Published in Dev Cell on December 01, 2003
miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature (2009) 10.26
Gene regulatory networks in the evolution and development of the heart. Science (2006) 7.67
Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature (2010) 6.69
Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature (2009) 4.68
Retinoic acid synthesis and signaling during early organogenesis. Cell (2008) 4.52
An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell (2007) 3.74
Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol Rev (2007) 3.41
Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol (2006) 2.81
Transcriptional and epigenetic dynamics during specification of human embryonic stem cells. Cell (2013) 2.64
Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science (2009) 2.60
Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci U S A (2007) 2.56
Origins and fates of cardiovascular progenitor cells. Cell (2008) 2.55
Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development (2006) 2.41
A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat Neurosci (2008) 2.36
Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev Biol (2008) 2.34
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet (2008) 2.29
Vessel and blood specification override cardiac potential in anterior mesoderm. Dev Cell (2007) 2.16
Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling. J Clin Invest (2007) 2.12
A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. J Clin Invest (2010) 2.06
Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res (2011) 2.05
Clonally dominant cardiomyocytes direct heart morphogenesis. Nature (2012) 2.03
Zebrafish as a model to study cardiac development and human cardiac disease. Cardiovasc Res (2011) 2.03
Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. J Cell Biol (2007) 2.02
Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs. Nature (2013) 2.00
Myocardial lineage development. Circ Res (2010) 1.98
Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart. J Cell Biol (2005) 1.93
Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart. Development (2009) 1.93
Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo. J Mol Cell Cardiol (2009) 1.88
Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity. Dev Biol (2008) 1.88
Distinct origins and genetic programs of head muscle satellite cells. Dev Cell (2009) 1.86
Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes. J Clin Invest (2008) 1.80
Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proc Natl Acad Sci U S A (2007) 1.80
Effect of human donor cell source on differentiation and function of cardiac induced pluripotent stem cells. J Am Coll Cardiol (2014) 1.77
Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology. PLoS One (2011) 1.73
Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium. Proc Natl Acad Sci U S A (2012) 1.73
A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat Cell Biol (2009) 1.73
Cardiac regenerative capacity and mechanisms. Annu Rev Cell Dev Biol (2012) 1.70
Notch post-translationally regulates β-catenin protein in stem and progenitor cells. Nat Cell Biol (2011) 1.66
Antagonism between retinoic acid and fibroblast growth factor signaling during limb development. Cell Rep (2013) 1.65
Latent TGF-β binding protein 3 identifies a second heart field in zebrafish. Nature (2011) 1.64
Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity. Immunity (2013) 1.62
Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis. Proc Natl Acad Sci U S A (2007) 1.60
The role of secondary heart field in cardiac development. Dev Biol (2009) 1.60
Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. J Clin Invest (2010) 1.57
GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium. Mol Cell Biol (2008) 1.56
Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation. J Cell Biol (2011) 1.56
Epithelial-to-mesenchymal and endothelial-to-mesenchymal transition: from cardiovascular development to disease. Circulation (2012) 1.53
Bmp2 instructs cardiac progenitors to form the heart-valve-inducing field. Dev Biol (2006) 1.52
FRS2α-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity. Circ Res (2011) 1.52
Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves. J Clin Invest (2010) 1.51
Retinoic acid deficiency alters second heart field formation. Proc Natl Acad Sci U S A (2008) 1.51
An emerging consensus on cardiac regeneration. Nat Med (2014) 1.50
Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J Clin Invest (2009) 1.50
Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev Cell (2010) 1.49
Vascular smooth muscle progenitor cells: building and repairing blood vessels. Circ Res (2011) 1.46
Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proc Natl Acad Sci U S A (2007) 1.46
FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes. J Clin Invest (2005) 1.46
Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res (2013) 1.46
CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circ Res (2012) 1.46
BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development. Dev Dyn (2008) 1.44
HCN4 dynamically marks the first heart field and conduction system precursors. Circ Res (2013) 1.44
Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell (2012) 1.43
Transcriptional pathways in second heart field development. Semin Cell Dev Biol (2007) 1.43
Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor. Nature (2013) 1.42
Identification of downstream genetic pathways of Tbx1 in the second heart field. Dev Biol (2008) 1.39
A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest (2011) 1.39
