Published in Front Immunol on June 05, 2012
Entamoeba histolytica-Induced Mucin Exocytosis Is Mediated by VAMP8 and Is Critical in Mucosal Innate Host Defense. MBio (2017) 1.38
Mast cell mediators: their differential release and the secretory pathways involved. Front Immunol (2014) 1.04
Different activation signals induce distinct mast cell degranulation strategies. J Clin Invest (2016) 0.99
Vesicular trafficking and signaling for cytokine and chemokine secretion in mast cells. Front Immunol (2014) 0.94
A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells. Immunity (2013) 0.89
The cell surface proteome of Entamoeba histolytica. Mol Cell Proteomics (2013) 0.89
Characterization of mast cell secretory granules and their cell biology. DNA Cell Biol (2014) 0.78
Differential Effects of Munc18s on Multiple Degranulation-Relevant Trans-SNARE Complexes. PLoS One (2015) 0.77
Current Status and Future Directions of Botulinum Neurotoxins for Targeting Pain Processing. Toxins (Basel) (2015) 0.77
Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex. J Cell Biol (2016) 0.76
Immunoprofiling of human uterine mast cells identifies three phenotypes and expression of ERβ and glucocorticoid receptor. F1000Res (2017) 0.75
Deciphering new molecular mechanisms of mast cell activation. Front Immunol (2013) 0.75
Vesicular polyamine transporter mediates vesicular storage and release of polyamine from mast cells. J Biol Chem (2017) 0.75
Munc13-4 functions as a Ca2+ sensor for homotypic secretory granule fusion to generate endosomal exocytic vacuoles. Mol Biol Cell (2017) 0.75
Predominant Rab-GTPase amplicons contributing to oral squamous cell carcinoma progression to metastasis. Oncotarget (2015) 0.75
Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion. EMBO J (2016) 0.75
The transcriptional program, functional heterogeneity, and clinical targeting of mast cells. J Exp Med (2017) 0.75
Phosphorylation of SNAP-23 regulates its dynamic membrane association during Mast Cell exocytosis. Biol Open (2017) 0.75
Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell (1980) 23.17
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution. Nature (1998) 15.80
Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol (2009) 13.01
The synaptic vesicle cycle. Annu Rev Neurosci (2004) 12.25
A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion. Cell (1993) 10.66
Membrane fusion: grappling with SNARE and SM proteins. Science (2009) 8.98
Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. Nature (2000) 6.96
Synaptic assembly of the brain in the absence of neurotransmitter secretion. Science (2000) 5.89
Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy. Cell (1997) 5.72
Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev (2011) 5.20
Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3). Cell (2003) 4.94
A genomic perspective on membrane compartment organization. Nature (2001) 4.80
Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. Cell (2003) 4.55
Selective activation of cognate SNAREpins by Sec1/Munc18 proteins. Cell (2007) 4.26
The molecular machinery for secretion is conserved from yeast to neurons. Proc Natl Acad Sci U S A (1993) 4.22
Mast cells as a source of both preformed and immunologically inducible TNF-alpha/cachectin. Nature (1990) 4.21
How does synaptotagmin trigger neurotransmitter release? Annu Rev Biochem (2008) 4.20
Three modes of synaptic vesicular recycling revealed by single-vesicle imaging. Nature (2003) 3.72
New developments in mast cell biology. Nat Immunol (2008) 3.72
Secretory lysosomes. Nat Rev Mol Cell Biol (2002) 3.70
Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily. Mol Cell Biol (1991) 3.68
Complexins regulate a late step in Ca2+-dependent neurotransmitter release. Cell (2001) 3.49
Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science (2009) 3.30
An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming. Nature (2001) 3.18
Mast cell-orchestrated immunity to pathogens. Nat Rev Immunol (2010) 3.12
T cells use two directionally distinct pathways for cytokine secretion. Nat Immunol (2006) 3.01
Molecular regulation of mast cell activation. J Allergy Clin Immunol (2006) 2.77
Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11. Hum Mol Genet (2005) 2.70
Secretory mechanisms in cell-mediated cytotoxicity. Annu Rev Cell Dev Biol (2007) 2.63
The energetics of membrane fusion from binding, through hemifusion, pore formation, and pore enlargement. J Membr Biol (2004) 2.59
Differential control of vesicle priming and short-term plasticity by Munc13 isoforms. Neuron (2002) 2.52
A role for the phagosome in cytokine secretion. Science (2005) 2.45
Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data. Nat Rev Immunol (2007) 2.42
Interdependence of PKC-dependent and PKC-independent pathways for presynaptic plasticity. Neuron (2007) 2.32
Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11. Am J Hum Genet (2009) 2.29
Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4. Nat Immunol (2007) 2.28
Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells. J Clin Invest (2009) 2.08
The ins and outs of IgE-dependent mast-cell exocytosis. Trends Immunol (2004) 2.01
Synaptic vesicle exocytosis. Cold Spring Harb Perspect Biol (2011) 1.97
Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex. Nat Struct Mol Biol (2011) 1.95
