Published in Free Radic Biol Med on January 24, 2007
Amelioration of acute kidney injury in lipopolysaccharide-induced systemic inflammatory response syndrome by an aldose reductase inhibitor, fidarestat. PLoS One (2012) 0.95
Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis. Cytokine (2009) 0.93
Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages. Free Radic Biol Med (2011) 0.92
Glutathionylated lipid aldehydes are products of adipocyte oxidative stress and activators of macrophage inflammation. Diabetes (2013) 0.87
Beta-glucogallin reduces the expression of lipopolysaccharide-induced inflammatory markers by inhibition of aldose reductase in murine macrophages and ocular tissues. Chem Biol Interact (2012) 0.85
A potential therapeutic role for aldose reductase inhibitors in the treatment of endotoxin-related inflammatory diseases. Expert Opin Investig Drugs (2012) 0.83
Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. Free Radic Biol Med (2011) 0.83
Targeting aldose reductase for the treatment of cancer. Curr Cancer Drug Targets (2011) 0.81
Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia. Invest Ophthalmol Vis Sci (2014) 0.80
Aldose reductase inhibition prevents lipopolysaccharide-induced glucose uptake and glucose transporter 3 expression in RAW264.7 macrophages. Int J Biochem Cell Biol (2010) 0.80
The complex role of iNOS in acutely rejecting cardiac transplants. Free Radic Biol Med (2008) 0.80
Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors. Free Radic Biol Med (2013) 0.78
AKR1B10 is induced by hyperglycaemia and lipopolysaccharide in patients with diabetic nephropathy. Cell Stress Chaperones (2013) 0.77
Identification of regulatory Hck and PAI-2 proteins in the monocyte response to PEG-containing matrices. Biomaterials (2009) 0.77
Proteomic analysis of the follicular fluid of Tianzhu white yak during diestrus. Int J Mol Sci (2014) 0.75
Aldose reductase mediates retinal microglia activation. Biochem Biophys Res Commun (2016) 0.75
The pathobiology of diabetic complications: a unifying mechanism. Diabetes (2005) 14.96
Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J (1991) 3.41
Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options. Endocr Rev (2005) 2.42
Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1. J Biol Chem (1998) 2.26
Nitric oxide signaling: no longer simply on or off. Trends Biochem Sci (2006) 1.79
BCL2 family of apoptosis-related genes: functions and clinical implications in cancer. Crit Rev Clin Lab Sci (2006) 1.59
Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis. Free Radic Biol Med (2000) 1.53
Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells. J Biol Chem (2002) 1.51
Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene. J Biol Chem (1997) 1.47
Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide. Circ Res (2001) 1.44
TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. J Immunol (2006) 1.41
Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation. Mol Cells (2003) 1.40
Role of nitric oxide in host defense in murine salmonellosis as a function of its antibacterial and antiapoptotic activities. Infect Immun (2002) 1.39
Toll-like receptor 4, nitric oxide, and myocardial depression in endotoxemia. Shock (2006) 1.39
Unknotting the roles of Bcl-2 and Bcl-xL in cell death. Biochem Biophys Res Commun (2005) 1.38
TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappaB in lipopolysaccharide-stimulated macrophages. FEBS Lett (2000) 1.37
Activation of nuclear factor-kappaB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase. Diabetes (2004) 1.33
Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection. FASEB J (2004) 1.33
Molecular mechanisms involved in the pathogenesis of septic shock. Arch Med Res (2005) 1.32
Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis. J Clin Invest (1999) 1.30
Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells. Diabetes (2005) 1.26
Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia. Eur J Pharmacol (2005) 1.20
Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy: interactions with aldose reductase. Diabetes (2004) 1.20
Nitric oxide via macrophage iNOS induces apoptosis following traumatic spinal cord injury. Brain Res Mol Brain Res (2000) 1.15
Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF-alpha in human lens epithelial cells. FASEB J (2002) 1.15
Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt. Diabetologia (2005) 1.15
Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells. Diabetes (2006) 1.13
SGLT-1-mediated glucose uptake protects intestinal epithelial cells against LPS-induced apoptosis and barrier defects: a novel cellular rescue mechanism? FASEB J (2005) 1.12
Overexpression of catalase in the mitochondrial or cytosolic compartment increases sensitivity of HepG2 cells to tumor necrosis factor-alpha-induced apoptosis. J Biol Chem (2000) 1.10
Inhibition of aldose reductase attenuates TNF-alpha-induced expression of adhesion molecules in endothelial cells. FASEB J (2004) 1.09
Involvement of aldose reductase in vascular smooth muscle cell growth and lesion formation after arterial injury. Arterioscler Thromb Vasc Biol (2000) 1.06
Nitric oxide signaling in the cardiovascular system: implications for heart failure. Curr Opin Cardiol (2006) 1.06
Selective recognition of glutathiolated aldehydes by aldose reductase. Biochemistry (2000) 1.05
Rengyolone inhibits inducible nitric oxide synthase expression and nitric oxide production by down-regulation of NF-kappaB and p38 MAP kinase activity in LPS-stimulated RAW 264.7 cells. Biochem Pharmacol (2006) 1.03
Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis: differential effects of sorbitol and mannitol. J Biol Chem (2003) 1.03
Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate. J Med Chem (2005) 1.02
Aldose reductase in diabetic microvascular complications. Curr Drug Targets (2005) 1.01
Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cells. FEBS Lett (2004) 0.99
Aldose reductase inhibition prevents glucose-induced apoptosis in cultured bovine retinal microvascular pericytes. Exp Eye Res (2000) 0.99
Selective inhibitors of inducible nitric oxide synthase: potential agents for the treatment of inflammatory diseases? Curr Top Med Chem (2006) 0.99
Aldose reductase inhibition restores endothelial cell function in diabetic rabbit aorta. J Cardiovasc Pharmacol (1993) 0.98
Nitric oxide is a key determinant of group B streptococcus-induced murine macrophage apoptosis. J Infect Dis (2005) 0.96
Role of mitogen-activated protein kinases in S-nitrosoglutathione-induced macrophage apoptosis. Biochemistry (1999) 0.95
IFN-gamma enhances bovine macrophage responsiveness to Mycobacterium bovis: Impact on bacterial replication, cytokine release and macrophage apoptosis. Immunol Cell Biol (2005) 0.95
The biology of endotoxin. Mol Biotechnol (2001) 0.94
EGF receptor-ERK pathway is the major signaling pathway that mediates upregulation of aldose reductase expression under oxidative stress. Free Radic Biol Med (2001) 0.94
Kinetic and structural characterization of the glutathione-binding site of aldose reductase. J Biol Chem (2000) 0.93
Tumor necrosis factor-alpha protects synovial cells from nitric oxide induced apoptosis through phosphoinositide 3-kinase Akt signal transduction. J Rheumatol (2006) 0.93
Involvement and dual effects of nitric oxide in septic shock. Inflamm Res (1998) 0.93
Glucose-induced hyperproliferation of cultured rat aortic smooth muscle cells through polyol pathway hyperactivity. Diabetologia (2001) 0.91
Evidence that lipopolysaccharide-induced cell death is mediated by accumulation of reactive oxygen species and activation of p38 in rat cortex and hippocampus. Exp Neurol (2003) 0.90
The naturally occurring biflavonoid, ochnaflavone, inhibits LPS-induced iNOS expression, which is mediated by ERK1/2 via NF-kappaB regulation, in RAW264.7 cells. Arch Biochem Biophys (2006) 0.90
Nitric oxide- and superoxide-dependent mitochondrial signaling in endotoxin-induced apoptosis in the rostral ventrolateral medulla of rats. Free Radic Biol Med (2005) 0.89
