Published in Cell on January 10, 2003
The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis. Proc Natl Acad Sci U S A (2006) 1.77
Muscarinic receptors and ligands in cancer. Am J Physiol Cell Physiol (2008) 1.42
Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight. J Neurochem (2008) 1.13
Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders. EMBO J (2004) 1.02
ID2 (inhibitor of DNA binding 2) is a rhythmically expressed transcriptional repressor required for circadian clock output in mouse liver. J Biol Chem (2009) 1.01
Acyltransferases in bacteria. Microbiol Mol Biol Rev (2013) 0.96
Transcriptomic variation of hepatopancreas reveals the energy metabolism and biological processes associated with molting in Chinese mitten crab, Eriocheir sinensis. Sci Rep (2015) 0.95
L-acetylcarnitine: a proposed therapeutic agent for painful peripheral neuropathies. Curr Neuropharmacol (2006) 0.87
Dynamic monitoring of carnitine and acetylcarnitine in the trimethylamine signal after exercise in human skeletal muscle by 7T 1H-MRS. Magn Reson Med (2012) 0.87
Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal. Biochem J (2004) 0.85
Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates. J Biol Chem (2006) 0.84
Crystal structure of rat carnitine palmitoyltransferase II (CPT-II). Biochem Biophys Res Commun (2006) 0.84
The importance of dynamics in substrate-assisted catalysis and specificity. J Am Chem Soc (2006) 0.84
An environment-dependent structural switch underlies the regulation of carnitine palmitoyltransferase 1A. J Biol Chem (2011) 0.83
Demonstration of N- and C-terminal domain intramolecular interactions in rat liver carnitine palmitoyltransferase 1 that determine its degree of malonyl-CoA sensitivity. Biochem J (2005) 0.83
The functions of cardiolipin in cellular metabolism-potential modifiers of the Barth syndrome phenotype. Chem Phys Lipids (2014) 0.83
Protective Effects of Oleic Acid Against Palmitic Acid-Induced Apoptosis in Pancreatic AR42J Cells and Its Mechanisms. Korean J Physiol Pharmacol (2013) 0.82
Structural basis for bacterial quorum sensing-mediated oxalogenesis. J Biol Chem (2014) 0.81
Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues. J Biol Chem (2010) 0.80
The CPT1C 5'UTR contains a repressing upstream open reading frame that is regulated by cellular energy availability and AMPK. PLoS One (2011) 0.80
Identification of a residue affecting fatty alcohol selectivity in wax ester synthase. Appl Environ Microbiol (2012) 0.80
Crystal structure of fatty acid/phospholipid synthesis protein PlsX from Enterococcus faecalis. J Struct Funct Genomics (2008) 0.78
Genome-wide Pathway Analysis Using Gene Expression Data of Colonic Mucosa in Patients with Inflammatory Bowel Disease. Inflamm Bowel Dis (2015) 0.78
Identification of New SRF Binding Sites in Genes Modulated by SRF Over-Expression in Mouse Hearts. Gene Regul Syst Bio (2011) 0.77
Metabolic Pathway Signatures Associated with Urinary Metabolite Biomarkers Differentiate Bladder Cancer Patients from Healthy Controls. Yonsei Med J (2016) 0.77
Structural basis for modification of flavonol and naphthol glucoconjugates by Nicotiana tabacum malonyltransferase (NtMaT1). Planta (2012) 0.76
Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia. PLoS One (2016) 0.75
Effect of acetyl-l-carnitine on ovarian cancer cells' proliferation, nerve growth factor receptor (Trk-A and p75) expression, and the cytotoxic potential of paclitaxel and carboplatin. Gynecol Oncol (2009) 0.75
Choline Acetyltransferase Mutations Causing Congenital Myasthenic Syndrome: Molecular Findings and Genotype-Phenotype Correlations. Hum Mutat (2015) 0.75
Regulating PPARδ signaling as a potential therapeutic strategy for skeletal muscle disorders in heart failure. Am J Physiol Heart Circ Physiol (2015) 0.75
Selective binding of choline by a phosphate-coordination-based triple helicate featuring an aromatic box. Nat Commun (2017) 0.75
Protein production and purification. Nat Methods (2008) 3.97
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nat Struct Biol (2002) 3.92
Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. Nature (2006) 2.95
UNC119 is required for G protein trafficking in sensory neurons. Nat Neurosci (2011) 2.38
Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels. Nature (2004) 2.38
Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents. Nat Struct Mol Biol (2006) 2.21
Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease. J Biol Chem (2003) 2.15
Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1. Nature (2007) 1.94
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc Natl Acad Sci U S A (2009) 1.84
Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature (2009) 1.83
Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity. Proc Natl Acad Sci U S A (2005) 1.73
Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase. Science (2003) 1.63
Identification of a quality-control mechanism for mRNA 5'-end capping. Nature (2010) 1.58
Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature (2010) 1.58
Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate. J Med Chem (2002) 1.56
Targeting the human cancer pathway protein interaction network by structural genomics. Mol Cell Proteomics (2008) 1.54
Bacterial neuraminidase facilitates mucosal infection by participating in biofilm production. J Clin Invest (2006) 1.54
Crystal structure of 1-deoxy-D-xylulose 5-phosphate synthase, a crucial enzyme for isoprenoids biosynthesis. J Biol Chem (2006) 1.53
Optimal alignment for enzymatic proton transfer: structure of the Michaelis complex of triosephosphate isomerase at 1.2-A resolution. Proc Natl Acad Sci U S A (2002) 1.53
Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction. Nat Struct Mol Biol (2008) 1.51
Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL. J Biol Chem (2004) 1.50
Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase. Proc Natl Acad Sci U S A (2006) 1.50
Quantum chemical 13C(alpha) chemical shift calculations for protein NMR structure determination, refinement, and validation. Proc Natl Acad Sci U S A (2008) 1.50
An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2. Biochem Biophys Res Commun (2002) 1.45
Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP. Biochemistry (2004) 1.44
Molecular basis for the inhibition of the carboxyltransferase domain of acetyl-coenzyme-A carboxylase by haloxyfop and diclofop. Proc Natl Acad Sci U S A (2004) 1.41
Conserved surface features form the double-stranded RNA binding site of non-structural protein 1 (NS1) from influenza A and B viruses. J Biol Chem (2007) 1.40
Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursors. Mol Cell (2007) 1.38
Structure and function of malic enzymes, a new class of oxidative decarboxylases. Biochemistry (2003) 1.37
A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product. Mol Cell (2004) 1.32
Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with CP-640186. Structure (2004) 1.30
Crystal structures of the BAR-PH and PTB domains of human APPL1. Structure (2007) 1.30
A serendipitous discovery that in situ proteolysis is essential for the crystallization of yeast CPSF-100 (Ydh1p). Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 1.27
A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A. Structure (2009) 1.26
A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. Mol Cell (2013) 1.25
Crystal structure of human Taspase1, a crucial protease regulating the function of MLL. Structure (2005) 1.24
Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease. Hum Mol Genet (2008) 1.23
Structural and biochemical studies of the 5'→3' exoribonuclease Xrn1. Nat Struct Mol Biol (2011) 1.22
Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7). Hum Mutat (2004) 1.22
Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery. Expert Opin Ther Targets (2007) 1.19
Crystal structure of the alpha(6)beta(6) holoenzyme of propionyl-coenzyme A carboxylase. Nature (2010) 1.18
Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain. EMBO J (2002) 1.17
Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism. J Biol Chem (2009) 1.15
The use of in situ proteolysis in the crystallization of murine CstF-77. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 1.13
Functional assignment based on structural analysis: crystal structure of the yggJ protein (HI0303) of Haemophilus influenzae reveals an RNA methyltransferase with a deep trefoil knot. Proteins (2003) 1.12
Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1. Biochem Biophys Res Commun (2005) 1.12
Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens. Proc Natl Acad Sci U S A (2004) 1.11
Structure and function of carnitine acyltransferases. Ann N Y Acad Sci (2004) 1.11
Is dimerization required for the catalytic activity of bacterial biotin carboxylase? Mol Cell (2006) 1.11
Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643. J Biol Chem (2002) 1.09
Computational design of catalytic dyads and oxyanion holes for ester hydrolysis. J Am Chem Soc (2012) 1.08
Dxo1 is a new type of eukaryotic enzyme with both decapping and 5'-3' exoribonuclease activity. Nat Struct Mol Biol (2012) 1.08
Structure of histone mRNA stem-loop, human stem-loop binding protein, and 3'hExo ternary complex. Science (2013) 1.07
