Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo.

PubWeight™: 2.56‹?› | Rank: Top 1%

🔗 View Article (PMC 61149)

Published in Proc Natl Acad Sci U S A on November 20, 2001

Authors

C Roggia1, Y Gao, S Cenci, M N Weitzmann, G Toraldo, G Isaia, R Pacifici

Author Affiliations

1: Division of Bone and Mineral Diseases, Washington University School of Medicine and Barnes-Jewish Hospital, St. Louis, MO 63110, USA.

Articles citing this

(truncated to the top 100)

Estrogen deficiency and bone loss: an inflammatory tale. J Clin Invest (2006) 3.45

The gut microbiota regulates bone mass in mice. J Bone Miner Res (2012) 2.92

A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest (2003) 2.37

Osteoimmunology: interactions of the bone and immune system. Endocr Rev (2008) 2.32

B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo. Blood (2007) 2.16

IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J Clin Invest (2006) 2.15

Disorders of bone remodeling. Annu Rev Pathol (2011) 2.05

The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: is a revision needed? J Bone Miner Res (2011) 1.95

Inflammatory bone loss: pathogenesis and therapeutic intervention. Nat Rev Drug Discov (2012) 1.91

Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator. Proc Natl Acad Sci U S A (2003) 1.75

IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells. Proc Natl Acad Sci U S A (2002) 1.65

Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formation. Proc Natl Acad Sci U S A (2006) 1.64

Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents. PLoS One (2008) 1.60

Estrogen and the skeleton. Trends Endocrinol Metab (2012) 1.46

Role of RANKL and RANK in bone loss and arthritis. Ann Rheum Dis (2002) 1.35

Ovariectomy disregulates osteoblast and osteoclast formation through the T-cell receptor CD40 ligand. Proc Natl Acad Sci U S A (2010) 1.33

T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab (2009) 1.32

Estrogen prevents bone loss through transforming growth factor beta signaling in T cells. Proc Natl Acad Sci U S A (2004) 1.32

Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation. Proc Natl Acad Sci U S A (2007) 1.31

Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens. Mol Endocrinol (2010) 1.24

HIV: inflammation and bone. Curr HIV/AIDS Rep (2012) 1.23

The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis. Scientifica (Cairo) (2013) 1.20

Estrogen deficiency induces the differentiation of IL-17 secreting Th17 cells: a new candidate in the pathogenesis of osteoporosis. PLoS One (2012) 1.19

The immune system and bone. Arch Biochem Biophys (2010) 1.19

Cellular senescence, ageing and disease. Age (Dordr) (2008) 1.17

The molecular mechanism of osteoclastogenesis in rheumatoid arthritis. Arthritis Res (2002) 1.16

Calcineurin regulates bone formation by the osteoblast. Proc Natl Acad Sci U S A (2005) 1.16

A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss. J Clin Invest (2006) 1.15

An IL-7-dependent rebound in thymic T cell output contributes to the bone loss induced by estrogen deficiency. Proc Natl Acad Sci U S A (2005) 1.13

TNF signaling contributes to the development of nociceptive sensitization in a tibia fracture model of complex regional pain syndrome type I. Pain (2007) 1.11

Mouse mandible contains distinctive mesenchymal stem cells. J Dent Res (2010) 1.05

Differential cytokine regulation by NF-kappaB and AP-1 in Jurkat T-cells. BMC Immunol (2010) 1.04

T cells: critical bone regulators in health and disease. Bone (2010) 1.04

Bone mineral density in rheumatoid arthritis patients 1 year after adalimumab therapy: arrest of bone loss. Ann Rheum Dis (2008) 1.04

Disruption of PTH receptor 1 in T cells protects against PTH-induced bone loss. PLoS One (2010) 1.03

The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling. Biomaterials (2013) 1.03

Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and inflammation. Arthritis Res Ther (2005) 1.02

Estrogen and bone: insights from estrogen-resistant, aromatase-deficient, and normal men. Bone (2008) 1.01

Receptor activator of NF-{kappa}B (RANK) cytoplasmic IVVY535-538 motif plays an essential role in tumor necrosis factor-{alpha} (TNF)-mediated osteoclastogenesis. J Biol Chem (2010) 1.00

Daidzein prevents the increase in CD4+CD28null T cells and B lymphopoesis in ovariectomized mice: a key mechanism for anti-osteoclastogenic effect. PLoS One (2011) 0.98