Stem cell heterogeneity: implications for aging and regenerative medicine. Blood (2012) 1.38
Retinoic acid controls heart anteroposterior patterning by down-regulating Isl1 through the Fgf8 pathway. Dev Dyn (2008) 1.38
Zebrafish cardiac development requires a conserved secondary heart field. Development (2011) 1.38
Tbx1 regulates proliferation and differentiation of multipotent heart progenitors. Circ Res (2009) 1.37
Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart. Development (2008) 1.37
MicroRNAs: regulating a change of heart. Circulation (2009) 1.37
The pathogenesis of atrial and atrioventricular septal defects with special emphasis on the role of the dorsal mesenchymal protrusion. Differentiation (2012) 1.34
Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Dev Cell (2010) 1.33
Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. Diabetes (2009) 1.33
Role of stem cells in cardiovascular biology. J Thromb Haemost (2011) 1.31
A caudal proliferating growth center contributes to both poles of the forming heart tube. Circ Res (2008) 1.31
Genetic fate mapping identifies second heart field progenitor cells as a source of adipocytes in arrhythmogenic right ventricular cardiomyopathy. Circ Res (2009) 1.28
Regeneration of the heart. EMBO Mol Med (2011) 1.27
Bioengineering heart muscle: a paradigm for regenerative medicine. Annu Rev Biomed Eng (2011) 1.26
Highly efficient induction and long-term maintenance of multipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions. Cell Res (2013) 1.26
Cardiovascular development and the colonizing cardiac neural crest lineage. ScientificWorldJournal (2007) 1.26
Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes. Mol Cell Endocrinol (2009) 1.25
Versican proteolysis mediates myocardial regression during outflow tract development. Dev Dyn (2007) 1.24
Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells. Nat Biotechnol (2015) 1.22
sonic hedgehog is required in pulmonary endoderm for atrial septation. Development (2009) 1.22
Role of homeobox genes in the patterning, specification, and differentiation of ectodermal appendages in mammals. J Cell Physiol (2008) 1.21
Islet1 derivatives in the heart are of both neural crest and second heart field origin. Circ Res (2012) 1.18
Early cardiac development: a view from stem cells to embryos. Cardiovasc Res (2012) 1.18
From fish to amphibians to mammals: in search of novel strategies to optimize cardiac regeneration. J Cell Biol (2009) 1.17
Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development (2008) 1.16
Developmental and regenerative biology of multipotent cardiovascular progenitor cells. Circ Res (2011) 1.16
A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells. Nat Cell Biol (2013) 1.16
Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease. Dis Model Mech (2009) 1.16
Patterning of the heart field in the chick. Dev Biol (2008) 1.15
Human embryonic stem cells and cardiac repair. Transplant Rev (Orlando) (2008) 1.15
Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. Circ Res (2009) 1.15
Common variation in ISL1 confers genetic susceptibility for human congenital heart disease. PLoS One (2010) 1.15
Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury. PLoS One (2012) 1.14
Lost in transgenesis: a user's guide for genetically manipulating the mouse in cardiac research. Circ Res (2012) 1.14
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature (2005) 9.44
A myocardial lineage derives from Tbx18 epicardial cells. Nature (2008) 6.15
Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat Cell Biol (2011) 4.64
Superoxide flashes in single mitochondria. Cell (2008) 4.08
Embryonic stem cell potency fluctuates with endogenous retrovirus activity. Nature (2012) 3.96
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell (2005) 3.96
Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest (2006) 3.72
Transcriptional codes and the control of neuronal identity. Annu Rev Neurosci (2002) 3.48
ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med (2002) 3.36
Vascular remodeling of the mouse yolk sac requires hemodynamic force. Development (2007) 3.26
A functional study of miR-124 in the developing neural tube. Genes Dev (2007) 3.21
Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction. J Am Coll Cardiol (2003) 3.20
YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes Dev (2008) 3.16
Selective stimulation of astrocyte calcium in situ does not affect neuronal excitatory synaptic activity. Neuron (2007) 3.15
Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc Natl Acad Sci U S A (2002) 3.13
Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors. Neuron (2003) 3.08
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest (2009) 2.98
LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions. Cell (2002) 2.94
Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains. Cell (2005) 2.88
Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol (2006) 2.81
Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay. Mol Cell (2011) 2.73
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell (2013) 2.43
Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice. Circ Res (2005) 2.42
Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development (2006) 2.41
Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells. Genes Dev (2005) 2.40
Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res (2002) 2.36
A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat Neurosci (2008) 2.36
Small CTD phosphatases function in silencing neuronal gene expression. Science (2005) 2.23