Mutations in the Drosophila Rop gene suggest a function in general secretion and synaptic transmission. Neuron (1994) 1.94
Basophils and mast cells: morphologic insights into their biology, secretory patterns, and function. Prog Allergy (1984) 1.94
Shouts, whispers and the kiss of death: directional secretion in T cells. Nat Immunol (2008) 1.92
Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells. Cell (1998) 1.88
SNAREs and traffic. Biochim Biophys Acta (2005) 1.87
Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells. Mol Biol Cell (2004) 1.85
Membrane traffic within the Golgi apparatus. Annu Rev Cell Dev Biol (2009) 1.78
SNAREing immunity: the role of SNAREs in the immune system. Nat Rev Immunol (2006) 1.77
At the junction of SNARE and SM protein function. Curr Opin Cell Biol (2010) 1.65
The unc-18 gene encodes a novel protein affecting the kinetics of acetylcholine metabolism in the nematode Caenorhabditis elegans. J Neurochem (1992) 1.65
Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. J Neurosci (2006) 1.61
A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic. J Biol Chem (1995) 1.57
Compound exocytosis: mechanisms and functional significance. Traffic (2006) 1.56
FcepsilonR1 and toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cells. Blood (2005) 1.54
Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization. J Clin Invest (2005) 1.49
Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release. Cell (2011) 1.49
Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms. Proc Natl Acad Sci U S A (2008) 1.48
Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform. Biochem J (2000) 1.48
Molecular identification of two novel Munc-18 isoforms expressed in non-neuronal tissues. J Biol Chem (1995) 1.48
Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome. Mol Biol Cell (1998) 1.43
Cytokine secretion in macrophages and other cells: pathways and mediators. Immunobiology (2009) 1.43
Exocytotic fusion is activated by Rab3a peptides. Nature (1992) 1.41
Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation. Cell (2008) 1.41
Compound versus multigranular exocytosis in peritoneal mast cells. J Gen Physiol (1990) 1.41
Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha. J Biol Chem (2005) 1.39
Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis. J Cell Sci (2003) 1.38
Cytokine release from innate immune cells: association with diverse membrane trafficking pathways. Blood (2011) 1.34
Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18. J Biol Chem (1999) 1.32
The crystal structure of a Munc13 C-terminal module exhibits a remarkable similarity to vesicle tethering factors. Structure (2011) 1.32
Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules. Mol Cell Biol (2002) 1.26
VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways. Blood (2008) 1.26
Transfection analysis of functional roles of complexin I and II in the exocytosis of two different types of secretory vesicles. Biochem Biophys Res Commun (1999) 1.23
Phosphorylation of SNAP-23 regulates exocytosis from mast cells. J Biol Chem (2004) 1.23
The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion. Curr Biol (2003) 1.22
Rab27b regulates mast cell granule dynamics and secretion. Traffic (2007) 1.22
Munc18c heterozygous knockout mice display increased susceptibility for severe glucose intolerance. Diabetes (2005) 1.22
The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice. J Neurosci (2001) 1.22
Ternary SNARE complexes are enriched in lipid rafts during mast cell exocytosis. Traffic (2006) 1.21
Control of vesicle fusion by a tyrosine phosphatase. Nat Cell Biol (2004) 1.21
Inhibition of degranulation and interleukin-6 production in mast cells derived from mice deficient in protein kinase Cbeta. Blood (2000) 1.19
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. Eur J Immunol (2008) 1.15
The death domain of Rab3 guanine nucleotide exchange protein in GDP/GTP exchange activity in living cells. Biochem J (2002) 1.15
The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane. Blood (2011) 1.14
Human monocytes and neutrophils store transforming growth factor-alpha in a subpopulation of cytoplasmic granules. Blood (1997) 1.14
Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells. J Exp Med (1999) 1.13
IL-1 induces vesicular secretion of IL-6 without degranulation from human mast cells. J Immunol (2003) 1.11
SNARE complex regulation by phosphorylation. Cell Biochem Biophys (2006) 1.10
Involvement of the ras-like GTPase rab3d in RBL-2H3 mast cell exocytosis following stimulation via high affinity IgE receptors (Fc epsilonRI). J Immunol (1997) 1.08
The functions of Munc18-1 in regulated exocytosis. Ann N Y Acad Sci (2009) 1.08
Vesicle-associated membrane protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) selectively required for sequential granule-to-granule fusion. J Biol Chem (2011) 1.07
Complexin II facilitates exocytotic release in mast cells by enhancing Ca2+ sensitivity of the fusion process. J Cell Sci (2005) 1.04
The last exon of SNAP-23 regulates granule exocytosis from mast cells. J Biol Chem (2001) 1.03
Munc18-2/syntaxin3 complexes are spatially separated from syntaxin3-containing SNARE complexes. FEBS Lett (2003) 1.03
Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells. J Immunol (2008) 1.03