A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss. Eur J Immunol (2009) 0.98

Akt fine-tunes NF-κB-dependent gene expression during T cell activation. J Biol Chem (2011) 0.97

Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis. Proc Natl Acad Sci U S A (2004) 0.97

IL-17 mediates estrogen-deficient osteoporosis in an Act1-dependent manner. J Cell Biochem (2012) 0.97

Osteoimmunology and the influence of pro-inflammatory cytokines on osteoclasts. Biochem Med (Zagreb) (2013) 0.97

The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. Endocrinology (2011) 0.96

IFN-γ and TNF-α synergistically induce mesenchymal stem cell impairment and tumorigenesis via NFκB signaling. Stem Cells (2013) 0.96

The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis. Bone (2012) 0.95

Regulation of bone turnover by sex steroids in men. J Bone Miner Res (2008) 0.95

IL-7 up-regulates TNF-alpha-dependent osteoclastogenesis in patients affected by solid tumor. PLoS One (2006) 0.95

Identification of the homeobox protein Prx1 (MHox, Prrx-1) as a regulator of osterix expression and mediator of tumor necrosis factor α action in osteoblast differentiation. J Bone Miner Res (2011) 0.93

Postmenopausal osteoporosis, T cells, and immune dysfunction. Proc Natl Acad Sci U S A (2004) 0.93

Gender dimorphisms in progenitor and stem cell function in cardiovascular disease. J Cardiovasc Transl Res (2010) 0.92

FSH and TSH in the regulation of bone mass: the pituitary/immune/bone axis. Clin Dev Immunol (2013) 0.92

Forum on aging and skeletal health: summary of the proceedings of an ASBMR workshop. J Bone Miner Res (2011) 0.90

Targeted deletion of histidine decarboxylase gene in mice increases bone formation and protects against ovariectomy-induced bone loss. Proc Natl Acad Sci U S A (2003) 0.90

Systemic bone effects of biologic therapies in rheumatoid arthritis and ankylosing spondylitis. Osteoporos Int (2010) 0.89

Premature T cell senescence in Ovx mice is inhibited by repletion of estrogen and medicarpin: a possible mechanism for alleviating bone loss. Osteoporos Int (2011) 0.89

Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy. J Clin Invest (2004) 0.89

Role of direct estrogen receptor signaling in wear particle-induced osteolysis. Biomaterials (2012) 0.89

Oestrogen deficiency modulates particle-induced osteolysis. Arthritis Res Ther (2011) 0.88

Immune regulation of osteoclast function in postmenopausal osteoporosis: a critical interdisciplinary perspective. Int J Med Sci (2012) 0.88

Osteoclasts-Key Players in Skeletal Health and Disease. Microbiol Spectr (2016) 0.88

Bone loss in surgically ovariectomized premenopausal women is associated with T lymphocyte activation and thymic hypertrophy. J Investig Med (2013) 0.87

T cells and post menopausal osteoporosis in murine models. Arthritis Res Ther (2007) 0.87

Production of IL-7 is increased in ovariectomized mice, but not RANKL mRNA expression by osteoblasts/stromal cells in bone, and IL-7 enhances generation of osteoclast precursors in vitro. J Bone Miner Metab (2007) 0.87

Nuclear receptors in bone physiology and diseases. Physiol Rev (2013) 0.86

Osteoblast-induced osteoclast apoptosis by fas ligand/FAS pathway is required for maintenance of bone mass. Cell Death Differ (2015) 0.85

Transplantation of SHED prevents bone loss in the early phase of ovariectomy-induced osteoporosis. J Dent Res (2014) 0.85

Lymphocytes and the Dap12 adaptor are key regulators of osteoclast activation associated with gonadal failure. PLoS One (2007) 0.85

T-cells and B-cells in osteoporosis. Curr Opin Endocrinol Diabetes Obes (2014) 0.84

Is aspirin treatment an appropriate intervention to osteoporosis? Fut Rheumatol (2008) 0.83

Interactions between the immune system and bone. World J Orthop (2011) 0.83

Cell biology of osteoimmunology. Wien Med Wochenschr (2010) 0.82

Stem cell transplantation improves aging-related diseases. Front Cell Dev Biol (2014) 0.81

Co-administration of aspirin and allogeneic adipose-derived stromal cells attenuates bone loss in ovariectomized rats through the anti-inflammatory and chemotactic abilities of aspirin. Stem Cell Res Ther (2015) 0.81