Osmotic response element is required for the induction of aldose reductase by tumor necrosis factor-alpha. J Biol Chem (1999) 0.89
Structure of a glutathione conjugate bound to the active site of aldose reductase. Proteins (2006) 0.89
Inducible nitric oxide synthase and apoptosis in murine proximal tubule epithelial cells. Toxicol Sci (2006) 0.89
Nitric oxide sensitizes tumor cells to dendritic cell-mediated apoptosis, uptake, and cross-presentation. Cancer Res (2005) 0.89
Aldose reductase regulates TGF-beta1-induced production of fibronectin and type IV collagen in cultured rat mesangial cells. Nephrology (Carlton) (2006) 0.88
N-acetylcysteine prevents nitrosative stress-associated depression of blood pressure and heart rate in streptozotocin diabetic rats. J Cardiovasc Pharmacol (2006) 0.88
Glutathione levels determine apoptosis in macrophages. Biochem Biophys Res Commun (1998) 0.87
Tumour necrosis factor-alpha and nitric oxide mediate apoptosis by D-galactosamine in a primary culture of rat hepatocytes: exacerbation of cell death by cocultured Kupffer cells. Can J Gastroenterol (2002) 0.86
Inducible nitric oxide synthase and apoptosis-related factors in the synovial tissues of temporomandibular joints with internal derangement and osteoarthritis. J Oral Maxillofac Surg (2003) 0.86
Overexpression of regucalcin suppresses apoptotic cell death in cloned normal rat kidney proximal tubular epithelial NRK52E cells: change in apoptosis-related gene expression. J Cell Biochem (2005) 0.85
Nitric oxide and peroxynitrite induce cellular death in bovine chromaffin cells: evidence for a mixed necrotic and apoptotic mechanism with caspases activation. J Neurosci Res (2006) 0.82
Effects of glucose and an aldose reductase inhibitor on albumin permeation through a layer of cultured bovine vascular endothelial cells. Horm Metab Res (1995) 0.82
Plasma leptin and its relationship with lipid peroxidation and nitric oxide in obese female patients with or without hypertension. Arch Med Res (2006) 0.81
Gamma-glutamyl transpeptidase activity mediates NF-kappaB activation through lipid peroxidation in human leukemia U937 cells. Mol Cell Biochem (2002) 0.81
The role of prostaglandin E2 and nitric oxide in cell death in J774 murine macrophages. Eur J Pharmacol (1998) 0.80
Dehydrodiisoeugenol, an isoeugenol dimer, inhibits lipopolysaccharide-stimulated nuclear factor kappa B activation and cyclooxygenase-2 expression in macrophages. Arch Biochem Biophys (2005) 0.80
The role and regulation of apoptosis in sepsis. J Endotoxin Res (2005) 0.78
The role of NO in macrophage dysfunction at early stage after burn injury. Burns (2005) 0.78
Aldose reductase inhibition prevents endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci (2007) 1.61
Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells. J Biol Chem (2002) 1.51
Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages. J Biol Chem (2006) 1.46
Activation of nuclear factor-kappaB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase. Diabetes (2004) 1.33
Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells. Cancer Res (2006) 1.27
Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells. Diabetes (2005) 1.26
Identification of novel mutations causing familial primary congenital glaucoma in Indian pedigrees. Invest Ophthalmol Vis Sci (2002) 1.18
Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Circulation (2006) 1.17
Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF-alpha in human lens epithelial cells. FASEB J (2002) 1.15
Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells. Diabetes (2006) 1.13
Inhibition of aldose reductase prevents experimental allergic airway inflammation in mice. PLoS One (2009) 1.11
Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation. Carcinogenesis (2008) 1.10
Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders. Chem Biol Interact (2011) 1.09
Correlations of genotype with phenotype in Indian patients with primary congenital glaucoma. Invest Ophthalmol Vis Sci (2004) 1.09
