Mitochondrial poly(A) polymerase and polyadenylation.

Extensive alternative polyadenylation during zebrafish development. Genome Res (2012) 2.07

A large number of nuclear genes in the human parasite blastocystis require mRNA polyadenylation to create functional termination codons. Genome Biol Evol (2014) 1.40

Cytoplasmic RNA: a case of the tail wagging the dog. Nat Rev Mol Cell Biol (2013) 1.24

A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression. Hum Mol Genet (2014) 0.94

APADB: a database for alternative polyadenylation and microRNA regulation events. Database (Oxford) (2014) 0.90

Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers. PLoS Genet (2015) 0.89

FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation. RNA (2015) 0.89

Structure and function of pre-mRNA 5'-end capping quality control and 3'-end processing. Biochemistry (2014) 0.84

The application of RNA-seq to the comprehensive analysis of plant mitochondrial transcriptomes. Mol Genet Genomics (2014) 0.82

FAM46 proteins are novel eukaryotic non-canonical poly(A) polymerases. Nucleic Acids Res (2016) 0.80

From end to end: tRNA editing at 5'- and 3'-terminal positions. Int J Mol Sci (2014) 0.80

Population-level expression variability of mitochondrial DNA-encoded genes in humans. Eur J Hum Genet (2014) 0.76

In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings. Plant Cell (2016) 0.76

circTAIL-seq, a targeted method for deep analysis of RNA 3' tails, reveals transcript-specific differences by multiple metrics. RNA (2016) 0.76

Constructive edge of uridylation-induced RNA degradation. RNA Biol (2016) 0.75

Global analyses of Ceratocystis cacaofunesta mitochondria: from genome to proteome. BMC Genomics (2013) 0.75

Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria. PLoS Genet (2016) 0.75

Role of MicroRNA in Metabolic Shift During Heart Failure. Am J Physiol Heart Circ Physiol (2016) 0.75

Comparative Phylogenomic Assessment of Mitochondrial Introgression among Several Species of Chipmunks (Tamias). Genome Biol Evol (2017) 0.75

Patterns of cross-contamination in a multispecies population genomic project: detection, quantification, impact, and solutions. BMC Biol (2017) 0.75

Effect of light and prey availability on gene expression of the mixotrophic chrysophyte, Ochromonas sp. BMC Genomics (2017) 0.75

Evolution of miRNA tailing by 3' terminal uridylyl transferases in Metazoa. Genome Biol Evol (2017) 0.75

Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis. Microbiol Mol Biol Rev (1999) 11.32

Protein factors in pre-mRNA 3'-end processing. Cell Mol Life Sci (2008) 3.44

DNA polymerase beta-like nucleotidyltransferase superfamily: identification of three new families, classification and evolutionary history. Nucleic Acids Res (1999) 3.32

The ends of the affair: capping and polyadenylation. Nat Struct Biol (2000) 3.31

Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. Genes Dev (2008) 3.30

Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation. Cell (2004) 3.10

A history of poly A sequences: from formation to factors to function. Prog Nucleic Acid Res Mol Biol (2002) 2.93

The human mitochondrial transcriptome. Cell (2011) 2.70

PNPASE regulates RNA import into mitochondria. Cell (2010) 2.54

RNA-specific ribonucleotidyl transferases. RNA (2007) 2.15

Pentatricopeptide repeat proteins stimulate mRNA adenylation/uridylation to activate mitochondrial translation in trypanosomes. Mol Cell (2011) 2.10

Human mitochondrial mRNAs are stabilized with polyadenylation regulated by mitochondria-specific poly(A) polymerase and polynucleotide phosphorylase. J Biol Chem (2005) 2.02

Crystal structure of mammalian poly(A) polymerase in complex with an analog of ATP. EMBO J (2000) 1.96

Mechanism of poly(A) polymerase: structure of the enzyme-MgATP-RNA ternary complex and kinetic analysis. Structure (2007) 1.83

Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase. Nucleic Acids Res (2004) 1.73