Slp4-a/granuphilin-a interacts with syntaxin-2/3 in a Munc18-2-dependent manner. J Biol Chem (2005) 1.01
Perturbation of a very late step of regulated exocytosis by a secretory carrier membrane protein (SCAMP2)-derived peptide. J Biol Chem (2002) 0.99
Rat basophilic leukemia cells express syntaxin-3 and VAMP-7 in granule membranes. Biochem Biophys Res Commun (2000) 0.99
Involvement of Rab27 in antigen-induced histamine release from rat basophilic leukemia 2H3 cells. Biochem Biophys Res Commun (2004) 0.98
Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM. Immunity (2005) 2.27
Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells. J Clin Invest (2009) 2.08
Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cells. J Leukoc Biol (2010) 1.73
Mast cell-mediated remodeling and fibrinolytic activity protect against fatal glomerulonephritis. J Immunol (2006) 1.63
Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis. J Cell Sci (2003) 1.38
VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways. Blood (2008) 1.26
Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls multiple activating responses and prevents renal inflammation. J Immunol (2008) 1.20
Inhibitory ITAM signaling traps activating receptors with the phosphatase SHP-1 to form polarized "inhibisome" clusters. Sci Signal (2011) 1.19
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. Eur J Immunol (2008) 1.15
The death domain of Rab3 guanine nucleotide exchange protein in GDP/GTP exchange activity in living cells. Biochem J (2002) 1.15
Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria. J Exp Med (2011) 1.13
Serum tryptase determination in patients with acute allergic reactions. J Allergy Clin Immunol (2013) 1.08
Munc18-2/syntaxin3 complexes are spatially separated from syntaxin3-containing SNARE complexes. FEBS Lett (2003) 1.03
Genetic evidence for the aggravation of Plasmodium falciparum malaria by interleukin 4. J Infect Dis (2009) 1.01
Vav1 is a component of transcriptionally active complexes. J Exp Med (2002) 0.98
Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis. J Immunol (2010) 0.97
IgG1 and IVIg induce inhibitory ITAM signaling through FcγRIII controlling inflammatory responses. Blood (2012) 0.95
Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils. Biochim Biophys Acta (2008) 0.93
Fc alpha receptor I activation induces leukocyte recruitment and promotes aggravation of glomerulonephritis through the FcR gamma adaptor. Eur J Immunol (2007) 0.92
Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis. J Clin Invest (2014) 0.89
Mast cells as cellular sensors in inflammation and immunity. Front Immunol (2011) 0.89
Stimulus-secretion coupling by high-affinity IgE receptor: new developments. FEBS Lett (2010) 0.89
The glomerular response to IgA deposition in IgA nephropathy. Semin Nephrol (2008) 0.88
Hypoallergens for allergen-specific immunotherapy by directed molecular evolution of mite group 2 allergens. J Biol Chem (2006) 0.86
Carbon monoxide has antioxidative properties in the liver involving p38 MAP kinase pathway in a murine model of systemic inflammation. Microcirculation (2010) 0.85
Ara h 2 and Ara h 6 sensitization predicts peanut allergy in Mediterranean pediatric patients. Pediatr Allergy Immunol (2014) 0.84
Enhanced basophil reactivities during severe malaria and their relationship with the Plasmodium falciparum histamine-releasing factor translationally controlled tumor protein. Infect Immun (2012) 0.84
Pivotal advance: IgE accelerates in vitro development of mast cells and modifies their phenotype. J Leukoc Biol (2008) 0.83
The German Research Network on Schizophrenia--impact on the management of schizophrenia. Dialogues Clin Neurosci (2006) 0.81
Genotype combinations of two IL4 polymorphisms influencing IL-4 plasma levels are associated with different risks of severe malaria in the Malian population. Immunogenetics (2015) 0.81
IgA Fc receptor I signals apoptosis through the FcRgamma ITAM and affects tumor growth. Blood (2006) 0.80
Total serum tryptase levels are higher in young infants. Pediatr Allergy Immunol (2011) 0.80
Local and systemic activation of the mononuclear phagocyte system in aseptic loosening of total hip arthroplasty. J Clin Immunol (2009) 0.79
Correlation between invasiveness of colorectal tumor cells and adhesive potential under flow. Anticancer Res (2004) 0.79
Mast cell chymase protects against renal fibrosis in murine unilateral ureteral obstruction. Kidney Int (2013) 0.78
Link between endocarditis on porcine bioprosthetic valves and allergy to pork. Int J Cardiol (2012) 0.77
Long-term prognostic value of component-resolved diagnosis in infants and toddlers with peanut allergy. Pediatr Allergy Immunol (2014) 0.77
Cisplatin-based chemotherapy for pulmonary metastasized germ cell tumors of the testis--be aware of acute respiratory distress syndrome. Onkologie (2009) 0.77
IgA Fc receptor I is a molecular switch that determines IgA activating or inhibitory functions. Contrib Nephrol (2007) 0.76
Jet exhaust particles alter human dendritic cell maturation. Inflamm Res (2010) 0.75
The function of mast cells in autoimmune glomerulonephritis. Methods Mol Biol (2015) 0.75
A retrospective observational single-centre study on the burden of immune thrombocytopenia (ITP). Onkologie (2012) 0.75