Inhibition of aldose reductase attenuates TNF-alpha-induced expression of adhesion molecules in endothelial cells. FASEB J (2004) 1.09
Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells. Mol Cancer Ther (2010) 1.09
Prevention of posterior capsular opacification through aldose reductase inhibition. Invest Ophthalmol Vis Sci (2008) 1.07
Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes. Diabetes (2002) 1.06
Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages. Cytokine (2006) 1.05
Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cells. Exp Eye Res (2007) 1.03
Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-alpha via protein kinase C-delta and TNF-alpha converting enzyme in vascular smooth muscle cells. Endocrinology (2008) 1.01
Inhibition of aldose reductase prevents lipopolysaccharide-induced inflammatory response in human lens epithelial cells. Invest Ophthalmol Vis Sci (2006) 1.01
Aldose reductase: a novel therapeutic target for inflammatory pathologies. Int J Biochem Cell Biol (2009) 1.00
Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cells. FEBS Lett (2004) 0.99
Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett (2007) 0.98
Aldose reductase-regulated tumor necrosis factor-alpha production is essential for high glucose-induced vascular smooth muscle cell growth. Endocrinology (2007) 0.96
Aldose reductase inhibition suppresses the expression of Th2 cytokines and airway inflammation in ovalbumin-induced asthma in mice. J Immunol (2009) 0.95
Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo. Angiogenesis (2011) 0.95
Disease-causing mutations in proteins: structural analysis of the CYP1B1 mutations causing primary congenital glaucoma in humans. Biophys J (2006) 0.95
Measurement and identification of S-glutathiolated proteins. Methods Enzymol (2010) 0.94
Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis. Cytokine (2009) 0.93
Aldose reductase deficiency protects sugar-induced lens opacification in rats. Chem Biol Interact (2011) 0.93
Glutathione level regulates HNE-induced genotoxicity in human erythroleukemia cells. Toxicol Appl Pharmacol (2007) 0.92
Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages. Free Radic Biol Med (2011) 0.92
Post-translational protein modification by carotenoid cleavage products. Biofactors (2011) 0.91
Metabolism of lipid derived aldehyde, 4-hydroxynonenal in human lens epithelial cells and rat lens. Invest Ophthalmol Vis Sci (2003) 0.90
Aldose reductase inhibition prevents metaplasia of airway epithelial cells. PLoS One (2010) 0.89
Structure of a glutathione conjugate bound to the active site of aldose reductase. Proteins (2006) 0.89
Inhibition of aldose reductase prevents colon cancer metastasis. Carcinogenesis (2011) 0.88
Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci (2012) 0.88
Nitric oxide regulates the polyol pathway of glucose metabolism in vascular smooth muscle cells. FASEB J (2003) 0.88
Molecular cloning and oxidative modification of human lens ALDH1A1: implication in impaired detoxification of lipid aldehydes. J Toxicol Environ Health A (2009) 0.88
4-Hydroxynonenal in the pathogenesis and progression of human diseases. Curr Med Chem (2014) 0.87
L-Arginine prevents metabolic effects of high glucose in diabetic mice. FEBS Lett (2008) 0.87
Cadmium-induced apoptotic death of human retinal pigment epithelial cells is mediated by MAPK pathway. Exp Eye Res (2009) 0.87
Novel mutation in FOXC1 wing region causing Axenfeld-Rieger anomaly. Invest Ophthalmol Vis Sci (2002) 0.87
Aldose reductase inhibition prevents allergic airway remodeling through PI3K/AKT/GSK3β pathway in mice. PLoS One (2013) 0.87
Preventive effects of ethyl pyruvate on endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci (2011) 0.87
Aldose reductase regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycle. Endocrinology (2010) 0.86
Studies on the genotoxicity of endosulfan in different tissues of fresh water fish Mystus vittatus using the comet assay. Arch Environ Contam Toxicol (2007) 0.86
Acute toxicity bioassays of mercuric chloride and malathion on air-breathing fish Channa punctatus (Bloch). Ecotoxicol Environ Saf (2005) 0.85