Structure of yeast poly(A) polymerase alone and in complex with 3'-dATP. Science (2000) 1.70

Polyadenylation and degradation of human mitochondrial RNA: the prokaryotic past leaves its mark. Mol Cell Biol (2005) 1.67

3' adenylation determines mRNA abundance and monitors completion of RNA editing in T. brucei mitochondria. EMBO J (2008) 1.63

Structural basis for UTP specificity of RNA editing TUTases from Trypanosoma brucei. EMBO J (2005) 1.61

Messenger RNA stability in mitochondria: different means to an end. Trends Genet (2004) 1.57

Mitochondrial protein synthesis: RNA with the properties of Eukaryotic messenger RNA. Proc Natl Acad Sci U S A (1973) 1.56

Human mitochondrial mRNAs--like members of all families, similar but different. Biochim Biophys Acta (2010) 1.53

Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis. Mol Cell Biol (2006) 1.49

The yeast mitochondrial degradosome. Its composition, interplay between RNA helicase and RNase activities and the role in mitochondrial RNA metabolism. J Biol Chem (2002) 1.46

Stable PNPase RNAi silencing: its effect on the processing and adenylation of human mitochondrial RNA. RNA (2007) 1.43

Investigation of a pathogenic mtDNA microdeletion reveals a translation-dependent deadenylation decay pathway in human mitochondria. Hum Mol Genet (2003) 1.42

The Cid1 family of non-canonical poly(A) polymerases. Yeast (2006) 1.37

UTP-bound and Apo structures of a minimal RNA uridylyltransferase. J Mol Biol (2006) 1.36

RNA editing in the acceptor stem of squid mitochondrial tRNA(Tyr). Nucleic Acids Res (1996) 1.34

The human cytoplasmic RNA terminal U-transferase ZCCHC11 targets histone mRNAs for degradation. RNA (2010) 1.33

Opposing effects of polyadenylation on the stability of edited and unedited mitochondrial RNAs in Trypanosoma brucei. Mol Cell Biol (2005) 1.32

Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance. Nucleic Acids Res (2009) 1.25

Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality. J Biol Chem (2009) 1.23

Mitochondrial RNA processing in trypanosomes. Res Microbiol (2011) 1.21

Polyadenylation creates the discriminator nucleotide of chicken mitochondrial tRNA(Tyr). J Mol Biol (1997) 1.20

New ways to meet your (3') end oligouridylation as a step on the path to destruction. Genes Dev (2008) 1.19

Polyadenylation and beyond: emerging roles for noncanonical poly(A) polymerases. Wiley Interdiscip Rev RNA (2010) 1.18

PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria. Nucleic Acids Res (2011) 1.18

Cytoplasmic polyadenylation and translational control. Curr Opin Genet Dev (2011) 1.15

Polyadenylation-assisted RNA degradation processes in plants. Trends Plant Sci (2009) 1.14

RNA uridylyltransferases. Cell Mol Life Sci (2005) 1.14

RNA polyadenylation and decay in mitochondria and chloroplasts. Prog Mol Biol Transl Sci (2009) 1.12

RNA turnover in human mitochondria: more questions than answers? Biochim Biophys Acta (2010) 1.11

To polyadenylate or to deadenylate: that is the question. Cell Cycle (2010) 1.09

Dual role of the RNA substrate in selectivity and catalysis by terminal uridylyl transferases. Proc Natl Acad Sci U S A (2007) 1.08

A protein-protein interaction map of trypanosome ~20S editosomes. J Biol Chem (2009) 1.08

Defective mitochondrial mRNA maturation is associated with spastic ataxia. Am J Hum Genet (2010) 1.08

Structure and function of the polymerase core of TRAMP, a RNA surveillance complex. Proc Natl Acad Sci U S A (2010) 1.08

Targeting of the cytosolic poly(A) binding protein PABPC1 to mitochondria causes mitochondrial translation inhibition. Nucleic Acids Res (2010) 1.07

