Published in Biochemistry on January 28, 2003
Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism. Proc Natl Acad Sci U S A (2006) 4.09
Protein kinases: evolution of dynamic regulatory proteins. Trends Biochem Sci (2010) 3.61
Identification and functional analysis of in vivo phosphorylation sites of the Arabidopsis BRASSINOSTEROID-INSENSITIVE1 receptor kinase. Plant Cell (2005) 3.48
Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation. EMBO J (2003) 2.93
Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem J (2004) 2.78
A walk-through of the yeast mating pheromone response pathway. Peptides (2005) 2.47
Phosphoproteomic analysis of Her2/neu signaling and inhibition. Proc Natl Acad Sci U S A (2006) 2.30
Identification of features regulating OST1 kinase activity and OST1 function in guard cells. Plant Physiol (2006) 1.89
Plant and animal pathogen recognition receptors signal through non-RD kinases. PLoS Pathog (2006) 1.87
Defining the conserved internal architecture of a protein kinase. Biochim Biophys Acta (2009) 1.76
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2. J Cell Biol (2010) 1.73
Raf family kinases: old dogs have learned new tricks. Genes Cancer (2011) 1.72
Syk and pTyr'd: Signaling through the B cell antigen receptor. Biochim Biophys Acta (2009) 1.55
HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction. J Biol Chem (2006) 1.51
Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations. Sci Signal (2014) 1.49
Rice XB15, a protein phosphatase 2C, negatively regulates cell death and XA21-mediated innate immunity. PLoS Biol (2008) 1.42
Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site. Protein Sci (2004) 1.41
Src kinase activation: A switched electrostatic network. Protein Sci (2006) 1.40
Mek1 kinase is regulated to suppress double-strand break repair between sister chromatids during budding yeast meiosis. Mol Cell Biol (2007) 1.38
Blue light-induced autophosphorylation of phototropin is a primary step for signaling. Proc Natl Acad Sci U S A (2008) 1.37
Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs. Structure (2007) 1.34
Evolutionary constraints associated with functional specificity of the CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK, and CK2alpha. Protein Sci (2004) 1.33
An electrostatic network and long-range regulation of Src kinases. Protein Sci (2008) 1.30
Ligand-induced global transitions in the catalytic domain of protein kinase A. Proc Natl Acad Sci U S A (2009) 1.25
Determinants for activation of the atypical AGC kinase Greatwall during M phase entry. Mol Cell Biol (2012) 1.25
Seeing is believing: peptide-based fluorescent sensors of protein tyrosine kinase activity. Chembiochem (2007) 1.18
Structural basis for the regulation of protein kinase A by activation loop phosphorylation. J Biol Chem (2012) 1.14
Release of ADP from the catalytic subunit of protein kinase A: a molecular dynamics simulation study. Protein Sci (2005) 1.09
Partitioning RS domain phosphorylation in an SR protein through the CLK and SRPK protein kinases. J Mol Biol (2013) 1.08
Reconstruction of protein networks from an atlas of maize seed proteotypes. Proc Natl Acad Sci U S A (2013) 1.07
Chlamydophila pneumoniae PknD exhibits dual amino acid specificity and phosphorylates Cpn0712, a putative type III secretion YscD homolog. J Bacteriol (2007) 1.06
Unactivated PKR exists in an open conformation capable of binding nucleotides. Biochemistry (2006) 1.06
NbLRK1, a lectin-like receptor kinase protein of Nicotiana benthamiana, interacts with Phytophthora infestans INF1 elicitin and mediates INF1-induced cell death. Planta (2008) 1.04
How does activation loop phosphorylation modulate catalytic activity in the cAMP-dependent protein kinase: a theoretical study. Protein Sci (2006) 1.04
Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2. Elife (2014) 1.01
Elucidation of XA21-mediated innate immunity. Cell Microbiol (2010) 1.01
