Published in J Cell Biol on December 30, 2002
Adherens junctions: from molecules to morphogenesis. Nat Rev Mol Cell Biol (2010) 3.97
Cadherins and cancer: how does cadherin dysfunction promote tumor progression? Oncogene (2008) 3.63
Force measurements in E-cadherin-mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42. J Cell Biol (2004) 3.06
Catenins: keeping cells from getting their signals crossed. Dev Cell (2006) 2.70
NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev (2003) 2.55
Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron (2003) 2.37
Depletion of E-cadherin disrupts establishment but not maintenance of cell junctions in Madin-Darby canine kidney epithelial cells. Mol Biol Cell (2006) 2.22
Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation. Physiol Rev (2011) 2.06
The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex. J Cell Biol (2005) 2.03
Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses. Proc Natl Acad Sci U S A (2004) 1.99
Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA. Mol Biol Cell (2004) 1.98
Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts. Mol Biol Cell (2005) 1.93
PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J (2004) 1.89
Requirement of ZO-1 for the formation of belt-like adherens junctions during epithelial cell polarization. J Cell Biol (2007) 1.79
Type I gamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin. J Cell Biol (2007) 1.78
Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization. J Cell Biol (2004) 1.74
ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. Mol Cell Biol (2004) 1.70
E-cadherin engagement stimulates proliferation via Rac1. J Cell Biol (2006) 1.61
Myofibroblast development is characterized by specific cell-cell adherens junctions. Mol Biol Cell (2004) 1.56
miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution. Dev Biol (2009) 1.56
Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments. J Cell Biol (2004) 1.52
Cadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epithelia. Mol Biol Cell (2009) 1.46
Human foetal osteoblastic cell response to polymer-demixed nanotopographic interfaces. J R Soc Interface (2005) 1.34
Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. Proc Natl Acad Sci U S A (2003) 1.33
Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility. Mol Biol Cell (2004) 1.33
E-cadherin adhesion activates c-Src signaling at cell-cell contacts. Mol Biol Cell (2007) 1.33
Regulation of N-cadherin dynamics at neuronal contacts by ligand binding and cytoskeletal coupling. Mol Biol Cell (2005) 1.29
FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration? J Cell Biol (2004) 1.27
Multicellular dynamics during epithelial elongation. Semin Cell Dev Biol (2008) 1.27
Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Mol Biol Cell (2005) 1.24
Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG. J Cell Biol (2004) 1.20
The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Mol Biol Cell (2007) 1.18
Cadherin-mediated intercellular adhesion and signaling cascades involving small GTPases. Cold Spring Harb Perspect Biol (2009) 1.17
Classical cadherin adhesion molecules: coordinating cell adhesion, signaling and the cytoskeleton. J Mol Histol (2004) 1.17
N-cadherin acts in concert with Slit1-Robo2 signaling in regulating aggregation of placode-derived cranial sensory neurons. Development (2009) 1.14
Polarity in mammalian epithelial morphogenesis. Cold Spring Harb Perspect Biol (2013) 1.14
VASP involvement in force-mediated adherens junction strengthening. Biochem Biophys Res Commun (2008) 1.09
Junctional music that the nucleus hears: cell-cell contact signaling and the modulation of gene activity. Cold Spring Harb Perspect Biol (2009) 1.09
N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts. Proc Natl Acad Sci U S A (2010) 1.07
Phosphorylation of N-cadherin-associated cortactin by Fer kinase regulates N-cadherin mobility and intercellular adhesion strength. Mol Biol Cell (2005) 1.04
PTP-PEST controls motility, adherens junction assembly, and Rho GTPase activity in colon cancer cells. Am J Physiol Cell Physiol (2010) 1.04
Peptide Bbeta(15-42) preserves endothelial barrier function in shock. PLoS One (2009) 1.02
Phosphatidylinositol-4,5 bisphosphate produced by PIP5KIgamma regulates gelsolin, actin assembly, and adhesion strength of N-cadherin junctions. Mol Biol Cell (2007) 1.00
Spatial control of exocytosis. Curr Opin Cell Biol (2003) 0.97
Multicomponent analysis of junctional movements regulated by myosin II isoforms at the epithelial zonula adherens. PLoS One (2011) 0.97
Cross talk between focal adhesion kinase and cadherins: role in regulating endothelial barrier function. Microvasc Res (2011) 0.96
