Published in J Biol Chem on January 31, 2003
The ADAMTS metalloproteinases. Biochem J (2005) 3.95
ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression. Dev Cell (2009) 2.20
ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein. FASEB J (2006) 1.43
The secreted metalloprotease ADAMTS20 is required for melanoblast survival. PLoS Genet (2008) 1.34
ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis. Arthritis Res Ther (2005) 1.30
ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein. J Biol Chem (2006) 1.27
A genomic analysis of rat proteases and protease inhibitors. Genome Res (2004) 1.27
Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage. Osteoarthritis Cartilage (2005) 1.24
The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis. Nat Clin Pract Rheumatol (2009) 1.20
Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma. Mol Cancer Res (2010) 1.19
Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation. Development (2010) 1.12
Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization. BMC Evol Biol (2005) 1.11
The role of ADAMTSs in arthritis. Protein Cell (2010) 1.03
Cancer models in Caenorhabditis elegans. Dev Dyn (2010) 0.98
Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate. PLoS Genet (2015) 0.95
Evolutionary divergence and functions of the ADAM and ADAMTS gene families. Hum Genomics (2009) 0.94
The secreted AdamTS-A metalloprotease is required for collective cell migration. Development (2013) 0.88
ADAMTS proteoglycanases in the physiological and pathological central nervous system. J Neuroinflammation (2013) 0.85
Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion? PLoS One (2011) 0.83
A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression. Genesis (2014) 0.82
ADAMTS-18: a metalloproteinase with multiple functions. Front Biosci (Landmark Ed) (2014) 0.82
Galnt1 is required for normal heart valve development and cardiac function. PLoS One (2015) 0.81
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation. Mediators Inflamm (2014) 0.79
Tissue architecture in the Caenorhabditis elegans gonad depends on interactions among fibulin-1, type IV collagen and the ADAMTS extracellular protease. Genetics (2012) 0.79
Regulation of synaptic extracellular matrix composition is critical for proper synapse morphology. J Neurosci (2014) 0.78
The Function and Roles of ADAMTS-7 in Inflammatory Diseases. Mediators Inflamm (2015) 0.75
The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases. Open Access Rheumatol (2009) 0.75
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
Signatures of mutational processes in human cancer. Nature (2013) 21.63
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
International network of cancer genome projects. Nature (2010) 20.35
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature (2011) 13.18
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet (2011) 6.43
Genome analysis of the platypus reveals unique signatures of evolution. Nature (2008) 5.74
Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer (2002) 5.57
Genomic instability in laminopathy-based premature aging. Nat Med (2005) 4.54
An immunosurveillance mechanism controls cancer cell ploidy. Science (2012) 4.35
Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem (2007) 4.22
Human and mouse proteases: a comparative genomic approach. Nat Rev Genet (2003) 4.02
Comparative and demographic analysis of orang-utan genomes. Nature (2011) 3.83
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nat Genet (2002) 3.78
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging. Nat Med (2008) 3.34
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature (2005) 3.31
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A (2004) 3.27
Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia. Nat Genet (2012) 3.08
The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. Oncogene (2005) 3.01
Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis. Blood (2008) 2.75
Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nat Genet (2003) 2.69
POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia. Nat Genet (2013) 2.62
Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins. J Biol Chem (2002) 2.31
Supercomplex assembly determines electron flux in the mitochondrial electron transport chain. Science (2013) 2.24
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol (2011) 2.23
Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies. Int J Dev Biol (2004) 2.23
Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. J Biol Chem (2002) 2.15
Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Biochem Biophys Res Commun (2004) 2.13
Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors. Hum Mol Genet (2005) 2.06
LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity. PLoS One (2007) 2.01
Landscape of somatic mutations and clonal evolution in mantle cell lymphoma. Proc Natl Acad Sci U S A (2013) 2.00