TNFR1 signaling resistance associated with female stem cell cytokine production is independent of TNFR2-mediated pathways. Am J Physiol Regul Integr Comp Physiol (2008) 0.80

Possible role of S-equol on bone loss via amelioration of inflammatory indices in ovariectomized mice. J Clin Biochem Nutr (2013) 0.80

The role of T cells in osteoporosis, an update. Int J Clin Exp Pathol (2009) 0.80

A Bone Anabolic Effect of RANKL in a Murine Model of Osteoporosis Mediated Through FoxP3+ CD8 T Cells. J Bone Miner Res (2015) 0.79

The effect of Astragalus extractive on alveolar bone rebuilding progress of tooth extracted socket of ovariectomied rats. Afr J Tradit Complement Altern Med (2014) 0.79

Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics. J Clin Invest (2016) 0.79

Assessing the effects of estrogen on the dynamics of breast cancer. Comput Math Methods Med (2012) 0.79

A C >T polymorphism located at position -1 of the Kozak sequence of CD40 gene is associated with low bone mass in Spanish postmenopausal women. Osteoporos Int (2007) 0.79

Technetium-99 conjugated with methylene diphosphonate ameliorates ovariectomy-induced osteoporotic phenotype without causing osteonecrosis in the jaw. Calcif Tissue Int (2012) 0.78

Cross-talk between T cells and osteoclasts in bone resorption. Bonekey Rep (2012) 0.77

The role of the immune system in the physiopathology of osteoporosis. Clin Cases Miner Bone Metab (2012) 0.77

Ratio of urine albumin to creatinine attenuates the association of dementia with hip fracture risk. J Clin Endocrinol Metab (2014) 0.77

Endogenous estrogen may prevent bone loss in postmenopausal hemodialysis patients throughout life. Osteoporos Int (2010) 0.77

Strain differences in the attenuation of bone accrual in a young growing mouse model of insulin resistance. J Bone Miner Metab (2015) 0.77

The role of IL-1β in the bone loss during rheumatic diseases. Mediators Inflamm (2015) 0.76

Halofuginone prevents estrogen-deficient osteoporosis in mice. J Cell Biochem (2012) 0.76

Bone structural effects of variation in the TNFRSF1B gene encoding the tumor necrosis factor receptor 2. Osteoporos Int (2007) 0.76

Selective oestrogen receptor modulators lasofoxifene and bazedoxifene inhibit joint inflammation and osteoporosis in ovariectomised mice with collagen-induced arthritis. Rheumatology (Oxford) (2015) 0.76

Brucella and Osteoarticular Cell Activation: Partners in Crime. Front Microbiol (2017) 0.75

Identification of B cells participated in the mechanism of postmenopausal women osteoporosis using microarray analysis. Int J Clin Exp Med (2015) 0.75

Necrostatin-1 treatment inhibits osteocyte necroptosis and trabecular deterioration in ovariectomized rats. Sci Rep (2016) 0.75

Bone phenotypes in response to gonadotropin misexpression: the role for gonadotropins in postmenopausal osteoporosis. Int J Gen Med (2008) 0.75

WSS25, a sulfated polysaccharide, inhibits RANKL-induced mouse osteoclast formation by blocking SMAD/ID1 signaling. Acta Pharmacol Sin (2015) 0.75

From the gut to the strut: where inflammation reigns, bone abstains. J Clin Invest (2016) 0.75

Articles cited by this

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell (1998) 17.76

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A (1998) 12.61

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature (1999) 12.32

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature (1999) 8.23

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev (1998) 7.81

Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev (1999) 7.69

T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature (2000) 6.49

Rheumatoid arthritis. Cell (1996) 6.01

TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest (2000) 5.78

Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med (1995) 5.27

Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med (2000) 5.02

Two TNF receptors. Immunol Today (1992) 4.87

Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin. Science (1982) 4.00

Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha. J Clin Invest (2000) 3.15

Tumor necrosis factor-alpha induces differentiation of and bone resorption by osteoclasts. J Biol Chem (2000) 2.80

Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells. Proc Natl Acad Sci U S A (1991) 2.44

Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection. J Clin Invest (2000) 2.32

Activated T lymphocytes support osteoclast formation in vitro. Biochem Biophys Res Commun (1999) 2.28

Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells. Exp Cell Res (1999) 2.06

Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency. J Clin Invest (1997) 1.81

Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period. Endocrinology (1995) 1.75

Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an interleukin-1and tumor necrosis factor-mediated stimulation of macrophage colony-stimulating factor production. J Biol Chem (1996) 1.55

The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage. Endocrinology (1997) 1.45

The functional block of TNF but not of IL-6 prevents bone loss in ovariectomized mice. J Bone Miner Res (1997) 1.42

Estrogen blocks M-CSF gene expression and osteoclast formation by regulating phosphorylation of Egr-1 and its interaction with Sp-1. J Clin Invest (1998) 1.38

Cytokines, estrogen, and postmenopausal osteoporosis--the second decade. Endocrinology (1998) 1.33

M-CSF neutralization and egr-1 deficiency prevent ovariectomy-induced bone loss. J Clin Invest (2000) 1.33

Depletion of CD4 and CD8 T lymphocytes in mice in vivo enhances 1,25-dihydroxyvitamin D3-stimulated osteoclast-like cell formation in vitro by a mechanism that is dependent on prostaglandin synthesis. J Immunol (2000) 1.13

Analysis of gene expression in human bone biopsies by polymerase chain reaction: evidence for enhanced cytokine expression in postmenopausal osteoporosis. J Bone Miner Res (1994) 1.08

Effects of T cell adoptive transfer into nude mice on alveolar bone resorption induced by endotoxin. J Periodontal Res (1996) 1.08

T-cell development in the absence of a thymus: the number, the phenotype, and the functional capacity of T lymphocytes in nude mice. Am J Anat (1984) 1.05

Differentiating between orchiectomized rats and controls using measurements of trabecular bone density: a comparison among DXA, histomorphometry, and peripheral quantitative computerized tomography. Calcif Tissue Int (1995) 1.02

Estrogen loss upregulates hematopoiesis in the mouse: a mediating role of IL-6. Exp Hematol (1995) 1.02

Combined inter-observer and inter-method variation in bone histomorphometry. Bone (1992) 1.01

Cytokines and T-lymphocyte subsets in healthy post-menopausal women: estrogen retards bone loss without affecting the release of IL-1 or IL-1ra. Bone (1997) 0.94

T lymphocyte subsets in osteoporosis. Effect of 1-alpha hydroxyvitamin D3. Miner Electrolyte Metab (1984) 0.94

T lymphocytes are not the target for estradiol-mediated suppression of DTH in reconstituted female severe combined immunodeficient (SCID) mice. Clin Exp Immunol (1998) 0.91

Anabolic effect of aminoterminally truncated fibroblast growth factor 4 (FGF4) on bone. Bone (1999) 0.88

T lymphocyte surface antigen markers in osteoporosis. J Bone Miner Res (1990) 0.87

Application of automatic image segmentation to tibiae and vertebrae from ovariectomized rats. Bone (1997) 0.86

Quantitative bone histomorphometry and circulating T lymphocyte subsets in postmenopausal osteoporosis. J Bone Miner Res (1990) 0.84

Immunological function in osteoporosis. Clin Immunol Immunopathol (1985) 0.84

Differential distribution of nerve terminals immunoreactive for substance P and cholecystokinin in the sympathetic preganglionic cell column of the filefish Stephanolepis cirrhifer. J Comp Neurol (2000) 0.80

Articles by these authors

A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci U S A (1998) 6.47

Analysis of human transcriptomes. Nat Genet (1999) 6.14

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell (1995) 4.35

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proc Natl Acad Sci U S A (1997) 4.13

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell (2000) 3.82

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc Natl Acad Sci U S A (2000) 3.21

Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha. J Clin Invest (2000) 3.15

Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine. Neuron (2001) 3.10

One-dimensional electrical contact to a two-dimensional material. Science (2013) 2.87

Meta-analysis of endoscopic submucosal dissection versus endoscopic mucosal resection for tumors of the gastrointestinal tract. Endoscopy (2009) 2.84

Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37

Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell responses and protective immunity. Nat Med (2005) 2.28

Hofstadter's butterfly and the fractal quantum Hall effect in moiré superlattices. Nature (2013) 2.13

Spectro-temporal modulation transfer functions and speech intelligibility. J Acoust Soc Am (1999) 2.08

Non-invasive prenatal testing for trisomies 21, 18 and 13: clinical experience from 146,958 pregnancies. Ultrasound Obstet Gynecol (2015) 2.07