Elm1 kinase activates the spindle position checkpoint kinase Kin4. J Cell Biol (2010) 1.01
Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proc Natl Acad Sci U S A (2012) 0.99
Phytochrome Kinase Substrate 4 is phosphorylated by the phototropin 1 photoreceptor. EMBO J (2012) 0.95
Monitoring spindle orientation: Spindle position checkpoint in charge. Cell Div (2010) 0.95
Structural basis of the regulatory mechanism of the plant CIPK family of protein kinases controlling ion homeostasis and abiotic stress. Proc Natl Acad Sci U S A (2014) 0.94
Genome-wide identification, characterization and phylogenetic analysis of the rice LRR-kinases. PLoS One (2011) 0.93
Analysis of mitogen-activated protein kinase activation and interactions with regulators and substrates. Methods (2006) 0.89
Nucleotide release sequences in the protein kinase SRPK1 accelerate substrate phosphorylation. Biochemistry (2012) 0.87
Identification of in vitro autophosphorylation sites and effects of phosphorylation on the Arabidopsis CRINKLY4 (ACR4) receptor-like kinase intracellular domain: insights into conformation, oligomerization, and activity. Biochemistry (2011) 0.86
Genome-wide identification, characterization and expression analysis of populus leucine-rich repeat receptor-like protein kinase genes. BMC Genomics (2013) 0.86
Regulating SR protein phosphorylation through regions outside the kinase domain of SRPK1. J Mol Biol (2011) 0.85
Mechanisms regulating the protein kinases of Saccharomyces cerevisiae. Eukaryot Cell (2007) 0.85
Cloning and characterization of a maize SnRK2 protein kinase gene confers enhanced salt tolerance in transgenic Arabidopsis. Plant Cell Rep (2011) 0.83
Analysis of monomeric and dimeric phosphorylated forms of protein kinase R. Biochemistry (2010) 0.80
A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases. ACS Med Chem Lett (2012) 0.80
Reg1 protein regulates phosphorylation of all three Snf1 isoforms but preferentially associates with the Gal83 isoform. Eukaryot Cell (2011) 0.80
Structural basis of nSH2 regulation and lipid binding in PI3Kα. Oncotarget (2014) 0.79
Activating Mutations in PIK3CA Lead to Widespread Modulation of the Tyrosine Phosphoproteome. J Proteome Res (2015) 0.78
Mass spectrometry-based proteomics: qualitative identification to activity-based protein profiling. Wiley Interdiscip Rev Syst Biol Med (2012) 0.78
Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer. Oncotarget (2016) 0.78
Atomistic insights into the lung cancer-associated L755P mutation in HER2 resistance to lapatinib: a molecular dynamics study. J Mol Model (2015) 0.77
Conserved phosphorylation sites in the activation loop of the Arabidopsis phytosulfokine receptor PSKR1 differentially affect kinase and receptor activity. Biochem J (2015) 0.76
Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases. Sci Rep (2015) 0.76
Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer. Proc Natl Acad Sci U S A (2017) 0.76
Calmodulin binds HER2 and modulates HER2 signaling. Biochim Biophys Acta (2010) 0.76
Multiple steps to activate FAK's kinase domain: adaptation to confined environments? Biophys J (2013) 0.75
The activation loop of PIP5K functions as a membrane sensor essential for lipid substrate processing. Sci Adv (2016) 0.75
Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases. PLoS Biol (2016) 0.75
Effects of FGFR2 kinase activation loop dynamics on catalytic activity. PLoS Comput Biol (2017) 0.75
Phosphorylation of the kinase domain regulates autophosphorylation of myosin IIIA and its translocation in microvilli. Biochemistry (2014) 0.75
A computational protocol to evaluate the effects of protein mutants in the kinase gatekeeper position on the binding of ATP substrate analogues. BMC Res Notes (2017) 0.75
Acidic C-terminal domains autoregulate the RNA chaperone Hfq. Elife (2017) 0.75
Chemotherapeutic drug selectivity between wild-type and mutant BRaf kinases in colon cancer. J Mol Model (2016) 0.75