Autophagy is essential for mouse sense of balance. J Clin Invest (2010) 1.81
Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). FASEB J (2007) 1.74
Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models. Biochim Biophys Acta (2009) 1.73
A role of matrix metalloproteinase-8 in atherosclerosis. Circ Res (2009) 1.72
Matrix metalloproteinases and tumor progression. Adv Exp Med Biol (2003) 1.61
Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice. EMBO J (2012) 1.58
Matrix metalloproteinase-19 expression in dermal wounds and by fibroblasts in culture. J Invest Dermatol (2003) 1.57
Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion. Cancer Res (2008) 1.57
Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response. Genes Dev (2012) 1.54
Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia. Genome Res (2013) 1.51
Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome. Am J Hum Genet (2011) 1.51
Splicing-directed therapy in a new mouse model of human accelerated aging. Sci Transl Med (2011) 1.49
Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53. EMBO J (2011) 1.42
The Degradome database: mammalian proteases and diseases of proteolysis. Nucleic Acids Res (2008) 1.40
Premature aging in mice activates a systemic metabolic response involving autophagy induction. Hum Mol Genet (2008) 1.38
Nuclear envelope defects cause stem cell dysfunction in premature-aging mice. J Cell Biol (2008) 1.36
Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions. Blood (2005) 1.32
Both abscisic acid (ABA)-dependent and ABA-independent pathways govern the induction of NCED3, AAO3 and ABA1 in response to salt stress. Plant Cell Environ (2006) 1.31
Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis. Haematologica (2009) 1.27
A genomic analysis of rat proteases and protease inhibitors. Genome Res (2004) 1.27
Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function. Proc Natl Acad Sci U S A (2010) 1.21
Structural and enzymatic characterization of Drosophila Dm2-MMP, a membrane-bound matrix metalloproteinase with tissue-specific expression. J Biol Chem (2002) 1.21
Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. Blood (2011) 1.19
Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma. Mol Cancer Res (2010) 1.19
Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells. J Clin Invest (2009) 1.19
Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. Hum Mutat (2011) 1.14
Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells. Cell Cycle (2012) 1.14
The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway. J Cell Sci (2007) 1.13
Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors. Biol Chem (2004) 1.12
Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer. Cancer Res (2009) 1.10
Comparative analysis of cancer genes in the human and chimpanzee genomes. BMC Genomics (2006) 1.10
Defective extracellular pyrophosphate metabolism promotes vascular calcification in a mouse model of Hutchinson-Gilford progeria syndrome that is ameliorated on pyrophosphate treatment. Circulation (2013) 1.10
Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution. Cell Microbiol (2007) 1.09
MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO). J Clin Invest (2005) 1.07
Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient mice. Mol Cell Biol (2004) 1.06
Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease. Aging Cell (2010) 1.06
New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment. Front Pharmacol (2012) 1.05
The dual role of fibulins in tumorigenesis. Cancer Lett (2012) 1.03
Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells. PLoS One (2010) 1.02
Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection. PLoS Genet (2012) 1.02
Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer. Mol Cancer (2010) 1.02
Loss of genes implicated in gastric function during platypus evolution. Genome Biol (2008) 1.02
The evolutionary biography of chronic lymphocytic leukemia. Nat Genet (2013) 1.02
Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10. PLoS One (2010) 1.01
Comparative genomic analysis of human and chimpanzee proteases. Genomics (2005) 1.01
Néstor-Guillermo progeria syndrome: a novel premature aging condition with early onset and chronic development caused by BANF1 mutations. Am J Med Genet A (2011) 1.01
The functional and pathologic relevance of autophagy proteases. J Clin Invest (2015) 1.01
Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish. J Biol Chem (2004) 1.00
Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms. Hum Mol Genet (2009) 0.98
Reprogramming aging and progeria. Curr Opin Cell Biol (2012) 0.98
The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland. Genes Dev (2014) 0.98
Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice. J Biol Chem (2008) 0.98
Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas. Nat Commun (2013) 0.96