Published in FEBS Lett on January 30, 2003
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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science (2004) 19.19
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest (2004) 11.05
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science (2010) 9.61
Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med (2002) 9.01
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood (2002) 7.58
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet (2003) 5.82
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med (2007) 5.18
Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A (2005) 5.05
Regulation of iron metabolism by hepcidin. Annu Rev Nutr (2006) 3.96
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Hepcidin is decreased in TFR2 hemochromatosis. Blood (2004) 3.46
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Suppression of hepcidin during anemia requires erythropoietic activity. Blood (2006) 3.32
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The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell (2007) 2.99
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The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci U S A (2005) 2.10
Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood (2005) 2.08
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The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J Biol Chem (2002) 1.89
The role of hepcidin in iron metabolism. Acta Haematol (2009) 1.88
Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors. J Immunol (2003) 1.88
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Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans. Blood (2012) 1.85
Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology (2011) 1.82
Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J Immunol (2003) 1.82
Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. Blood (2007) 1.78
Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Blood Cells Mol Dis (2007) 1.76
Definition of the viral targets of protective HIV-1-specific T cell responses. J Transl Med (2011) 1.73
Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J Clin Invest (2007) 1.72
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Severe hemochromatosis in a Portuguese family associated with a new mutation in the 5'-UTR of the HAMP gene. Blood (2004) 1.64
Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae. BMC Infect Dis (2004) 1.63
The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood (2005) 1.60
Urinary hepcidin in congenital chronic anemias. Pediatr Blood Cancer (2007) 1.58
Cationic polypeptides are required for antibacterial activity of human airway fluid. J Immunol (2002) 1.58
Increased genomic copy number of DEFA1/DEFA3 is associated with susceptibility to severe sepsis in Chinese Han population. Anesthesiology (2010) 1.58
Involvement of hepcidin in the anemia of multiple myeloma. Clin Cancer Res (2008) 1.57
Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens. J Immunol (2006) 1.55
By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide. J Immunol (2003) 1.54
The molecular basis of hepcidin-resistant hereditary hemochromatosis. Blood (2009) 1.51
Beyond help: direct effector functions of human immunodeficiency virus type 1-specific CD4(+) T cells. J Virol (2004) 1.51
Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization. Haematologica (2009) 1.51
Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Blood (2012) 1.51
Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis. J Clin Endocrinol Metab (2010) 1.50
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. J Exp Med (2014) 1.49
Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload. J Clin Invest (2011) 1.49
Hepcidin and iron-loading anemias. Haematologica (2006) 1.49
Reduced serum hepcidin levels in patients with chronic hepatitis C. J Hepatol (2009) 1.48
Epitope-dependent avidity thresholds for cytotoxic T-lymphocyte clearance of virus-infected cells. J Virol (2007) 1.48
Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood (2004) 1.44
Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. Cell Metab (2012) 1.42
Differential regulation of beta-defensin expression in human skin by microbial stimuli. J Immunol (2005) 1.41
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Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions. Infect Immun (2005) 1.41
Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site. Blood Cells Mol Dis (2007) 1.40
The theta-defensin, retrocyclin, inhibits HIV-1 entry. AIDS Res Hum Retroviruses (2003) 1.40
Murine gammaherpesvirus 68 open reading frame 31 is required for viral replication. J Virol (2004) 1.40
Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis. Infect Immun (2006) 1.40
Clinical efficacy of gene-modified stem cells in adenosine deaminase-deficient immunodeficiency. J Clin Invest (2017) 1.39
Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function. Blood (2005) 1.38
Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project. Blood (2010) 1.37
Epitope escape mutation and decay of human immunodeficiency virus type 1-specific CTL responses. J Immunol (2003) 1.36
Antimicrobial factors in the cervical mucus plug. Am J Obstet Gynecol (2002) 1.35
Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes. J Immunol (2008) 1.34
A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin. Blood (2013) 1.34
Expression of antimicrobial defensins in the male reproductive tract of rats, mice, and humans. Biol Reprod (2003) 1.32
Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood (2012) 1.32
TGF-alpha regulates TLR expression and function on epidermal keratinocytes. J Immunol (2005) 1.31
Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor. J Clin Invest (2006) 1.30
Molecular and clinical correlates in iron overload associated with mutations in ferroportin. Haematologica (2006) 1.23
Biomimetic enzyme nanocomplexes and their use as antidotes and preventive measures for alcohol intoxication. Nat Nanotechnol (2013) 1.23
Requirement for deoxycytidine kinase in T and B lymphocyte development. Proc Natl Acad Sci U S A (2009) 1.23
Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors. Haematologica (2011) 1.21
Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis. Blood Cells Mol Dis (2007) 1.20
Inhibition of hepcidin transcription by growth factors. Hepatology (2012) 1.17
A biochemical fluorometric method for assessing the oxidative properties of HDL. J Lipid Res (2011) 1.17
Impacts of epitope expression kinetics and class I downregulation on the antiviral activity of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes. J Virol (2004) 1.17
HIV-1 adapts to a retrocyclin with cationic amino acid substitutions that reduce fusion efficiency of gp41. J Immunol (2006) 1.17