Regulation of motor neuron specification by phosphorylation of neurogenin 2. Neuron (2008) 2.20
An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest (2008) 2.19
The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics. Neuron (2007) 2.19
Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy. Circulation (2006) 2.07
Isl1Cre reveals a common Bmp pathway in heart and limb development. Development (2006) 2.04
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest (2010) 2.04
Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling. Science (2008) 2.01
Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. Cell (2007) 2.00
Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle. J Cell Biol (2006) 2.00
Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects. Am J Physiol Heart Circ Physiol (2007) 1.99
T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development (2005) 1.92
Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat Med (2011) 1.88
Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J (2004) 1.88
Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. Genes Dev (2011) 1.86
Loss of enigma homolog protein results in dilated cardiomyopathy. Circ Res (2010) 1.85
Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Mol Ther (2011) 1.85
Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest (2014) 1.82
Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proc Natl Acad Sci U S A (2007) 1.80
In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Nature (2013) 1.79
Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. Neuron (2005) 1.77
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. J Mol Cell Cardiol (2009) 1.72
Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell (2006) 1.71
Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells. J Gen Physiol (2010) 1.71
Inhibition of retroviral pathogenesis by RNA interference. Curr Biol (2002) 1.70
Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. J Clin Invest (2005) 1.61
Analysis of embryonic motoneuron gene regulation: derepression of general activators function in concert with enhancer factors. Development (2004) 1.60
Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J Clin Invest (2012) 1.59
Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat Genet (2007) 1.59
Development of circuits that generate simple rhythmic behaviors in vertebrates. Curr Opin Neurobiol (2005) 1.59
SnapShot: spinal cord development. Cell (2011) 1.56
A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity. Neuron (2004) 1.54
Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord. Neuron (2007) 1.52
Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet (2009) 1.48
Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice. Proc Natl Acad Sci U S A (2008) 1.48
Magnitude of binocular vision controlled by islet-2 repression of a genetic program that specifies laterality of retinal axon pathfinding. Cell (2004) 1.47
In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase. J Neurosci (2013) 1.47
Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function. J Clin Invest (2011) 1.46
Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling. J Biol Chem (2003) 1.44
Dynamics of Z-band based proteins in developing skeletal muscle cells. Cell Motil Cytoskeleton (2005) 1.43
Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis. Development (2003) 1.42
Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature (2012) 1.42
A regulatory network to segregate the identity of neuronal subtypes. Dev Cell (2008) 1.41
Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation. J Clin Invest (2013) 1.40
Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum. J Cell Sci (2009) 1.40
Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle. Am J Physiol Heart Circ Physiol (2005) 1.35
Cell-cell connection to cardiac disease. Trends Cardiovasc Med (2009) 1.34
Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium. Dev Biol (2006) 1.32
Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals. Cell Res (2011) 1.32
E-Tmod capping of actin filaments at the slow-growing end is required to establish mouse embryonic circulation. Am J Physiol Heart Circ Physiol (2003) 1.31
Motor axon pathfinding. Cold Spring Harb Perspect Biol (2010) 1.31
Rapid muscle-specific gene expression changes after a single bout of eccentric contractions in the mouse. Am J Physiol Cell Physiol (2003) 1.30
TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells. Genome Res (2012) 1.29
alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture. Circulation (2006) 1.28
PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes. Mol Cell Biol (2005) 1.27
Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. J Neurosci (2010) 1.25
Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility. Circulation (2013) 1.25
FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code. Neuron (2006) 1.25
FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner. J Clin Invest (2005) 1.25
Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle. Am J Physiol Cell Physiol (2007) 1.25
Reduced thin filament length in nebulin-knockout skeletal muscle alters isometric contractile properties. Am J Physiol Cell Physiol (2009) 1.24
MicroRNA expression signature in atrial fibrillation with mitral stenosis. Physiol Genomics (2011) 1.24
Expression of the hyperpolarization-activated cyclic nucleotide-gated cation channel HCN4 during mouse heart development. Gene Expr Patterns (2003) 1.24
A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C. J Biol Chem (2003) 1.23
Presenilin-dependent receptor processing is required for axon guidance. Cell (2011) 1.22