Human polynucleotide phosphorylase: location matters. Trends Cell Biol (2007) 1.05

Differential stability of mitochondrial mRNA in HeLa cells. Acta Biochim Pol (2005) 1.04

Polyadenylation in mammalian mitochondria: insights from recent studies. Biochim Biophys Acta (2008) 1.02

Identification of discrete polyadenylate-containing RNA components transcribed from HeLa cell mitochondrial DNA. Proc Natl Acad Sci U S A (1974) 1.00

Structure of the mitochondrial editosome-like complex associated TUTase 1 reveals divergent mechanisms of UTP selection and domain organization. J Mol Biol (2010) 0.99

In vitro reconstitution and characterization of the yeast mitochondrial degradosome complex unravels tight functional interdependence. J Mol Biol (2007) 0.99

Kinetic studies of yeast polyA polymerase indicate an induced fit mechanism for nucleotide specificity. Biochemistry (2005) 0.99

Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase. Mol Cell (2011) 0.98

The role of a conserved dodecamer sequence in yeast mitochondrial gene expression. Genome (1989) 0.97

Functional polypeptides can be synthesized from human mitochondrial transcripts lacking termination codons. Biochem J (2004) 0.96

The 3' ends of mature transcripts are generated by a processosome complex in fission yeast mitochondria. J Mol Biol (2008) 0.95

Transcription and RNA-processing in fission yeast mitochondria. RNA (2005) 0.95

Balance between transcription and RNA degradation is vital for Saccharomyces cerevisiae mitochondria: reduced transcription rescues the phenotype of deficient RNA degradation. Mol Biol Cell (2005) 0.95

Polyadenylation and degradation of mRNA in mammalian mitochondria: a missing link? Biochem Soc Trans (2008) 0.92

Targeted depletion of a mitochondrial nucleotidyltransferase suggests the presence of multiple enzymes that polymerize mRNA 3' tails in Trypanosoma brucei mitochondria. Mol Biochem Parasitol (2007) 0.90

Polyadenylation in Arabidopsis and Chlamydomonas organelles: the input of nucleotidyltransferases, poly(A) polymerases and polynucleotide phosphorylase. Plant J (2009) 0.87

A novel nuclear-encoded mitochondrial poly(A) polymerase PAPD1 is a potential candidate gene for the extreme obesity related phenotypes in mammals. Int J Biol Sci (2006) 0.83

Heat stress enhances the accumulation of polyadenylated mitochondrial transcripts in Arabidopsis thaliana. PLoS One (2008) 0.83

Mitochondrial polyriboadenylate polymerase: relative lack of activity in hepatomas. Science (1972) 0.81

Purification and characterization of an RNA dodecamer sequence binding protein from mitochondria of Saccharomyces cerevisiae. Biochem Biophys Res Commun (1999) 0.78

Protein production and purification. Nat Methods (2008) 3.97

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nat Struct Biol (2002) 3.92

Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. Nature (2006) 2.95

UNC119 is required for G protein trafficking in sensory neurons. Nat Neurosci (2011) 2.38

Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels. Nature (2004) 2.38

Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents. Nat Struct Mol Biol (2006) 2.21

Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease. J Biol Chem (2003) 2.15

Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1. Nature (2007) 1.94

Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc Natl Acad Sci U S A (2009) 1.84

Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature (2009) 1.83

Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity. Proc Natl Acad Sci U S A (2005) 1.73

Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase. Science (2003) 1.63

Identification of a quality-control mechanism for mRNA 5'-end capping. Nature (2010) 1.58

Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature (2010) 1.58

Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate. J Med Chem (2002) 1.56

Targeting the human cancer pathway protein interaction network by structural genomics. Mol Cell Proteomics (2008) 1.54

Bacterial neuraminidase facilitates mucosal infection by participating in biofilm production. J Clin Invest (2006) 1.54

Crystal structure of 1-deoxy-D-xylulose 5-phosphate synthase, a crucial enzyme for isoprenoids biosynthesis. J Biol Chem (2006) 1.53

