vav1 and PU.1 are recruited to the CD11b promoter in APL-derived promyelocytes: role of Vav1 in modulating PU.1-containing complexes during ATRA-induced differentiation. Exp Cell Res (2009) 0.91
Parallel deficits in linear growth and mental development in low-income Mexican infants in the second year of life. Public Health Nutr (2006) 0.91
Evidence for neuronal expression of functional Fc (epsilon and gamma) receptors. J Allergy Clin Immunol (2010) 0.90
Naive T cells sense the cysteine protease allergen papain through protease-activated receptor 2 and propel TH2 immunity. J Allergy Clin Immunol (2012) 0.89
Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis. J Clin Invest (2014) 0.89