Mitochondrial poly(A) polymerase and polyadenylation. Biochim Biophys Acta (2011) 1.03
Structural studies of the pigeon cytosolic NADP(+)-dependent malic enzyme. Protein Sci (2002) 1.02
Functional insights from structural genomics. J Struct Funct Genomics (2007) 1.02
Enzymatic basis for N-glycan sialylation: structure of rat α2,6-sialyltransferase (ST6GAL1) reveals conserved and unique features for glycan sialylation. J Biol Chem (2013) 1.01
Molecular mechanism for the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP and fumarate. Structure (2002) 1.01
The structure of human ubiquitin in 2-methyl-2,4-pentanediol: a new conformational switch. Protein Sci (2011) 1.00
Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1. Biochemistry (2008) 0.99
Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex. Nat Commun (2012) 0.98
Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism. Structure (2003) 0.98
Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase. Mol Cell (2011) 0.98
Computational design of a protein-based enzyme inhibitor. J Mol Biol (2013) 0.98
A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim. Proc Natl Acad Sci U S A (2009) 0.96
The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity. Nat Commun (2012) 0.96
Delineating the structural blueprint of the pre-mRNA 3'-end processing machinery. Mol Cell Biol (2014) 0.96
Crystal structure of urea carboxylase provides insights into the carboxyltransfer reaction. J Biol Chem (2012) 0.96
Structural conservation of the myoviridae phage tail sheath protein fold. Structure (2011) 0.94
Structure of the Bateman2 domain of yeast Snf4: dimeric association and relevance for AMP binding. Structure (2007) 0.94
An unanticipated architecture of the 750-kDa α6β6 holoenzyme of 3-methylcrotonyl-CoA carboxylase. Nature (2011) 0.94
Structural and functional evidence for Bacillus subtilis PaiA as a novel N1-spermidine/spermine acetyltransferase. J Biol Chem (2005) 0.94
Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. Hum Genet (2010) 0.94
Cryo-EM analysis reveals new insights into the mechanism of action of pyruvate carboxylase. Structure (2010) 0.94
Computational design of an unnatural amino acid dependent metalloprotein with atomic level accuracy. J Am Chem Soc (2013) 0.93
Use of a synthetic salicylic acid analog to investigate the roles of methyl salicylate and its esterases in plant disease resistance. J Biol Chem (2009) 0.93
Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding. Biochemistry (2008) 0.93
Crystal structures of respiratory pathogen neuraminidases. Biochem Biophys Res Commun (2009) 0.92
Distinct domains in ORF52 tegument protein mediate essential functions in murine gammaherpesvirus 68 virion tegumentation and secondary envelopment. J Virol (2011) 0.92
Crystal structure of the PH-BEACH domains of human LRBA/BGL. Biochemistry (2004) 0.92
Structural genomics reveals EVE as a new ASCH/PUA-related domain. Proteins (2009) 0.92
Molecular insights into the biosynthesis of the F420 coenzyme. J Biol Chem (2008) 0.91
Dual functional roles of ATP in the human mitochondrial malic enzyme. Biochemistry (2004) 0.90
An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. Genes Dev (2012) 0.90
Mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by pinoxaden. Proc Natl Acad Sci U S A (2010) 0.90
Real-time fluorescence detection of exoribonucleases. RNA (2009) 0.89
Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins (2011) 0.89
Spherical assemblies from π-conjugated alternating copolymers: toward optoelectronic colloidal crystals. J Am Chem Soc (2013) 0.88
Methyl esterase 1 (StMES1) is required for systemic acquired resistance in potato. Mol Plant Microbe Interact (2010) 0.88
Structural and functional studies of the abundant tegument protein ORF52 from murine gammaherpesvirus 68. J Biol Chem (2007) 0.87
A large conformational change in the putative ATP pyrophosphatase PF0828 induced by ATP binding. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.87
Structural and biochemical studies of the substrate selectivity of carnitine acetyltransferase. J Biol Chem (2004) 0.86
Identification of SERPINB1 as a physiological inhibitor of human granzyme H. J Immunol (2012) 0.85
Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2. Bioorg Med Chem Lett (2009) 0.85
Structures of domains I and IV from YbbR are representative of a widely distributed protein family. Protein Sci (2011) 0.84
Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity. J Biol Chem (2004) 0.84
Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates. J Biol Chem (2006) 0.84