Published in Am J Physiol Heart Circ Physiol on January 23, 2003
Restricted inactivation of serum response factor to the cardiovascular system. Proc Natl Acad Sci U S A (2004) 2.98
Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton. Blood (2010) 1.99
Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality. J Cell Biol (2003) 1.44
Tropomodulin1 is required for membrane skeleton organization and hexagonal geometry of fiber cells in the mouse lens. J Cell Biol (2009) 1.30
Tropomodulins: pointed-end capping proteins that regulate actin filament architecture in diverse cell types. Cytoskeleton (Hoboken) (2012) 1.30
Molecular basis of tropomyosin binding to tropomodulin, an actin-capping protein. J Mol Biol (2007) 1.29
Tropomodulin1 is required in the heart but not the yolk sac for mouse embryonic development. Circ Res (2008) 1.22
Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology. J Cell Biol (2010) 1.21
Dynamic regulation of sarcomeric actin filaments in striated muscle. Cytoskeleton (Hoboken) (2010) 1.17
Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle. J Cell Sci (2010) 1.15
New components of the Drosophila fusome suggest it plays novel roles in signaling and transport. Dev Biol (2008) 1.14
The interaction of tropomodulin with tropomyosin stabilizes thin filaments in cardiac myocytes. J Cell Biol (2003) 1.13
Leiomodin 1, a new serum response factor-dependent target gene expressed preferentially in differentiated smooth muscle cells. J Biol Chem (2011) 1.10
Cytoplasmic gamma-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers. J Cell Biol (2011) 1.06
Tmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lens. PLoS One (2012) 1.01
Identification of residues within tropomodulin-1 responsible for its localization at the pointed ends of the actin filaments in cardiac myocytes. J Biol Chem (2010) 0.99
Leiomodin 3 and tropomodulin 4 have overlapping functions during skeletal myofibrillogenesis. J Cell Sci (2014) 0.99
Tropomodulin capping of actin filaments in striated muscle development and physiology. J Biomed Biotechnol (2011) 0.98
Sarcomeric actin organization is synergistically promoted by tropomodulin, ADF/cofilin, AIP1 and profilin in C. elegans. J Cell Sci (2008) 0.93
Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality. Proc Natl Acad Sci U S A (2015) 0.89
Erythroid development in the mammalian embryo. Blood Cells Mol Dis (2013) 0.84
Tropomodulin protects α-catenin-dependent junctional-actin networks under stress during epithelial morphogenesis. Curr Biol (2012) 0.83
Erythrocyte tropomodulin isoforms with and without the N-terminal actin-binding domain. J Biol Chem (2010) 0.82
Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo. Dev Dyn (2014) 0.80
The modern primitives: applying new technological approaches to explore the biology of the earliest red blood cells. ISRN Hematol (2013) 0.79
Phosphorylation of tropomodulin1 contributes to the regulation of actin filament architecture in cardiac muscle. FASEB J (2014) 0.78
Defective erythroid maturation in gelsolin mutant mice. Haematologica (2012) 0.78
Tropomodulins and tropomyosins: working as a team. J Muscle Res Cell Motil (2013) 0.78
Formation, contraction, and mechanotransduction of myofribrils in cardiac development: clues from genetics. Biochem Res Int (2012) 0.76
Lmod2 piggyBac mutant mice exhibit dilated cardiomyopathy. Cell Biosci (2016) 0.76
The minus-end actin capping protein, UNC-94/tropomodulin, regulates development of the Caenorhabditis elegans intestine. Dev Dyn (2014) 0.76
Actin in striated muscle: recent insights into assembly and maintenance. Biophys Rev (2011) 0.75
Tropomodulins and Leiomodins: Actin Pointed End Caps and Nucleators in Muscles. Biophys J (2017) 0.75
Role of Active Contraction and Tropomodulins in Regulating Actin Filament Length and Sarcomere Structure in Developing Zebrafish Skeletal Muscle. Front Physiol (2016) 0.75
The cardiomyopathy-associated K15N mutation in tropomyosin alters actin filament pointed end dynamics. Arch Biochem Biophys (2017) 0.75
Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell (2003) 8.00
A myocardial lineage derives from Tbx18 epicardial cells. Nature (2008) 6.15
Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat Cell Biol (2011) 4.64
Superoxide flashes in single mitochondria. Cell (2008) 4.08
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell (2005) 3.96
Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest (2006) 3.72
ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med (2002) 3.36
Vascular remodeling of the mouse yolk sac requires hemodynamic force. Development (2007) 3.26
Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction. J Am Coll Cardiol (2003) 3.20
Selective stimulation of astrocyte calcium in situ does not affect neuronal excitatory synaptic activity. Neuron (2007) 3.15
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest (2009) 2.98
Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol (2006) 2.81
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell (2013) 2.43
Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice. Circ Res (2005) 2.42
Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res (2002) 2.36
Drosophila as a model for the identification of genes causing adult human heart disease. Proc Natl Acad Sci U S A (2006) 2.22
An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest (2008) 2.19
Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy. Circulation (2006) 2.07
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest (2010) 2.04
Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle. J Cell Biol (2006) 2.00
Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects. Am J Physiol Heart Circ Physiol (2007) 1.99
T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development (2005) 1.92
Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat Med (2011) 1.88
Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J (2004) 1.88
Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes. RNA (2003) 1.87
Loss of enigma homolog protein results in dilated cardiomyopathy. Circ Res (2010) 1.85
Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest (2014) 1.82
Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proc Natl Acad Sci U S A (2007) 1.80
In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Nature (2013) 1.79
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. J Mol Cell Cardiol (2009) 1.72
Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells. J Gen Physiol (2010) 1.71
Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics (2012) 1.65
Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. J Clin Invest (2005) 1.61
Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J Clin Invest (2012) 1.59
Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum. RNA (2008) 1.49
Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet (2009) 1.48
Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice. Proc Natl Acad Sci U S A (2008) 1.48
In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase. J Neurosci (2013) 1.47
Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function. J Clin Invest (2011) 1.46
Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling. J Biol Chem (2003) 1.44
Dynamics of Z-band based proteins in developing skeletal muscle cells. Cell Motil Cytoskeleton (2005) 1.43
Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis. Development (2003) 1.42
Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature (2012) 1.42
Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation. J Clin Invest (2013) 1.40
Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum. J Cell Sci (2009) 1.40
Ca-activation and stretch-activation in insect flight muscle. Biophys J (2004) 1.38
Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle. Am J Physiol Heart Circ Physiol (2005) 1.35
Cell-cell connection to cardiac disease. Trends Cardiovasc Med (2009) 1.34
Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals. Cell Res (2011) 1.32
Rapid muscle-specific gene expression changes after a single bout of eccentric contractions in the mouse. Am J Physiol Cell Physiol (2003) 1.30
alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture. Circulation (2006) 1.28
PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes. Mol Cell Biol (2005) 1.27
Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility. Circulation (2013) 1.25
FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner. J Clin Invest (2005) 1.25
Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle. Am J Physiol Cell Physiol (2007) 1.25
Reduced thin filament length in nebulin-knockout skeletal muscle alters isometric contractile properties. Am J Physiol Cell Physiol (2009) 1.24
Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. J Biol Chem (2002) 1.24
A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C. J Biol Chem (2003) 1.23
Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death. Hum Mol Genet (2008) 1.22
Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. J Clin Invest (2008) 1.18
Smad7 is required for the development and function of the heart. J Biol Chem (2008) 1.18
Morphology and ultrastructure of differentiating three-dimensional mammalian skeletal muscle in a collagen gel. Muscle Nerve (2007) 1.17
Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures. Circ Res (2007) 1.15
Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer. Circulation (2002) 1.14
Nuclear Ca2+ sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes. Cell Calcium (2007) 1.14
Biophysical regulation of histone acetylation in mesenchymal stem cells. Biophys J (2011) 1.14
Nebulin plays a direct role in promoting strong actin-myosin interactions. FASEB J (2009) 1.14
Electron tomography of cryofixed, isometrically contracting insect flight muscle reveals novel actin-myosin interactions. PLoS One (2010) 1.13
A mighty small heart: the cardiac proteome of adult Drosophila melanogaster. PLoS One (2011) 1.13
3-D nanomechanics of an erythrocyte junctional complex in equibiaxial and anisotropic deformations. Ann Biomed Eng (2005) 1.13
Characterization and in vivo functional analysis of splice variants of cypher. J Biol Chem (2002) 1.13
Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy. Proc Natl Acad Sci U S A (2013) 1.13
Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation (2013) 1.12
Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart. Am J Physiol Heart Circ Physiol (2003) 1.11
Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes. J Biol Chem (2012) 1.10
Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine. Circulation (2009) 1.10
Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1. Mol Cell Biol (2012) 1.09
Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation (2009) 1.08
Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem (2012) 1.07
Thymosin beta 4 is dispensable for murine cardiac development and function. Circ Res (2011) 1.05
"Z"eroing in on the role of Cypher in striated muscle function, signaling, and human disease. Trends Cardiovasc Med (2007) 1.04
Molecular modeling of averaged rigor crossbridges from tomograms of insect flight muscle. J Struct Biol (2002) 1.04
Cross-bridge number, position, and angle in target zones of cryofixed isometrically active insect flight muscle. Biophys J (2004) 1.04
The type 2 inositol (1,4,5)-trisphosphate (InsP3) receptor determines the sensitivity of InsP3-induced Ca2+ release to ATP in pancreatic acinar cells. J Biol Chem (2008) 1.02
Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver. Hepatology (2010) 1.01
Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. Mol Cell Biol (2008) 1.01
Electron tomography of fast frozen, stretched rigor fibers reveals elastic distortions in the myosin crossbridges. J Struct Biol (2004) 1.01
Genetic analysis of anterior posterior expression gradients in the developing mammalian forebrain. Cereb Cortex (2006) 1.00
Methods for identifying and averaging variable molecular conformations in tomograms of actively contracting insect flight muscle. J Struct Biol (2009) 0.99
Phosphorylation and the N-terminal extension of the regulatory light chain help orient and align the myosin heads in Drosophila flight muscle. J Struct Biol (2009) 0.99
The LIM-only protein FHL2 regulates cyclin D1 expression and cell proliferation. J Biol Chem (2008) 0.98
Electron tomography of swollen rigor fibers of insect flight muscle reveals a short and variably angled S2 domain. J Mol Biol (2006) 0.98
Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. Mol Biol Cell (2012) 0.97
ALP/Enigma PDZ-LIM domain proteins in the heart. J Mol Cell Biol (2009) 0.97
Protofilament and hexagon: a three-dimensional mechanical model for the junctional complex in the erythrocyte membrane skeleton. Ann Biomed Eng (2003) 0.97
Four and half lim protein 2 (FHL2) stimulates osteoblast differentiation. J Bone Miner Res (2005) 0.96
Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses. Proc Natl Acad Sci U S A (2013) 0.95
Contributions of different intraarticular tissues to the acute phase elevation of synovial fluid MMP-2 following rat ACL rupture. J Orthop Res (2009) 0.94
Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity. J Cell Biol (2013) 0.94
Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells. J Leukoc Biol (2006) 0.93