Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer.

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Published in Proc Natl Acad Sci U S A on January 23, 2017

Authors

Lalima G Ahuja1, Alexandr P Kornev1, Christopher L McClendon2, Gianluigi Veglia3,4, Susan S Taylor5,6

Author Affiliations

1: Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093.
2: Cardiovascular and Metabolic Diseases, Medicinal Chemistry, Pfizer Biomedical Institute, Pfizer, Inc., Cambridge, MA 02139.
3: Department of Chemistry, University of Minnesota, Minneapolis, MN 55455.
4: Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455.
5: Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093; staylor@ucsd.edu.
6: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093.

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