Published in Microvasc Res on August 16, 2011
VEGF-induced vascular permeability is mediated by FAK. Dev Cell (2012) 1.85
Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat. Proc Natl Acad Sci U S A (2012) 1.22
Extracellular matrix in the trabecular meshwork: intraocular pressure regulation and dysregulation in glaucoma. Exp Eye Res (2015) 1.02
Helicobacter pylori-induced alteration of epithelial cell signaling and polarity: a possible mechanism of gastric carcinoma etiology and disparity. Cytoskeleton (Hoboken) (2013) 0.84
Astragalus Polysaccharide Suppresses the Expression of Adhesion Molecules through the Regulation of the p38 MAPK Signaling Pathway in Human Cardiac Microvascular Endothelial Cells after Ischemia-Reperfusion Injury. Evid Based Complement Alternat Med (2013) 0.81
Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion. PLoS Genet (2014) 0.80
Phospholipase D signaling mediates reactive oxygen species-induced lung endothelial barrier dysfunction. Pulm Circ (2013) 0.78
Role of focal adhesion kinase in oocyte-follicle communication. Mol Reprod Dev (2014) 0.76
Regulatory pathways affecting vascular stabilization via VE-cadherin dynamics: insights from zebrafish (Danio rerio). J Cereb Blood Flow Metab (2014) 0.76
The Novel Antitubulin Agent TR-764 Strongly Reduces Tumor Vasculature and Inhibits HIF-1α Activation. Sci Rep (2016) 0.75
FAK contributes to proteinuria in hypercholesterolaemic rats and modulates podocyte F-actin re-organization via activating p38 in response to ox-LDL. J Cell Mol Med (2016) 0.75
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science (1997) 24.61
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature (1997) 14.91
Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell (1996) 14.75
Linking colorectal cancer to Wnt signaling. Cell (2000) 11.58
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature (1998) 9.30
Regulation of cadherin-mediated adhesion in morphogenesis. Nat Rev Mol Cell Biol (2005) 9.27
Deconstructing the cadherin-catenin-actin complex. Cell (2005) 8.39
Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood (1998) 7.70
Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell (2005) 7.62
Cell-to-substrate contacts in living fibroblasts: an interference reflexion study with an evaluation of the technique. J Cell Sci (1976) 6.82
Structural basis of cell-cell adhesion by cadherins. Nature (1995) 6.56
FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol (2000) 6.54
Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J Cell Biol (1993) 5.86
Regulation of cadherin adhesive activity. J Cell Biol (2000) 5.63
Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol (1985) (2001) 5.63
The locomotion of fibroblasts in culture. IV. Electron microscopy of the leading lamella. Exp Cell Res (1971) 5.49
Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. Genes Dev (2006) 5.45
Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. J Cell Biol (1994) 5.03
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol (2002) 5.02
Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J Cell Biol (1998) 4.91
Assembly of the cadherin-catenin complex in vitro with recombinant proteins. J Cell Sci (1994) 4.81
Structural basis of calcium-induced E-cadherin rigidification and dimerization. Nature (1996) 4.49
Paxillin and focal adhesion signalling. Nat Cell Biol (2000) 4.37
E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J Cell Biol (1994) 4.34
The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell (2001) 4.32
Intercellular adhesion, signalling and the cytoskeleton. Nat Cell Biol (2002) 4.29
E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. J Cell Biol (2001) 4.04
C-cadherin ectodomain structure and implications for cell adhesion mechanisms. Science (2002) 4.03
A novel role for p120 catenin in E-cadherin function. J Cell Biol (2002) 4.01
Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion. J Cell Biol (2007) 3.76
Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions. J Cell Biol (1993) 3.64
E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation. J Cell Sci (1999) 3.55
Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways. Curr Opin Cell Biol (1997) 3.52
Adhesions of fibroblasts to substratum during contact inhibition observed by interference reflection microscopy. Exp Cell Res (1975) 3.50
Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Proc Natl Acad Sci U S A (1999) 3.49
Cadherin engagement regulates Rho family GTPases. J Biol Chem (2001) 3.47
Formation of cell-to-substrate contacts during fibroblast motility: an interference-reflexion study. J Cell Sci (1980) 3.47
Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev (2009) 3.47
Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion. Science (1998) 3.39
The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin). J Cell Biol (1995) 3.27
The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends Biochem Sci (1998) 3.24
The cadherin-catenin adhesion system in signaling and cancer. J Clin Invest (2002) 3.23
A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation. EMBO J (1999) 3.20
Differential regulation of cell motility and invasion by FAK. J Cell Biol (2003) 3.15
p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system. EMBO J (1993) 3.06
Localization of specificity determining sites in cadherin cell adhesion molecules. Cell (1990) 2.99
Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol (2002) 2.84
Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion. Cell (2010) 2.83
Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system. Blood (1996) 2.76
Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK. Mol Cell Biol (1993) 2.75
E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity. J Cell Biol (2001) 2.72
Rho-family GTPases in cadherin-mediated cell-cell adhesion. Nat Rev Mol Cell Biol (2001) 2.68
The p120 catenin family: complex roles in adhesion, signaling and cancer. J Cell Sci (2000) 2.65
Rho and Rac but not Cdc42 regulate endothelial cell permeability. J Cell Sci (2001) 2.64
Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression. Proc Natl Acad Sci U S A (2007) 2.64
E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts. J Biol Chem (2001) 2.63
Structure of the dimerization and beta-catenin-binding region of alpha-catenin. Mol Cell (2000) 2.61
RNA and RNA binding proteins participate in early stages of cell spreading through spreading initiation centers. Cell (2004) 2.57
Structure-function analysis of cell adhesion by neural (N-) cadherin. Neuron (1998) 2.57
Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood (2004) 2.53
Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. Nat Cell Biol (2002) 2.50
Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. Genes Dev (2004) 2.49
Quick-freeze, deep-etch visualization of the cytoskeleton beneath surface differentiations of intestinal epithelial cells. J Cell Biol (1981) 2.45
Epac1 regulates integrity of endothelial cell junctions through VE-cadherin. FEBS Lett (2005) 2.45
p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherin. Mol Biol Cell (2005) 2.37
Direct cadherin-activated cell signaling: a view from the plasma membrane. J Cell Biol (2002) 2.33
VEGF signalling: integration and multi-tasking in endothelial cell biology. Biochem Soc Trans (2003) 2.31
Cell-cell adhesion and signalling. Curr Opin Cell Biol (2002) 2.29
Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actinin. FASEB J (2005) 2.29
Focal adhesion kinase: a potential target in cancer therapy. Biochem Pharmacol (2006) 2.25
Lysosomal targeting of E-cadherin: a unique mechanism for the down-regulation of cell-cell adhesion during epithelial to mesenchymal transitions. Mol Cell Biol (2005) 2.19
Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex. Nat Cell Biol (2007) 2.18
Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation. J Biol Chem (2000) 2.12
Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion. J Cell Biol (2004) 2.02
E-cadherin regulates the function of the EphA2 receptor tyrosine kinase. Cell Growth Differ (1999) 2.01
RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates endothelial barrier function in mouse lungs. Circ Res (2007) 1.99
VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam. Mol Biol Cell (2002) 1.97
Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells. J Cell Biol (1999) 1.83
Thrombin-induced increase in endothelial permeability is associated with changes in cell-to-cell junction organization. Arterioscler Thromb Vasc Biol (1996) 1.78
Shear stress-mediated cytoskeletal remodeling and cortactin translocation in pulmonary endothelial cells. Am J Respir Cell Mol Biol (2002) 1.78
Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion. Mol Cell Biol (2006) 1.76
Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability. J Biol Chem (2005) 1.74
Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin. J Biol Chem (1999) 1.72
Focal adhesion kinase regulation of N-WASP subcellular localization and function. J Biol Chem (2003) 1.70
Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography. EMBO J (2004) 1.69
Two-step adhesive binding by classical cadherins. Nat Struct Mol Biol (2010) 1.67
Vascular endothelial (VE)-cadherin: only an intercellular glue? Exp Cell Res (1999) 1.66
Depletion of the inositol 1,4,5-trisphosphate-sensitive intracellular Ca2+ store in vascular endothelial cells activates the agonist-sensitive Ca(2+)-influx pathway. Biochem J (1992) 1.66
Density-dependent inhibition of growth involves prevention of EGF receptor activation by E-cadherin-mediated cell-cell adhesion. Exp Cell Res (1996) 1.60
Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis. Cancer Lett (2009) 1.59
Remodeling of the adherens junctions during morphogenesis. Curr Top Dev Biol (2009) 1.55
Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer. Semin Cell Dev Biol (2004) 1.55
S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin. J Appl Physiol (1985) (2002) 1.52
Cadherin engagement inhibits RhoA via p190RhoGAP. J Biol Chem (2003) 1.50
Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells. Mol Cell Biol (2001) 1.49
Extrajunctional distribution of N-cadherin in cultured human endothelial cells. J Cell Sci (1992) 1.48
Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature. Blood (2005) 1.48
KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin. Mol Cell Biol (2009) 1.44
FERM control of FAK function: implications for cancer therapy. Cell Cycle (2008) 1.43
Paxillin-beta-catenin interactions are involved in Rac/Cdc42-mediated endothelial barrier-protective response to oxidized phospholipids. Am J Physiol Lung Cell Mol Physiol (2007) 1.37