Biological degradation of resin acids in wood chips by wood-inhabiting fungi. Appl Environ Microbiol (1995) 2.04

Down-regulation of the filamentous actin cross-linking activity of cortactin by Src-mediated tyrosine phosphorylation. J Biol Chem (1997) 2.04

Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice. J Clin Invest (1994) 2.00

Surface display of a parasite antigen in the ciliate Tetrahymena thermophila. Nat Biotechnol (1999) 1.99

Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Proc Natl Acad Sci U S A (2000) 1.90

PR39, a peptide regulator of angiogenesis. Nat Med (2000) 1.90

The forearm flap. Clin Plast Surg (1982) 1.90

Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product. Mol Pharmacol (1999) 1.89

Quantitative heel ultrasound in a population-based study in Italy and its relationship with fracture history: the ESOPO study. Osteoporos Int (2005) 1.80

Causes of death among people with convulsive epilepsy in rural West China: a prospective study. Neurology (2011) 1.77

Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period. Endocrinology (1995) 1.75

Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines. Blood (2000) 1.74

High prevalence of hypovitaminosis D in female type 2 diabetic population. Diabetes Care (2001) 1.74

Crystal structure of the thiamin diphosphate-dependent enzyme pyruvate decarboxylase from the yeast Saccharomyces cerevisiae at 2.3 A resolution. J Mol Biol (1996) 1.74

Spontaneous release of interleukin 1 from human blood monocytes reflects bone formation in idiopathic osteoporosis. Proc Natl Acad Sci U S A (1987) 1.70

Gamma-S crystallin gene (CRYGS) mutation causes dominant progressive cortical cataract in humans. J Med Genet (2005) 1.68

Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67

Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3). Diabetologia (2008) 1.66

Expression of a family of complementary-strand transcripts in Epstein-Barr virus-infected cells. Proc Natl Acad Sci U S A (1992) 1.66

Connexin43 null mice reveal that astrocytes express multiple connexins. Brain Res Brain Res Rev (2000) 1.61

The synthesis of sialylated oligosaccharides using a CMP-Neu5Ac synthetase/sialyltransferase fusion. Nat Biotechnol (1998) 1.61

Amelotin--a Novel Secreted, Ameloblast-specific Protein. J Dent Res (2005) 1.59

Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia. Proc Natl Acad Sci U S A (1998) 1.57

Drug monitoring in nonconventional biological fluids and matrices. Clin Pharmacokinet (1996) 1.57

Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56

Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an interleukin-1and tumor necrosis factor-mediated stimulation of macrophage colony-stimulating factor production. J Biol Chem (1996) 1.55

Molecular characteristics of non-small cell lung cancer. Proc Natl Acad Sci U S A (2001) 1.53

The in-vitro effects of nicotine and cotinine on sperm motility. Hum Reprod (1997) 1.53

Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD. J Clin Invest (1999) 1.50

Interleukin-1 receptor antagonist decreases bone loss and bone resorption in ovariectomized rats. J Clin Invest (1994) 1.50

Immediate post-abortal insertion of the frameless GyneFix IUD: initial experience in China. Br J Fam Plann (2000) 1.50

Strong constraints on the rare decays B(s)(0) → μ+ μ- and B0 → μ+ μ-. Phys Rev Lett (2012) 1.50

Insulin-like growth factor binding protein 5 suppresses tumor growth and metastasis of human osteosarcoma. Oncogene (2011) 1.50

First observation of the decays B(0) → D(+)K(-)π(+)π(-) and B(-) → D(0)K(-)π(+)π(-). Phys Rev Lett (2012) 1.50

Whole-body biodistribution, radiation absorbed dose and brain SPECT imaging with iodine-123-beta-CIT in healthy human subjects. J Nucl Med (1994) 1.49

The osteoporosis care gap in men with fragility fractures: the Canadian Multicentre Osteoporosis Study. Osteoporos Int (2007) 1.48

Determination of maternal-fetal biomarkers of prenatal exposure to ethanol: a review. J Pharm Biomed Anal (2012) 1.47

Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kappa B ligand (RANKL)-induced JNK activation. J Biol Chem (2000) 1.47

Improving adherence to and persistence with oral therapy of osteoporosis. Osteoporos Int (2015) 1.46

Voltage dependence of macroscopic and unitary currents of gap junction channels formed by mouse connexin50 expressed in rat neuroblastoma cells. J Physiol (1999) 1.46

Anatomy of vasculature of 850 spleen specimens and its application in partial splenectomy. Surgery (1996) 1.45

