Published in Proc Natl Acad Sci U S A on January 21, 2003
Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS One (2011) 3.10
Identifying and targeting ROS1 gene fusions in non-small cell lung cancer. Clin Cancer Res (2012) 2.66
Novel targets in non-small cell lung cancer: ROS1 and RET fusions. Oncologist (2013) 2.04
Molecular pathways: ROS1 fusion proteins in cancer. Clin Cancer Res (2013) 1.94
Chromosome 3 anomalies investigated by genome wide SNP analysis of benign, low malignant potential and low grade ovarian serous tumours. PLoS One (2011) 1.53
Neoplasia driven by mutant c-KIT is mediated by intracellular, not plasma membrane, receptor signaling. Mol Cell Biol (2006) 1.33
Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases. Mol Cell Biol (2005) 1.30
Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types. PLoS Genet (2013) 1.19
The oncogenic lung cancer fusion kinase CD74-ROS activates a novel invasiveness pathway through E-Syt1 phosphorylation. Cancer Res (2012) 1.10
Advances and challenges in the molecular biology and treatment of glioblastoma-is there any hope for the future? Ann Transl Med (2015) 1.04
PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations. Proc Natl Acad Sci U S A (2015) 0.97
Mouse model for ROS1-rearranged lung cancer. PLoS One (2013) 0.88
ROS1 signaling regulates epithelial differentiation in the epididymis. Endocrinology (2014) 0.85
Testing for ROS1 in non-small cell lung cancer: a review with recommendations. Virchows Arch (2016) 0.83
ROS1 expression in invasive ductal carcinoma of the breast related to proliferation activity. Yonsei Med J (2013) 0.79
Synergistic Effects of Crizotinib and Temozolomide in Experimental FIG-ROS1 Fusion-Positive Glioblastoma. Cancer Growth Metastasis (2015) 0.78
Crystallization and preliminary X-ray crystallographic studies of the coiled-coil domain of PIST. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.76
Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. Oncotarget (2016) 0.75
Cytoplasmic c-ros oncogene 1 receptor tyrosine kinase expression may be associated with the development of human oral squamous cell carcinoma. Oncol Lett (2015) 0.75
The ortholog of the human proto-oncogene ROS1 is required for epithelial development in C. elegans. Genesis (2013) 0.75
Recent Advances in Targeting ROS1 in Lung Cancer. J Thorac Oncol (2017) 0.75
Improved retroviral vectors for gene transfer and expression. Biotechniques (1989) 19.48
SH2 domains recognize specific phosphopeptide sequences. Cell (1993) 17.28
Oncogenic kinase signalling. Nature (2001) 16.30
Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol (1991) 15.04
Coiled coils: a highly versatile protein folding motif. Trends Cell Biol (2001) 5.55
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol Cell Biol (1994) 5.02
Protein-protein interactions define specificity in signal transduction. Genes Dev (2000) 3.62
Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science (1990) 3.58
Critical role for Gab2 in transformation by BCR/ABL. Cancer Cell (2002) 2.42
The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways. Proc Natl Acad Sci U S A (1996) 1.98
Characterization of an activated human ros gene. Mol Cell Biol (1986) 1.97
Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule. Mol Cell Biol (1986) 1.89
Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase. Mol Cell Biol (1993) 1.64
A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein. EMBO J (1997) 1.60
The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis. Genes Dev (1996) 1.39
ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain. Blood (2000) 1.38
The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. Mol Cell Biol (1995) 1.38
Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6. J Biol Chem (2001) 1.23
Transient and locally restricted expression of the ros1 protooncogene during mouse development. EMBO J (1991) 1.14
Enhanced transformation by a plasma membrane-associated met oncoprotein: activation of a phosphoinositide 3'-kinase-dependent autocrine loop involving hyaluronic acid and CD44. Mol Cell Biol (2000) 1.10
Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3). Blood (2002) 1.06
Efficient cell transformation by the Tpr-Met oncoprotein is dependent upon tyrosine 489 in the carboxy-terminus. Oncogene (1995) 1.05
A single point mutation switches the specificity of group III Src homology (SH) 2 domains to that of group I SH2 domains. J Biol Chem (1995) 1.04
Chromosome 1 rearrangements involving the genes TPR and NTRK1 produce structurally different thyroid-specific TRK oncogenes. Genes Chromosomes Cancer (1997) 1.02
Comparative role of phosphotyrosine kinase domains of c-ros and c-ret protooncogenes in metanephric development with respect to growth factors and matrix morphogens. Dev Biol (1996) 1.02
Characterization of the ros1-gene products expressed in human glioblastoma cell lines. Oncogene Res (1989) 1.01
Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation. J Biol Chem (1999) 1.00
Transforming properties of the Huntingtin interacting protein 1/ platelet-derived growth factor beta receptor fusion protein. J Biol Chem (1999) 0.99
The receptor tyrosine kinases: role in cancer progression. Surg Oncol Clin N Am (2001) 0.97
Recognition and regulation of primary-sequence motifs by signaling modular domains. Prog Biophys Mol Biol (1999) 0.97
Tissue and epithelial cell-specific expression of chicken proto-oncogene c-ros in several organs suggests that it may play roles in their development and mature functions. Oncogene (1994) 0.90
Characterization of the chronic myelomonocytic leukemia associated TEL-PDGF beta R fusion protein. Oncogene (1999) 0.87
Expression of the ROS1 oncogene for tyrosine receptor kinase in adult human meningiomas. Cancer Genet Cytogenet (1995) 0.85
Two chimeric receptors of epidermal growth factor receptor and c-Ros that differ in their transmembrane domains have opposite effects on cell growth. Mol Cell Biol (1996) 0.85