Optimal alignment for enzymatic proton transfer: structure of the Michaelis complex of triosephosphate isomerase at 1.2-A resolution. Proc Natl Acad Sci U S A (2002) 1.53

Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction. Nat Struct Mol Biol (2008) 1.51

Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL. J Biol Chem (2004) 1.50

Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase. Proc Natl Acad Sci U S A (2006) 1.50

Quantum chemical 13C(alpha) chemical shift calculations for protein NMR structure determination, refinement, and validation. Proc Natl Acad Sci U S A (2008) 1.50

An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2. Biochem Biophys Res Commun (2002) 1.45

Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP. Biochemistry (2004) 1.44

Molecular basis for the inhibition of the carboxyltransferase domain of acetyl-coenzyme-A carboxylase by haloxyfop and diclofop. Proc Natl Acad Sci U S A (2004) 1.41

Conserved surface features form the double-stranded RNA binding site of non-structural protein 1 (NS1) from influenza A and B viruses. J Biol Chem (2007) 1.40

Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursors. Mol Cell (2007) 1.38

Structure and function of malic enzymes, a new class of oxidative decarboxylases. Biochemistry (2003) 1.37

Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport. Cell (2003) 1.32

A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product. Mol Cell (2004) 1.32

Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with CP-640186. Structure (2004) 1.30

Crystal structures of the BAR-PH and PTB domains of human APPL1. Structure (2007) 1.30

A serendipitous discovery that in situ proteolysis is essential for the crystallization of yeast CPSF-100 (Ydh1p). Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 1.27

A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A. Structure (2009) 1.26

A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. Mol Cell (2013) 1.25

Crystal structure of human Taspase1, a crucial protease regulating the function of MLL. Structure (2005) 1.24

Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease. Hum Mol Genet (2008) 1.23

Structural and biochemical studies of the 5'→3' exoribonuclease Xrn1. Nat Struct Mol Biol (2011) 1.22

Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7). Hum Mutat (2004) 1.22

Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery. Expert Opin Ther Targets (2007) 1.19

Crystal structure of the alpha(6)beta(6) holoenzyme of propionyl-coenzyme A carboxylase. Nature (2010) 1.18

Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain. EMBO J (2002) 1.17

Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism. J Biol Chem (2009) 1.15

The use of in situ proteolysis in the crystallization of murine CstF-77. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 1.13

Functional assignment based on structural analysis: crystal structure of the yggJ protein (HI0303) of Haemophilus influenzae reveals an RNA methyltransferase with a deep trefoil knot. Proteins (2003) 1.12

Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1. Biochem Biophys Res Commun (2005) 1.12

Structure and function of carnitine acyltransferases. Ann N Y Acad Sci (2004) 1.11

Is dimerization required for the catalytic activity of bacterial biotin carboxylase? Mol Cell (2006) 1.11

Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens. Proc Natl Acad Sci U S A (2004) 1.11

Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643. J Biol Chem (2002) 1.09

Dxo1 is a new type of eukaryotic enzyme with both decapping and 5'-3' exoribonuclease activity. Nat Struct Mol Biol (2012) 1.08

Computational design of catalytic dyads and oxyanion holes for ester hydrolysis. J Am Chem Soc (2012) 1.08

Structure of histone mRNA stem-loop, human stem-loop binding protein, and 3'hExo ternary complex. Science (2013) 1.07

Structural studies of the pigeon cytosolic NADP(+)-dependent malic enzyme. Protein Sci (2002) 1.02

Functional insights from structural genomics. J Struct Funct Genomics (2007) 1.02

Molecular mechanism for the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP and fumarate. Structure (2002) 1.01

Enzymatic basis for N-glycan sialylation: structure of rat α2,6-sialyltransferase (ST6GAL1) reveals conserved and unique features for glycan sialylation. J Biol Chem (2013) 1.01

The structure of human ubiquitin in 2-methyl-2,4-pentanediol: a new conformational switch. Protein Sci (2011) 1.00

Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1. Biochemistry (2008) 0.99

Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex. Nat Commun (2012) 0.98

Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism. Structure (2003) 0.98

Computational design of a protein-based enzyme inhibitor. J Mol Biol (2013) 0.98

Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase. Mol Cell (2011) 0.98

A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim. Proc Natl Acad Sci U S A (2009) 0.96

The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity. Nat Commun (2012) 0.96

Crystal structure of urea carboxylase provides insights into the carboxyltransfer reaction. J Biol Chem (2012) 0.96

Delineating the structural blueprint of the pre-mRNA 3'-end processing machinery. Mol Cell Biol (2014) 0.96

Structural conservation of the myoviridae phage tail sheath protein fold. Structure (2011) 0.94

Structure of the Bateman2 domain of yeast Snf4: dimeric association and relevance for AMP binding. Structure (2007) 0.94

An unanticipated architecture of the 750-kDa α6β6 holoenzyme of 3-methylcrotonyl-CoA carboxylase. Nature (2011) 0.94

Cryo-EM analysis reveals new insights into the mechanism of action of pyruvate carboxylase. Structure (2010) 0.94

Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. Hum Genet (2010) 0.94

Structural and functional evidence for Bacillus subtilis PaiA as a novel N1-spermidine/spermine acetyltransferase. J Biol Chem (2005) 0.94

A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression. Hum Mol Genet (2014) 0.94

Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding. Biochemistry (2008) 0.93

Computational design of an unnatural amino acid dependent metalloprotein with atomic level accuracy. J Am Chem Soc (2013) 0.93

Use of a synthetic salicylic acid analog to investigate the roles of methyl salicylate and its esterases in plant disease resistance. J Biol Chem (2009) 0.93

Distinct domains in ORF52 tegument protein mediate essential functions in murine gammaherpesvirus 68 virion tegumentation and secondary envelopment. J Virol (2011) 0.92

Crystal structures of respiratory pathogen neuraminidases. Biochem Biophys Res Commun (2009) 0.92

Crystal structure of the PH-BEACH domains of human LRBA/BGL. Biochemistry (2004) 0.92

Structural genomics reveals EVE as a new ASCH/PUA-related domain. Proteins (2009) 0.92

Molecular insights into the biosynthesis of the F420 coenzyme. J Biol Chem (2008) 0.91

Dual functional roles of ATP in the human mitochondrial malic enzyme. Biochemistry (2004) 0.90

An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. Genes Dev (2012) 0.90

Mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by pinoxaden. Proc Natl Acad Sci U S A (2010) 0.90

Real-time fluorescence detection of exoribonucleases. RNA (2009) 0.89

Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins (2011) 0.89

Spherical assemblies from π-conjugated alternating copolymers: toward optoelectronic colloidal crystals. J Am Chem Soc (2013) 0.88

Methyl esterase 1 (StMES1) is required for systemic acquired resistance in potato. Mol Plant Microbe Interact (2010) 0.88

Structural and functional studies of the abundant tegument protein ORF52 from murine gammaherpesvirus 68. J Biol Chem (2007) 0.87

A large conformational change in the putative ATP pyrophosphatase PF0828 induced by ATP binding. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.87

Structural and biochemical studies of the substrate selectivity of carnitine acetyltransferase. J Biol Chem (2004) 0.86

Identification of SERPINB1 as a physiological inhibitor of human granzyme H. J Immunol (2012) 0.85

Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2. Bioorg Med Chem Lett (2009) 0.85

Structures of domains I and IV from YbbR are representative of a widely distributed protein family. Protein Sci (2011) 0.84

Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity. J Biol Chem (2004) 0.84

Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates. J Biol Chem (2006) 0.84

Crystal structure of human retinoblastoma binding protein 9. Proteins (2009) 0.84

Crystal structure of rat carnitine palmitoyltransferase II (CPT-II). Biochem Biophys Res Commun (2006) 0.84