Synthesis, quantification, characterization, and signaling properties of glutathionyl conjugates of enals. Methods Enzymol (2010) 0.85
Investigation of the genotoxicity of malathion to freshwater teleost fish Channa punctatus (Bloch) using the micronucleus test and comet assay. Arch Environ Contam Toxicol (2009) 0.85
Prevention of endotoxin-induced uveitis in rats by plant sterol guggulsterone. Invest Ophthalmol Vis Sci (2010) 0.84
Aldose reductase catalyzes reduction of the lipid peroxidation product 4-oxonon-2-enal. Chem Res Toxicol (2003) 0.83
A potential therapeutic role for aldose reductase inhibitors in the treatment of endotoxin-related inflammatory diseases. Expert Opin Investig Drugs (2012) 0.83
Aldose reductase inhibition prevents colon cancer growth by restoring phosphatase and tensin homolog through modulation of miR-21 and FOXO3a. Antioxid Redox Signal (2012) 0.83
Inhibition of fiber cell globulization and hyperglycemia-induced lens opacification by aminopeptidase inhibitor bestatin. Invest Ophthalmol Vis Sci (2002) 0.83
Retracted Piceatannol suppresses endotoxin-induced ocular inflammation in rats. Int Immunopharmacol (2013) 0.83
Genotoxicity evaluation of acute doses of endosulfan to freshwater teleost Channa punctatus (Bloch) by alkaline single-cell gel electrophoresis. Ecotoxicol Environ Saf (2005) 0.82
Aldose reductase mediates the mitogenic signals of cytokines. Chem Biol Interact (2003) 0.82
Protective effects of magnesium lithospermate B against diabetic atherosclerosis via Nrf2-ARE-NQO1 transcriptional pathway. Atherosclerosis (2010) 0.82
Aldose reductase deficiency protects from autoimmune- and endotoxin-induced uveitis in mice. Invest Ophthalmol Vis Sci (2011) 0.82
Role of aldose reductase in TNF-alpha-induced apoptosis of vascular endothelial cells. Chem Biol Interact (2003) 0.82
Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages. Free Radic Biol Med (2010) 0.82
Targeting aldose reductase for the treatment of cancer. Curr Cancer Drug Targets (2011) 0.81
Aldose reductase inhibition prevents lipopolysaccharide-induced glucose uptake and glucose transporter 3 expression in RAW264.7 macrophages. Int J Biochem Cell Biol (2010) 0.80
Genotoxic effects of carotenoid breakdown products in human retinal pigment epithelial cells. Curr Eye Res (2009) 0.80
Amelioration of experimental autoimmune uveoretinitis by aldose reductase inhibition in Lewis rats. Invest Ophthalmol Vis Sci (2011) 0.80
Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression. Eur J Cancer (2013) 0.79
Inhibition of aldose reductase attenuates endotoxin signals in human non-pigmented ciliary epithelial cells. Exp Eye Res (2010) 0.79
Aldose reductase prevents aldehyde toxicity in cultured human lens epithelial cells. Exp Eye Res (2006) 0.78
Pathobiology of renal-specific oxidoreductase/myo-inositol oxygenase in diabetic nephropathy: its implications in tubulointerstitial fibrosis. Am J Physiol Renal Physiol (2010) 0.78
Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors. Free Radic Biol Med (2013) 0.78
Aldose reductase regulates acrolein-induced cytotoxicity in human small airway epithelial cells. Free Radic Biol Med (2013) 0.78
Negative regulation of the protection of eIF2alpha phosphorylation activity by a unique acidic domain present at the N-terminus of p67. Exp Cell Res (2003) 0.77
Regulation of lens aldose reductase activity by nitric oxide. Exp Eye Res (2005) 0.77
Oxidative stress-induced up-regulation of the chloride channel and Na+/Ca2+ exchanger during cataractogenesis in diabetic rats. J Diabetes Complications (2004) 0.77
Aldose reductase inhibition for the treatment of asthma. Expert Rev Clin Immunol (2010) 0.77
Aldose reductase inhibition suppresses airway inflammation. Chem Biol Interact (2011) 0.77
Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma. Respir Res (2011) 0.77
Relevance of renal-specific oxidoreductase in tubulogenesis during mammalian nephron development. Am J Physiol Renal Physiol (2002) 0.76