Biochemical and functional characterization of the murine ros protooncogene. Oncogene (1994) 0.83
Differential expression of ros oncogene in primary human astrocytomas and astrocytoma cell lines. Cancer Res (1990) 0.82
Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc. Br J Cancer (2002) 0.80
Analysis of oncogene expression in primary human gliomas: evidence for increased expression of the ros oncogene. Cancer Genet Cytogenet (1994) 0.79
Modulatory effect of the transmembrane domain of the protein-tyrosine kinase encoded by oncogene ros: biological function and substrate interaction. Proc Natl Acad Sci U S A (1994) 0.79
Annotation of functional variation in personal genomes using RegulomeDB. Genome Res (2012) 11.47
Gene Ontology annotations at SGD: new data sources and annotation methods. Nucleic Acids Res (2007) 9.03
Saccharomyces Genome Database: the genomics resource of budding yeast. Nucleic Acids Res (2011) 8.57
Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev (2009) 5.21
Genome Snapshot: a new resource at the Saccharomyces Genome Database (SGD) presenting an overview of the Saccharomyces cerevisiae genome. Nucleic Acids Res (2006) 3.59
Saccharomyces Genome Database provides mutant phenotype data. Nucleic Acids Res (2009) 3.38
Expanded protein information at SGD: new pages and proteome browser. Nucleic Acids Res (2006) 3.31
Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). Genes Chromosomes Cancer (2003) 2.67
Training Future Scientists: Predicting First-year Minority Student Participation in Health Science Research. Res High Educ (2008) 2.66
A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9. Proc Natl Acad Sci U S A (2002) 2.19
Inclusion of immigrant status in smoking prevalence statistics. Am J Public Health (2003) 2.16
Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development (2004) 2.14
Mutational analysis of the N-terminal DNA-binding domain of sleeping beauty transposase: critical residues for DNA binding and hyperactivity in mammalian cells. Mol Cell Biol (2004) 1.97
YeastMine--an integrated data warehouse for Saccharomyces cerevisiae data as a multipurpose tool-kit. Database (Oxford) (2012) 1.92
An overview of the BioCreative 2012 Workshop Track III: interactive text mining task. Database (Oxford) (2013) 1.82
ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res (2006) 1.80
Huntington's disease: can mice lead the way to treatment? Neuron (2011) 1.71
Single-step detection of mutant huntingtin in animal and human tissues: a bioassay for Huntington's disease. Anal Biochem (2009) 1.64
Migrants and tuberculosis: analysing epidemiological data with ethnography. Aust N Z J Public Health (2008) 1.46
Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching. J Am Chem Soc (2012) 1.44
Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol (2008) 1.35
A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8. Mol Ther (2007) 1.19
Using computational predictions to improve literature-based Gene Ontology annotations: a feasibility study. Database (Oxford) (2011) 1.17
Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations. Cancer Res (2010) 1.16
Strain-specific differences in two large Mycobacterium tuberculosis genotype clusters in isolates collected from homeless patients in New York City from 2001 to 2004. J Clin Microbiol (2006) 1.03
TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis. J Immunol (2010) 0.97
Epigenetic regulation of c-ROS receptor tyrosine kinase expression in malignant gliomas. Cancer Res (2009) 0.96
Diffusion-weighted imaging in acute hyperammonemic encephalopathy. Neurohospitalist (2013) 0.96
Health insurance moderates the association between immigrant length of stay and health status. J Immigr Minor Health (2012) 0.96
Tuberculosis and syndemics: implications for Pacific health in New Zealand. Soc Sci Med (2009) 0.95
Treatment of neuroblastoma in patients with neurocristopathy syndromes. J Pediatr Hematol Oncol (2003) 0.89
Role of the WT1 tumor suppressor in murine hematopoiesis. Blood (2002) 0.89
Constraints upon food provisioning practices in 'busy' women's lives: trade-offs which demand convenience. Appetite (2007) 0.88
ROS1 signaling regulates epithelial differentiation in the epididymis. Endocrinology (2014) 0.85
Cost analysis of near-infrared spectroscopy tissue oximetry for monitoring autologous free tissue breast reconstruction. J Reconstr Microsurg (2011) 0.85
Orphan nuclear receptor NR4A2 induces synoviocyte proliferation, invasion, and matrix metalloproteinase 13 transcription. Arthritis Rheum (2012) 0.85
Peripheral blood stem cell support reduces the toxicity of intensive chemotherapy for children and adolescents with metastatic sarcomas. Cancer (2002) 0.84
The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring Cohort. J Hypertens (2009) 0.83
Comprehensive profiling of the cell surface proteome of Sy5Y neuroblastoma cells yields a subset of proteins associated with tumor differentiation. J Proteome Res (2009) 0.83
Occupational status and health insurance among immigrants: effects by generation, length of residence in U.S., and race. J Immigr Minor Health (2008) 0.80
Synthesis of novel migrastatin and dorrigocin A analogues from D-glucal. Chemistry (2008) 0.78
Does fascia lata repair facilitate closure and does it affect compartment pressures of the anterolateral thigh flap donor site? Plast Reconstr Surg (2007) 0.78
Clinical and molecular study in congenital muscular dystrophy with partial laminin alpha 2 (LAMA2) deficiency. Hum Mutat (2003) 0.77
Huntington's disease: A transcriptional report card from the peripheral blood: can it measure disease progression in Huntington's disease? Eur J Hum Genet (2006) 0.76
Advanced locoregional therapies in breast. Ann Surg Oncol (2014) 0.75
Discourses of disease: representations of tuberculosis within New Zealand newspapers 2002-2004. Soc Sci Med (2007) 0.75
N-Glycosyl-thiophene-2-carboxamides: synthesis, structure and effects on the growth of diverse cell types. Carbohydr Res (2006) 0.75