T cell activation induces human osteoclast formation via receptor activator of nuclear factor kappaB ligand-dependent and -independent mechanisms. J Bone Miner Res (2001) 1.43

Polyglycylation of tubulin is essential and affects cell motility and division in Tetrahymena thermophila. J Cell Biol (2000) 1.43

The functional block of TNF but not of IL-6 prevents bone loss in ovariectomized mice. J Bone Miner Res (1997) 1.42

Determination of the X(3872) meson quantum numbers. Phys Rev Lett (2013) 1.42

FK506 in the treatment of children with nephrotic syndrome of different pathological types. Clin Nephrol (2006) 1.42

Identification of STAT3 as a specific substrate of breast tumor kinase. Oncogene (2006) 1.40

Estrogen blocks M-CSF gene expression and osteoclast formation by regulating phosphorylation of Egr-1 and its interaction with Sp-1. J Clin Invest (1998) 1.38

Eukaryotic cytosolic chaperonin contains t-complex polypeptide 1 and seven related subunits. Proc Natl Acad Sci U S A (1993) 1.37

The maize mitochondrial genome: dynamic, yet functional. Trends Genet (1995) 1.37

Cytokines, estrogen, and postmenopausal osteoporosis--the second decade. Endocrinology (1998) 1.33

M-CSF neutralization and egr-1 deficiency prevent ovariectomy-induced bone loss. J Clin Invest (2000) 1.33

Effects of new smoking regulations in Italy. Ann Oncol (2005) 1.32

Theoretical fluorescence induction curves derived from coupled differential equations describing the primary photochemistry of photosystem II by an exciton-radical pair equilibrium. Biophys J (1993) 1.29

Inducible nonlymphoid expression of Fas ligand is responsible for superantigen-induced peripheral deletion of T cells. Immunity (1998) 1.26

Measurement of the electron charge asymmetry in inclusive W production in pp collisions at sqrt[s]=7  TeV. Phys Rev Lett (2012) 1.23

The chicken beta-globin gene promoter forms a novel "cinched" tetrahelical structure. J Biol Chem (1996) 1.22

Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody. Neuroscience (2007) 1.21

First observation of CP violation in the decays of B(s)0 mesons. Phys Rev Lett (2013) 1.21

Cord serum cotinine as a biomarker of fetal exposure to cigarette smoke at the end of pregnancy. Environ Health Perspect (2000) 1.20

Search for new physics in the multijet and missing transverse momentum final state in proton-proton collisions at √s = 7 TeV. Phys Rev Lett (2012) 1.19

Azimuthal anisotropy of charged particles at high transverse momenta in Pb-Pb collisions at sqrt[s(NN)] = 2.76  TeV. Phys Rev Lett (2012) 1.19

Predictive role of capsule endoscopy on the insertion route of double-balloon enteroscopy. Endoscopy (2009) 1.19

Complex nature of the major viral polyadenylated transcripts in Epstein-Barr virus-associated tumors. J Virol (1993) 1.19

HSP27: mechanisms of cellular protection against neuronal injury. Curr Mol Med (2009) 1.18

Household and community determinants of exposure to involuntary smoking: a study of urinary cotinine in children and adolescents. Am J Epidemiol (1995) 1.16

Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis. Osteoporos Int (2009) 1.13

Dictionary building via unsupervised hierarchical motif discovery in the sequence space of natural proteins. Proteins (1999) 1.13

Osteoporosis: diagnosis with lateral and posteroanterior dual x-ray absorptiometry compared with quantitative CT. Radiology (1994) 1.13

Polymorphonuclear neutrophils and their mediators in gingival tissues from generalized aggressive periodontitis. J Periodontol (2001) 1.12

Functional interactions between Drosophila bHLH/PAS, Sox, and POU transcription factors regulate CNS midline expression of the slit gene. J Neurosci (2000) 1.11

Search for a W' or techni-ρ decaying into WZ in pp Collisions at sqrt[s] = 7  TeV. Phys Rev Lett (2012) 1.10

Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy. Phys Rev Lett (2012) 1.09

Clear cell odontogenic carcinoma: a clinicopathologic and immunocytochemical study of 5 cases. Arch Pathol Lab Med (2001) 1.09

Strontium ranelate reduces the risk of vertebral fracture in young postmenopausal women with severe osteoporosis. Ann Rheum Dis (2008) 1.09