Cortactin is a functional target of E-cadherin-activated Src family kinases in MCF7 epithelial monolayers. J Biol Chem (2009) 0.95
Rho activation is apically restricted by Arhgap1 in neural crest cells and drives epithelial-to-mesenchymal transition. Development (2013) 0.91
Positive expression of E-cadherin suppresses cell adhesion to fibronectin via reduction of alpha5beta1 integrin in human breast carcinoma cells. J Cancer Res Clin Oncol (2006) 0.89
Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. Dev Biol (2011) 0.88
Drosophila E-cadherin and its binding partner Armadillo/ beta-catenin are required for axonal pathway choices in the developing larval brain. Dev Biol (2009) 0.88
Xenopus delta-catenin is essential in early embryogenesis and is functionally linked to cadherins and small GTPases. J Cell Sci (2009) 0.88
Phosphatidylinositol 3'-kinase signalling supports cell height in established epithelial monolayers. J Mol Histol (2010) 0.88
Biomimetic emulsions reveal the effect of mechanical forces on cell-cell adhesion. Proc Natl Acad Sci U S A (2012) 0.88
Crossroads of integrins and cadherins in epithelia and stroma remodeling. Cell Adh Migr (2012) 0.88
Adhesive but not signaling activity of Drosophila N-cadherin is essential for target selection of photoreceptor afferents. Dev Biol (2007) 0.88
Molecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk? J Signal Transduct (2011) 0.87
Cadherin point mutations alter cell sorting and modulate GTPase signaling. J Cell Sci (2012) 0.85
A bistable model of cell polarity. PLoS One (2012) 0.85
CRIM1 complexes with ß-catenin and cadherins, stabilizes cell-cell junctions and is critical for neural morphogenesis. PLoS One (2012) 0.83
WT1-interacting protein (Wtip) regulates podocyte phenotype by cell-cell and cell-matrix contact reorganization. Am J Physiol Renal Physiol (2011) 0.81
N-cadherin is depleted from proximal tubules in experimental and human acute kidney injury. Histochem Cell Biol (2010) 0.81
Which FGF ligands are involved in lens induction? Dev Biol (2009) 0.81
CDH2 and CDH11 act as regulators of stem cell fate decisions. Stem Cell Res (2015) 0.80
PTP-PEST targets a novel tyrosine site in p120 catenin to control epithelial cell motility and Rho GTPase activity. J Cell Sci (2013) 0.79
Novel mechanism regulating endothelial permeability via T-cadherin-dependent VE-cadherin phosphorylation and clathrin-mediated endocytosis. Mol Cell Biochem (2013) 0.79
Steady-state increase of cAMP-response element binding protein, Rac, and PAK signaling in presenilin-deficient neurons. J Neurochem (2007) 0.79
Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT. J Biol Chem (2011) 0.79
Modeling presenilin-dependent familial Alzheimer's disease: emphasis on presenilin substrate-mediated signaling and synaptic function. Int J Alzheimers Dis (2010) 0.78
N-Cadherin-Mediated Signaling Regulates Cell Phenotype for Nucleus Pulposus Cells of the Intervertebral Disc. Cell Mol Bioeng (2015) 0.78
Metamorphosis of mesothelial cells with active horizontal motility in tissue culture. Sci Rep (2013) 0.77
The molecular pathogenetic role of cell adhesion in endocrine neoplasia. J Clin Pathol (2005) 0.76
The Misregulation of Cell Adhesion Components during Tumorigenesis: Overview and Commentary. J Oncol (2010) 0.76
The Role of E-Cadherin in Maintaining the Barrier Function of Corneal Epithelium after Treatment with Cultured Autologous Oral Mucosa Epithelial Cell Sheet Grafts for Limbal Stem Deficiency. J Ophthalmol (2016) 0.75
Pharmacology of cell adhesion molecules of the nervous system. Curr Neuropharmacol (2007) 0.75
Distinct Rho GTPase activities regulate epithelial cell localization of the adhesion molecule CEACAM1: involvement of the CEACAM1 transmembrane domain. Mol Cell Biol (2003) 0.75
Differential role of nonmuscle myosin II isoforms during blebbing of MCF-7 cells. Mol Biol Cell (2017) 0.75
E-cadherin roles in animal biology: A perspective on thyroid hormone-influence. Cell Commun Signal (2016) 0.75
Endothelial Cell Signaling and Ventilator-Induced Lung Injury (VILI): Molecular Mechanisms, Genomic Analyses & Therapeutic Targets. Am J Physiol Lung Cell Mol Physiol (2016) 0.75
Small Rho GTPase-mediated actin dynamics at endothelial adherens junctions. Small GTPases (2016) 0.75
Cigarette smoke disrupts monolayer integrity by altering epithelial cell-cell adhesion and cortical tension. Am J Physiol Lung Cell Mol Physiol (2017) 0.75
Rho GTPases and the actin cytoskeleton. Science (1998) 28.19
Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu Rev Biophys Biomol Struct (2000) 10.11
Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell (2000) 8.13
Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell (1999) 7.33
Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev (2002) 6.54
Interplay between Rac and Rho in the control of substrate contact dynamics. Curr Biol (1999) 5.29
Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein. J Cell Biol (1998) 5.03
PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr Biol (1995) 4.52
Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J Cell Biol (1997) 4.27
Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos. Cell (1994) 4.24
Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium. Dev Cell (2002) 4.01
Inhibition of invasion of epithelial cells by Tiam1-Rac signaling. Science (1997) 3.89
p120 catenin regulates the actin cytoskeleton via Rho family GTPases. J Cell Biol (2000) 3.60
Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion. Dev Cell (2002) 3.60
Cadherin regulates dendritic spine morphogenesis. Neuron (2002) 3.55
Cadherin engagement regulates Rho family GTPases. J Biol Chem (2001) 3.47
Inhibition of RhoA by p120 catenin. Nat Cell Biol (2000) 3.33
Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function. Curr Biol (1997) 3.16
Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction. Curr Biol (1999) 3.00
Lateral dimerization is required for the homophilic binding activity of C-cadherin. J Cell Biol (1996) 2.95
Drosophila oocyte localization is mediated by differential cadherin-based adhesion. Nature (1998) 2.90
Cadherin-directed actin assembly: E-cadherin physically associates with the Arp2/3 complex to direct actin assembly in nascent adhesive contacts. Curr Biol (2002) 2.74
E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts. J Biol Chem (2001) 2.63
Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity. J Cell Biol (1998) 2.60
Cytomechanics of cadherin-mediated cell-cell adhesion. Curr Opin Cell Biol (1998) 2.54
Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites. J Cell Sci (2001) 2.38
Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila. Development (2002) 2.37
N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts. J Cell Biol (2002) 2.29
Regulation of C-cadherin function during activin induced morphogenesis of Xenopus animal caps. J Cell Biol (1994) 2.17
Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation. J Biol Chem (2000) 2.12
Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex. J Biol Chem (1999) 2.06
Cadherins and tissue formation: integrating adhesion and signaling. Bioessays (1999) 2.05
Cadherin-mediated cell sorting not determined by binding or adhesion specificity. J Cell Biol (2002) 1.98
VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam. Mol Biol Cell (2002) 1.97
Regulation of cadherin function by Rho and Rac: modulation by junction maturation and cellular context. Mol Biol Cell (1999) 1.94
Cadherins and their connections: adhesion junctions have broader functions. Curr Opin Cell Biol (1999) 1.93
E-cadherin-mediated cell-cell attachment activates Cdc42. J Biol Chem (2000) 1.87
Dynamics of ligand-induced, Rac1-dependent anchoring of cadherins to the actin cytoskeleton. J Cell Biol (2002) 1.84
Abelson kinase regulates epithelial morphogenesis in Drosophila. J Cell Biol (2001) 1.62
Rho family GTPases: more than simple switches. Trends Cell Biol (2000) 1.60
Rapid epithelial-sheet sealing in the Caenorhabditis elegans embryo requires cadherin-dependent filopodial priming. Curr Biol (1999) 1.57
Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. Proc Natl Acad Sci U S A (2001) 1.41
Regulation of cell-cell adhesion of MDCK cells by Cdc42 and Rac1 small GTPases. Biochem Biophys Res Commun (1997) 1.40
The tumor-suppressor function of E-cadherin. Am J Hum Genet (1998) 1.25
Molecular mechanism for orienting membrane and actin dynamics to nascent cell-cell contacts in epithelial cells. J Biol Chem (2002) 1.17
Epithelial cell shape: cadherins and small GTPases. Exp Cell Res (2000) 1.14
Rac1 protects epithelial cells against anoikis. J Biol Chem (2001) 1.07
Interaction of the adaptor protein Shc and the adhesion molecule cadherin. J Biol Chem (1997) 1.03
Myosin 2 is a key Rho kinase target necessary for the local concentration of E-cadherin at cell-cell contacts. Mol Biol Cell (2005) 3.43
Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens. Nat Cell Biol (2010) 2.51
Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization. J Cell Biol (2004) 1.74
E-cadherin adhesion activates c-Src signaling at cell-cell contacts. Mol Biol Cell (2007) 1.33
A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens. Mol Biol Cell (2012) 1.22
IL-1 signalling determines the fate of skin grafts expressing non-self protein in keratinocytes. Exp Dermatol (2010) 0.75